LRP5 (LDL receptor related protein 5) - Rat Genome Database

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Gene: LRP5 (LDL receptor related protein 5) Sus scrofa
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Symbol: LRP5
Name: LDL receptor related protein 5
RGD ID: 14030019
Description: ENCODES a protein that exhibits toxin transmembrane transporter activity (ortholog); INVOLVED IN anatomical structure regression (ortholog); anterior/posterior pattern specification (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); Bone Fractures (ortholog); FOUND IN integral component of membrane (inferred); plasma membrane (inferred); receptor complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: low-density lipoprotein receptor-related protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IBA,IEA)
anatomical structure regression  (IEA,ISO)
anterior/posterior pattern specification  (IBA,IEA,ISO)
apoptotic process involved in blood vessel morphogenesis  (IEA,ISO)
bone development  (ISO)
bone marrow development  (IBA,IEA)
bone morphogenesis  (IBA,IEA)
bone remodeling  (IBA,IEA,ISO)
branching involved in mammary gland duct morphogenesis  (IBA,IEA,ISO)
canonical Wnt signaling pathway  (IEA)
cell migration involved in gastrulation  (IEA,ISO)
cell-cell signaling involved in mammary gland development  (IEA,ISO)
cholesterol homeostasis  (IBA,IEA)
cholesterol metabolic process  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
endocytosis  (IEA)
extracellular matrix-cell signaling  (IEA)
gastrulation with mouth forming second  (IBA,IEA,ISO)
glucose catabolic process  (IEA)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of protein serine/threonine kinase activity  (IEA)
Norrin signaling pathway  (IEA)
osteoblast development  (IBA,IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of fat cell differentiation  (IEA)
positive regulation of mesenchymal cell proliferation  (IEA)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA)
positive regulation of transcription, DNA-templated  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of blood pressure  (IEA)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IBA,IEA,ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (IEA)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (IBA,IEA)
somatic stem cell population maintenance  (IEA,ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,298,866 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)Ensembl
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBI
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBI
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBI
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBI
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBI
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBI
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBI
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)Ensembl
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBI
Lrp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 4 3 5 2 22 2 3 1
Below cutoff 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014086   ⟹   ENSSSCP00000013700
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000026471   ⟹   ENSSSCP00000022247
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,533,596 - 4,653,916 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053598   ⟹   ENSSSCP00000042172
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000056493   ⟹   ENSSSCP00000059615
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,540,308 - 4,653,940 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077359   ⟹   ENSSSCP00000063616
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl24,534,391 - 4,653,910 (-)Ensembl
RefSeq Acc Id: XM_021082719   ⟹   XP_020938378
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,533,721 - 4,653,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082720   ⟹   XP_020938379
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,533,721 - 4,653,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082721   ⟹   XP_020938380
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,533,721 - 4,652,823 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082722   ⟹   XP_020938381
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,540,248 - 4,653,997 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021082723   ⟹   XP_020938382
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.124,540,248 - 4,653,997 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020938378   ⟸   XM_021082719
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020938379   ⟸   XM_021082720
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020938380   ⟸   XM_021082721
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020938382   ⟸   XM_021082723
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020938381   ⟸   XM_021082722
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000022247   ⟸   ENSSSCT00000026471
RefSeq Acc Id: ENSSSCP00000059615   ⟸   ENSSSCT00000056493
RefSeq Acc Id: ENSSSCP00000063616   ⟸   ENSSSCT00000077359
RefSeq Acc Id: ENSSSCP00000042172   ⟸   ENSSSCT00000053598
RefSeq Acc Id: ENSSSCP00000013700   ⟸   ENSSSCT00000014086
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012885 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013700 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000022247 UniProtKB/TrEMBL
  ENSSSCP00000042172 UniProtKB/TrEMBL
  ENSSSCP00000059615 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063616 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014086 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000026471 UniProtKB/TrEMBL
  ENSSSCT00000053598 UniProtKB/TrEMBL
  ENSSSCT00000056493 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000077359 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  LRP5/6 UniProtKB/TrEMBL
NCBI Gene LRP5 ENTREZGENE
Pfam Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PIRSF LDL_recpt-rel_p5/6 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
UniProt A0A287ADT1_PIG UniProtKB/TrEMBL
  A0A287BTN6_PIG UniProtKB/TrEMBL
  A0A5G2QIA1_PIG UniProtKB/TrEMBL
  A0A5K1UUD2_PIG UniProtKB/TrEMBL
  F1RVQ4_PIG UniProtKB/TrEMBL
UniProt Secondary I3LDW2 UniProtKB/TrEMBL
VGNC ID VGNC:98075 ENTREZGENE