Art2a (ADP-ribosyltransferase 2a) - Rat Genome Database

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Gene: Art2a (ADP-ribosyltransferase 2a) Mus musculus
Analyze
Symbol: Art2a
Name: ADP-ribosyltransferase 2a
RGD ID: 11210
MGI Page MGI
Description: Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosyltransferase 2a pseudogene; ADP-ribosyltransferase 2a, pseudogene; ADP-ribosyltransferase C2 and C3 toxin-like 2; Art; Art2a-ps; ARTC2; Ly92a; mono(ADP-ribosyl)transferase 2A; NAD(+) glycohydrolase; Rt; Rt-; Rt-6; Rt6; Rt6-; Rt6-1; T-cell differentiation marker Rt6 homolog 1; T-cell ecto-ADP-ribosyltransferase 1; T-cell mono(ADP-ribosyl)transferase 1; T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 1
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,201,657 - 101,210,072 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,201,660 - 101,210,072 (-)EnsemblGRCm39 Ensembl
GRCm387101,552,453 - 101,560,865 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,552,453 - 101,560,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,700,967 - 108,709,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,426,597 - 101,429,623 (-)NCBIMGSCv36mm8
Celera7101,916,272 - 101,923,770 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1671854   PMID:2362814   PMID:7547715   PMID:7966280   PMID:8605984   PMID:8631807   PMID:8811076   PMID:8812442   PMID:9300695   PMID:9722956   PMID:9841866   PMID:9914505  
PMID:10349636   PMID:10369930   PMID:10585447   PMID:11011142   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11587854   PMID:12070318   PMID:12370300   PMID:12466851   PMID:12477932  
PMID:15749861   PMID:16141072   PMID:16141073   PMID:16261419   PMID:16455971   PMID:16585549   PMID:16920929   PMID:17579037   PMID:17947697   PMID:19542469   PMID:20975043   PMID:21357538  
PMID:21873635   PMID:22781627   PMID:23575529   PMID:29463868  


Genomics

Comparative Map Data
Art2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,201,657 - 101,210,072 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,201,660 - 101,210,072 (-)EnsemblGRCm39 Ensembl
GRCm387101,552,453 - 101,560,865 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,552,453 - 101,560,865 (-)EnsemblGRCm38mm10GRCm38
MGSCv377108,700,967 - 108,709,379 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367101,426,597 - 101,429,623 (-)NCBIMGSCv36mm8
Celera7101,916,272 - 101,923,770 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.6NCBI
ART2P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,520,951 - 72,521,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,519,986 - 72,521,733 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,231,995 - 72,232,684 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,909,643 - 71,910,332 (+)NCBINCBI36Build 36hg18NCBI36
Celera1169,533,947 - 69,534,636 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,524,718 - 68,525,407 (+)NCBIHuRef
CHM1_11172,115,306 - 72,115,995 (+)NCBICHM1_1
T2T-CHM13v2.01172,447,428 - 72,448,117 (+)NCBIT2T-CHM13v2.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:538
Count of miRNA genes:381
Interacting mature miRNAs:434
Transcripts:ENSMUST00000173420
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000173420   ⟹   ENSMUSP00000134404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7101,201,660 - 101,210,072 (-)Ensembl
GRCm38.p6 Ensembl7101,552,453 - 101,560,865 (-)Ensembl
Ensembl Acc Id: ENSMUST00000249068   ⟹   ENSMUSP00000159553
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7101,201,931 - 101,205,103 (-)Ensembl
RefSeq Acc Id: NR_033804
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397101,201,657 - 101,210,072 (-)NCBI
GRCm387101,552,453 - 101,560,865 (-)ENTREZGENE
MGSCv377108,700,967 - 108,709,379 (-)RGD
Celera7101,916,272 - 101,923,770 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Ensembl Acc Id: ENSMUSP00000134404   ⟸   ENSMUST00000173420
Ensembl Acc Id: ENSMUSP00000159553   ⟸   ENSMUST00000249068
Protein Domains
TR mART core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17981-F1-model_v2 AlphaFold P17981 1-287 view protein structure

Promoters
RGD ID:8664971
Promoter ID:EPDNEW_M10517
Type:single initiation site
Name:Art2a-ps_1
Description:Mus musculus ADP-ribosyltransferase 2a, pseudogene (Art2a-ps),transcript variant 1, non-coding, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387101,560,865 - 101,560,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107546 AgrOrtholog
Ensembl Genes ENSMUSG00000092517 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000173420 ENTREZGENE
InterPro ADP-ribosyltransferase_ARG UniProtKB/Swiss-Prot
  ART UniProtKB/Swiss-Prot
KEGG Report mmu:11871 UniProtKB/Swiss-Prot
MGD MGI:107546 ENTREZGENE
NCBI Gene 11871 ENTREZGENE
PANTHER ADP-RIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
  T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 1-RELATED UniProtKB/Swiss-Prot
Pfam ART UniProtKB/Swiss-Prot
PhenoGen Art2a PhenoGen
PRINTS RIBTRNSFRASE UniProtKB/Swiss-Prot
PROSITE ART UniProtKB/Swiss-Prot
  TR_MART UniProtKB/Swiss-Prot
Superfamily-SCOP ADP-ribosylation UniProtKB/Swiss-Prot
UniProt NAR2A_MOUSE UniProtKB/Swiss-Prot
  O35278 ENTREZGENE
  P17981 ENTREZGENE
  Q0VB79 ENTREZGENE
  Q64173 ENTREZGENE
UniProt Secondary O35278 UniProtKB/Swiss-Prot
  Q0VB79 UniProtKB/Swiss-Prot
  Q64173 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-03-19 Art2a  ADP-ribosyltransferase 2a  Art2a-ps  ADP-ribosyltransferase 2a, pseudogene  Symbol and/or name change 5135510 APPROVED
2011-07-27 Art2a-ps  ADP-ribosyltransferase 2a, pseudogene  Art2a  ADP-ribosyltransferase 2a  Symbol and/or name change 5135510 APPROVED