GUCY2C (guanylate cyclase 2C) - Rat Genome Database

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Gene: GUCY2C (guanylate cyclase 2C) Pan paniscus
Analyze
Symbol: GUCY2C
Name: guanylate cyclase 2C
RGD ID: 12041700
Description: ENCODES a protein that exhibits guanylate cyclase activity (ortholog); toxic substance binding (ortholog); INVOLVED IN regulation of cell population proliferation (ortholog); response to toxic substance (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); autosomal dominant intellectual developmental disorder 6 (ortholog); Colorectal Neoplasms (ortholog); FOUND IN endoplasmic reticulum membrane (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanylate cyclase 2C (heat stable enterotoxin receptor); guanylyl cyclase C; heat-stable enterotoxin receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,056,633 - 20,140,432 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,053,393 - 20,137,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,608,794 - 14,687,190 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,007,612 - 15,091,778 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,008,099 - 15,091,647 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GUCY2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21020,056,633 - 20,140,432 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,053,393 - 20,137,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01214,608,794 - 14,687,190 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11215,007,612 - 15,091,778 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,008,099 - 15,091,647 (-)Ensemblpanpan1.1panPan2
GUCY2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,612,632 - 14,696,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1214,612,632 - 14,696,599 (-)EnsemblGRCh38hg38GRCh38
GRCh371214,765,566 - 14,849,533 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,656,843 - 14,740,696 (-)NCBINCBI36Build 36hg18NCBI36
Build 341214,656,842 - 14,740,696NCBI
Celera1219,910,604 - 19,994,546 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,534,894 - 14,618,836 (-)NCBIHuRef
CHM1_11214,731,376 - 14,815,291 (-)NCBICHM1_1
T2T-CHM13v2.01214,490,079 - 14,574,057 (-)NCBIT2T-CHM13v2.0
Gucy2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,674,282 - 136,758,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,674,282 - 136,758,763 (-)EnsemblGRCm39 Ensembl
GRCm386136,697,284 - 136,781,742 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,697,284 - 136,781,765 (-)EnsemblGRCm38mm10GRCm38
MGSCv376136,645,805 - 136,730,263 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,661,481 - 136,745,938 (-)NCBIMGSCv36mm8
Celera6139,693,560 - 139,778,559 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.67NCBI
Gucy2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84171,299,715 - 171,380,296 (-)NCBIGRCr8
mRatBN7.24169,568,505 - 169,649,092 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,568,529 - 169,649,092 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4175,864,053 - 175,943,958 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04171,644,965 - 171,725,559 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04170,269,703 - 170,349,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04170,659,993 - 170,740,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,659,998 - 170,740,274 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04234,917,953 - 234,998,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,740,202 - 173,791,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14173,985,329 - 174,036,240 (-)NCBI
Celera4158,151,931 - 158,232,578 (-)NCBICelera
RH 3.4 Map41029.8RGD
Cytogenetic Map4q43NCBI
Gucy2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541311,410,586 - 11,489,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541311,410,586 - 11,489,201 (-)NCBIChiLan1.0ChiLan1.0
GUCY2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,915,552 - 31,989,748 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,917,604 - 31,989,551 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,459,047 - 14,531,591 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,224,305 - 32,296,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2732,224,094 - 32,296,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12732,113,413 - 32,186,004 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02732,072,317 - 32,144,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,190,563 - 14,263,769 (-)NCBIUU_Cfam_GSD_1.0
Gucy2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494593,015,174 - 93,083,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365872,742,911 - 2,810,969 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365872,742,911 - 2,811,139 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCY2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,534,787 - 14,668,746 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,534,883 - 14,613,255 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,696,570 - 20,777,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucy2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475223,286,093 - 23,357,662 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475223,285,987 - 23,357,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000026889   ⟹   ENSPPAP00000006115
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1215,008,099 - 15,091,647 (-)Ensembl
RefSeq Acc Id: XM_055095429   ⟹   XP_054951404
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21020,056,633 - 20,140,432 (-)NCBI
NHGRI_mPanPan11220,053,393 - 20,137,193 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054951404 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000006115.1
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000006115   ⟸   ENSPPAT00000026889
RefSeq Acc Id: XP_054951404   ⟸   XM_055095429
- UniProtKB: A0A2R8ZNL7 (UniProtKB/TrEMBL)
Protein Domains
Guanylate cyclase   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000024389 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000026889.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/TrEMBL
  GC-C_PK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene GUCY2C ENTREZGENE
PANTHER GUANYLYL CYCLASE UniProtKB/TrEMBL
  HEAT-STABLE ENTEROTOXIN RECEPTOR UniProtKB/TrEMBL
Pfam Guanylate_cyc UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART CYCc UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
  SSF55073 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZNL7 ENTREZGENE, UniProtKB/TrEMBL