Lrp6 (low density lipoprotein receptor-related protein 6) - Rat Genome Database

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Gene: Lrp6 (low density lipoprotein receptor-related protein 6) Mus musculus
Symbol: Lrp6
Name: low density lipoprotein receptor-related protein 6
RGD ID: 1312374
Description: Enables Wnt-protein binding activity; apolipoprotein binding activity; and toxin transmembrane transporter activity. Involved in cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of neuron projection development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of Wnt signaling pathway, planar cell polarity pathway. Located in early endosome and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study fatty liver disease and neural tube defect. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C030016K15Rik; Cd; crooked; Gw; low density lipoprotein-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; RIKEN cDNA C030016K15 gene; ska; ska26; ska; skax; skax26
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396134,423,439 - 134,543,876 (-)NCBIGRCm39mm39
GRCm39 Ensembl6134,423,439 - 134,543,928 (-)Ensembl
GRCm386134,446,476 - 134,566,913 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,446,476 - 134,566,965 (-)EnsemblGRCm38mm10GRCm38
MGSCv376134,400,434 - 134,516,931 (-)NCBIGRCm37mm9NCBIm37
MGSCv366134,415,902 - 134,532,475 (-)NCBImm8
Celera6137,380,826 - 137,512,292 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1,4-phenylenediamine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
chloroprene  (ISO)
clofibric acid  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
ethanol  (EXP,ISO)
ethosuximide  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
gingerol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
kojic acid  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
niclosamide  (ISO)
paclitaxel  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
tert-butyl hydroperoxide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IGI,IMP)
axis elongation  (IMP)
axis elongation involved in somitogenesis  (IGI)
bone morphogenesis  (IMP)
bone remodeling  (IGI)
branching involved in mammary gland duct morphogenesis  (IMP)
canonical Wnt signaling pathway  (IBA,IGI,IMP,ISO)
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development  (IMP)
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  (IMP)
cell migration involved in gastrulation  (IGI)
cell-cell adhesion  (ISO)
cellular response to cholesterol  (ISO)
cerebellum morphogenesis  (IMP)
cerebral cortex cell migration  (IMP)
cerebral cortex development  (IMP)
chemical synaptic transmission  (IBA,ISO)
convergent extension  (IGI)
dopaminergic neuron differentiation  (IMP)
dorsal/ventral axis specification  (IMP)
embryonic camera-type eye morphogenesis  (IMP)
embryonic digit morphogenesis  (IGI,IMP)
embryonic forelimb morphogenesis  (IGI,IMP)
embryonic hindlimb morphogenesis  (IGI,IMP)
embryonic limb morphogenesis  (IGI)
embryonic pattern specification  (IMP)
embryonic retina morphogenesis in camera-type eye  (IMP)
endocytosis  (IEA)
external genitalia morphogenesis  (IMP)
face morphogenesis  (IMP)
forebrain development  (IMP)
forebrain generation of neurons  (IMP)
forebrain radial glial cell differentiation  (IGI)
formation of radial glial scaffolds  (IGI)
gastrulation with mouth forming second  (IGI)
generation of neurons  (IMP)
heart looping  (IGI)
limb morphogenesis  (IGI,IMP)
mammary gland duct morphogenesis  (IGI)
mammary placode formation  (IMP)
midbrain development  (IMP)
midbrain-hindbrain boundary development  (IMP)
morphogenesis of an epithelium  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of fat cell differentiation  (IMP)
negative regulation of non-canonical Wnt signaling pathway  (IGI)
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis  (IGI)
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis  (IGI)
negative regulation of planar cell polarity pathway involved in neural tube closure  (IGI)
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis  (IGI)
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis  (IGI)
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis  (IGI)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein serine/threonine kinase activity  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
neural crest cell differentiation  (ISO)
neural crest formation  (ISO)
neural tube closure  (IGI,IMP)
neural tube development  (IGI)
Norrin signaling pathway  (IDA)
odontogenesis of dentin-containing tooth  (IMP)
pericardium morphogenesis  (IGI)
positive regulation of apoptotic process  (IMP)
positive regulation of bone resorption  (IMP)
positive regulation of cell cycle  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-binding transcription factor activity  (IBA,IMP,ISO)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of neuron projection development  (IGI)
positive regulation of ossification  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO)
post-anal tail morphogenesis  (IGI,IMP)
primitive streak formation  (IGI)
protein localization to plasma membrane  (ISO)
receptor-mediated endocytosis involved in cholesterol transport  (IBA,IMP)
regulation of cell development  (IMP)
regulation of cell population proliferation  (IMP)
regulation of transcription, DNA-templated  (ISO)
response to folic acid  (IMP)
response to peptide hormone  (ISO)
retina morphogenesis in camera-type eye  (IMP)
roof of mouth development  (IMP)
skeletal system morphogenesis  (IMP)
somitogenesis  (IGI)
thalamus development  (IMP)
trachea cartilage morphogenesis  (IGI)
Wnt signaling pathway  (ISO)
Wnt signaling pathway involved in forebrain neuroblast division  (IGI,IMP)
Wnt signaling pathway involved in somitogenesis  (IBA,IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amnion morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal bone structure  (IAGP)
abnormal brown adipose tissue morphology  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal coat appearance  (IEA)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal digit morphology  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal external female genitalia morphology  (IAGP)
abnormal external male genitalia morphology  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal fatty acids level  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal frontal bone morphology  (IEA)
abnormal germ layer development  (IAGP)
abnormal head morphology  (IAGP)
abnormal head movements  (IEA)
abnormal head shape  (IEA)
abnormal head size  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal joint morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal midbrain morphology  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal molar cusp morphology  (IAGP)
abnormal neural tube closure  (IAGP)
abnormal nose morphology  (IEA)
abnormal orientation of outer hair cell stereociliary bundles  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal outer ear morphology  (IEA)
abnormal paraxial mesoderm morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal sacral vertebrae morphology  (IEA)
abnormal skeleton morphology  (IAGP)
abnormal somite development  (IAGP)
abnormal tail bud morphology  (IAGP)
abnormal tail ring morphology  (IAGP)
abnormal tarsal bone morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal tooth development  (IEA)
abnormal tooth eruption  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vertebrae development  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent apical ectodermal ridge  (IAGP)
absent carpal bone  (IAGP)
absent endoderm  (IAGP)
absent fibula  (IAGP)
absent inferior colliculus  (IAGP)
absent metacarpal bones  (IAGP)
absent paraxial mesoderm  (IAGP)
absent somites  (IAGP)
absent vertebrae  (IAGP)
anophthalmia  (IEA)
caudal body truncation  (IAGP)
caudal vertebral fusion  (IAGP)
cleft palate  (IAGP)
cleft upper lip  (IAGP)
craniorachischisis  (IAGP)
curly tail  (IAGP)
decreased birth body size  (IEA)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased bone mineral density  (IAGP)
decreased circulating glucose level  (IAGP)
decreased cranium height  (IAGP)
decreased embryo size  (IAGP)
decreased fetal size  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased molar number  (IAGP)
decreased somite size  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased susceptibility to induced hypothermia  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IEA)
dilated renal tubules  (IAGP)
ectopic cartilage  (IAGP)
embryonic lethality before implantation, incomplete penetrance  (IAGP)
enlarged liver  (IAGP)
exencephaly  (IAGP)
failure of bone ossification  (IAGP)
failure of eyelid fusion  (IAGP)
forebrain hypoplasia  (IAGP)
fused dorsal root ganglion  (IAGP)
growth retardation of molars  (IEA)
hemivertebra  (IAGP)
hepatic steatosis  (IAGP)
hyperlipidemia  (IAGP)
improved glucose tolerance  (IAGP)
incomplete somite formation  (IAGP)
increased brown fat cell number  (IAGP)
increased cholesterol level  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating bilirubin level  (IAGP)
increased circulating creatinine level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased circulating VLDL triglyceride level  (IAGP)
increased forebrain size  (IAGP)
increased insulin sensitivity  (IAGP)
increased liver cholesterol level  (IAGP)
increased liver triglyceride level  (IAGP)
insulin resistance  (IAGP)
kidney cyst  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
liver fibrosis  (IAGP)
liver inflammation  (IAGP)
long upper incisors  (IEA)
microphthalmia  (IAGP)
monodactyly  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
osteoporosis  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydactyly  (IAGP)
postnatal growth retardation  (IEA)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IEA)
protruding tongue  (IAGP)
retina coloboma  (IAGP)
rib fusion  (IAGP)
short incisors  (IEA)
short limbs  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short Meckel's cartilage  (IAGP)
short tail  (IAGP)
sirenomelia  (IAGP)
small caudal vertebrae  (IEA)
small cranium  (IEA)
small kidney  (IAGP)
small lower incisors  (IAGP)
small molars  (IAGP)
small tail bud  (IAGP)
sparse hair  (IAGP)
spina bifida  (IAGP)
spina bifida cystica  (IAGP)
spina bifida occulta  (IAGP)
split sternum  (IAGP)
synostosis  (IAGP)
thin neurocranium  (IEA)
vertebral fusion  (IAGP)
vestigial tail  (IAGP)

Additional References at PubMed
PMID:591875   PMID:5088022   PMID:5893447   PMID:7003792   PMID:7604039   PMID:7909665   PMID:8522158   PMID:9704021   PMID:10349636   PMID:10545599   PMID:11029008   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11431694   PMID:12412008   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12573468   PMID:12579474   PMID:12581525   PMID:12626757   PMID:12812787  
PMID:12904583   PMID:14610273   PMID:14681479   PMID:14715945   PMID:15035989   PMID:15064719   PMID:15115753   PMID:15142971   PMID:15143170   PMID:15226823   PMID:15265030   PMID:15271658  
PMID:15342465   PMID:15342729   PMID:15358670   PMID:15384171   PMID:15466886   PMID:15469977   PMID:15489334   PMID:15537447   PMID:15800025   PMID:15880584   PMID:15923619   PMID:16102745  
PMID:16126904   PMID:16141072   PMID:16141073   PMID:16263759   PMID:16466971   PMID:16543246   PMID:16564009   PMID:16602821   PMID:16815997   PMID:16920270   PMID:17002572   PMID:17050573  
PMID:17064353   PMID:17335347   PMID:17376403   PMID:17389516   PMID:17488095   PMID:17569865   PMID:17698587   PMID:17888405   PMID:18256198   PMID:18258849   PMID:18351675   PMID:18502762  
PMID:18505367   PMID:18505732   PMID:18509060   PMID:18524778   PMID:18528331   PMID:18606138   PMID:18635608   PMID:18800919   PMID:18948618   PMID:18985738   PMID:19023080   PMID:19056682  
PMID:19075000   PMID:19147944   PMID:19503830   PMID:19515997   PMID:19562671   PMID:19576224   PMID:19653321   PMID:19672307   PMID:19700620   PMID:19705442   PMID:19718039   PMID:19795512  
PMID:19795519   PMID:19857465   PMID:19910923   PMID:20093360   PMID:20160075   PMID:20359476   PMID:20724449   PMID:20843827   PMID:21185284   PMID:21228006   PMID:21237142   PMID:21267068  
PMID:21337463   PMID:21375506   PMID:21406690   PMID:21531785   PMID:21623369   PMID:21625468   PMID:21677750   PMID:21678468   PMID:21731673   PMID:21866564   PMID:21873635   PMID:21887268  
PMID:21903671   PMID:21905163   PMID:21924256   PMID:21991325   PMID:22232553   PMID:22343533   PMID:22357953   PMID:22433869   PMID:22461561   PMID:22491013   PMID:22576936   PMID:22907437  
PMID:23293290   PMID:23302695   PMID:23306204   PMID:23400998   PMID:23572575   PMID:23609180   PMID:23637775   PMID:23638027   PMID:23652555   PMID:23675479   PMID:23743975   PMID:23756208  
PMID:23773994   PMID:23845000   PMID:23884893   PMID:23925701   PMID:23968836   PMID:24113179   PMID:24140542   PMID:24191021   PMID:24203697   PMID:24447593   PMID:24506864   PMID:24556500  
PMID:24639464   PMID:24661562   PMID:24692544   PMID:24700412   PMID:24859004   PMID:24952961   PMID:25009587   PMID:25083995   PMID:25088803   PMID:25242217   PMID:25710911   PMID:25727890  
PMID:25802278   PMID:25847683   PMID:25902418   PMID:25917329   PMID:26034040   PMID:26047795   PMID:26049137   PMID:26273529   PMID:26288816   PMID:26443636   PMID:26489464   PMID:26772978  
PMID:26840599   PMID:27031698   PMID:27045006   PMID:27250245   PMID:27321946   PMID:27480124   PMID:27789627   PMID:27803037   PMID:27864382   PMID:27919787   PMID:28133444   PMID:28341812  
PMID:28378742   PMID:28425175   PMID:28978771   PMID:29176883   PMID:29344294   PMID:29413898   PMID:29602775   PMID:29626090   PMID:29656209   PMID:30070011   PMID:30201296   PMID:30254141  
PMID:30325689   PMID:30332639   PMID:30567484   PMID:30664649   PMID:30668923   PMID:30711569   PMID:30713111   PMID:31073040   PMID:31239337   PMID:31452509   PMID:31609038   PMID:31638173  
PMID:31747615   PMID:31811407   PMID:32325033   PMID:32369449   PMID:32571845   PMID:32767654   PMID:32820125   PMID:32822074   PMID:32905882   PMID:32917787   PMID:32973339   PMID:33164872  
PMID:33192541   PMID:34032267   PMID:34431536  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396134,423,439 - 134,543,876 (-)NCBIGRCm39mm39
GRCm39 Ensembl6134,423,439 - 134,543,928 (-)Ensembl
GRCm386134,446,476 - 134,566,913 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,446,476 - 134,566,965 (-)EnsemblGRCm38mm10GRCm38
MGSCv376134,400,434 - 134,516,931 (-)NCBIGRCm37mm9NCBIm37
MGSCv366134,415,902 - 134,532,475 (-)NCBImm8
Celera6137,380,826 - 137,512,292 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.37NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1212,116,025 - 12,267,044 (-)EnsemblGRCh38hg38GRCh38
GRCh381212,116,025 - 12,267,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371212,268,959 - 12,419,978 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,160,226 - 12,311,078 (-)NCBINCBI36hg18NCBI36
Build 341212,164,957 - 12,311,013NCBI
Celera1217,412,009 - 17,562,835 (-)NCBI
Cytogenetic Map12p13.2NCBI
HuRef1212,034,207 - 12,184,947 (-)NCBIHuRef
CHM1_11212,234,005 - 12,384,830 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.24167,266,581 - 167,400,155 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4167,270,353 - 167,400,497 (-)Ensembl
Rnor_6.04168,194,054 - 168,323,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,194,927 - 168,323,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,475,530 - 232,606,101 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,337,114 - 171,444,932 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14171,582,253 - 171,717,580 (-)NCBI
Celera4155,870,415 - 155,972,673 (-)NCBICelera
Cytogenetic Map4q43NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554139,080,914 - 9,237,650 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,080,901 - 9,237,644 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11212,508,108 - 12,658,074 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1212,508,108 - 12,657,973 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01212,121,411 - 12,288,590 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12734,003,334 - 34,166,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2734,003,539 - 34,161,437 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,280,309 - 12,442,407 (-)NCBI
ROS_Cfam_1.02734,310,832 - 34,473,060 (+)NCBI
ROS_Cfam_1.0 Ensembl2734,310,825 - 34,468,519 (+)Ensembl
UMICH_Zoey_3.12734,203,210 - 34,365,409 (+)NCBI
UNSW_CanFamBas_1.02734,153,217 - 34,315,758 (+)NCBI
UU_Cfam_GSD_1.02712,010,982 - 12,174,011 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494595,337,435 - 95,417,648 (+)NCBI
SpeTri2.0NW_0049365875,065,200 - 5,143,029 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl560,149,028 - 60,314,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1560,149,041 - 60,318,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2563,564,404 - 63,674,461 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11112,016,542 - 12,170,496 (-)NCBIChlSab1.1chlSab2
ChlSab1.11112,016,542 - 12,170,496 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,021,560 - 12,170,663 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606923,151,738 - 23,306,613 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462475225,605,444 - 25,756,573 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386134,541,670 - 134,542,020UniSTSGRCm38
MGSCv376134,491,688 - 134,492,038UniSTSGRCm37
Celera6137,486,564 - 137,486,914UniSTS
Cytogenetic Map6G1UniSTS
cM Map663.8UniSTS
cM Map663.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6G1UniSTS
cM Map663.8UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386134,450,647 - 134,451,011UniSTSGRCm38
MGSCv376134,400,665 - 134,401,029UniSTSGRCm37
Celera6137,387,912 - 137,388,276UniSTS
Cytogenetic Map6G1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386134,450,647 - 134,450,943UniSTSGRCm38
MGSCv376134,400,665 - 134,400,961UniSTSGRCm37
Celera6137,387,912 - 137,388,208UniSTS
Cytogenetic Map6G1UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386134,484,301 - 134,485,718UniSTSGRCm38
MGSCv376134,434,319 - 134,435,736UniSTSGRCm37
Celera6137,424,662 - 137,426,079UniSTS
Cytogenetic Map6G1UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110838217144838360Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111165485145165578Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112269957147052561Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114368732145656013Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115242853146429238Mouse
4141194Cyx_mcycloheximide tasting (mouse)Not determined115569842149572401Mouse
4141889Qui_mquinine sensitivity, taste (mouse)Not determined115569842149572401Mouse
4141295Rua_mraffinose acetate tasting (mouse)Not determined115569842149572401Mouse
1301927Etohcta6_methanol conditioned taste aversion 6 (mouse)Not determined6115601042149601187Mouse
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116852888149736546Mouse
1301152Athsq2_matherosclerosis susceptibility QTL 2 (mouse)Not determined6117082986149736546Mouse
1301804Bulb2_mbulb size 2 (mouse)Not determined6120439808149736546Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124357314145656013Mouse
1302089Wta2_mweight adult 2 (mouse)Not determined6125323797149736546Mouse
10412134Cmv4_mcytomegalovirus resistance 4 (mouse)Not determined6127838217136045152Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128235142149736546Mouse
4141151Ath38_matherosclerosis 38 (mouse)Not determined128518894136316178Mouse
1301027Hdlq12_mHDL QTL 12 (mouse)Not determined6128655856149736546Mouse
10053680Lith25_mlithogenic gene 25 (mouse)Not determined6128655856149736546Mouse
10766452Sle23_msystematic lupus erythematosus susceptibility 23 (mouse)6128655856149736546Mouse
10412215Cmv3_mcytomegalovirus resistance 3 (mouse)Not determined6128834894137439929Mouse
1301084Bpq5_mblood pressure QTL 5 (mouse)Not determined6129428986149736546Mouse
1301686Trmq1_mT cell ratio modifier QTL 1 (mouse)Not determined6129428986149736546Mouse
4141974Skmw14_mskeletal muscle weight 14 (mouse)Not determined6129428986149736546Mouse
1301620Insq8_minsulin QTL 8 (mouse)Not determined6129633481149736546Mouse
1558959Eamcd2_mexperimental autoimmune myocarditis 2 (mouse)Not determined6130052456149736546Mouse
14746990Manh61_mmandible shape 61 (mouse)6130254857149736546Mouse
14746999Mancz6_mmandible centroid size 6 (mouse)6130254857149736546Mouse
12879916Shm5_msperm head morphology 5 (mouse)6132289569145656013Mouse
1301820Mop1_mmorphine preference 1 (mouse)Not determined6132601042146429238Mouse
12910121Lvic3_mliver iron content 3 (mouse)6134119450136045152Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1422
Count of miRNA genes:703
Interacting mature miRNAs:877
Transcripts:ENSMUST00000032322, ENSMUST00000111950, ENSMUST00000126836
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000032322   ⟹   ENSMUSP00000032322
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,423,439 - 134,543,876 (-)Ensembl
GRCm38.p6 Ensembl6134,446,476 - 134,566,913 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111950
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,427,446 - 134,448,256 (-)Ensembl
GRCm38.p6 Ensembl6134,450,483 - 134,471,293 (-)Ensembl
RefSeq Acc Id: ENSMUST00000126836   ⟹   ENSMUSP00000144733
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,488,247 - 134,543,928 (-)Ensembl
GRCm38.p6 Ensembl6134,511,284 - 134,566,965 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203016
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,438,726 - 134,441,971 (-)Ensembl
GRCm38.p6 Ensembl6134,461,763 - 134,465,008 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203235
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,517,737 - 134,518,677 (-)Ensembl
GRCm38.p6 Ensembl6134,540,774 - 134,541,714 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203773
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6134,439,361 - 134,444,724 (-)Ensembl
GRCm38.p6 Ensembl6134,462,398 - 134,467,761 (-)Ensembl
RefSeq Acc Id: NM_008514   ⟹   NP_032540
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm396134,423,439 - 134,543,876 (-)NCBI
GRCm386134,446,476 - 134,566,913 (-)NCBI
MGSCv376134,400,434 - 134,516,931 (-)RGD
Celera6137,380,826 - 137,512,292 (-)ENTREZGENE
RefSeq Acc Id: XM_006505657   ⟹   XP_006505720
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm396134,423,445 - 134,543,683 (-)NCBI
GRCm386134,447,370 - 134,566,720 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_032540   ⟸   NM_008514
- Peptide Label: precursor
- UniProtKB: O88572 (UniProtKB/Swiss-Prot),   A0A0R4J0A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006505720   ⟸   XM_006505657
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000032322   ⟸   ENSMUST00000032322
RefSeq Acc Id: ENSMUSP00000144733   ⟸   ENSMUST00000126836
Protein Domains
EGF-like   LDL-receptor class A

RGD ID:6839585
Promoter ID:MM_KWN:47973
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain,   Liver,   Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv366134,420,771 - 134,421,271 (-)MPROMDB
RGD ID:6839584
Promoter ID:MM_KWN:47975
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:OTTMUST00000050309,   OTTMUST00000050314
Mouse AssemblyChrPosition (strand)Source
MGSCv366134,516,856 - 134,517,392 (-)MPROMDB
RGD ID:6891282
Promoter ID:EPDNEW_M9092
Type:initiation region
Description:Mus musculus low density lipoprotein receptor-related protein6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm386134,566,955 - 134,567,015EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1298218 AgrOrtholog
Ensembl Genes ENSMUSG00000030201 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032322 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000144733 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032322 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000126836 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRP5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16974 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp6 PhenoGen
PIRSF LDL_recpt-rel_p5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-03 Lrp6  low density lipoprotein receptor-related protein 6  C030016K15Rik  RIKEN cDNA C030016K15 gene  Data Merged 737654 PROVISIONAL