LRP5 (LDL receptor related protein 5) - Rat Genome Database

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Gene: LRP5 (LDL receptor related protein 5) Pan paniscus
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Symbol: LRP5
Name: LDL receptor related protein 5
RGD ID: 11858708
Description: ENCODES a protein that exhibits coreceptor activity involved in Wnt signaling pathway (ortholog); toxin transmembrane transporter activity (ortholog); Wnt-activated receptor activity (ortholog); INVOLVED IN adipose tissue development (ortholog); anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); Bone Fractures (ortholog); FOUND IN plasma membrane (ortholog); receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC103783353; low-density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
anatomical structure regression  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
bone development  (ISO)
bone marrow development  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (ISO)
branching involved in mammary gland duct morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell migration involved in gastrulation  (ISO)
cell-cell signaling involved in mammary gland development  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
embryonic digit morphogenesis  (ISO)
extracellular matrix-cell signaling  (ISO)
gastrulation with mouth forming second  (ISO)
glucose catabolic process  (ISO)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
Norrin signaling pathway  (ISO)
osteoblast development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of apoptotic process  (ISO)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (ISO)
somatic stem cell population maintenance  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,298,866 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBI
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBI
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBI
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBI
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBI
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBI
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBI
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)Ensembl
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBI
Lrp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032011   ⟹   ENSPPAP00000009370
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032017   ⟹   ENSPPAP00000009376
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1166,738,489 - 66,839,817 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032024   ⟹   ENSPPAP00000009383
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1166,738,489 - 66,839,817 (+)Ensembl
RefSeq Acc Id: XM_008954187   ⟹   XP_008952435
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11166,794,645 - 66,840,019 (+)NCBI
Mhudiblu_PPA_v01163,488,113 - 63,534,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034933196   ⟹   XP_034789087
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01163,396,511 - 63,534,103 (+)NCBI
RefSeq Acc Id: XM_034933197   ⟹   XP_034789088
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01163,430,383 - 63,534,103 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008952435 (Get FASTA)   NCBI Sequence Viewer  
  XP_034789087 (Get FASTA)   NCBI Sequence Viewer  
  XP_034789088 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008952435   ⟸   XM_008954187
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034789087   ⟸   XM_034933196
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034789088   ⟸   XM_034933197
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000009376   ⟸   ENSPPAT00000032017
RefSeq Acc Id: ENSPPAP00000009370   ⟸   ENSPPAT00000032011
RefSeq Acc Id: ENSPPAP00000009383   ⟸   ENSPPAT00000032024


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027899 Ensembl
NCBI Gene LRP5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 LRP5  LDL receptor related protein 5  LOC103783353  low-density lipoprotein receptor-related protein 5-like  Data Merged 737654 PROVISIONAL