MTARC2 (mitochondrial amidoxime reducing component 2) - Rat Genome Database

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Gene: MTARC2 (mitochondrial amidoxime reducing component 2) Homo sapiens
Analyze
Symbol: MTARC2
Name: mitochondrial amidoxime reducing component 2
RGD ID: 1606267
HGNC Page HGNC:26064
Description: Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FLJ20605; MARC2; moco sulfurase C-terminal domain-containing protein 2; MOCO sulphurase C-terminal domain containing 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2; MOSC domain-containing protein 2; MOSC domain-containing protein 2, mitochondrial; MOSC2; RP11-270A6.1
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: MTARC2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,748,322 - 220,784,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,748,225 - 220,784,815 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,921,664 - 220,958,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,988,299 - 219,024,222 (+)NCBINCBI36Build 36hg18NCBI36
Celera1194,141,035 - 194,176,957 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1191,596,292 - 191,632,216 (+)NCBIHuRef
CHM1_11222,194,135 - 222,230,058 (+)NCBICHM1_1
T2T-CHM13v2.01219,988,028 - 220,024,522 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11076863   PMID:11230166   PMID:11256614   PMID:11886751   PMID:12477932   PMID:14702039   PMID:15342556   PMID:15489334   PMID:15489336   PMID:16381901   PMID:16710414   PMID:16973608  
PMID:19875103   PMID:20379614   PMID:20808825   PMID:20861021   PMID:20877624   PMID:21029045   PMID:21803866   PMID:21873635   PMID:21916412   PMID:22924387   PMID:23086957   PMID:23376485  
PMID:23703616   PMID:24423752   PMID:24500710   PMID:25045021   PMID:25425164   PMID:25713076   PMID:26186194   PMID:26378779   PMID:26760575   PMID:28057766   PMID:28514442   PMID:29568061  
PMID:29676528   PMID:31617661   PMID:31871319   PMID:32877691   PMID:33087821   PMID:33961781   PMID:34079125   PMID:34315543   PMID:35256949   PMID:36538041   PMID:37774976  


Genomics

Comparative Map Data
MTARC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,748,322 - 220,784,815 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,748,225 - 220,784,815 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,921,664 - 220,958,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,988,299 - 219,024,222 (+)NCBINCBI36Build 36hg18NCBI36
Celera1194,141,035 - 194,176,957 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1191,596,292 - 191,632,216 (+)NCBIHuRef
CHM1_11222,194,135 - 222,230,058 (+)NCBICHM1_1
T2T-CHM13v2.01219,988,028 - 220,024,522 (+)NCBIT2T-CHM13v2.0
Mtarc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,545,263 - 184,579,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,545,265 - 184,578,648 (-)EnsemblGRCm39 Ensembl
GRCm381184,813,066 - 184,846,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,813,068 - 184,846,451 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,636,947 - 186,669,726 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,513,856 - 186,546,635 (-)NCBIMGSCv36mm8
Celera1191,775,533 - 191,808,292 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.12NCBI
Mtarc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81398,894,347 - 98,928,754 (-)NCBIGRCr8
mRatBN7.21396,362,810 - 96,397,284 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1398,871,474 - 98,903,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,270,651 - 100,302,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,453,707 - 97,485,716 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013102,724,266 - 102,755,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13102,724,348 - 102,756,174 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,401,548 - 107,432,904 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413100,809,306 - 100,838,648 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113100,998,348 - 101,027,691NCBI
Celera1395,883,189 - 95,914,342 (-)NCBICelera
Cytogenetic Map13q26NCBI
MTARC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2128,615,340 - 28,654,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1128,577,172 - 28,616,492 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01196,333,803 - 196,371,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11201,368,306 - 201,405,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1201,369,424 - 201,405,602 (+)Ensemblpanpan1.1panPan2
MTARC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13815,426,884 - 15,451,701 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3815,426,666 - 15,451,136 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3815,457,261 - 15,493,511 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03815,451,758 - 15,487,926 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3815,451,494 - 15,522,862 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13815,459,348 - 15,495,474 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,813,447 - 15,849,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03816,106,377 - 16,142,896 (+)NCBIUU_Cfam_GSD_1.0
Mtarc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,258,120 - 56,295,420 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366501,506,329 - 1,543,712 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366501,506,471 - 1,543,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTARC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1010,156,728 - 10,189,924 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11010,156,732 - 10,194,371 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21012,363,633 - 12,387,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTARC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,745,754 - 8,782,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,748,605 - 8,782,379 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,029,599 - 9,066,624 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtarc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248354,146,766 - 4,163,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248354,146,910 - 4,163,292 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MTARC2
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q41(chr1:215206760-222004068)x1 copy number loss See cases [RCV000050298] Chr1:215206760..222004068 [GRCh38]
Chr1:215380103..222177410 [GRCh37]
Chr1:213446726..220244033 [NCBI36]
Chr1:1q41
pathogenic
GRCh38/hg38 1q32.3-44(chr1:214023812-248918469)x3 copy number gain See cases [RCV000050981] Chr1:214023812..248918469 [GRCh38]
Chr1:214197155..249212668 [GRCh37]
Chr1:212263778..247179291 [NCBI36]
Chr1:1q32.3-44
pathogenic
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.2-44(chr1:209646207-248931113)x3 copy number gain See cases [RCV000051861] Chr1:209646207..248931113 [GRCh38]
Chr1:209819552..249225312 [GRCh37]
Chr1:207886175..247191935 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41(chr1:215447347-221971832)x3 copy number gain See cases [RCV000051874] Chr1:215447347..221971832 [GRCh38]
Chr1:215620690..222145174 [GRCh37]
Chr1:213687313..220211797 [NCBI36]
Chr1:1q41
pathogenic
NM_017898.3(MARC2):c.273-2415G>A single nucleotide variant Lung cancer [RCV000090532] Chr1:220752532 [GRCh38]
Chr1:220925874 [GRCh37]
Chr1:1q41
uncertain significance
GRCh38/hg38 1q32.2-44(chr1:209963625-248918469)x3 copy number gain See cases [RCV000134979] Chr1:209963625..248918469 [GRCh38]
Chr1:210136970..249212668 [GRCh37]
Chr1:208203593..247179291 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41(chr1:220673535-223683512)x1 copy number loss See cases [RCV000135795] Chr1:220673535..223683512 [GRCh38]
Chr1:220846877..223871214 [GRCh37]
Chr1:218913500..221937837 [NCBI36]
Chr1:1q41
pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh38/hg38 1q32.2-44(chr1:207346642-248930485)x3 copy number gain See cases [RCV000143727] Chr1:207346642..248930485 [GRCh38]
Chr1:207519987..249224684 [GRCh37]
Chr1:205586610..247191307 [NCBI36]
Chr1:1q32.2-44
pathogenic
GRCh38/hg38 1q41(chr1:215206760-222004068)x1 copy number loss See cases [RCV000148255] Chr1:215206760..222004068 [GRCh38]
Chr1:215380103..222177410 [GRCh37]
Chr1:213446726..220244033 [NCBI36]
Chr1:1q41
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
Single allele deletion Loeys-Dietz syndrome 4 [RCV000210452] Chr1:215588712..222145072 [GRCh37]
Chr1:1q41
pathogenic
Single allele deletion Usher syndrome [RCV000505151] Chr1:216066818..222607612 [GRCh38]
Chr1:216240159..222780953 [GRCh37]
Chr1:1q41
likely pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q41-44(chr1:214697099-249224684)x3 copy number gain See cases [RCV000449210] Chr1:214697099..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q41-44(chr1:218252551-249224684)x3 copy number gain not provided [RCV000684700] Chr1:218252551..249224684 [GRCh37]
Chr1:1q41-44
pathogenic
GRCh37/hg19 1q41(chr1:220659314-220984506)x1 copy number loss not provided [RCV000684704] Chr1:220659314..220984506 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1q41(chr1:219379258-222049547)x3 copy number gain not provided [RCV000848714] Chr1:219379258..222049547 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q41-42.11(chr1:219734913-224104993)x1 copy number loss not provided [RCV001005174] Chr1:219734913..224104993 [GRCh37]
Chr1:1q41-42.11
pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
NM_017898.5(MTARC2):c.911G>A (p.Arg304Lys) single nucleotide variant Inborn genetic diseases [RCV003293221] Chr1:220781804 [GRCh38]
Chr1:220955146 [GRCh37]
Chr1:1q41
likely benign
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44
pathogenic
GRCh37/hg19 1q41-43(chr1:219916966-239004378)x3 copy number gain not provided [RCV001005175] Chr1:219916966..239004378 [GRCh37]
Chr1:1q41-43
pathogenic
GRCh37/hg19 1q32.2-44(chr1:210152794-249218992)x3 copy number gain See cases [RCV001194578] Chr1:210152794..249218992 [GRCh37]
Chr1:1q32.2-44
pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44
uncertain significance
Single allele deletion Loeys-Dietz syndrome 4 [RCV001837015] Chr1:215199578..223035427 [GRCh37]
Chr1:1q41
pathogenic
NC_000001.10:g.(?_218520044)_(220986760_?)del deletion Martsolf syndrome [RCV003116596] Chr1:218520044..220986760 [GRCh37]
Chr1:1q41
pathogenic
NC_000001.10:g.(?_220088791)_(220986760_?)dup duplication not provided [RCV003119870] Chr1:220088791..220986760 [GRCh37]
Chr1:1q41
uncertain significance
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44
pathogenic
NM_017898.5(MTARC2):c.563G>C (p.Gly188Ala) single nucleotide variant Inborn genetic diseases [RCV003262558] Chr1:220761774 [GRCh38]
Chr1:220935116 [GRCh37]
Chr1:1q41
uncertain significance
GRCh38/hg38 1q32.2-42.13(chr1:228006998-228061271)x2 copy number loss Orofacial cleft 2 [RCV002481175] Chr1:228006998..228061271 [GRCh38]
Chr1:1q32.2-42.13
association
GRCh37/hg19 1q41(chr1:214853277-222111742)x1 copy number loss not provided [RCV003484033] Chr1:214853277..222111742 [GRCh37]
Chr1:1q41
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1092
Count of miRNA genes:717
Interacting mature miRNAs:797
Transcripts:ENST00000359316, ENST00000366913, ENST00000425560, ENST00000469583, ENST00000472447, ENST00000496078
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-76375  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371220,957,889 - 220,957,993UniSTSGRCh37
Build 361219,024,512 - 219,024,616RGDNCBI36
Celera1194,177,247 - 194,177,351RGD
Cytogenetic Map1q41UniSTS
HuRef1191,632,506 - 191,632,610UniSTS
TNG Radiation Hybrid Map1109611.0UniSTS
GeneMap99-GB4 RH Map1706.23UniSTS
RH122974  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371220,950,623 - 220,950,908UniSTSGRCh37
Build 361219,017,246 - 219,017,531RGDNCBI36
Celera1194,169,981 - 194,170,266RGD
Cytogenetic Map1q41UniSTS
HuRef1191,625,239 - 191,625,524UniSTS
TNG Radiation Hybrid Map1109617.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2315 1985 1650 594 613 454 2550 1390 1951 367 1223 1446 149 1200 1649 1
Low 102 527 71 30 638 11 1783 778 1768 47 228 133 26 1 4 1139 4 2
Below cutoff 8 472 555 10 10 5 2 6 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001331042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011509684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007061333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008486083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_247029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA843271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK000612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL359353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX191529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP194343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU567145 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000359316   ⟹   ENSP00000352266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,748,269 - 220,784,240 (+)Ensembl
RefSeq Acc Id: ENST00000366913   ⟹   ENSP00000355880
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,748,322 - 220,784,815 (+)Ensembl
RefSeq Acc Id: ENST00000425560   ⟹   ENSP00000416442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,754,972 - 220,780,149 (+)Ensembl
RefSeq Acc Id: ENST00000469583   ⟹   ENSP00000435450
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,748,225 - 220,755,060 (+)Ensembl
RefSeq Acc Id: ENST00000472447
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,779,962 - 220,784,184 (+)Ensembl
RefSeq Acc Id: ENST00000496078
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1220,756,278 - 220,761,764 (+)Ensembl
RefSeq Acc Id: NM_001317338   ⟹   NP_001304267
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,748,322 - 220,784,815 (+)NCBI
CHM1_11222,194,047 - 222,230,616 (+)NCBI
T2T-CHM13v2.01219,988,028 - 220,024,522 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001331042   ⟹   NP_001317971
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,748,322 - 220,784,815 (+)NCBI
T2T-CHM13v2.01219,988,028 - 220,024,522 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017898   ⟹   NP_060368
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,748,322 - 220,784,815 (+)NCBI
GRCh371220,921,325 - 220,958,157 (+)NCBI
Build 361218,988,299 - 219,024,222 (+)NCBI Archive
Celera1194,141,035 - 194,176,957 (+)RGD
HuRef1191,596,292 - 191,632,216 (+)ENTREZGENE
CHM1_11222,194,047 - 222,230,616 (+)NCBI
T2T-CHM13v2.01219,988,028 - 220,024,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011509684   ⟹   XP_011507986
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,751,330 - 220,781,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047423617   ⟹   XP_047279573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,755,131 - 220,781,932 (+)NCBI
RefSeq Acc Id: XM_054337291   ⟹   XP_054193266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01219,990,980 - 220,021,639 (+)NCBI
RefSeq Acc Id: XM_054337292   ⟹   XP_054193267
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01219,994,836 - 220,021,639 (+)NCBI
RefSeq Acc Id: XR_007061333
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,748,322 - 220,780,055 (+)NCBI
RefSeq Acc Id: XR_008486083
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01219,988,028 - 220,019,762 (+)NCBI
RefSeq Acc Id: NP_060368   ⟸   NM_017898
- Peptide Label: isoform a precursor
- UniProtKB: Q9H066 (UniProtKB/Swiss-Prot),   Q7L317 (UniProtKB/Swiss-Prot),   Q5VXC7 (UniProtKB/Swiss-Prot),   Q5VT67 (UniProtKB/Swiss-Prot),   Q0JSK7 (UniProtKB/Swiss-Prot),   D3DTB3 (UniProtKB/Swiss-Prot),   B2D0R5 (UniProtKB/Swiss-Prot),   Q9NWU0 (UniProtKB/Swiss-Prot),   Q969Z3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011507986   ⟸   XM_011509684
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001304267   ⟸   NM_001317338
- Peptide Label: isoform a precursor
- UniProtKB: Q9H066 (UniProtKB/Swiss-Prot),   Q7L317 (UniProtKB/Swiss-Prot),   Q5VXC7 (UniProtKB/Swiss-Prot),   Q5VT67 (UniProtKB/Swiss-Prot),   Q0JSK7 (UniProtKB/Swiss-Prot),   D3DTB3 (UniProtKB/Swiss-Prot),   B2D0R5 (UniProtKB/Swiss-Prot),   Q9NWU0 (UniProtKB/Swiss-Prot),   Q969Z3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001317971   ⟸   NM_001331042
- Peptide Label: isoform b precursor
- UniProtKB: Q969Z3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000352266   ⟸   ENST00000359316
RefSeq Acc Id: ENSP00000416442   ⟸   ENST00000425560
RefSeq Acc Id: ENSP00000435450   ⟸   ENST00000469583
RefSeq Acc Id: ENSP00000355880   ⟸   ENST00000366913
RefSeq Acc Id: XP_047279573   ⟸   XM_047423617
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054193266   ⟸   XM_054337291
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054193267   ⟸   XM_054337292
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q969Z3-F1-model_v2 AlphaFold Q969Z3 1-335 view protein structure

Promoters
RGD ID:6786063
Promoter ID:HG_KWN:7411
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:ENST00000366914,   OTTHUMT00000090911,   OTTHUMT00000090913,   UC001HMR.1,   UC009XDX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361218,987,981 - 218,988,481 (+)MPROMDB
RGD ID:6859032
Promoter ID:EPDNEW_H2680
Type:initiation region
Name:MARC2_1
Description:mitochondrial amidoxime reducing component 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381220,748,323 - 220,748,383EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:26064 AgrOrtholog
COSMIC MTARC2 COSMIC
Ensembl Genes ENSG00000117791 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000359316 ENTREZGENE
  ENST00000359316.6 UniProtKB/Swiss-Prot
  ENST00000366913 ENTREZGENE
  ENST00000366913.8 UniProtKB/Swiss-Prot
  ENST00000425560.1 UniProtKB/TrEMBL
  ENST00000469583.1 UniProtKB/TrEMBL
GTEx ENSG00000117791 GTEx
HGNC ID HGNC:26064 ENTREZGENE
Human Proteome Map MTARC2 Human Proteome Map
InterPro MoCF_Sase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOSC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase-like_insert_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:54996 UniProtKB/Swiss-Prot
NCBI Gene 54996 ENTREZGENE
OMIM 614127 OMIM
PANTHER MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOLYBDOPTERIN COFACTOR SULFURASE MOSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MOSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MOSC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MOSC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP MOSC N-terminal domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50800 UniProtKB/Swiss-Prot
UniProt B2D0R5 ENTREZGENE
  D3DTB3 ENTREZGENE
  F6V6Z1_HUMAN UniProtKB/TrEMBL
  MARC2_HUMAN UniProtKB/Swiss-Prot
  Q0JSK7 ENTREZGENE
  Q5VT67 ENTREZGENE
  Q5VXC7 ENTREZGENE
  Q7L317 ENTREZGENE
  Q969Z3 ENTREZGENE
  Q9H066 ENTREZGENE
  Q9NWU0 ENTREZGENE
  X1WI34_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2D0R5 UniProtKB/Swiss-Prot
  D3DTB3 UniProtKB/Swiss-Prot
  Q0JSK7 UniProtKB/Swiss-Prot
  Q5VT67 UniProtKB/Swiss-Prot
  Q5VXC7 UniProtKB/Swiss-Prot
  Q7L317 UniProtKB/Swiss-Prot
  Q9H066 UniProtKB/Swiss-Prot
  Q9NWU0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-01 MTARC2  mitochondrial amidoxime reducing component 2  MARC2  mitochondrial amidoxime reducing component 2  Symbol and/or name change 5135510 APPROVED
2011-11-22 MARC2  mitochondrial amidoxime reducing component 2  MOSC2  MOCO sulphurase C-terminal domain containing 2  Symbol and/or name change 5135510 APPROVED