PARP2 (poly(ADP-ribose) polymerase 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PARP2 (poly(ADP-ribose) polymerase 2) Homo sapiens
Analyze
Symbol: PARP2
Name: poly(ADP-ribose) polymerase 2
RGD ID: 1602134
HGNC Page HGNC:272
Description: Enables several functions, including pentosyltransferase activity; poly-ADP-D-ribose binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Involved in DNA metabolic process; DNA repair-dependent chromatin remodeling; and protein auto-ADP-ribosylation. Located in nucleolus and nucleoplasm. Is active in site of DNA damage.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase diphtheria toxin-like 2; ADPRT-2; ADPRT2; ADPRTL2; ADPRTL3; ARTD2; DNA ADP-ribosyltransferase PARP2; hPARP-2; NAD(+) ADP-ribosyltransferase 2; pADPRT-2; PARP-2; poly (ADP-ribose) polymerase 2; poly (ADP-ribose) polymerase family, member 2; poly (ADP-ribosyl) transferase-like 2; poly [ADP-ribose] polymerase 2; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,343,635 - 20,357,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,343,615 - 20,357,904 (+)EnsemblGRCh38hg38GRCh38
GRCh371420,811,794 - 20,826,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,881,613 - 19,895,903 (+)NCBINCBI36Build 36hg18NCBI36
Celera14672,919 - 687,220 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14933,616 - 947,915 (+)NCBIHuRef
CHM1_11420,813,199 - 20,827,472 (+)NCBICHM1_1
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
nucleolus  (IBA,IDA,IEA)
nucleoplasm  (IDA,IEA)
nucleus  (IDA,IEA)
site of DNA damage  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, etal., Mol Cell. 2015 Jun 18;58(6):935-46. doi: 10.1016/j.molcel.2015.05.007.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Alpha-lipoic acid attenuates cardiac hypertrophy via downregulation of PARP-2 and subsequent activation of SIRT-1. Zhang L, etal., Eur J Pharmacol. 2014 Dec 5;744:203-10. doi: 10.1016/j.ejphar.2014.09.037. Epub 2014 Sep 30.
Additional References at PubMed
PMID:7260241   PMID:10329013   PMID:10338144   PMID:10364231   PMID:10644454   PMID:11948190   PMID:12065591   PMID:12217960   PMID:14699148   PMID:14702039   PMID:15615785   PMID:16344560  
PMID:16461352   PMID:17518695   PMID:18339380   PMID:18353725   PMID:18587655   PMID:18644123   PMID:18676401   PMID:19064572   PMID:19505873   PMID:19607827   PMID:19666485   PMID:19806447  
PMID:19913121   PMID:20092359   PMID:20504901   PMID:20522537   PMID:20628086   PMID:21577210   PMID:21812934   PMID:21825151   PMID:21873635   PMID:23291187   PMID:24365238   PMID:24782312  
PMID:25043379   PMID:25133494   PMID:25281560   PMID:25544563   PMID:25609649   PMID:25665578   PMID:25724268   PMID:25800440   PMID:26186194   PMID:26496610   PMID:26513298   PMID:26673720  
PMID:26674097   PMID:26704974   PMID:27067600   PMID:27087568   PMID:27248496   PMID:27300349   PMID:27471034   PMID:27609421   PMID:27708353   PMID:27926873   PMID:27965414   PMID:28190768  
PMID:28192407   PMID:28514442   PMID:28628639   PMID:29036662   PMID:29467415   PMID:29509190   PMID:30104678   PMID:30154076   PMID:30321391   PMID:30463901   PMID:30471916   PMID:30686591  
PMID:30804502   PMID:30833792   PMID:30880404   PMID:30940648   PMID:31076518   PMID:31129062   PMID:31266892   PMID:31470122   PMID:31473101   PMID:31527615   PMID:31741433   PMID:32028527  
PMID:32221289   PMID:32360251   PMID:32757651   PMID:32785980   PMID:32939087   PMID:33087277   PMID:33141820   PMID:33275888   PMID:33637726   PMID:33649352   PMID:33925170   PMID:33961781  
PMID:34051087   PMID:34066057   PMID:34108479   PMID:34199944   PMID:34210965   PMID:34731617   PMID:34732825   PMID:34795260   PMID:35271311   PMID:35944360   PMID:36215168   PMID:36424410  
PMID:36526897   PMID:36543142   PMID:36574265   PMID:36724073   PMID:37216533   PMID:37326017   PMID:37351597   PMID:38029688   PMID:38803224  


Genomics

Comparative Map Data
PARP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,343,635 - 20,357,904 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,343,615 - 20,357,904 (+)EnsemblGRCh38hg38GRCh38
GRCh371420,811,794 - 20,826,063 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361419,881,613 - 19,895,903 (+)NCBINCBI36Build 36hg18NCBI36
Celera14672,919 - 687,220 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef14933,616 - 947,915 (+)NCBIHuRef
CHM1_11420,813,199 - 20,827,472 (+)NCBICHM1_1
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBIT2T-CHM13v2.0
Parp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,045,347 - 51,058,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,045,298 - 51,058,758 (+)EnsemblGRCm39 Ensembl
GRCm381450,807,897 - 50,821,301 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,807,841 - 50,821,301 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,427,621 - 51,440,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361449,729,897 - 49,743,251 (+)NCBIMGSCv36mm8
Celera1447,099,033 - 47,112,197 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.25NCBI
Parp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,494,722 - 26,517,893 (+)NCBIGRCr8
mRatBN7.21524,034,069 - 24,044,340 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,034,106 - 24,044,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1526,805,300 - 26,815,532 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01527,764,036 - 27,774,257 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,013,838 - 26,024,070 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,739,416 - 27,749,650 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,739,251 - 27,749,648 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,571,841 - 31,582,075 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,790,296 - 26,801,086 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11526,806,027 - 26,816,785 (+)NCBI
Celera1524,353,597 - 24,363,829 (+)NCBICelera
Cytogenetic Map15p14NCBI
Parp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,140,460 - 1,151,491 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555501,138,976 - 1,152,293 (+)NCBIChiLan1.0ChiLan1.0
PARP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21521,850,677 - 21,864,950 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,067,164 - 21,081,440 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,215,727 - 1,230,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,268,986 - 19,282,960 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,269,046 - 19,282,853 (+)Ensemblpanpan1.1panPan2
PARP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,705,966 - 17,716,743 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,705,975 - 17,716,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,191,050 - 18,201,770 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01517,964,896 - 17,975,837 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1517,964,862 - 17,975,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,647,938 - 17,657,915 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,702,653 - 17,713,344 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,831,425 - 17,842,255 (+)NCBIUU_Cfam_GSD_1.0
Parp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,573,779 - 77,583,748 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936877554,473 - 564,903 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936877554,969 - 564,905 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,535,076 - 78,551,375 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,535,072 - 78,551,393 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,563,415 - 83,579,720 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12920,862,787 - 20,877,752 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2920,863,380 - 20,877,644 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,544,206 - 25,558,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,313,217 - 4,325,968 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,312,243 - 4,326,058 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PARP2
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2
pathogenic
GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1 copy number loss See cases [RCV000051483] Chr14:19755249..22741281 [GRCh38]
Chr14:20223408..23210490 [GRCh37]
Chr14:19293248..22280330 [NCBI36]
Chr14:14q11.2
pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12
pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q11.2(chr14:20127290-21376436)x3 copy number gain See cases [RCV000053804] Chr14:20127290..21376436 [GRCh38]
Chr14:20595449..21844595 [GRCh37]
Chr14:19665289..20914435 [NCBI36]
Chr14:14q11.2
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2(chr14:20289246-20418076)x3 copy number gain See cases [RCV000136784] Chr14:20289246..20418076 [GRCh38]
Chr14:20757405..20886235 [GRCh37]
Chr14:19827245..19956075 [NCBI36]
Chr14:14q11.2
benign
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3
pathogenic
GRCh37/hg19 14q11.2-12(chr14:19100682-28730087) copy number gain not provided [RCV000767822] Chr14:19100682..28730087 [GRCh37]
Chr14:14q11.2-12
pathogenic
GRCh37/hg19 14q11.2-12(chr14:19794561-27768254)x3 copy number gain See cases [RCV000240285] Chr14:19794561..27768254 [GRCh37]
Chr14:14q11.2-12
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3 copy number gain See cases [RCV000448273] Chr14:19794561..34049214 [GRCh37]
Chr14:14q11.2-13.1
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
NM_001042618.2(PARP2):c.1100A>G (p.Lys367Arg) single nucleotide variant not specified [RCV004305105] Chr14:20356030 [GRCh38]
Chr14:20824189 [GRCh37]
Chr14:14q11.2
uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2(chr14:20731947-20971784)x3 copy number gain not provided [RCV000750936] Chr14:20731947..20971784 [GRCh37]
Chr14:14q11.2
benign
GRCh37/hg19 14q11.2(chr14:20743269-20969733)x3 copy number gain not provided [RCV000750937] Chr14:20743269..20969733 [GRCh37]
Chr14:14q11.2
benign
NM_001042618.2(PARP2):c.477C>T (p.Ala159=) single nucleotide variant not provided [RCV000901959] Chr14:20351102 [GRCh38]
Chr14:20819261 [GRCh37]
Chr14:14q11.2
likely benign
NM_001042618.2(PARP2):c.37A>G (p.Arg13Gly) single nucleotide variant not specified [RCV004292623] Chr14:20343678 [GRCh38]
Chr14:20811837 [GRCh37]
Chr14:14q11.2
likely benign
NM_001042618.2(PARP2):c.443G>A (p.Ser148Asn) single nucleotide variant not provided [RCV000960551] Chr14:20351068 [GRCh38]
Chr14:20819227 [GRCh37]
Chr14:14q11.2
benign
NM_001042618.2(PARP2):c.1033T>C (p.Leu345=) single nucleotide variant not provided [RCV000960552] Chr14:20355963 [GRCh38]
Chr14:20824122 [GRCh37]
Chr14:14q11.2
benign
GRCh37/hg19 14q11.2(chr14:20511672-21174548)x3 copy number gain not provided [RCV000846276] Chr14:20511672..21174548 [GRCh37]
Chr14:14q11.2
uncertain significance
GRCh37/hg19 14q11.2(chr14:20511672-20903963)x3 copy number gain not provided [RCV000848234] Chr14:20511672..20903963 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1632T>C (p.Asn544=) single nucleotide variant not provided [RCV000909437] Chr14:20357716 [GRCh38]
Chr14:20825875 [GRCh37]
Chr14:14q11.2
benign
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3 copy number gain not provided [RCV001006605] Chr14:20511672..44829030 [GRCh37]
Chr14:14q11.2-21.2
pathogenic
NM_001042618.2(PARP2):c.665A>G (p.Asp222Gly) single nucleotide variant not provided [RCV001617039] Chr14:20354149 [GRCh38]
Chr14:20822308 [GRCh37]
Chr14:14q11.2
benign
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3 copy number gain not provided [RCV001249358] Chr14:20511672..42881888 [GRCh37]
Chr14:14q11.2-21.1
not provided
GRCh37/hg19 14q11.2(chr14:20511672-21915516)x1 copy number loss not provided [RCV001259176] Chr14:20511672..21915516 [GRCh37]
Chr14:14q11.2
pathogenic
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203) copy number gain Seizure [RCV002280625] Chr14:20511672..47481203 [GRCh37]
Chr14:14q11.2-21.3
pathogenic
NC_000014.9:g.20013858_20436718dup duplication 14q11.2 microduplication syndrome [RCV001837230] Chr14:20013858..20436718 [GRCh38]
Chr14:14q11.2
uncertain significance
GRCh37/hg19 14q11.2(chr14:20664697-21017250) copy number gain not specified [RCV002053087] Chr14:20664697..21017250 [GRCh37]
Chr14:14q11.2
uncertain significance
GRCh37/hg19 14q11.2(chr14:20690196-23114522)x1 copy number loss not provided [RCV002474574] Chr14:20690196..23114522 [GRCh37]
Chr14:14q11.2
pathogenic
NM_001042618.2(PARP2):c.841C>T (p.His281Tyr) single nucleotide variant not specified [RCV004220484] Chr14:20354886 [GRCh38]
Chr14:20823045 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1359G>A (p.Met453Ile) single nucleotide variant not specified [RCV004114794] Chr14:20357080 [GRCh38]
Chr14:20825239 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.455G>A (p.Cys152Tyr) single nucleotide variant not specified [RCV004131240] Chr14:20351080 [GRCh38]
Chr14:20819239 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1499A>G (p.His500Arg) single nucleotide variant not specified [RCV004123393] Chr14:20357466 [GRCh38]
Chr14:20825625 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.17G>C (p.Arg6Pro) single nucleotide variant not specified [RCV004145999] Chr14:20343658 [GRCh38]
Chr14:20811817 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1417C>G (p.Leu473Val) single nucleotide variant not specified [RCV004150317] Chr14:20357138 [GRCh38]
Chr14:20825297 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1670G>A (p.Arg557Gln) single nucleotide variant not specified [RCV004236668] Chr14:20357754 [GRCh38]
Chr14:20825913 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.202+13G>A single nucleotide variant not specified [RCV004167010] Chr14:20345100 [GRCh38]
Chr14:20813259 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.238C>G (p.Pro80Ala) single nucleotide variant not specified [RCV004190182] Chr14:20345429 [GRCh38]
Chr14:20813588 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.856A>G (p.Met286Val) single nucleotide variant not specified [RCV004082005] Chr14:20354901 [GRCh38]
Chr14:20823060 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.865T>C (p.Cys289Arg) single nucleotide variant not specified [RCV004280364] Chr14:20354910 [GRCh38]
Chr14:20823069 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.35G>T (p.Gly12Val) single nucleotide variant not specified [RCV004278008] Chr14:20343676 [GRCh38]
Chr14:20811835 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.425G>A (p.Gly142Glu) single nucleotide variant not specified [RCV004264848] Chr14:20351050 [GRCh38]
Chr14:20819209 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1526C>T (p.Ala509Val) single nucleotide variant not specified [RCV004276129] Chr14:20357493 [GRCh38]
Chr14:20825652 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.625G>C (p.Glu209Gln) single nucleotide variant not specified [RCV004258992] Chr14:20354109 [GRCh38]
Chr14:20822268 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.448G>A (p.Val150Met) single nucleotide variant not specified [RCV004250381] Chr14:20351073 [GRCh38]
Chr14:20819232 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.908G>A (p.Arg303His) single nucleotide variant not specified [RCV004331520] Chr14:20355757 [GRCh38]
Chr14:20823916 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.955C>G (p.Gln319Glu) single nucleotide variant not specified [RCV004360478] Chr14:20355804 [GRCh38]
Chr14:20823963 [GRCh37]
Chr14:14q11.2
uncertain significance
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1
pathogenic
GRCh37/hg19 14q11.2(chr14:20511672-20903963)x3 copy number gain not specified [RCV003987062] Chr14:20511672..20903963 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.19C>G (p.Arg7Gly) single nucleotide variant not specified [RCV004502646] Chr14:20343660 [GRCh38]
Chr14:20811819 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.202+37C>G single nucleotide variant not specified [RCV004502647] Chr14:20345124 [GRCh38]
Chr14:20813283 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1297G>A (p.Ala433Thr) single nucleotide variant not specified [RCV004502643] Chr14:20356657 [GRCh38]
Chr14:20824816 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.815T>C (p.Ile272Thr) single nucleotide variant not specified [RCV004502649] Chr14:20354860 [GRCh38]
Chr14:20823019 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.857T>C (p.Met286Thr) single nucleotide variant not specified [RCV004502650] Chr14:20354902 [GRCh38]
Chr14:20823061 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1250C>A (p.Ser417Tyr) single nucleotide variant not specified [RCV004502642] Chr14:20356610 [GRCh38]
Chr14:20824769 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.1546G>A (p.Val516Ile) single nucleotide variant not specified [RCV004502645] Chr14:20357513 [GRCh38]
Chr14:20825672 [GRCh37]
Chr14:14q11.2
likely benign
NM_001042618.2(PARP2):c.1147G>A (p.Asp383Asn) single nucleotide variant not specified [RCV004502641] Chr14:20356352 [GRCh38]
Chr14:20824511 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.143A>C (p.Lys48Thr) single nucleotide variant not specified [RCV004502644] Chr14:20345028 [GRCh38]
Chr14:20813187 [GRCh37]
Chr14:14q11.2
uncertain significance
NM_001042618.2(PARP2):c.301G>A (p.Val101Ile) single nucleotide variant not specified [RCV004502648] Chr14:20346890 [GRCh38]
Chr14:20815049 [GRCh37]
Chr14:14q11.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1319
Count of miRNA genes:660
Interacting mature miRNAs:739
Transcripts:ENST00000250416, ENST00000429687, ENST00000527384, ENST00000527915, ENST00000528465, ENST00000529465, ENST00000530598, ENST00000532299, ENST00000534664, ENST00000539930, ENST00000555140
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G24108  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371420,825,925 - 20,826,030UniSTSGRCh37
Build 361419,895,765 - 19,895,870RGDNCBI36
Celera14687,082 - 687,187RGD
Cytogenetic Map14q11.2-q12UniSTS
HuRef14947,777 - 947,882UniSTS
G31064  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371420,825,895 - 20,826,030UniSTSGRCh37
Build 361419,895,735 - 19,895,870RGDNCBI36
Celera14687,052 - 687,187RGD
Cytogenetic Map14q11.2-q12UniSTS
HuRef14947,747 - 947,882UniSTS
RH93704  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371420,825,620 - 20,825,808UniSTSGRCh37
Build 361419,895,460 - 19,895,648RGDNCBI36
Celera14686,777 - 686,965RGD
Cytogenetic Map14q11.2-q12UniSTS
HuRef14947,472 - 947,660UniSTS
GeneMap99-GB4 RH Map140.0UniSTS
G59489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371420,825,925 - 20,826,029UniSTSGRCh37
Build 361419,895,765 - 19,895,869RGDNCBI36
Celera14687,082 - 687,186RGD
Cytogenetic Map14q11.2-q12UniSTS
HuRef14947,777 - 947,881UniSTS
TNG Radiation Hybrid Map14176.0UniSTS
G36285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371420,819,155 - 20,819,264UniSTSGRCh37
Build 361419,888,995 - 19,889,104RGDNCBI36
Celera14680,300 - 680,409RGD
Cytogenetic Map14q11.2-q12UniSTS
HuRef14940,991 - 941,100UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2286 1746 1447 357 1163 204 4268 1827 3319 250 1408 1569 167 1093 2717 3
Low 152 1217 279 267 761 261 88 368 407 168 45 43 8 1 111 71 2 2
Below cutoff 1 27 26 8 1 7 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001042618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047430869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF085734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF479321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ236876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ236912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK001980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL355075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX008892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU541261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA354586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000250416   ⟹   ENSP00000250416
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,343,615 - 20,357,904 (+)Ensembl
RefSeq Acc Id: ENST00000429687   ⟹   ENSP00000392972
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,343,635 - 20,357,904 (+)Ensembl
RefSeq Acc Id: ENST00000527384
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,354,642 - 20,355,955 (+)Ensembl
RefSeq Acc Id: ENST00000527915   ⟹   ENSP00000432283
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,343,637 - 20,357,903 (+)Ensembl
RefSeq Acc Id: ENST00000528465
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,350,699 - 20,354,108 (+)Ensembl
RefSeq Acc Id: ENST00000529465   ⟹   ENSP00000431867
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,343,628 - 20,354,947 (+)Ensembl
RefSeq Acc Id: ENST00000530598
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,355,796 - 20,357,509 (+)Ensembl
RefSeq Acc Id: ENST00000532299
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,355,161 - 20,356,392 (+)Ensembl
RefSeq Acc Id: ENST00000534664
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,355,910 - 20,356,750 (+)Ensembl
RefSeq Acc Id: ENST00000539930   ⟹   ENSP00000445524
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,355,782 - 20,357,776 (+)Ensembl
RefSeq Acc Id: ENST00000555140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1420,352,513 - 20,354,123 (+)Ensembl
RefSeq Acc Id: NM_001042618   ⟹   NP_001036083
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,343,635 - 20,357,904 (+)NCBI
GRCh371420,811,773 - 20,826,063 (+)ENTREZGENE
Build 361419,881,613 - 19,895,903 (+)NCBI Archive
HuRef14933,616 - 947,915 (+)ENTREZGENE
CHM1_11420,813,199 - 20,827,472 (+)NCBI
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005484   ⟹   NP_005475
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,343,635 - 20,357,904 (+)NCBI
GRCh371420,811,773 - 20,826,063 (+)ENTREZGENE
Build 361419,881,613 - 19,895,903 (+)NCBI Archive
HuRef14933,616 - 947,915 (+)ENTREZGENE
CHM1_11420,813,199 - 20,827,472 (+)NCBI
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005267247   ⟹   XP_005267304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,343,635 - 20,357,904 (+)NCBI
GRCh371420,811,773 - 20,826,063 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020912   ⟹   XP_016876401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,343,635 - 20,357,904 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047430869   ⟹   XP_047286825
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,354,147 - 20,357,904 (+)NCBI
RefSeq Acc Id: XM_054375240   ⟹   XP_054231215
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBI
RefSeq Acc Id: XM_054375241   ⟹   XP_054231216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01414,540,530 - 14,554,811 (+)NCBI
RefSeq Acc Id: XM_054375242   ⟹   XP_054231217
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01414,551,049 - 14,554,811 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001036083 (Get FASTA)   NCBI Sequence Viewer  
  NP_005475 (Get FASTA)   NCBI Sequence Viewer  
  XP_005267304 (Get FASTA)   NCBI Sequence Viewer  
  XP_016876401 (Get FASTA)   NCBI Sequence Viewer  
  XP_047286825 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189115 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189116 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189117 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231215 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231216 (Get FASTA)   NCBI Sequence Viewer  
  XP_054231217 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD29857 (Get FASTA)   NCBI Sequence Viewer  
  AAL77437 (Get FASTA)   NCBI Sequence Viewer  
  BAA92017 (Get FASTA)   NCBI Sequence Viewer  
  BAF82768 (Get FASTA)   NCBI Sequence Viewer  
  BAG62594 (Get FASTA)   NCBI Sequence Viewer  
  CAB41505 (Get FASTA)   NCBI Sequence Viewer  
  CAB65088 (Get FASTA)   NCBI Sequence Viewer  
  CAC07442 (Get FASTA)   NCBI Sequence Viewer  
  EAW66476 (Get FASTA)   NCBI Sequence Viewer  
  EAW66477 (Get FASTA)   NCBI Sequence Viewer  
  EAW66478 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000250416
  ENSP00000250416.5
  ENSP00000392972
  ENSP00000392972.3
  ENSP00000431867.2
  ENSP00000432283.1
  ENSP00000445524.1
  ENSP00000517361.1
  ENSP00000517362.1
GenBank Protein Q9UGN5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_005475   ⟸   NM_005484
- Peptide Label: isoform 1
- UniProtKB: Q9UMR4 (UniProtKB/Swiss-Prot),   Q9NUV2 (UniProtKB/Swiss-Prot),   Q9Y6C8 (UniProtKB/Swiss-Prot),   Q9UGN5 (UniProtKB/Swiss-Prot),   Q8TEU4 (UniProtKB/Swiss-Prot),   A8K214 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001036083   ⟸   NM_001042618
- Peptide Label: isoform 2
- UniProtKB: A8K214 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005267304   ⟸   XM_005267247
- Peptide Label: isoform X1
- UniProtKB: G3V167 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016876401   ⟸   XM_017020912
- Peptide Label: isoform X2
- UniProtKB: G3V167 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000392972   ⟸   ENST00000429687
RefSeq Acc Id: ENSP00000445524   ⟸   ENST00000539930
RefSeq Acc Id: ENSP00000432283   ⟸   ENST00000527915
RefSeq Acc Id: ENSP00000250416   ⟸   ENST00000250416
RefSeq Acc Id: ENSP00000431867   ⟸   ENST00000529465
RefSeq Acc Id: XP_047286825   ⟸   XM_047430869
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054231215   ⟸   XM_054375240
- Peptide Label: isoform X1
- UniProtKB: G3V167 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231216   ⟸   XM_054375241
- Peptide Label: isoform X2
- UniProtKB: G3V167 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054231217   ⟸   XM_054375242
- Peptide Label: isoform X3
Protein Domains
PARP alpha-helical   PARP catalytic   WGR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UGN5-F1-model_v2 AlphaFold Q9UGN5 1-583 view protein structure

Promoters
RGD ID:6791784
Promoter ID:HG_KWN:18754
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001042618,   NM_005484,   UC001VXB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361419,881,084 - 19,881,584 (+)MPROMDB
RGD ID:7226949
Promoter ID:EPDNEW_H19220
Type:initiation region
Name:PARP2_1
Description:poly(ADP-ribose) polymerase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381420,343,635 - 20,343,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:272 AgrOrtholog
COSMIC PARP2 COSMIC
Ensembl Genes ENSG00000129484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000291803 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000250416 ENTREZGENE
  ENST00000250416.9 UniProtKB/Swiss-Prot
  ENST00000429687 ENTREZGENE
  ENST00000429687.8 UniProtKB/Swiss-Prot
  ENST00000527915.5 UniProtKB/TrEMBL
  ENST00000529465.6 UniProtKB/TrEMBL
  ENST00000539930.1 UniProtKB/TrEMBL
  ENST00000708822.1 UniProtKB/Swiss-Prot
  ENST00000708823.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.142.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WGR domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000129484 GTEx
  ENSG00000291803 GTEx
HGNC ID HGNC:272 ENTREZGENE
Human Proteome Map PARP2 Human Proteome Map
InterPro Poly(ADP-ribose)pol_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WGR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WGR_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10038 UniProtKB/Swiss-Prot
NCBI Gene 10038 ENTREZGENE
OMIM 607725 OMIM
PANTHER DNA LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POLY [ADP-RIBOSE] POLYMERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PARP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARP_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24592 PharmGKB
PROSITE PARP_ALPHA_HD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF142921 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47587 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K214 ENTREZGENE, UniProtKB/TrEMBL
  E9PJ27_HUMAN UniProtKB/TrEMBL
  G3V167 ENTREZGENE, UniProtKB/TrEMBL
  H0YH02_HUMAN UniProtKB/TrEMBL
  PARP2_HUMAN UniProtKB/Swiss-Prot
  Q8TEU4 ENTREZGENE
  Q9NUV2 ENTREZGENE
  Q9UGN5 ENTREZGENE
  Q9UMR4 ENTREZGENE
  Q9Y6C8 ENTREZGENE
UniProt Secondary Q8TEU4 UniProtKB/Swiss-Prot
  Q9NUV2 UniProtKB/Swiss-Prot
  Q9UMR4 UniProtKB/Swiss-Prot
  Q9Y6C8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-10 PARP2  poly(ADP-ribose) polymerase 2  PARP2  poly (ADP-ribose) polymerase 2  Symbol and/or name change 5135510 APPROVED
2015-11-10 PARP2  poly(ADP-ribose) polymerase 2  PARP2  poly (ADP-ribose) polymerase 2  Symbol and/or name change 5135510 APPROVED