GSTA1 (glutathione S-transferase alpha 1) - Rat Genome Database

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Gene: GSTA1 (glutathione S-transferase alpha 1) Homo sapiens
Analyze
Symbol: GSTA1
Name: glutathione S-transferase alpha 1
RGD ID: 1349200
HGNC Page HGNC
Description: Enables several functions, including glutathione peroxidase activity; glutathione transferase activity; and steroid delta-isomerase activity. Involved in epithelial cell differentiation; glutathione derivative biosynthetic process; and unsaturated fatty acid metabolic process. Acts upstream of or within glutathione metabolic process. Located in cytosol. Implicated in asthma and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; glutathione S-transferase A1; glutathione S-transferase Ha subunit 1; GST class-alpha member 1; GST HA subunit 1; GST, class alpha, 1; GST-epsilon; GST2; GSTA1-1; GTH1; MGC131939; S-(hydroxyalkyl)glutathione lyase A1; testicular tissue protein Li 80
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,791,371 - 52,803,860 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,791,371 - 52,803,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,656,169 - 52,668,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,789 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
1,2-Dibromo-3-chloropropane  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
13-oxo-9,11-octadecadienoic acid  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine  (EXP)
2-allylphenol  (EXP)
2-hexenal  (ISO)
2-phenylpropanal  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylpyridine  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenol  (ISO)
4-Propylphenol  (EXP)
5-Hydroxythalidomide  (EXP)
8-anilinonaphthalene-1-sulfonic acid  (EXP)
acetamide  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
alpha-linolenic acid  (EXP)
alpha-methyl-L-dopa  (EXP)
alternariol  (EXP)
amitrole  (ISO)
androst-4-ene-3,17-dione  (EXP)
androst-5-ene-3,17-dione  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (EXP)
atazanavir sulfate  (EXP)
atrazine  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (ISO)
benzoic acid  (EXP)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromosulfophthalein  (EXP,ISO)
bucladesine  (EXP)
busulfan  (EXP)
butane-2,3-dione  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (EXP)
chenodeoxycholic acid  (EXP)
chlorambucil  (EXP)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
cholic acid  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
cortisol  (EXP)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
DDT  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP)
dicrotophos  (EXP)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP)
diquat  (ISO)
dopamine  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (ISO)
enzyme inhibitor  (ISO)
Erucin  (ISO)
etacrynic acid  (EXP,ISO)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
genistein  (ISO)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
GW 7647  (EXP,ISO)
herbicide  (ISO)
hexadecanoic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hypericin  (EXP)
iodide salt  (ISO)
iomeprol  (ISO)
isomethyleugenol  (EXP)
kaempferol  (EXP)
ketoconazole  (EXP,ISO)
KT 5720  (EXP)
L-ascorbic acid  (EXP)
lauroyl-CoA  (EXP)
lead diacetate  (EXP,ISO)
linoleic acid  (EXP)
lithocholic acid  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP)
mefenamic acid  (EXP)
MeIQx  (EXP)
menadione  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
metformin  (ISO)
methotrexate  (EXP)
methyl methacrylate  (EXP)
microcystin RR  (EXP)
microcystin-LR  (EXP)
mifepristone  (EXP)
myristoyl-CoA  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nevirapine  (EXP)
nickel atom  (EXP)
nitrofen  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oleic acid  (EXP)
oleoyl-CoA  (EXP)
oxaliplatin  (ISO)
palmitoyl ethanolamide  (ISO)
palmitoyl-CoA  (EXP)
panobinostat  (EXP)
paracetamol  (EXP)
parathion-methyl  (EXP)
phenanthrene  (EXP)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (ISO)
phenytoin  (EXP)
PhIP  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
prostaglandin A2  (EXP)
prostaglandin J2  (EXP)
pyrazines  (EXP)
pyrene  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rifampicin  (EXP)
rifamycins  (EXP)
rimonabant  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-hexylglutathione  (EXP)
silicon dioxide  (ISO)
stavudine  (ISO)
stearoyl-CoA  (EXP)
streptozocin  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (EXP)
tamoxifen  (ISO)
tartrazine  (EXP)
tert-butyl ethyl ether  (ISO)
tetrachloromethane  (ISO)
tetrahydrothiophene  (EXP)
tetraphene  (EXP)
thioacetamide  (ISO)
Thiotepa  (EXP)
topotecan  (ISO)
toremifene  (ISO)
triadimefon  (ISO)
triclosan  (EXP)
Tris(1-aziridinyl)phosphine oxide  (EXP)
Tris(2,3-dibromopropyl) phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
urethane  (EXP)
usnic acid  (EXP)
valproic acid  (EXP)
xanthohumol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,IDA,ISO,TAS)
extracellular exosome  (HDA)
organelle membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1330133   PMID:1530570   PMID:1731620   PMID:2018473   PMID:2604726   PMID:3031680   PMID:3036131   PMID:3138230   PMID:3678589   PMID:3800996   PMID:7888077   PMID:8185623  
PMID:8242618   PMID:8307579   PMID:8331657   PMID:8431482   PMID:8591048   PMID:8598105   PMID:8663064   PMID:8889548   PMID:9084911   PMID:9503014   PMID:10053036   PMID:10213291  
PMID:10791551   PMID:11152686   PMID:11535243   PMID:11550208   PMID:11668220   PMID:11692074   PMID:11747461   PMID:11851347   PMID:11931663   PMID:12042665   PMID:12087351   PMID:12093480  
PMID:12139976   PMID:12206662   PMID:12211029   PMID:12447480   PMID:12473455   PMID:12477932   PMID:12516103   PMID:12524083   PMID:12871945   PMID:14690442   PMID:15128049   PMID:15182170  
PMID:15202795   PMID:15319294   PMID:15333749   PMID:15489334   PMID:15525789   PMID:15616829   PMID:15746160   PMID:15757902   PMID:15797627   PMID:15808404   PMID:15893769   PMID:15900282  
PMID:15952767   PMID:16116487   PMID:16190865   PMID:16280386   PMID:16365014   PMID:16421451   PMID:16599007   PMID:16624487   PMID:16624829   PMID:16786188   PMID:16865249   PMID:17021248  
PMID:17071629   PMID:17086718   PMID:17197702   PMID:17207965   PMID:17333241   PMID:17374652   PMID:17425746   PMID:17601350   PMID:17631926   PMID:17644396   PMID:17716224   PMID:17899366  
PMID:18065725   PMID:18066575   PMID:18161889   PMID:18186040   PMID:18214047   PMID:18224491   PMID:18300949   PMID:18414193   PMID:18430527   PMID:18476723   PMID:18496131   PMID:18635758  
PMID:18641537   PMID:18644106   PMID:18784548   PMID:18791061   PMID:18854779   PMID:18977241   PMID:18992148   PMID:19027952   PMID:19056867   PMID:19062541   PMID:19076156   PMID:19343046  
PMID:19376514   PMID:19448608   PMID:19491810   PMID:19515364   PMID:19584821   PMID:19618965   PMID:19639209   PMID:19696793   PMID:19789190   PMID:19896490   PMID:19902075   PMID:19953622  
PMID:19959275   PMID:20032816   PMID:20056632   PMID:20100551   PMID:20102361   PMID:20200426   PMID:20207535   PMID:20216541   PMID:20237496   PMID:20331903   PMID:20367187   PMID:20368715  
PMID:20377137   PMID:20391138   PMID:20437058   PMID:20529827   PMID:20606271   PMID:20672371   PMID:20833278   PMID:21093063   PMID:21163259   PMID:21169260   PMID:21492153   PMID:21530062  
PMID:21530499   PMID:21749698   PMID:21832049   PMID:21844655   PMID:21873635   PMID:21988832   PMID:22002059   PMID:22040239   PMID:22079734   PMID:22475179   PMID:22633257   PMID:22697302  
PMID:22893351   PMID:22906494   PMID:22959778   PMID:22993865   PMID:23251616   PMID:23292236   PMID:23376485   PMID:23394311   PMID:23460799   PMID:23533145   PMID:23570881   PMID:23647087  
PMID:23649628   PMID:23650189   PMID:23731957   PMID:23824909   PMID:24075358   PMID:24192117   PMID:24215845   PMID:24276031   PMID:24344877   PMID:24390679   PMID:24423050   PMID:24471578  
PMID:24612768   PMID:24782212   PMID:24914957   PMID:25111321   PMID:25251951   PMID:25374180   PMID:25565670   PMID:25730183   PMID:25778330   PMID:25867434   PMID:26186194   PMID:26222310  
PMID:26321410   PMID:26419450   PMID:26552558   PMID:26691424   PMID:27179909   PMID:27449362   PMID:27500405   PMID:27568660   PMID:27631264   PMID:27936036   PMID:28267438   PMID:28401601  
PMID:28514442   PMID:28677395   PMID:29087247   PMID:29165597   PMID:30431119   PMID:30963629   PMID:31834435   PMID:32235678   PMID:33002252   PMID:33924269   PMID:33961781  


Genomics

Comparative Map Data
GSTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,791,371 - 52,803,860 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,791,371 - 52,803,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,656,169 - 52,668,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,789 (-)NCBICHM1_1
Gsta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,703,476 - 23,720,121 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)Ensembl
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Celera921,278,681 - 21,295,265 (-)NCBICelera
Cytogenetic Map9q13NCBI

Position Markers
G66731  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37652,658,878 - 52,659,162UniSTSGRCh37
GRCh37652,617,607 - 52,617,891UniSTSGRCh37
Build 36652,725,566 - 52,725,850RGDNCBI36
Celera654,278,700 - 54,278,984RGD
Celera654,319,957 - 54,320,241UniSTS
Cytogenetic Map6p12.1UniSTS
HuRef652,448,825 - 52,449,109UniSTS
HuRef652,489,623 - 52,489,907UniSTS
G66732  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37652,657,589 - 52,657,885UniSTSGRCh37
GRCh37652,616,308 - 52,616,606UniSTSGRCh37
Build 36652,724,267 - 52,724,565RGDNCBI36
Celera654,277,401 - 54,277,699RGD
Celera654,318,668 - 54,318,964UniSTS
Cytogenetic Map6p12.1UniSTS
HuRef652,447,526 - 52,447,824UniSTS
HuRef652,488,334 - 52,488,630UniSTS
G66733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37652,656,431 - 52,656,856UniSTSGRCh37
GRCh37652,615,150 - 52,615,580UniSTSGRCh37
Build 36652,723,109 - 52,723,539RGDNCBI36
Celera654,276,243 - 54,276,673RGD
Celera654,317,510 - 54,317,935UniSTS
Cytogenetic Map6p12.1UniSTS
HuRef652,446,368 - 52,446,798UniSTS
HuRef652,487,176 - 52,487,601UniSTS
RH15792  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37652,656,638 - 52,656,781UniSTSGRCh37
Build 36652,764,597 - 52,764,740RGDNCBI36
Celera654,317,717 - 54,317,860RGD
Cytogenetic Map6p12.1UniSTS
HuRef652,487,383 - 52,487,526UniSTS
GeneMap99-GB4 RH Map6630.02UniSTS
NCBI RH Map61631.6UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:265
Interacting mature miRNAs:275
Transcripts:ENST00000334575, ENST00000476213, ENST00000493331
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 5 257 151 2 151 55 17 12
Medium 533 43 415 384 190 262 23 10 11 195 733 265 125 3 15
Low 550 735 222 78 255 38 1360 148 482 78 425 543 39 1 252 809 3 2
Below cutoff 906 1560 625 7 570 8 2021 1165 2174 52 148 490 2 707 1306 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001319059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005249034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL096729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY532928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC110891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG430521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI762344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM973137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA841071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC339498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M15872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S49975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000334575   ⟹   ENSP00000335620
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,791,371 - 52,803,816 (-)Ensembl
RefSeq Acc Id: ENST00000476213
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,794,133 - 52,803,860 (-)Ensembl
RefSeq Acc Id: ENST00000493331
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,791,664 - 52,799,297 (-)Ensembl
RefSeq Acc Id: NM_001319059   ⟹   NP_001305988
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,791,371 - 52,803,816 (-)NCBI
CHM1_1652,658,375 - 52,670,890 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145740   ⟹   NP_665683
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,791,371 - 52,803,816 (-)NCBI
GRCh37652,656,178 - 52,668,664 (-)ENTREZGENE
Build 36652,764,347 - 52,776,616 (-)NCBI Archive
HuRef652,486,923 - 52,499,385 (-)ENTREZGENE
CHM1_1652,658,375 - 52,670,890 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005249034   ⟹   XP_005249091
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,792,049 - 52,803,827 (-)NCBI
GRCh37652,656,178 - 52,668,664 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_665683   ⟸   NM_145740
- Peptide Label: isoform 1
- UniProtKB: P08263 (UniProtKB/Swiss-Prot),   A0A140VJK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005249091   ⟸   XM_005249034
- Peptide Label: isoform X1
- UniProtKB: B7Z1F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305988   ⟸   NM_001319059
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: ENSP00000335620   ⟸   ENST00000334575
Protein Domains
GST C-terminal   GST N-terminal

Promoters
RGD ID:7208331
Promoter ID:EPDNEW_H9911
Type:initiation region
Name:GSTA1_1
Description:glutathione S-transferase alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,803,816 - 52,803,876EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p12.3-11.2(chr6:50971182-57432788)x1 copy number loss See cases [RCV000134922] Chr6:50971182..57432788 [GRCh38]
Chr6:50938895..57297586 [GRCh37]
Chr6:51046854..57405545 [NCBI36]
Chr6:6p12.3-11.2
pathogenic
GRCh38/hg38 6p12.3-12.1(chr6:51093754-53859634)x4 copy number gain See cases [RCV000137095] Chr6:51093754..53859634 [GRCh38]
Chr6:51061467..53724432 [GRCh37]
Chr6:51169426..53832391 [NCBI36]
Chr6:6p12.3-12.1
pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1
pathogenic|uncertain significance
GRCh37/hg19 6p12.2(chr6:52615096-52657414)x3 copy number gain See cases [RCV000446003] Chr6:52615096..52657414 [GRCh37]
Chr6:6p12.2
benign
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p12.2(chr6:52612632-52689508)x1 copy number loss not provided [RCV000745720] Chr6:52612632..52689508 [GRCh37]
Chr6:6p12.2
benign
GRCh37/hg19 6p12.2(chr6:52617731-52689508)x1 copy number loss not provided [RCV000745721] Chr6:52617731..52689508 [GRCh37]
Chr6:6p12.2
benign
GRCh37/hg19 6p12.2(chr6:52623807-52662102)x1 copy number loss not provided [RCV000745722] Chr6:52623807..52662102 [GRCh37]
Chr6:6p12.2
benign
NM_145740.5(GSTA1):c.174T>G (p.Val58=) single nucleotide variant not provided [RCV000924611] Chr6:52796280 [GRCh38]
Chr6:52661078 [GRCh37]
Chr6:6p12.2
likely benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_145740.5(GSTA1):c.15C>T (p.Pro5=) single nucleotide variant not provided [RCV000900374] Chr6:52799253 [GRCh38]
Chr6:52664051 [GRCh37]
Chr6:6p12.2
benign
NM_145740.5(GSTA1):c.272+4C>T single nucleotide variant not provided [RCV000891389] Chr6:52796178 [GRCh38]
Chr6:52660976 [GRCh37]
Chr6:6p12.2
benign
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1
likely pathogenic
GRCh37/hg19 6p12.2(chr6:52653495-52860229)x3 copy number gain not provided [RCV001258722] Chr6:52653495..52860229 [GRCh37]
Chr6:6p12.2
likely benign
GRCh37/hg19 6p12.2-12.1(chr6:52657712-53622715)x3 copy number gain not provided [RCV001258723] Chr6:52657712..53622715 [GRCh37]
Chr6:6p12.2-12.1
uncertain significance
NC_000006.11:g.(?_51930764)_(52906034_?)del deletion not provided [RCV001346439] Chr6:51930764..52906034 [GRCh37]
Chr6:6p12.2-12.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4626 AgrOrtholog
COSMIC GSTA1 COSMIC
Ensembl Genes ENSG00000243955 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000335620 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000334575 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000243955 GTEx
HGNC ID HGNC:4626 ENTREZGENE
Human Proteome Map GSTA1 Human Proteome Map
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2938 ENTREZGENE
OMIM 138359 OMIM
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTA1 RGD, PharmGKB
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140VJK4 ENTREZGENE, UniProtKB/TrEMBL
  B7Z1F9 ENTREZGENE, UniProtKB/TrEMBL
  GSTA1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q14750 UniProtKB/Swiss-Prot
  Q5GHF8 UniProtKB/Swiss-Prot
  Q5SZC1 UniProtKB/Swiss-Prot