NEFM (neurofilament medium chain) - Rat Genome Database

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Gene: NEFM (neurofilament medium chain) Pan paniscus
Analyze
Symbol: NEFM
Name: neurofilament medium chain
RGD ID: 11905130
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); signaling receptor binding (ortholog); toxic substance binding (ortholog); INVOLVED IN axo-dendritic transport (ortholog); axon regeneration (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); congenital hypothyroidism (ortholog); FOUND IN axon (ortholog); cytoskeleton (ortholog); intermediate filament (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neurofilament medium; neurofilament medium polypeptide; neurofilament, medium polypeptide
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2743,421,006 - 43,426,459 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1819,155,199 - 19,160,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0824,181,335 - 24,186,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1821,097,646 - 21,103,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,098,005 - 21,107,468 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NEFM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2743,421,006 - 43,426,459 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1819,155,199 - 19,160,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0824,181,335 - 24,186,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1821,097,646 - 21,103,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,098,005 - 21,107,468 (+)Ensemblpanpan1.1panPan2
NEFM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38824,913,761 - 24,919,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl824,913,758 - 24,919,098 (+)EnsemblGRCh38hg38GRCh38
GRCh37824,771,274 - 24,776,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,827,179 - 24,832,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 34824,827,211 - 24,832,511NCBI
Celera823,734,685 - 23,740,017 (+)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef823,315,978 - 23,321,310 (+)NCBIHuRef
CHM1_1824,973,582 - 24,978,914 (+)NCBICHM1_1
T2T-CHM13v2.0825,188,914 - 25,194,246 (+)NCBIT2T-CHM13v2.0
Nefm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,356,994 - 68,362,453 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1468,320,039 - 68,362,295 (-)EnsemblGRCm39 Ensembl
GRCm381468,119,545 - 68,125,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,082,590 - 68,124,846 (-)EnsemblGRCm38mm10GRCm38
MGSCv371468,737,602 - 68,743,061 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361467,073,367 - 67,078,143 (-)NCBIMGSCv36mm8
Celera1465,887,284 - 65,892,688 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1435.46NCBI
Nefm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81546,535,857 - 46,541,161 (-)NCBIGRCr8
mRatBN7.21542,360,449 - 42,365,753 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1542,360,454 - 42,365,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1544,225,130 - 44,230,434 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01545,375,350 - 45,380,655 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01543,820,704 - 43,826,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01544,855,307 - 44,860,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,855,310 - 44,860,604 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01546,736,787 - 46,741,632 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,698,371 - 47,703,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11547,714,153 - 47,719,121 (-)NCBI
Celera1542,015,992 - 42,021,311 (-)NCBICelera
Cytogenetic Map15p12NCBI
Nefm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540347,920,408 - 47,926,922 (+)NCBIChiLan1.0ChiLan1.0
NEFM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,493,517 - 32,498,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,493,675 - 32,498,570 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2533,076,970 - 33,082,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02532,692,550 - 32,697,657 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2532,692,550 - 32,697,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12532,647,982 - 32,653,102 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,497,397 - 32,502,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02532,663,548 - 32,668,651 (-)NCBIUU_Cfam_GSD_1.0
Nefm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,410,240 - 10,415,458 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367571,663,399 - 1,668,075 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367571,662,905 - 1,668,707 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEFM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1148,955,346 - 8,967,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,117,172 - 10,122,612 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEFM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,039,187 - 23,044,668 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl823,039,282 - 23,044,667 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605219,128,898 - 19,136,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nefm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475820,030,450 - 20,036,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008977209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000036246   ⟹   ENSPPAP00000013573
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl821,098,005 - 21,107,468 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000036252   ⟹   ENSPPAP00000013580
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl821,098,005 - 21,102,771 (+)Ensembl
RefSeq Acc Id: XM_008977209   ⟹   XP_008975457
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2743,421,006 - 43,426,459 (+)NCBI
NHGRI_mPanPan1819,155,199 - 19,160,653 (+)NCBI
Mhudiblu_PPA_v0824,181,335 - 24,186,701 (+)NCBI
PanPan1.1821,097,646 - 21,103,263 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008975457 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013573.1
  ENSPPAP00000013580
  ENSPPAP00000013580.1
Reference Protein Sequences
RefSeq Acc Id: XP_008975457   ⟸   XM_008977209
- UniProtKB: A0A2R9A8H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000013580   ⟸   ENSPPAT00000036252
RefSeq Acc Id: ENSPPAP00000013573   ⟸   ENSPPAT00000036246
Protein Domains
IF rod


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036246.1 UniProtKB/TrEMBL
  ENSPPAT00000036252.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/TrEMBL
  Intermed_filament_DNA-bd UniProtKB/TrEMBL
  Keratin_I UniProtKB/TrEMBL
NCBI Gene NEFM ENTREZGENE
PANTHER GLIAL FIBRILLARY ACIDIC PROTEIN UniProtKB/TrEMBL
  PTHR45652:SF3 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Filament_head UniProtKB/TrEMBL
PRINTS TYPE1KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/TrEMBL
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A2R9A8H7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ADJ3_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-30 NEFM  neurofilament medium chain  NEFM  neurofilament medium  Symbol and/or name change 5135510 APPROVED