Lrp5 (LDL receptor related protein 5) - Rat Genome Database

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Gene: Lrp5 (LDL receptor related protein 5) Chinchilla lanigera
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Symbol: Lrp5
Name: LDL receptor related protein 5
RGD ID: 9040848
Description: ENCODES a protein that exhibits coreceptor activity involved in Wnt signaling pathway (ortholog); toxin transmembrane transporter activity (ortholog); Wnt receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); Bone Fractures (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
anatomical structure regression  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
bone development  (ISO)
bone marrow development  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell migration involved in gastrulation  (ISO)
cell-cell signaling involved in mammary gland development  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
embryonic digit morphogenesis  (ISO)
extracellular matrix-cell signaling  (ISO)
gastrulation with mouth forming second  (ISO)
glucose catabolic process  (ISO)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
mesodermal cell migration  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
Norrin signaling pathway  (ISO)
osteoblast development  (ISO)
osteoblast proliferation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISO)
somatic stem cell population maintenance  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,298,412 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
T2T-CHM13v2.01168,317,024 - 68,454,184 (+)NCBI
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)Ensembl
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBI
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBI
ROS_Cfam_1.0 Ensembl1850,355,578 - 50,464,034 (-)Ensembl
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBI
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBI
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBI
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBI
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBIVero_WHO_p1.0
Lrp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,438,274 - 18,551,338 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000023916   ⟹   ENSCLAP00000023690
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000023917   ⟹   ENSCLAP00000023691
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542217,394,575 - 17,475,590 (-)Ensembl
RefSeq Acc Id: XM_013514225   ⟹   XP_013369679
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013514226   ⟹   XP_013369680
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013369679 (Get FASTA)   NCBI Sequence Viewer  
  XP_013369680 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013369680   ⟸   XM_013514226
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013369679   ⟸   XM_013514225
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000023690   ⟸   ENSCLAT00000023916
RefSeq Acc Id: ENSCLAP00000023691   ⟸   ENSCLAT00000023917
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000023690 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAP00000023691 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023916 ENTREZGENE, UniProtKB/TrEMBL
  ENSCLAT00000023917 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  LRP5/6 UniProtKB/TrEMBL
NCBI Gene Lrp5 ENTREZGENE
Pfam Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PIRSF LDL_recpt-rel_p5/6 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/TrEMBL
UniProt A0A8C2W431_CHILA UniProtKB/TrEMBL
  A0A8C2W624_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Lrp5  LDL receptor related protein 5    low density lipoprotein receptor-related protein 5  Symbol and/or name change 5135510 APPROVED