RAC1 (Rac family small GTPase 1) - Rat Genome Database

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Gene: RAC1 (Rac family small GTPase 1) Sus scrofa
Analyze
Symbol: RAC1
Name: Rac family small GTPase 1
RGD ID: 13845955
Description: ENCODES a protein that exhibits ATPase binding (ortholog); G protein activity (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); actin filament polymerization (ortholog); PARTICIPATES IN Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 48 (ortholog); breast cancer (ortholog); Cardiomegaly (ortholog); FOUND IN cytosol (ortholog); early endosome membrane (ortholog); GABA-ergic synapse (ortholog); INTERACTS WITH cyclosporin A
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actin filament organization  (IBA,ISO)
actin filament polymerization  (ISO)
anatomical structure arrangement  (ISO)
angiotensin-activated signaling pathway involved in heart process  (ISO)
auditory receptor cell morphogenesis  (ISO)
axon guidance  (ISO)
bone resorption  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (IBA)
cell migration  (IEA,ISO)
cell motility  (IEA)
cell projection assembly  (IBA)
cell-cell junction organization  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebral cortex GABAergic interneuron development  (ISO)
cerebral cortex radially oriented cell migration  (ISO)
chemotaxis  (ISO)
cochlea morphogenesis  (ISO)
cortical cytoskeleton organization  (IBA,IEA)
cytoskeleton organization  (ISO)
dendrite development  (ISO)
dendrite morphogenesis  (ISO)
dopaminergic neuron differentiation  (ISO)
embryonic olfactory bulb interneuron precursor migration  (ISO)
endocytosis  (ISO)
engulfment of apoptotic cell  (IBA,IEA)
enzyme-linked receptor protein signaling pathway  (ISO)
epithelial cell morphogenesis  (ISO)
erythrocyte enucleation  (ISO)
establishment or maintenance of cell polarity  (IBA,IEA)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
hepatocyte growth factor receptor signaling pathway  (IEA)
homeostasis of number of cells within a tissue  (ISO)
hyperosmotic response  (ISO)
interneuron migration  (ISO)
lamellipodium assembly  (IEA,ISO)
localization  (IEA)
localization within membrane  (IEA)
mast cell chemotaxis  (ISO)
midbrain dopaminergic neuron differentiation  (ISO)
mitotic cytokinesis  (IEA)
motor neuron axon guidance  (IBA,IEA)
negative regulation of fibroblast migration  (IEA)
negative regulation of interleukin-23 production  (IEA)
neuron migration  (ISO)
neuron projection morphogenesis  (ISO)
non-canonical Wnt signaling pathway  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell-substrate adhesion  (IEA)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of filopodium assembly  (ISO)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of microtubule polymerization  (IEA)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of ovarian follicle development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
postsynaptic actin cytoskeleton organization  (ISO)
protein localization to plasma membrane  (ISO)
Rac protein signal transduction  (IBA)
regulation of actin cytoskeleton organization  (IBA,IEA)
regulation of cell adhesion involved in heart morphogenesis  (ISO)
regulation of cell migration  (IEA)
regulation of cell morphogenesis  (ISO)
regulation of cell shape  (IBA,IEA)
regulation of cell size  (IEA)
regulation of ERK5 cascade  (ISO)
regulation of fibroblast migration  (ISO)
regulation of lamellipodium assembly  (IEA)
regulation of neuron maturation  (ISO)
regulation of neuron migration  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neutrophil migration  (IBA)
regulation of nitric oxide biosynthetic process  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of respiratory burst  (IEA)
regulation of stress fiber assembly  (IEA)
ruffle assembly  (IEA)
ruffle organization  (IEA,ISO)
semaphorin-plexin signaling pathway  (ISO)
small GTPase-mediated signal transduction  (IEA,ISO)
sphingosine-1-phosphate receptor signaling pathway  (IEA)
substrate adhesion-dependent cell spreading  (IEA,ISO)
synaptic transmission, GABAergic  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:15679890   PMID:16129884   PMID:16428270   PMID:16978608   PMID:17145712   PMID:18387002   PMID:22301074   PMID:23389627   PMID:25660453   PMID:30032202   PMID:34745120  


Genomics

Comparative Map Data
RAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,374,527 - 6,403,967 (+)EnsemblGRCh38hg38GRCh38
GRCh3776,414,158 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36Build 36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
T2T-CHM13v2.076,493,927 - 6,523,370 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
Rac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,491,236 - 143,513,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,489,389 - 143,513,791 (-)EnsemblGRCm39 Ensembl
GRCm385143,505,481 - 143,528,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,503,634 - 143,528,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,266,349 - 144,288,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,761,100 - 143,783,611 (-)NCBIMGSCv36mm8
Celera5140,552,192 - 140,574,740 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.22NCBI
Rac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
Rac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,270,159 - 13,311,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,270,159 - 13,295,562 (-)NCBIChiLan1.0ChiLan1.0
RAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,267,125 - 11,296,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,591,833 - 59,621,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,039,379 - 7,068,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,559,590 - 6,599,814 (+)NCBIpanpan1.1PanPan1.1panPan2
RAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,726,259 - 11,758,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,655,494 - 11,757,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,358,080 - 13,382,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,733,309 - 11,759,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,733,323 - 11,759,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,609,365 - 11,633,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,589,106 - 11,613,379 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,817,075 - 11,841,312 (+)NCBIUU_Cfam_GSD_1.0
Rac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,822,631 - 139,837,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750107,689 - 122,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750107,689 - 122,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,911,598 - 30,934,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,912,841 - 30,933,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAC1
649 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000039540   ⟹   ENSSSCP00000051179
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl34,781,780 - 4,803,382 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077207   ⟹   ENSSSCP00000064350
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl34,783,265 - 4,793,472 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000091362   ⟹   ENSSSCP00000062132
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl34,783,265 - 4,793,910 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000095066   ⟹   ENSSSCP00000077998
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)Ensembl
RefSeq Acc Id: NM_001243585   ⟹   NP_001230514
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.134,783,053 - 4,803,510 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021085753   ⟹   XP_020941412
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.134,781,776 - 4,803,504 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020941412   ⟸   XM_021085753
- Peptide Label: isoform X1
- UniProtKB: A0A8W4FI56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230514   ⟸   NM_001243585
- UniProtKB: A0A4X1TUU9 (UniProtKB/TrEMBL),   A0A8D0PDP6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000051179   ⟸   ENSSSCT00000039540
RefSeq Acc Id: ENSSSCP00000062132   ⟸   ENSSSCT00000091362
RefSeq Acc Id: ENSSSCP00000064350   ⟸   ENSSSCT00000077207
RefSeq Acc Id: ENSSSCP00000077998   ⟸   ENSSSCT00000095066


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015056492 UniProtKB/TrEMBL
  ENSSSCG00025029339 UniProtKB/TrEMBL
  ENSSSCG00030005152 UniProtKB/TrEMBL
  ENSSSCG00035005819 UniProtKB/TrEMBL
  ENSSSCG00040075365 UniProtKB/TrEMBL
  ENSSSCG00045012934 UniProtKB/TrEMBL
  ENSSSCG00050030372 UniProtKB/TrEMBL
  ENSSSCG00055014928 UniProtKB/TrEMBL
  ENSSSCG00060069198 UniProtKB/TrEMBL
  ENSSSCG00065048098 UniProtKB/TrEMBL
  ENSSSCG00070011854 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039540.3 UniProtKB/TrEMBL
  ENSSSCT00000077207.2 UniProtKB/TrEMBL
  ENSSSCT00000091362.1 UniProtKB/TrEMBL
  ENSSSCT00000095066 ENTREZGENE
  ENSSSCT00000095066.1 UniProtKB/TrEMBL
  ENSSSCT00015075577.1 UniProtKB/TrEMBL
  ENSSSCT00025039927.1 UniProtKB/TrEMBL
  ENSSSCT00025040057.1 UniProtKB/TrEMBL
  ENSSSCT00030007044.1 UniProtKB/TrEMBL
  ENSSSCT00030007052.1 UniProtKB/TrEMBL
  ENSSSCT00030007061.1 UniProtKB/TrEMBL
  ENSSSCT00035007287.1 UniProtKB/TrEMBL
  ENSSSCT00035007293.1 UniProtKB/TrEMBL
  ENSSSCT00040104637.1 UniProtKB/TrEMBL
  ENSSSCT00045022066.1 UniProtKB/TrEMBL
  ENSSSCT00045022130.1 UniProtKB/TrEMBL
  ENSSSCT00045022159.1 UniProtKB/TrEMBL
  ENSSSCT00050040825.1 UniProtKB/TrEMBL
  ENSSSCT00055029582.1 UniProtKB/TrEMBL
  ENSSSCT00060094528.1 UniProtKB/TrEMBL
  ENSSSCT00060094587.1 UniProtKB/TrEMBL
  ENSSSCT00065065803.1 UniProtKB/TrEMBL
  ENSSSCT00070023104.1 UniProtKB/TrEMBL
  ENSSSCT00070023112.1 UniProtKB/TrEMBL
  ENSSSCT00070023122.1 UniProtKB/TrEMBL
  ENSSSCT00070023126.1 UniProtKB/TrEMBL
  ENSSSCT00070023139.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report ssc:100627149 UniProtKB/TrEMBL
NCBI Gene RAC1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
  PTHR24072:SF350 UniProtKB/TrEMBL
  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 UniProtKB/TrEMBL
  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3 UniProtKB/TrEMBL
  RAS-RELATED PROTEIN RAC1-RELATED UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A287B4G4_PIG UniProtKB/TrEMBL
  A0A4X1TPV7_PIG UniProtKB/TrEMBL
  A0A4X1TUT3_PIG UniProtKB/TrEMBL
  A0A4X1TUT7_PIG UniProtKB/TrEMBL
  A0A4X1TUU2_PIG UniProtKB/TrEMBL
  A0A4X1TUU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QQK3_PIG UniProtKB/TrEMBL
  A0A5G2QVC6_PIG UniProtKB/TrEMBL
  A0A8D0PDP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UNF0_PIG UniProtKB/TrEMBL
  A0A8D0VB44_PIG UniProtKB/TrEMBL
  A0A8D1HC37_PIG UniProtKB/TrEMBL
  A0A8D1KVR5_PIG UniProtKB/TrEMBL
  A0A8D1WKD8_PIG UniProtKB/TrEMBL
  A0A8W4FI56 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92047 ENTREZGENE