Serping1 (serine (or cysteine) peptidase inhibitor, clade G, member 1) - Rat Genome Database

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Gene: Serping1 (serine (or cysteine) peptidase inhibitor, clade G, member 1) Mus musculus
Analyze
Symbol: Serping1
Name: serine (or cysteine) peptidase inhibitor, clade G, member 1
RGD ID: 1552805
MGI Page MGI
Description: Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway and negative regulation of endopeptidase activity. Located in extracellular space. Is expressed in several structures, including cerebral cortex; genitourinary system; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C1 esterase inhibitor; C1 Inh; C1 inhibitor; C1-inhibiting factor; C1I; C1INH; C1INH.; C1n; C1nh; complement component 1 inhibitor; plasma protease C1 inhibitor; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1; serine (or cysteine) proteinase inhibitor, clade G, member 1; serpin G1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,595,704 - 84,605,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,595,731 - 84,605,788 (-)EnsemblGRCm39 Ensembl
GRCm38284,765,360 - 84,775,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,765,387 - 84,775,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,605,517 - 84,615,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,566,224 - 84,576,243 (-)NCBIMGSCv36mm8
Celera286,360,569 - 86,370,824 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
butanal  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
danazol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (EXP)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
flutamide  (ISO)
folic acid  (EXP)
folpet  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
hydralazine  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
isotretinoin  (ISO)
lansoprazole  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methcathinone  (ISO)
methimazole  (ISO)
morphine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
olanzapine  (ISO)
omeprazole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
Ptaquiloside  (EXP)
rabeprazole  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
2. Myocardial infarction induces atrial inflammation that can be prevented by C1-esterase inhibitor. Begieneman MP, etal., J Clin Pathol. 2016 Dec;69(12):1093-1099. doi: 10.1136/jclinpath-2016-203639. Epub 2016 May 6.
3. Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia. Birnbaum J, etal., J Int Med Res. 2008 Jul-Aug;36(4):748-59.
4. Detection of C1 inhibitor (SERPING1/C1NH) mutations in exon 8 in patients with hereditary angioedema: evidence for 10 novel mutations. Blanch A, etal., Hum Mutat. 2002 Nov;20(5):405-6.
5. The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant. Bos IG, etal., J Biol Chem 2003 Aug 8;278(32):29463-70. Epub 2003 May 27.
6. Influence of C1-inhibitor on inflammation, edema and shock. Dickneite G Behring Inst Mitt. 1993 Dec;(93):299-305.
7. Refinement of tourniquet-induced peripheral ischemia/reperfusion injury in rats: comparison of 2 h vs 24 h reperfusion. Duehrkop C and Rieben R, Lab Anim. 2014 Apr;48(2):143-54. doi: 10.1177/0023677213516313.
8. C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage. Duehrkop C, etal., PLoS One. 2013 Aug 26;8(8):e72059. doi: 10.1371/journal.pone.0072059. eCollection 2013.
9. Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
10. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Fu J, etal., Biochem Biophys Res Commun. 2006 Oct 20;349(2):504-12. Epub 2006 Aug 22.
11. C1-inactivator is upregulated in glioblastoma. Förnvik K, etal., PLoS One. 2017 Sep 7;12(9):e0183086. doi: 10.1371/journal.pone.0183086. eCollection 2017.
12. Determination of a gene and environment risk model for age-related macular degeneration. Gibson J, etal., Br J Ophthalmol. 2010 Oct;94(10):1382-7. doi: 10.1136/bjo.2010.182568. Epub 2010 Jun 24.
13. Variation in complement component C1 inhibitor in age-related macular degeneration. Gibson J, etal., Immunobiology. 2012 Feb;217(2):251-5. doi: 10.1016/j.imbio.2011.07.015. Epub 2011 Jul 23.
14. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
15. C1-esterase inhibitor reduces infarct volume after cortical vein occlusion. Heimann A, etal., Brain Res. 1999 Aug 14;838(1-2):210-3.
16. Beneficial effects of C1 esterase inhibitor in murine traumatic shock. Kochilas L, etal., Shock. 1997 Sep;8(3):165-9.
17. Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
18. The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration. Lee AY, etal., Br J Ophthalmol. 2010 Jul;94(7):915-7. doi: 10.1136/bjo.2009.172007.
19. Molecular cloning, gene structure and expression profile of mouse C1 inhibitor. Lener M, etal., Eur J Biochem 1998 May 15;254(1):117-22.
20. MGDs mouse GO annotations MGD data from the GO Consortium
21. MGD IEA MGD IEA
22. The kallikrein-kinin system: current and future pharmacological targets. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
23. Association between the SERPING1 gene and age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese. Nakata I, etal., PLoS One. 2011 Apr 19;6(4):e19108. doi: 10.1371/journal.pone.0019108.
24. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
25. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. C1 inhibitor gene expression in patients with hereditary angioedema: quantitative evaluation by means of real-time RT-PCR. Pappalardo E, etal., J Allergy Clin Immunol. 2004 Sep;114(3):638-44.
28. Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects. Park KH, etal., Mol Vis. 2009;15:200-7. Epub 2009 Jan 23.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
35. Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. Su Z, etal., J Intern Med. 2014 Feb 4. doi: 10.1111/joim.12214.
36. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. Tomasi S, etal., PLoS One. 2011;6(7):e21999. Epub 2011 Jul 14.
37. Effects of C1 inhibitor and r-SP-C surfactant on oxygenation and histology in rats with lavage-induced acute lung injury. Vangerow B, etal., Intensive Care Med. 2001 Sep;27(9):1526-31.
38. Combined treatment with C1 esterase inhibitor and antithrombin III improves survival in severe acute experimental pancreatitis. Yamaguchi H, etal., Gut. 1997 Apr;40(4):531-5.
39. Effects of C1 inhibitor on endothelial cell activation in a rat hind limb ischemia-reperfusion injury model. Zhang S, etal., J Vasc Surg. 2018 Jan 27. pii: S0741-5214(17)32653-8. doi: 10.1016/j.jvs.2017.10.072.
40. Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema. Zuraw BL and Kalfus I, Am J Med. 2012 Sep;125(9):938.e1-7. doi: 10.1016/j.amjmed.2012.02.020. Epub 2012 Jul 14.
41. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. Zwijnenburg PJ, etal., J Infect Dis. 2007 Jul 1;196(1):115-23. Epub 2007 May 17.
Additional References at PubMed
PMID:9199246   PMID:9434962   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11956243   PMID:12421980   PMID:12477932   PMID:14610273   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16944957   PMID:17330941   PMID:17785834   PMID:18071075   PMID:18287559   PMID:18554416   PMID:18725516   PMID:18787060   PMID:18798549  
PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22159717   PMID:22705194   PMID:23341629   PMID:24006456   PMID:24172014   PMID:28535371   PMID:28670268   PMID:30882931  
PMID:31624071   PMID:32485229   PMID:34321999   PMID:34354123   PMID:35982894   PMID:38212417   PMID:38355793  


Genomics

Comparative Map Data
Serping1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,595,704 - 84,605,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,595,731 - 84,605,788 (-)EnsemblGRCm39 Ensembl
GRCm38284,765,360 - 84,775,444 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,765,387 - 84,775,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,605,517 - 84,615,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,566,224 - 84,576,243 (-)NCBIMGSCv36mm8
Celera286,360,569 - 86,370,824 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
SERPING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,597,685 - 57,614,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,597,387 - 57,619,171 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,365,158 - 57,382,321 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,121,603 - 57,138,902 (+)NCBINCBI36Build 36hg18NCBI36
Build 341157,121,733 - 57,138,895NCBI
Celera1154,721,543 - 54,738,843 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,713,821 - 53,731,117 (+)NCBIHuRef
CHM1_11157,231,240 - 57,248,536 (+)NCBICHM1_1
T2T-CHM13v2.01157,547,859 - 57,565,023 (+)NCBIT2T-CHM13v2.0
Serping1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,249,410 - 90,259,299 (-)NCBIGRCr8
mRatBN7.2369,842,726 - 69,852,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,842,739 - 69,852,034 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,224,542 - 73,233,831 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,823,206 - 81,832,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,582,111 - 79,591,395 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,161,230 - 72,171,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,161,189 - 72,171,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,681,813 - 78,691,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,968,808 - 67,978,102 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,865,179 - 67,874,474 (-)NCBI
Celera369,198,069 - 69,207,363 (-)NCBICelera
Cytogenetic Map3q24NCBI
Serping1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555112,545,285 - 2,557,982 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555112,545,337 - 2,557,850 (+)NCBIChiLan1.0ChiLan1.0
SERPING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,754,075 - 58,771,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,773,949 - 59,791,183 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,838,502 - 52,855,781 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,309,685 - 56,326,639 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,309,686 - 56,326,639 (+)Ensemblpanpan1.1panPan2
SERPING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,570,354 - 38,580,751 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,570,607 - 38,581,665 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,116,824 - 38,129,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,252,348 - 39,265,152 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,252,350 - 39,454,090 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11838,835,311 - 38,848,057 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,408,314 - 38,421,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,039,067 - 39,051,835 (-)NCBIUU_Cfam_GSD_1.0
Serping1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,797,581 - 14,810,679 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365814,908,458 - 4,924,645 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365814,911,403 - 4,924,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,324,158 - 13,338,663 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,324,160 - 13,338,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2212,957,676 - 12,972,291 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,617,122 - 15,634,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,616,674 - 15,633,855 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038112,967,736 - 112,984,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serping1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248643,091,083 - 3,103,090 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248643,091,397 - 3,103,084 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serping1
258 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:487
Count of miRNA genes:333
Interacting mature miRNAs:373
Transcripts:ENSMUST00000023994, ENSMUST00000111641, ENSMUST00000131456
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
11528549Sluc31_msusceptibility to lung cancer 31 (mouse)274524117129213005Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558901Skmw8_mskeletal muscle weight 8 (mouse)Not determined284008488118008593Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
4141657Mohg1_mmodifier of hg 1 (mouse)Not determined276678758103095823Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1301374Cplaq7_mcircadian period of locomotor activity 7 (mouse)Not determined276421483110421651Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
10043894Bw22_mbody weight QTL 22 (mouse)Not determined280895334114895334Mouse
15092054Egrme5_mearly growth rate, maternal effect 5 (mouse)282190187118004745Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
4142088Parms1_mpatched associated RMS 1 (mouse)Not determined74524117114123532Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse

Markers in Region
Serping1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38284,765,390 - 84,765,827UniSTSGRCm38
MGSCv37284,605,547 - 84,605,984UniSTSGRCm37
Celera286,360,599 - 86,361,036UniSTS
Cytogenetic Map2DUniSTS
cM Map2 UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000023994   ⟹   ENSMUSP00000023994
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl284,595,731 - 84,605,748 (-)Ensembl
GRCm38.p6 Ensembl284,765,387 - 84,775,404 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111641   ⟹   ENSMUSP00000107268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl284,595,850 - 84,605,788 (-)Ensembl
GRCm38.p6 Ensembl284,765,506 - 84,775,444 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl284,603,475 - 84,605,472 (-)Ensembl
GRCm38.p6 Ensembl284,773,131 - 84,775,128 (-)Ensembl
RefSeq Acc Id: NM_001420027   ⟹   NP_001406956
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39284,595,704 - 84,605,748 (-)NCBI
RefSeq Acc Id: NM_001420028   ⟹   NP_001406957
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39284,595,704 - 84,605,197 (-)NCBI
RefSeq Acc Id: NM_009776   ⟹   NP_033906
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39284,595,704 - 84,605,748 (-)NCBI
GRCm38284,765,360 - 84,775,429 (-)NCBI
MGSCv37284,605,517 - 84,615,586 (-)RGD
Celera286,360,569 - 86,370,824 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033906   ⟸   NM_009776
- Peptide Label: precursor
- UniProtKB: Q99M43 (UniProtKB/Swiss-Prot),   O88330 (UniProtKB/Swiss-Prot),   A2ATR7 (UniProtKB/Swiss-Prot),   Q9QX09 (UniProtKB/Swiss-Prot),   P97290 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000107268   ⟸   ENSMUST00000111641
Ensembl Acc Id: ENSMUSP00000023994   ⟸   ENSMUST00000023994
RefSeq Acc Id: NP_001406956   ⟸   NM_001420027
- Peptide Label: precursor
- UniProtKB: Q9QX09 (UniProtKB/Swiss-Prot),   Q99M43 (UniProtKB/Swiss-Prot),   P97290 (UniProtKB/Swiss-Prot),   O88330 (UniProtKB/Swiss-Prot),   A2ATR7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001406957   ⟸   NM_001420028
- Peptide Label: precursor
- UniProtKB: Q9QX09 (UniProtKB/Swiss-Prot),   Q99M43 (UniProtKB/Swiss-Prot),   P97290 (UniProtKB/Swiss-Prot),   O88330 (UniProtKB/Swiss-Prot),   A2ATR7 (UniProtKB/Swiss-Prot)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97290-F1-model_v2 AlphaFold P97290 1-504 view protein structure

Promoters
RGD ID:6832679
Promoter ID:MM_KWN:30008
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver,   Lung
Transcripts:ENSMUST00000111641,   NM_009776,   OTTMUST00000032880,   UC008KJD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36284,614,936 - 84,615,632 (-)MPROMDB
RGD ID:6877804
Promoter ID:EPDNEW_M2353
Type:initiation region
Name:Serping1_1
Description:Mus musculus serine peptidase inhibitor, clade G, member 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38284,775,404 - 84,775,464EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894696 AgrOrtholog
Ensembl Genes ENSMUSG00000023224 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023994 ENTREZGENE
  ENSMUST00000023994.10 UniProtKB/Swiss-Prot
  ENSMUST00000111641.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12258 UniProtKB/Swiss-Prot
MGD MGI:894696 ENTREZGENE
NCBI Gene 12258 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11461:SF159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Serping1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ATR7 ENTREZGENE
  A2ATR8_MOUSE UniProtKB/TrEMBL
  IC1_MOUSE UniProtKB/Swiss-Prot
  O88330 ENTREZGENE
  P97290 ENTREZGENE
  Q99M43 ENTREZGENE
  Q9QX09 ENTREZGENE
UniProt Secondary A2ATR7 UniProtKB/Swiss-Prot
  O88330 UniProtKB/Swiss-Prot
  Q99M43 UniProtKB/Swiss-Prot
  Q9QX09 UniProtKB/Swiss-Prot