Aqp10 (aquaporin 10) - Rat Genome Database

Name: Aqp10
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Aqp10 (aquaporin 10) Ictidomys tridecemlineatus

Analyze

Symbol:

Aqp10

Name:

aquaporin 10

RGD ID:

12552000

Description:

ENCODES a protein that exhibits channel activity (inferred); glycerol channel activity (inferred); urea transmembrane transporter activity (inferred); INVOLVED IN cellular response to acidic pH (inferred); glycerol transmembrane transport (inferred); polyol transmembrane transport (inferred); PARTICIPATES IN water transport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma membrane (inferred); intracellular membrane-bounded organelle (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

aquaporin-10

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AQP10 (aquaporin 10)	NCBI	Ortholog
Mus musculus (house mouse):	Aqp10-ps (aquaporin 10, pseudogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Aqp10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aqp10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AQP10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AQP10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AQP10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AQP10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aqp10 (aquaporin 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	24,950,993 - 24,954,469 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	3,980,659 - 3,984,394 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	3,981,254 - 3,984,895 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to acidic pH (IEA)

glycerol transmembrane transport (IEA)

polyol transmembrane transport (IEA)

protein homotetramerization (IEA)

response to toxic substance (IEA)

transmembrane transport (IEA)

water transport (IEA)

Cellular Component

basolateral plasma membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

channel activity (IEA)

glycerol channel activity (IEA)

protein binding (ISO)

urea transmembrane transporter activity (IEA)

water channel activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

water transport pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aqp10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	24,950,993 - 24,954,469 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	3,980,659 - 3,984,394 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	3,981,254 - 3,984,895 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AQP10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	154,321,093 - 154,325,325 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	154,321,090 - 154,325,325 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	154,293,569 - 154,297,801 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	152,560,216 - 152,564,425 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	151,106,664 - 151,110,873	NCBI
Celera	1	127,365,303 - 127,369,516 (+)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	125,657,284 - 125,661,501 (+)	NCBI		HuRef
CHM1_1	1	155,689,895 - 155,694,130 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	153,458,259 - 153,462,492 (+)	NCBI		T2T-CHM13v2.0

Aqp10-ps
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	89,870,751 - 89,877,041 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	89,872,016 - 89,875,998 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	89,963,444 - 89,969,734 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	89,964,709 - 89,968,658 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	89,767,366 - 89,773,656 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	90,091,325 - 90,092,558 (-)	NCBI		MGSCv36	mm8
Celera	3	89,999,953 - 90,006,243 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	39.19	NCBI

Aqp10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	177,699,717 - 177,704,620 (-)	NCBI		GRCr8
mRatBN7.2	2	175,402,609 - 175,407,677 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	175,403,263 - 175,406,815 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	2	189,309,151 - 189,314,092 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	208,732,677 - 208,734,879 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	169,344,930 - 169,349,241 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Aqp10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	845,749 - 848,738 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	845,749 - 848,738 (+)	NCBI	ChiLan1.0	ChiLan1.0

AQP10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	95,506,299 - 95,511,820 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	95,241,532 - 95,247,053 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	129,677,969 - 129,682,681 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	133,291,027 - 133,295,265 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	133,291,027 - 133,295,265 (+)	Ensembl	panpan1.1		panPan2

AQP10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	42,961,041 - 42,964,053 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	42,451,365 - 42,454,540 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	42,830,882 - 42,834,057 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	42,830,139 - 42,833,937 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	42,609,750 - 42,613,405 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	42,663,571 - 42,666,669 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	42,947,589 - 42,950,761 (-)	NCBI		UU_Cfam_GSD_1.0

AQP10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	95,450,150 - 95,453,256 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	95,449,268 - 95,453,663 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	104,328,003 - 104,332,534 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AQP10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	9,489,562 - 9,506,229 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	9,492,846 - 9,496,367 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	8,845,092 - 8,858,410 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aqp10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	3,014,351 - 3,022,248 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624885	3,014,853 - 3,032,920 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021730566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000014615 ⟹ ENSSTOP00000013093

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936580	3,980,659 - 3,984,394 (+)	Ensembl

RefSeq Acc Id:

XM_021730566 ⟹ XP_021586241

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	24,950,993 - 24,954,469 (+)	NCBI
SpeTri2.0	NW_004936580	3,981,254 - 3,984,895 (+)	NCBI

Sequence:

show sequence

GGCGTGCACTCTACTGAGCCACCACTCCAGCCCCAAGATAATTGGTTTTAAAGTCTGTTCCTTA
TCTTTTCCCCTGGCATGCAGGAGCTGTGTACCTATGCACACAGAATAGCAGTGGACAGAGATAG
CAAGACACCACCATGGCCCCGGATCAGCTGCTGGCCAAAATGAGGGGCTACTTTCGGATCCACA
GCCTCCTGGCCCGACAGTGCTTGGCAGAGTTTCTGGGTGTATTTGTGCTCATGCTCCTCACTCA
GGGGGCTGTGGCCCAGGCTGTCACCAGTGGAGAAACCAAAGGGAACTTCTTCACCATGTTTCTG
GCTGGTTCTCTGGCAGTTACAATAGCCATCTACGTGGCGGGCAATGTCTCAGGAGCTCACCTGA
ACCCAGCCTTCTCCCTAGCCATGTGCCTCCTGGGACGCTTCCCCTGGTCCATGCTCCCCATCTA
CTGCTTCGTGCAGCTGCTGTCTGCCTTCTGTGCCTCTGGAGCCACCTATGTTCTCTACTATGAT
GCTCTACAGAACTATACAGGGGGGAACCTGACAGTGACTGGCCCCAAGGAGACTGCCTCCATCT
TTGCCACCTATCCTGCCCCTTATTTGTCCCTGAACAATGGCTTCCTGGATCAGGTTTTGGGCAC
TGGGATCCTGATTGTGGGGCTCTTGGCCATCCTGGACGGACGCAACAAGGGAGTTCCTGTGGGT
CTGGAGCCCGTGGTGGTGGGGCTGCTGATCCTAGTCATTGGACTATCCATGGGTGTCAACTGTG
GGTTCCCACTCAACCCTGCCAGAGATCTGGGTCCACGGCTCTTCACCTACGTGGCTGGCTGGGG
CCCTGAAGTCTTCAGTGCTGGCAATGGCTGGTGGTGGGTGCCTGTGGTGGCCCCTTTGGTGGGG
GCTACCCTTGGCACAGCCACATACCAGCTGCTGGTGGCTCTGCACCACCCTGAAGACTCAGAGC
AAGGTCAGAAAAAAGCCTCAGACTTGGAAACTCCTGCCTCCGTTCAGATGCCCAGCCTCAGGGC
CTCTAGGAACGCAGTTGCTAAAAGTAGCCACCAGGGGGTGTCCACCCTGGACGCTGGCTTGGGA
GGGCAGCGGGAGTCTGCGGGGTGGAGGGCCGACAGGGGAACTTTCCTCTAGTCGGGTCCTGGCG
GGGAACTTGCCTCCAAACCTGGGTCCCCTCTGCCTGACTTCCAGCTCTTGTAAGCCCAGCGTCG
CGCGCCTCTGCCCCACAGGGGCGCTTCGCGGACGGTCCTTAGCGGCGGGGAAGCCGCTCCATCC
AGGGGGCGTGGTGGGGCGGCGGAGCACGGGCCGCCCTCGCCGGGTAGGCAGGGAGAGAAAGGCG
TGAGACGAGGCACGACCTCTCCGGCCAACCCGAGGCTGTGTGGTTCACGGAGAGCGAAGTGCCA
CGGGAGGAGCCGGGCGAGGAGAGCGGGCGAGGAGCCCGAGGCGGGGCCACGGGGAAGCTGGCGG
CGAGGAGGATCCGAGCTCGCCGCTTCGCCCGCCCCCTGGTCCTCCGGGCCCAAGATGCGCTTTT
TGCAAAGAAGGCAGCATTTCTCATTCGCTTCTTACGAATTAAAAGGAAAACCCTCCGCTACCTG
GACTCCCGCGTTGTCCGTTTGTTGAGAGGTGCGGGACGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021586241	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013093.3
GenBank Protein	KAG3281684	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021586241 ⟸ XM_021730566

- UniProtKB:

I3MN93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAPDQLLAKMRGYFRIHSLLARQCLAEFLGVFVLMLLTQGAVAQAVTSGETKGNFFTMFLAGSL
AVTIAIYVAGNVSGAHLNPAFSLAMCLLGRFPWSMLPIYCFVQLLSAFCASGATYVLYYDALQN
YTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGILIVGLLAILDGRNKGVPVGLEPV
VVGLLILVIGLSMGVNCGFPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATLG
TATYQLLVALHHPEDSEQGQKKASDLETPASVQMPSLRASRNAVAKSSHQGVSTLDAGLGGQRE
SAGWRADRGTFL

hide sequence

RefSeq Acc Id:

ENSSTOP00000013093 ⟸ ENSSTOT00000014615

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014619	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014615.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1080.10	UniProtKB/TrEMBL
InterPro	Aquaporin-like	UniProtKB/TrEMBL
	Aquaporin_10	UniProtKB/TrEMBL
	MIP	UniProtKB/TrEMBL
	MIP_CS	UniProtKB/TrEMBL
NCBI Gene	Aqp10	ENTREZGENE
PANTHER	AQUAPORIN OR AQUAGLYCEROPORIN RELATED	UniProtKB/TrEMBL
	AQUAPORIN-10	UniProtKB/TrEMBL
Pfam	MIP	UniProtKB/TrEMBL
PRINTS	AQUAPORIN10M	UniProtKB/TrEMBL
	MINTRINSICP	UniProtKB/TrEMBL
PROSITE	MIP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF81338	UniProtKB/TrEMBL
UniProt	I3MN93	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations