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Gene: GSTA1 (glutathione S-transferase alpha 1) Homo sapiens
Symbol: GSTA1
Name: glutathione S-transferase alpha 1
Description: This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; glutathione S-transferase A1; glutathione S-transferase Ha subunit 1; GST class-alpha member 1; GST HA subunit 1; GST, class alpha, 1; GST-epsilon; GST2; GSTA1-1; GTH1; MGC131939; S-(hydroxyalkyl)glutathione lyase A1; testicular tissue protein Li 80
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38652,791,371 - 52,803,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,656,178 - 52,668,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,890 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GSTA1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349200
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.