RHOG (ras homolog family member G) - Rat Genome Database

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Gene: RHOG (ras homolog family member G) Homo sapiens
Analyze
Symbol: RHOG
Name: ras homolog family member G
RGD ID: 1316030
HGNC Page HGNC
Description: Exhibits GTPase activity. Involved in several processes, including Ras protein signal transduction; activation of GTPase activity; and positive regulation of protein localization to plasma membrane. Localizes to extracellular exosome and focal adhesion.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ARHG; MGC125835; MGC125836; ras homolog gene family, member G (rho G); rho-related GTP-binding protein RhoG
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AL132765.1   RHOG2P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl113,826,978 - 3,840,959 (-)EnsemblGRCh38hg38GRCh38
GRCh38113,826,978 - 3,840,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37113,848,208 - 3,862,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,804,784 - 3,818,789 (-)NCBINCBI36hg18NCBI36
Build 34113,804,787 - 3,818,760NCBI
Celera113,853,361 - 3,867,364 (-)NCBI
Cytogenetic Map11p15.4NCBI
HuRef113,581,920 - 3,595,920 (-)NCBIHuRef
CHM1_1113,847,677 - 3,861,683 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1620121   PMID:8464478   PMID:8939998   PMID:9177787   PMID:9614181   PMID:10523675   PMID:10648409   PMID:10713718   PMID:11162552   PMID:11368848   PMID:11604131   PMID:11689693  
PMID:11909943   PMID:12376551   PMID:12477932   PMID:12545154   PMID:12730235   PMID:12879077   PMID:15199069   PMID:15620647   PMID:15761153   PMID:16188938   PMID:16339170   PMID:16568096  
PMID:16621998   PMID:16712791   PMID:17027967   PMID:17570359   PMID:17875742   PMID:19056867   PMID:19208761   PMID:19730683   PMID:20056178   PMID:20458337   PMID:20679435   PMID:21423176  
PMID:21873635   PMID:21930703   PMID:22251971   PMID:22268729   PMID:22383878   PMID:22683270   PMID:23376485   PMID:23533145   PMID:24106269   PMID:25065758   PMID:26186194   PMID:26496610  
PMID:26746014   PMID:27437949   PMID:27539661   PMID:27684187   PMID:27832197   PMID:28202690   PMID:28298427   PMID:28380382   PMID:28514442   PMID:28712289   PMID:29111377   PMID:29117863  
PMID:29180619   PMID:29454349   PMID:29467282   PMID:29564676   PMID:29568061   PMID:30196744   PMID:30397336   PMID:30463901   PMID:30781697   PMID:30914742   PMID:31091453   PMID:31586073  
PMID:31722399   PMID:31793126   PMID:32203420   PMID:32457219   PMID:32694731   PMID:32963317  


Genomics

Comparative Map Data
RHOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl113,826,978 - 3,840,959 (-)EnsemblGRCh38hg38GRCh38
GRCh38113,826,978 - 3,840,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37113,848,208 - 3,862,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,804,784 - 3,818,789 (-)NCBINCBI36hg18NCBI36
Build 34113,804,787 - 3,818,760NCBI
Celera113,853,361 - 3,867,364 (-)NCBI
Cytogenetic Map11p15.4NCBI
HuRef113,581,920 - 3,595,920 (-)NCBIHuRef
CHM1_1113,847,677 - 3,861,683 (-)NCBICHM1_1
Rhog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,888,330 - 101,899,325 (-)NCBIGRCm39mm39
GRCm39 Ensembl7101,888,330 - 101,905,261 (-)Ensembl
GRCm387102,239,123 - 102,250,118 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,239,123 - 102,256,054 (-)EnsemblGRCm38mm10GRCm38
MGSCv377109,387,637 - 109,398,632 (-)NCBIGRCm37mm9NCBIm37
MGSCv367102,112,947 - 102,123,917 (-)NCBImm8
Celera7102,607,383 - 102,618,359 (-)NCBICelera
Cytogenetic Map7E2NCBI
Rhog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21156,618,713 - 156,630,710 (-)NCBI
Rnor_6.0 Ensembl1167,335,248 - 167,347,671 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01167,336,147 - 167,347,720 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01173,524,755 - 173,536,310 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,724,016 - 159,735,532 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,803,032 - 159,814,376 (-)NCBI
Celera1154,686,683 - 154,698,201 (-)NCBICelera
Cytogenetic Map1q32NCBI
Rhog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,630,564 - 19,641,550 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,630,564 - 19,641,722 (-)NCBIChiLan1.0ChiLan1.0
RHOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1113,811,292 - 3,812,569 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,811,877 - 3,812,452 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0113,698,179 - 3,712,402 (-)NCBIMhudiblu_PPA_v0panPan3
RHOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,371,868 - 26,373,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,372,462 - 26,373,037 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,142,860 - 26,154,552 (-)NCBI
ROS_Cfam_1.02126,582,441 - 26,594,122 (-)NCBI
UMICH_Zoey_3.12126,373,770 - 26,385,459 (-)NCBI
UNSW_CanFamBas_1.02126,589,533 - 26,601,228 (-)NCBI
UU_Cfam_GSD_1.02126,491,823 - 26,503,514 (-)NCBI
Rhog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,477,814 - 59,488,467 (+)NCBI
SpeTri2.0NW_0049364981,077,354 - 1,088,003 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.196,283,558 - 6,295,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,080,898 - 7,092,000 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,881,857 - 62,896,073 (+)NCBI
ChlSab1.1 Ensembl162,881,941 - 62,895,529 (+)Ensembl
Vero_WHO_p1.0NW_02366604363,006,117 - 63,020,382 (-)NCBI
Rhog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248175,269,691 - 5,281,160 (-)NCBI

Position Markers
WI-9059  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,848,560 - 3,848,662UniSTSGRCh37
Build 36113,805,136 - 3,805,238RGDNCBI36
Celera113,853,713 - 3,853,815RGD
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,582,272 - 3,582,374UniSTS
D11S2344  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,860,860 - 3,860,896UniSTSGRCh37
GRCh37113,860,755 - 3,860,896UniSTSGRCh37
Build 36113,817,331 - 3,817,472RGDNCBI36
Celera113,865,906 - 3,866,047RGD
Celera113,866,011 - 3,866,047UniSTS
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,594,461 - 3,594,602UniSTS
HuRef113,594,566 - 3,594,602UniSTS
D11S2345  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,860,646 - 3,860,880UniSTSGRCh37
GRCh37113,860,646 - 3,860,775UniSTSGRCh37
Build 36113,817,222 - 3,817,351RGDNCBI36
Celera113,865,799 - 3,865,926RGD
Celera113,865,799 - 3,866,031UniSTS
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,594,354 - 3,594,481UniSTS
HuRef113,594,354 - 3,594,586UniSTS
D11S2346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,860,607 - 3,860,903UniSTSGRCh37
Build 36113,817,183 - 3,817,479RGDNCBI36
Celera113,865,760 - 3,866,054RGD
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,594,315 - 3,594,609UniSTS
ARHG_57  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,848,161 - 3,849,011UniSTSGRCh37
Build 36113,804,737 - 3,805,587RGDNCBI36
Celera113,853,314 - 3,854,164RGD
HuRef113,581,873 - 3,582,723UniSTS
D11S4526  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,847,961 - 3,848,238UniSTSGRCh37
Build 36113,804,537 - 3,804,814RGDNCBI36
Celera113,853,114 - 3,853,391RGD
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,581,673 - 3,581,950UniSTS
Whitehead-RH Map1138.6UniSTS
Whitehead-YAC Contig Map11 UniSTS
G05404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,851,972 - 3,852,200UniSTSGRCh37
Build 36113,808,548 - 3,808,776RGDNCBI36
Celera113,857,125 - 3,857,353RGD
Cytogenetic Map11p15.5-p15.4UniSTS
HuRef113,585,684 - 3,585,912UniSTS
Whitehead-YAC Contig Map11 UniSTS
D1Bda69  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37113,848,222 - 3,848,530UniSTSGRCh37
Build 36113,804,798 - 3,805,106RGDNCBI36
Celera113,853,375 - 3,853,683RGD

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1521
Count of miRNA genes:509
Interacting mature miRNAs:560
Transcripts:ENST00000351018, ENST00000396978, ENST00000396979, ENST00000533217
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 273 273 1
Medium 2431 2630 1674 574 1675 416 4330 2091 3307 406 1445 1606 170 1204 2763 4
Low 2 83 49 48 3 48 25 105 405 12 4 3 25 1
Below cutoff 2 1 1 13 1 8 2 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005252916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA424888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF498974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY563952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI196968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX359696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB125569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000351018   ⟹   ENSP00000339467
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl113,826,978 - 3,840,959 (-)Ensembl
RefSeq Acc Id: ENST00000396978   ⟹   ENSP00000380175
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl113,827,416 - 3,840,842 (-)Ensembl
RefSeq Acc Id: ENST00000396979   ⟹   ENSP00000380176
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl113,826,982 - 3,837,867 (-)Ensembl
RefSeq Acc Id: ENST00000533217   ⟹   ENSP00000436932
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl113,827,445 - 3,830,651 (-)Ensembl
RefSeq Acc Id: NM_001665   ⟹   NP_001656
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38113,826,978 - 3,840,959 (-)NCBI
GRCh37113,848,208 - 3,862,213 (-)ENTREZGENE
Build 36113,804,784 - 3,818,789 (-)NCBI Archive
HuRef113,581,920 - 3,595,920 (-)ENTREZGENE
CHM1_1113,847,677 - 3,861,683 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005252916   ⟹   XP_005252973
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38113,826,978 - 3,840,837 (-)NCBI
GRCh37113,848,208 - 3,862,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017719   ⟹   XP_016873208
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38113,826,978 - 3,830,646 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001656   ⟸   NM_001665
- UniProtKB: P84095 (UniProtKB/Swiss-Prot),   Q6ICQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005252973   ⟸   XM_005252916
- Peptide Label: isoform X1
- UniProtKB: P84095 (UniProtKB/Swiss-Prot),   Q6ICQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016873208   ⟸   XM_017017719
- Peptide Label: isoform X1
- UniProtKB: P84095 (UniProtKB/Swiss-Prot),   Q6ICQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000436932   ⟸   ENST00000533217
RefSeq Acc Id: ENSP00000339467   ⟸   ENST00000351018
RefSeq Acc Id: ENSP00000380176   ⟸   ENST00000396979
RefSeq Acc Id: ENSP00000380175   ⟸   ENST00000396978

Promoters
RGD ID:6789317
Promoter ID:HG_KWN:12074
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:UC009YEE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36113,805,381 - 3,806,027 (-)MPROMDB
RGD ID:6788824
Promoter ID:HG_KWN:12075
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000396979
Position:
Human AssemblyChrPosition (strand)Source
Build 36113,815,176 - 3,816,447 (-)MPROMDB
RGD ID:6788825
Promoter ID:HG_KWN:12076
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000396978,   NM_001665
Position:
Human AssemblyChrPosition (strand)Source
Build 36113,818,731 - 3,819,432 (-)MPROMDB
RGD ID:6853264
Promoter ID:EP74453
Type:initiation region
Name:HS_ARHG
Description:Ras homolog gene family, member G (rho G).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36113,818,764 - 3,818,824EPD
RGD ID:7219409
Promoter ID:EPDNEW_H15451
Type:initiation region
Name:RHOG_1
Description:ras homolog family member G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38113,840,954 - 3,841,014EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.4(chr11:3745061-7846057)x3 copy number gain See cases [RCV000053616] Chr11:3745061..7846057 [GRCh38]
Chr11:3766291..7867604 [GRCh37]
Chr11:3722867..7824180 [NCBI36]
Chr11:11p15.4
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.4(chr11:3685244-4414881)x3 copy number gain See cases [RCV000141996] Chr11:3685244..4414881 [GRCh38]
Chr11:3706474..4436111 [GRCh37]
Chr11:3663050..4392687 [NCBI36]
Chr11:11p15.4
uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.4(chr11:3629393-4111738)x3 copy number gain See cases [RCV000240195] Chr11:3629393..4111738 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:193187-5291338)x3 copy number gain See cases [RCV000446036] Chr11:193187..5291338 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-6644927)x3 copy number gain See cases [RCV000449417] Chr11:230615..6644927 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.4(chr11:3629582-4677492)x3 copy number gain See cases [RCV000511398] Chr11:3629582..4677492 [GRCh37]
Chr11:11p15.4
likely benign
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
Single allele duplication not provided [RCV000677966] Chr11:3676830..3849140 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3 copy number gain not provided [RCV000683369] Chr11:230615..9704511 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Russell-Silver syndrome [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.4(chr11:3667691-4039971)x3 copy number gain not provided [RCV001006376] Chr11:3667691..4039971 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:230615-4851537)x3 copy number gain See cases [RCV001263059] Chr11:230615..4851537 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
NM_001665.4(RHOG):c.35G>A (p.Gly12Glu) single nucleotide variant Inborn genetic diseases [RCV001265911] Chr11:3828104 [GRCh38]
Chr11:3849334 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:210300-8664358)x3 copy number gain Russell-Silver syndrome [RCV001263222] Chr11:210300..8664358 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
NC_000011.9:g.(?_298501)_(4113028_?)dup duplication Early infantile epileptic encephalopathy with suppression bursts [RCV001316682] Chr11:298501..4113028 [GRCh37]
Chr11:11p15.5-15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:10701-5080415)x2 copy number gain See cases [RCV001310286] Chr11:10701..5080415 [GRCh37]
Chr11:11p15.5-15.4
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:672 AgrOrtholog
COSMIC RHOG COSMIC
Ensembl Genes ENSG00000177105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000339467 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380175 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380176 UniProtKB/Swiss-Prot
  ENSP00000436932 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000351018 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396978 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396979 UniProtKB/Swiss-Prot
  ENST00000533217 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000177105 GTEx
HGNC ID HGNC:672 ENTREZGENE
Human Proteome Map RHOG Human Proteome Map
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:391 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 391 ENTREZGENE
OMIM 179505 OMIM
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24955 PharmGKB
PROSITE RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P84095 ENTREZGENE
  Q6ICQ8 ENTREZGENE, UniProtKB/TrEMBL
  RHOG_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary P35238 UniProtKB/Swiss-Prot
  Q8NI04 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-03-01 RHOG  ras homolog family member G  RHOG  ras homolog gene family, member G (rho G)  Symbol and/or name change 5135510 APPROVED