Slc29a4 (solute carrier family 29 (nucleoside transporters), member 4) - Rat Genome Database

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Gene: Slc29a4 (solute carrier family 29 (nucleoside transporters), member 4) Mus musculus
Analyze
Symbol: Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
RGD ID: 1558196
MGI Page MGI
Description: Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; toxin transport; and xenobiotic transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in brain and male reproductive gland or organ. Orthologous to human SLC29A4 (solute carrier family 29 member 4); PARTICIPATES IN metformin pharmacokinetics pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ENT; ENT4; equilibrative nucleoside transporter 4; MGC38048; mPM; mPMAT; solute carrier family 29 member 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395142,678,124 - 142,708,245 (+)NCBIGRCm39mm39
GRCm39 Ensembl5142,678,267 - 142,708,245 (+)Ensembl
GRCm385142,692,478 - 142,722,490 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5142,692,512 - 142,722,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv375143,178,055 - 143,198,443 (+)NCBIGRCm37mm9NCBIm37
MGSCv365142,954,391 - 142,977,880 (+)NCBImm8
Celera5139,765,811 - 139,776,351 (+)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:12446811   PMID:12477932   PMID:14681479   PMID:15448143   PMID:16873718   PMID:17408864   PMID:20858707   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23255610   PMID:24194600  
PMID:24952961   PMID:26376205   PMID:32170814  


Genomics

Comparative Map Data
Slc29a4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395142,678,124 - 142,708,245 (+)NCBIGRCm39mm39
GRCm39 Ensembl5142,678,267 - 142,708,245 (+)Ensembl
GRCm385142,692,478 - 142,722,490 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5142,692,512 - 142,722,490 (+)EnsemblGRCm38mm10GRCm38
MGSCv375143,178,055 - 143,198,443 (+)NCBIGRCm37mm9NCBIm37
MGSCv365142,954,391 - 142,977,880 (+)NCBImm8
Celera5139,765,811 - 139,776,351 (+)NCBICelera
Cytogenetic Map5G2NCBI
SLC29A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl75,274,369 - 5,306,912 (+)EnsemblGRCh38hg38GRCh38
GRCh3875,274,311 - 5,306,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3775,322,574 - 5,346,543 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,289,087 - 5,310,230 (+)NCBINCBI36hg18NCBI36
Build 3475,095,815 - 5,116,931NCBI
Celera75,287,760 - 5,304,022 (+)NCBI
Cytogenetic Map7p22.1NCBI
HuRef75,237,590 - 5,258,085 (+)NCBIHuRef
CHM1_175,322,266 - 5,343,242 (+)NCBICHM1_1
CRA_TCAGchr7v275,368,916 - 5,390,059 (+)NCBI
Slc29a4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21211,853,540 - 11,884,660 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1213,914,114 - 13,924,531 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01213,914,114 - 13,924,511 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01215,942,167 - 15,976,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,241,259 - 12,251,656 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11212,272,150 - 12,284,079 (-)NCBI
Celera1213,639,832 - 13,659,864 (-)NCBICelera
Cytogenetic Map12p11NCBI
Slc29a4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546010,155,899 - 10,181,974 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546010,155,916 - 10,181,974 (+)NCBIChiLan1.0ChiLan1.0
SLC29A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.175,559,540 - 5,576,771 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl75,560,565 - 5,575,637 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v075,538,436 - 5,559,506 (+)NCBIMhudiblu_PPA_v0panPan3
SLC29A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1612,607,708 - 12,634,572 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl612,608,713 - 12,622,478 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha614,078,449 - 14,105,244 (-)NCBI
ROS_Cfam_1.0612,743,923 - 12,770,753 (-)NCBI
UMICH_Zoey_3.1612,554,855 - 12,581,654 (-)NCBI
UNSW_CanFamBas_1.0612,488,064 - 12,514,839 (-)NCBI
UU_Cfam_GSD_1.0612,764,693 - 12,791,487 (-)NCBI
Slc29a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,863,645 - 140,887,329 (-)NCBI
SpeTri2.0NW_004936765854,712 - 868,001 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC29A4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl33,862,251 - 3,878,239 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.133,854,466 - 3,879,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.234,537,619 - 4,541,229 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC29A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12816,429,879 - 16,450,580 (-)NCBI
ChlSab1.1 Ensembl2816,429,413 - 16,450,324 (-)Ensembl
Vero_WHO_p1.0NW_0236660905,524,669 - 5,546,232 (+)NCBI
Slc29a4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474028,254,635 - 28,280,304 (-)NCBI

Position Markers
Slc29a4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G2UniSTS
cM Map581.56UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5134002093151834684Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119806972149423861Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124714580151834684Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121457140151834684Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129851021151834684Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109090176143090317Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129583274151834684Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118920110151834684Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109090176143090317Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115128044149128176Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115128044149128176Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125147702151834684Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121556974151834684Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109362284143362395Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5140000000153000000Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589271017146851125Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:379
Count of miRNA genes:291
Interacting mature miRNAs:310
Transcripts:ENSMUST00000058418
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000058418   ⟹   ENSMUSP00000059896
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5142,702,101 - 142,722,490 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198728   ⟹   ENSMUSP00000142674
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl5142,692,512 - 142,712,907 (+)Ensembl
RefSeq Acc Id: NM_146257   ⟹   NP_666369
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395142,687,856 - 142,708,245 (+)NCBI
GRCm385142,702,101 - 142,722,490 (+)NCBI
MGSCv375143,178,055 - 143,198,443 (+)RGD
Celera5139,765,836 - 139,776,351 (+)ENTREZGENE
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006504706   ⟹   XP_006504769
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395142,678,124 - 142,708,245 (+)NCBI
GRCm385142,692,478 - 142,722,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006504707   ⟹   XP_006504770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395142,687,834 - 142,708,243 (+)NCBI
GRCm385142,702,078 - 142,722,490 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036165132   ⟹   XP_036021025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395142,678,234 - 142,708,243 (+)NCBI
Protein Sequences
Protein RefSeqs NP_666369 (Get FASTA)   NCBI Sequence Viewer  
  XP_006504769 (Get FASTA)   NCBI Sequence Viewer  
  XP_006504770 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021025 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH25599 (Get FASTA)   NCBI Sequence Viewer  
  Q8R139 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_666369   ⟸   NM_146257
- UniProtKB: Q8R139 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006504769   ⟸   XM_006504706
- Peptide Label: isoform X1
- UniProtKB: Q8R139 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006504770   ⟸   XM_006504707
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000142674   ⟸   ENSMUST00000198728
RefSeq Acc Id: ENSMUSP00000059896   ⟸   ENSMUST00000058418
RefSeq Acc Id: XP_036021025   ⟸   XM_036165132
- Peptide Label: isoform X2

Promoters
RGD ID:6888640
Promoter ID:EPDNEW_M7771
Type:initiation region
Name:Slc29a4_1
Description:Mus musculus solute carrier family 29 , member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385142,702,121 - 142,702,181EPDNEW
RGD ID:6847956
Promoter ID:MM_ACW:40024
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:SLC29A4.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365143,168,191 - 143,168,691 (+)MPROMDB
RGD ID:6838362
Promoter ID:MM_KWN:44699
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_146257
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365143,178,061 - 143,178,561 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385330 AgrOrtholog
Ensembl Genes ENSMUSG00000050822 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000059896 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142674 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000058418 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000198728 UniProtKB/TrEMBL
InterPro ENT4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Eqnu_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report mmu:243328 UniProtKB/Swiss-Prot
MGD MGI:2385330 ENTREZGENE
NCBI Gene 243328 ENTREZGENE
PANTHER PTHR10332 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10332:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nucleoside_tran UniProtKB/Swiss-Prot
PhenoGen Slc29a4 PhenoGen
PIRSF ENT UniProtKB/Swiss-Prot
PRINTS DERENTRNSPRT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A0G2JE87_MOUSE UniProtKB/TrEMBL
  Q8R139 ENTREZGENE, UniProtKB/Swiss-Prot