Gsta4 (glutathione S-transferase alpha 4) - Rat Genome Database

Gsta4 (glutathione S-transferase alpha 4) - Rat Genome Database

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Gene: Gsta4 (glutathione S-transferase alpha 4) Heterocephalus glaber

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Symbol:

Gsta4

Name:

glutathione S-transferase alpha 4

RGD ID:

18909530

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); toxic substance binding (ortholog); INVOLVED IN cellular response to lithium ion (ortholog); response to herbicide (ortholog); response to nicotine (ortholog); PARTICIPATES IN glutathione conjugation pathway; ASSOCIATED WITH arteriosclerosis (ortholog); Burns (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

Previously known as:

glutathione S-transferase A4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	201,592 - 216,680 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624850	201,119 - 217,302 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	Burns		ISO	GSTA4 (Homo sapiens)	9068941	mRNA:altered expression:fat more ...	RGD	PMID:22038048 and REF_RGD_ID:5687774
Gsta4	Naked Mole-Rat	Experimental Diabetes Mellitus		ISO	Gsta4 (Rattus norvegicus)	9068941	protein:increased expression:pancreas more ...	RGD	PMID:14693714 and REF_RGD_ID:5687773
Gsta4	Naked Mole-Rat	Experimental Liver Cirrhosis	treatment	ISO	Gsta4 (Rattus norvegicus)	9068941		RGD	PMID:23075396 and REF_RGD_ID:9685568
Gsta4	Naked Mole-Rat	Insulin Resistance		ISO	GSTA4 (Homo sapiens)	9068941	mRNA:decreased expression:omental fat pad and subcutaneous adipose tissue (human)	RGD	PMID:20150287 and REF_RGD_ID:5687771
Gsta4	Naked Mole-Rat	Liver Injury		ISO	Gsta4 (Rattus norvegicus)	9068941	mRNA and protein:increased expression:liver	RGD	PMID:23159886 and REF_RGD_ID:10401911
Gsta4	Naked Mole-Rat	Spinal Cord Injuries		ISO	Gsta4 (Rattus norvegicus)	9068941	mRNA:increased expression:lumbar segment of spinal cord (rat)	RGD	PMID:22160604 and REF_RGD_ID:5687769

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	arteriosclerosis		ISO	GSTA4 (Homo sapiens)	9068941	CTD more ...	CTD	PMID:15064094 and PMID:20177342
Gsta4	Naked Mole-Rat	Chemical and Drug Induced Liver Injury		ISO	GSTA4 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25231249
Gsta4	Naked Mole-Rat	Parkinson's disease		ISO	GSTA4 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16510128
Gsta4	Naked Mole-Rat	pre-malignant neoplasm		ISO	GSTA4 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:20180811

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	cellular response to lithium ion		ISO	Gsta4 (Rattus norvegicus)	9068941		RGD	PMID:18082333 and REF_RGD_ID:2293846
Gsta4	Naked Mole-Rat	glutathione metabolic process	involved_in	IEA	PANTHER:PTN000170921	150520179		TreeGrafter	GO_REF:0000118
Gsta4	Naked Mole-Rat	response to herbicide		ISO	Gsta4 (Rattus norvegicus)	9068941	paraquat	RGD	PMID:20553223 and REF_RGD_ID:5130934
Gsta4	Naked Mole-Rat	response to nicotine		ISO	Gsta4 (Rattus norvegicus)	9068941		RGD	PMID:9774145 and REF_RGD_ID:5687770
Gsta4	Naked Mole-Rat	response to zinc ion		ISO	Gsta4 (Rattus norvegicus)	9068941		RGD	PMID:20553223 and REF_RGD_ID:5130934
Gsta4	Naked Mole-Rat	xenobiotic metabolic process	involved_in	IEA	PANTHER:PTN000170921	150520179		TreeGrafter	GO_REF:0000118

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	cytosol	located_in	ISO	GSTA4 (Homo sapiens)	9068941	PMID:15100242	FlyBase	PMID:15100242

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	glutathione transferase activity	enables	IEA	PANTHER:PTN000170921	150520179		TreeGrafter	GO_REF:0000118
Gsta4	Naked Mole-Rat	glutathione transferase activity	enables	IEA	InterPro:IPR003080	150520179		InterPro	GO_REF:0000002
Gsta4	Naked Mole-Rat	identical protein binding	enables	ISO	UniProtKB:O15217	9068941	PMID:16189514 more ...	IntAct	PMID:16189514 more ...
Gsta4	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:P09210	9068941	PMID:25910212 more ...	IntAct	PMID:25910212 more ...
Gsta4	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:P09210 and UniProtKB:Q96LR7	9068941	PMID:25416956	IntAct	PMID:25416956
Gsta4	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:O15116 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Gsta4	Naked Mole-Rat	protein binding	enables	ISO	UniProtKB:P19712-PRO_0000038050	9068941	PMID:24965446	AgBase	PMID:24965446
Gsta4	Naked Mole-Rat	protein homodimerization activity	enables	ISO	UniProtKB:O15217	9068941	PMID:10329152	UniProt	PMID:10329152
Gsta4	Naked Mole-Rat	toxic substance binding		ISO	(E)-4-hydroxynon-2-enal	9068941		RGD	PMID:11018474 and REF_RGD_ID:1641942

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gsta4	Naked Mole-Rat	glutathione conjugation pathway		ISO	GSTA4 (Homo sapiens)	9068941		RGD	PMID:10720752 and REF_RGD_ID:1358120
Gsta4	Naked Mole-Rat	glutathione conjugation pathway		ISO	Gsta4 (Rattus norvegicus)	9068941		RGD	PMID:11018474 and REF_RGD_ID:1641942

PMID:22301074	PMID:30032202

Gsta4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624850	201,592 - 216,680 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624850	201,119 - 217,302 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

GSTA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	52,977,953 - 52,995,284 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	52,977,948 - 52,995,304 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	52,842,751 - 52,860,082 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	52,950,710 - 52,968,099 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	52,950,709 - 52,968,099	NCBI
Celera	6	54,504,520 - 54,521,952 (-)	NCBI		Celera
Cytogenetic Map	6	p12.2	NCBI
HuRef	6	52,674,221 - 52,691,656 (-)	NCBI		HuRef
CHM1_1	6	52,844,511 - 52,861,941 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	52,817,518 - 52,834,853 (-)	NCBI		T2T-CHM13v2.0

Gsta4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	87,947,247 - 87,964,490 (+)	NCBI		GRCr8
mRatBN7.2	8	79,066,967 - 79,084,193 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	79,066,934 - 79,084,182 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	84,554,453 - 84,571,445 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	82,831,109 - 82,848,101 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	80,653,832 - 80,670,824 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	85,497,557 - 85,514,732 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	85,497,557 - 85,518,879 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	85,062,036 - 85,078,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	83,165,139 - 83,183,055	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	8	78,811,797 - 78,829,038 (+)	NCBI		Celera
Cytogenetic Map	8	q31	NCBI

GSTA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	67,449,101 - 67,466,562 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	63,325,479 - 63,342,938 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	52,532,942 - 52,550,404 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	54,171,609 - 54,189,032 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	54,171,318 - 54,188,976 (-)	Ensembl	panpan1.1		panPan2

GSTA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	20,426,724 - 20,443,200 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	20,426,726 - 20,443,200 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	20,321,558 - 20,337,691 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	20,924,034 - 20,940,269 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	20,923,735 - 20,940,277 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	20,429,613 - 20,445,821 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	20,534,140 - 20,550,406 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	20,672,284 - 20,688,436 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101958062
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	56,071,901 - 56,087,021 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	7,873,194 - 7,889,048 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	7,873,218 - 7,888,301 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GSTA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	46,635,902 - 46,656,450 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	46,635,903 - 46,656,491 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	134,379,987 - 134,400,475 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GSTA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	19,575,835 - 19,591,713 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	19,575,876 - 19,591,919 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	52,829,812 - 52,845,691 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_021247627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01089568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000002608 ⟹ ENSHGLP00000002556

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624850	201,592 - 216,680 (-)	Ensembl

RefSeq Acc Id:

XM_021247627 ⟹ XP_021103286

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624850	201,119 - 217,302 (-)	NCBI


Protein RefSeqs	XP_021103286	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000002556

RefSeq Acc Id:	XP_021103286 ⟸ XM_021247627
- UniProtKB:	A0AAX6S1B1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000002556 ⟸ ENSHGLT00000002608

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000001927	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000002608	ENTREZGENE
Gene3D-CATH	1.20.1050.10	UniProtKB/TrEMBL
	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Glutathione-S-Trfase_C-like	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Glutathione_S-Trfase	UniProtKB/TrEMBL
	Glutathione_S-Trfase_N	UniProtKB/TrEMBL
	GST_alpha	UniProtKB/TrEMBL
	GST_C	UniProtKB/TrEMBL
	GST_superfamily	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
NCBI Gene	Gsta4	ENTREZGENE
PANTHER	GLUTATHIONE S-TRANSFERASE	UniProtKB/TrEMBL
	GLUTATHIONE S-TRANSFERASE A4	UniProtKB/TrEMBL
Pfam	GST_C_3	UniProtKB/TrEMBL
	GST_N	UniProtKB/TrEMBL
PRINTS	GSTRNSFRASEA	UniProtKB/TrEMBL
PROSITE	GST_CTER	UniProtKB/TrEMBL
	GST_NTER	UniProtKB/TrEMBL
Superfamily-SCOP	GST C-terminal domain-like	UniProtKB/TrEMBL
	Thioredoxin-like	UniProtKB/TrEMBL
UniProt	A0AAX6S1B1	ENTREZGENE, UniProtKB/TrEMBL