Rac2 (Rac family small GTPase 2) - Rat Genome Database

Name: Rac2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rac2 (Rac family small GTPase 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Rac2

Name:

Rac family small GTPase 2

RGD ID:

12527617

Description:

ENCODES a protein that exhibits GTP binding (inferred); GTPase activity (inferred); nucleotide binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); bone resorption (ortholog); cell population proliferation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adenylosuccinase lyase deficiency (ortholog); Chronic Periodontitis (ortholog); FOUND IN actin filament (inferred); cell projection (inferred); cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,715,942 - 10,727,556 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,726,313 - 3,736,905 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,726,375 - 3,737,961 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

adenylosuccinase lyase deficiency (ISO)

Chronic Periodontitis (ISO)

Disease Progression (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

heart disease (ISO)

immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis (ISO)

immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia (ISO)

immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia (ISO)

juvenile myelomonocytic leukemia (ISO)

lymphoma (ISO)

melanoma (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

prostate cancer (ISO)

severe combined immunodeficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

actin filament organization (IEA)

bone resorption (ISO)

cell population proliferation (IEA,ISO)

cell projection assembly (IEA,ISO)

chemotaxis (IEA,ISO)

cortical cytoskeleton organization (IEA)

engulfment of apoptotic cell (IEA)

erythrocyte enucleation (IEA,ISO)

establishment or maintenance of cell polarity (IEA)

G protein-coupled receptor signaling pathway (IEA,ISO)

lymphocyte aggregation (IEA)

mast cell proliferation (IEA,ISO)

mitotic cytokinesis (IEA)

motor neuron axon guidance (IEA)

positive regulation of lamellipodium assembly (IEA)

positive regulation of mast cell proliferation (IEA,ISO)

positive regulation of neutrophil chemotaxis (IEA)

positive regulation of protein targeting to mitochondrion (ISO)

regulation of actin cytoskeleton organization (IEA)

regulation of cell shape (IEA)

regulation of cell-substrate adhesion (IEA)

regulation of mast cell chemotaxis (IEA)

regulation of mast cell degranulation (IEA)

regulation of neutrophil migration (IEA)

regulation of respiratory burst (IEA)

regulation of T cell proliferation (IEA)

small GTPase-mediated signal transduction (IEA)

Cellular Component

actin filament (IEA)

cell projection (IEA)

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

cytoskeleton (IEA)

cytosol (IEA)

lamellipodium (IEA)

membrane (IEA)

nuclear envelope (IEA)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase binding (IEA)

protein kinase regulator activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Rac2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,715,942 - 10,727,556 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	3,726,313 - 3,736,905 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	3,726,375 - 3,737,961 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	37,225,270 - 37,244,269 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	37,225,270 - 37,259,594 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,621,310 - 37,640,309 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,951,256 - 35,970,251 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,945,811 - 35,964,805	NCBI
Celera	22	21,422,402 - 21,441,189 (-)	NCBI		Celera
Cytogenetic Map	22	q13.1	NCBI
HuRef	22	20,586,313 - 20,605,449 (-)	NCBI		HuRef
CHM1_1	22	37,580,533 - 37,599,298 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,685,220 - 37,704,752 (-)	NCBI		T2T-CHM13v2.0

Rac2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,443,369 - 78,456,983 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,443,367 - 78,456,983 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,559,169 - 78,572,783 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,559,167 - 78,572,783 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,389,599 - 78,403,213 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,386,424 - 78,400,038 (-)	NCBI		MGSCv36	mm8
Celera	15	80,021,772 - 80,035,664 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.57	NCBI

Rac2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,981,825 - 112,009,201 (-)	NCBI		GRCr8
mRatBN7.2	7	110,101,344 - 110,128,718 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	110,116,260 - 110,128,720 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,866,531 - 111,878,841 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	114,090,071 - 114,102,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	114,057,780 - 114,070,175 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,769,708 - 119,797,111 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,783,849 - 119,797,098 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,772,951 - 119,786,184 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,520,066 - 116,532,482 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,554,295 - 116,566,712 (-)	NCBI
Celera	7	106,454,216 - 106,466,547 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

Rac2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,693,669 - 23,710,704 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,697,504 - 23,710,668 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	47,081,028 - 47,101,554 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,769,608 - 49,790,116 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	18,138,517 - 18,159,023 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,973,229 - 35,992,026 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,973,229 - 35,992,026 (-)	Ensembl	panpan1.1		panPan2

RAC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,295,597 - 27,311,864 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,295,640 - 27,311,397 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,250,607 - 27,266,864 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,087,974 - 28,104,244 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,088,002 - 28,104,243 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	27,809,701 - 27,825,938 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,118,381 - 28,134,648 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,296,231 - 28,312,501 (+)	NCBI		UU_Cfam_GSD_1.0

RAC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,553,433 - 10,573,014 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,553,986 - 10,571,082 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,149,403 - 8,166,396 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,930,799 - 19,949,381 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,929,892 - 19,949,376 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	105,878,666 - 105,897,462 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rac2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,589,017 - 10,601,661 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,589,017 - 10,620,652 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005322279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000024659 ⟹ ENSSTOP00000016883

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936492	3,726,313 - 3,736,905 (+)	Ensembl

RefSeq Acc Id:

XM_005322279 ⟹ XP_005322336

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	10,715,942 - 10,727,556 (+)	NCBI
SpeTri2.0	NW_004936492	3,726,375 - 3,737,961 (+)	NCBI

Sequence:

show sequence

GTGGCTGCTCCTCGCTGCTGCTGGGGCACCTGCCAGCCTCTGCACACCCCTGGCGCCTGGGGAA
GCTCTCCTGCCCTGCGCTGTCACTGCCGTCCCTCAGGCCCGGACACAATGCAGGCCATCAAGTG
TGTGGTGGTGGGAGATGGAGCCGTGGGAAAGACCTGCCTCCTCATCAGCTACACCACCAACGCC
TTCCCAGGAGAGTACATCCCCACCGTGTTTGACAACTACTCAGCCAATGTGATGGTGGACAGCA
AGCCCGTGAACCTGGGGCTGTGGGACACGGCTGGCCAGGAGGACTACGACCGCCTGCGGCCACT
TTCCTACCCCCAGACGGACGTCTTCCTCATCTGCTTCTCCCTCGTCAGCCCGGCCTCCTACGAG
AACGTCCGCGCTAAGTGGTTCCCCGAGGTGCGGCACCACTGCCCCAGCACCCCCATCATCCTGG
TGGGCACCAAGCTGGACCTGAGGGACGACAAGGACACCATCGAGAGGCTGAAGGAGAAGAAGCT
GGCACCCATCACGTACCCCCAGGGCCTGGCCCTGGCCAAGGAGATAGACTCTGTCAAGTACCTG
GAGTGCTCGGCCCTCACCCAGCGGGGCCTGAAGACCGTCTTCGACGAGGCCATCCGCGCCGTCC
TGTGCCCCCAGCCCACGCGGCAGCAGAAGCGCCCCTGCAGCCTCCTCTAGGTGCCCAGCCCTCC
CTCCCGGCGGTCCTGACCCTCTGGGGTCCCTGTCCAAAGCCCGATGGCTCCGCGGCCGGCCTGT
CCCCTCCCTGTGACGTTTCTTATGATGGCTGCAGAGCTTGGCTGACCGTCTCCGCTGGACGGCC
CTGGGCCGGGTCCTGACCCCAGGCTCCTGCCTCCCCAGGGCCCAGGGCCCCAGGTCAAGGGCAG
CCCACGCCCCCCACCCCAGGCCCTCTCCACGTTGACCTTCAGGGACAGGGTCTCGCCCTGATAC
TGGGTCCTGCTTCTCTGAAAGTCAGGCTGAGCAATACAGGGCCTTCGAAGCGGCTCCCCTGCCC
CTCGTTCTCCTTCTTTGAGGCGATGTGAACAGGTCGGTTCTCTTCCTCTCTGTGGTGCCCTCCC
CGCGACCTTCCGCTCACTCCAGGACCCTGAGCGCATCCTCCTGGGAGAGCCCTCCGCTGCTCCT
GCTCTGCCCGACAGGACTCTGCTGCCGCAAGTAGAAAACCCCGTTCAAGCTTCTGAAGCAGAAA
ATAAATATATGGCTCCCGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005322336	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000016883.1
	ENSSTOP00000028740.1
GenBank Protein	KAG3290998	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005322336 ⟸ XM_005322279
- UniProtKB:	I3MXN8 (UniProtKB/TrEMBL), A0A287D5F4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDY DRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIER LKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRPCSLL hide sequence

RefSeq Acc Id:

ENSSTOP00000016883 ⟸ ENSSTOT00000024659

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006784	UniProtKB/TrEMBL
	ENSSTOG00000023766	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000024659.2	UniProtKB/TrEMBL
	ENSSTOT00000031495.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
	Small_GTPase_Rho	UniProtKB/TrEMBL
NCBI Gene	Rac2	ENTREZGENE
PANTHER	PTHR24072	UniProtKB/TrEMBL
	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2	UniProtKB/TrEMBL
	RAS-RELATED PROTEIN RAC1-RELATED	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A287D5F4	ENTREZGENE, UniProtKB/TrEMBL
	I3MXN8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-08-15	Rac2	Rac family small GTPase 2		ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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