STING1 (stimulator of interferon response cGAMP interactor 1) - Rat Genome Database

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Gene: STING1 (stimulator of interferon response cGAMP interactor 1) Sus scrofa
Analyze
Symbol: STING1
Name: stimulator of interferon response cGAMP interactor 1
RGD ID: 13984414
Description: ENCODES a protein that exhibits 2',3'-cyclic GMP-AMP binding (ortholog); cyclic-di-GMP binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN activation of innate immune response (ortholog); autophagosome assembly (ortholog); cellular response to interferon-beta (ortholog); ASSOCIATED WITH Animal Toxoplasmosis (ortholog); autosomal dominant intellectual developmental disorder 31 (ortholog); brucellosis (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); endoplasmic reticulum-Golgi intermediate compartment membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: stimulator of interferon genes protein; STING; TMEM173; transmembrane protein 173
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2141,358,993 - 141,367,198 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12141,359,402 - 141,367,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22147,169,469 - 147,177,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:14681463   PMID:20346968   PMID:22301074   PMID:22312267   PMID:30032202  


Genomics

Comparative Map Data
STING1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2141,358,993 - 141,367,198 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12141,359,402 - 141,367,222 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22147,169,469 - 147,177,263 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STING1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385139,475,533 - 139,482,758 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5139,475,533 - 139,482,935 (-)EnsemblGRCh38hg38GRCh38
GRCh375138,855,118 - 138,862,343 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,835,733 - 138,842,476 (-)NCBINCBI36Build 36hg18NCBI36
Celera5134,930,158 - 134,937,391 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5133,997,951 - 134,005,182 (-)NCBIHuRef
CHM1_15138,287,678 - 138,294,915 (-)NCBICHM1_1
T2T-CHM13v2.05140,000,594 - 140,007,823 (-)NCBIT2T-CHM13v2.0
Sting1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391835,866,731 - 35,873,607 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1835,866,732 - 35,873,607 (-)EnsemblGRCm39 Ensembl
GRCm381835,733,678 - 35,740,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1835,733,679 - 35,740,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv371835,893,332 - 35,900,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361835,859,652 - 35,866,528 (-)NCBIMGSCv36mm8
Celera1836,189,779 - 36,196,655 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.23NCBI
Sting1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81827,606,196 - 27,612,544 (-)NCBIGRCr8
mRatBN7.21827,332,119 - 27,338,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1827,332,119 - 27,338,335 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1827,459,541 - 27,465,793 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,221,584 - 28,227,830 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01827,556,463 - 27,562,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01828,529,537 - 28,535,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1828,529,576 - 28,535,828 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01828,242,119 - 28,248,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41828,355,029 - 28,357,171 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1827,065,352 - 27,071,596 (-)NCBICelera
Cytogenetic Map18p11NCBI
Sting1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554181,083,613 - 1,100,448 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554181,091,022 - 1,097,064 (+)NCBIChiLan1.0ChiLan1.0
STING1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24134,741,514 - 134,750,786 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15132,881,061 - 132,890,364 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05134,845,689 - 134,852,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15140,967,399 - 140,989,653 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5140,967,399 - 140,973,846 (-)Ensemblpanpan1.1panPan2
STING1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1234,783,947 - 34,792,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl234,784,232 - 34,789,072 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha231,886,015 - 31,894,282 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0235,237,857 - 35,246,124 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl235,217,688 - 35,243,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1232,290,300 - 32,298,567 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,156,814 - 33,165,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0233,908,726 - 33,916,993 (-)NCBIUU_Cfam_GSD_1.0
Sting1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213153,048,662 - 153,055,631 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365318,555,637 - 8,562,885 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365318,555,966 - 8,562,829 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STING1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,153,576 - 42,160,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,153,026 - 42,160,907 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603435,727,193 - 35,734,956 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sting1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474332,273,385 - 32,283,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474332,277,197 - 32,283,346 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in STING1
314 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 17 2 3 3
Below cutoff 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005661703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005661704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013995167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013995168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013995169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013995170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013995171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021077058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK236607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ455509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP102079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01113504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN226147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC860780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000015677   ⟹   ENSSSCP00000015264
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2141,359,405 - 141,367,198 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000036520   ⟹   ENSSSCP00000028503
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2141,359,790 - 141,367,198 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088164   ⟹   ENSSSCP00000070997
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2141,358,993 - 141,365,565 (-)Ensembl
RefSeq Acc Id: NM_001142838   ⟹   NP_001136310
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,689 - 141,365,563 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005661703   ⟹   XP_005661760
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005661704   ⟹   XP_005661761
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,366,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013995167   ⟹   XP_013850621
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,096 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013995168   ⟹   XP_013850622
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,096 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013995169   ⟹   XP_013850623
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013995170   ⟹   XP_013850624
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013995171   ⟹   XP_013850625
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,213 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077058   ⟹   XP_020932717
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12141,359,402 - 141,367,222 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020932717   ⟸   XM_021077058
- Peptide Label: isoform X3
- UniProtKB: F1RGH2 (UniProtKB/TrEMBL),   A0A8D1CUC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661760   ⟸   XM_005661703
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VF02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850625   ⟸   XM_013995171
- Peptide Label: isoform X8
- UniProtKB: A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850623   ⟸   XM_013995169
- Peptide Label: isoform X6
- UniProtKB: A0A8D0ZTL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850624   ⟸   XM_013995170
- Peptide Label: isoform X7
- UniProtKB: A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850622   ⟸   XM_013995168
- Peptide Label: isoform X5
- UniProtKB: A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013850621   ⟸   XM_013995167
- Peptide Label: isoform X4
- UniProtKB: A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005661761   ⟸   XM_005661704
- Peptide Label: isoform X1
- UniProtKB: A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136310   ⟸   NM_001142838
- UniProtKB: B8XX90 (UniProtKB/Swiss-Prot),   A0A480PUE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000070997   ⟸   ENSSSCT00000088164
RefSeq Acc Id: ENSSSCP00000015264   ⟸   ENSSSCT00000015677
RefSeq Acc Id: ENSSSCP00000028503   ⟸   ENSSSCT00000036520


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014349 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005007193 UniProtKB/TrEMBL
  ENSSSCG00025044987 UniProtKB/TrEMBL
  ENSSSCG00030034333 UniProtKB/TrEMBL
  ENSSSCG00035040571 UniProtKB/TrEMBL
  ENSSSCG00040021146 UniProtKB/TrEMBL
  ENSSSCG00045018676 UniProtKB/TrEMBL
  ENSSSCG00050076169 UniProtKB/TrEMBL
  ENSSSCG00055003635 UniProtKB/TrEMBL
  ENSSSCG00070023347 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015677 ENTREZGENE
  ENSSSCT00000015677.5 UniProtKB/TrEMBL
  ENSSSCT00000036520.4 UniProtKB/TrEMBL
  ENSSSCT00000088164.1 UniProtKB/TrEMBL
  ENSSSCT00005010834.1 UniProtKB/TrEMBL
  ENSSSCT00005010928.1 UniProtKB/TrEMBL
  ENSSSCT00005010982.1 UniProtKB/TrEMBL
  ENSSSCT00005011020.1 UniProtKB/TrEMBL
  ENSSSCT00025061129.1 UniProtKB/TrEMBL
  ENSSSCT00025061335.1 UniProtKB/TrEMBL
  ENSSSCT00025061493.1 UniProtKB/TrEMBL
  ENSSSCT00030047557.1 UniProtKB/TrEMBL
  ENSSSCT00030047607.1 UniProtKB/TrEMBL
  ENSSSCT00035053878.1 UniProtKB/TrEMBL
  ENSSSCT00035053884.1 UniProtKB/TrEMBL
  ENSSSCT00035053897.1 UniProtKB/TrEMBL
  ENSSSCT00035053904.1 UniProtKB/TrEMBL
  ENSSSCT00040028503.1 UniProtKB/TrEMBL
  ENSSSCT00040028619.1 UniProtKB/TrEMBL
  ENSSSCT00045031760.1 UniProtKB/TrEMBL
  ENSSSCT00045031822.1 UniProtKB/TrEMBL
  ENSSSCT00050104567.1 UniProtKB/TrEMBL
  ENSSSCT00050104572.1 UniProtKB/TrEMBL
  ENSSSCT00050104591.1 UniProtKB/TrEMBL
  ENSSSCT00055007145.1 UniProtKB/TrEMBL
  ENSSSCT00055007155.1 UniProtKB/TrEMBL
  ENSSSCT00070046582.1 UniProtKB/TrEMBL
  ENSSSCT00070046595.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.5200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro STING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STING_C_chordates UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STING_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100217389 UniProtKB/Swiss-Prot
NCBI Gene TMEM173 ENTREZGENE
PANTHER PTHR34339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STIMULATOR OF INTERFERON GENES PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMEM173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A480PUE6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VCA6_PIG UniProtKB/TrEMBL
  A0A4X1VF02 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RHU4_PIG UniProtKB/TrEMBL
  A0A8D0I0T3_PIG UniProtKB/TrEMBL
  A0A8D0I0X4_PIG UniProtKB/TrEMBL
  A0A8D0IBW4_PIG UniProtKB/TrEMBL
  A0A8D0WHT7_PIG UniProtKB/TrEMBL
  A0A8D0WLN2_PIG UniProtKB/TrEMBL
  A0A8D0ZTL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CUC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DSW5_PIG UniProtKB/TrEMBL
  A0A8D1DSZ4_PIG UniProtKB/TrEMBL
  A0A8D1HYH7_PIG UniProtKB/TrEMBL
  A0A8D1TQR9_PIG UniProtKB/TrEMBL
  B8XX90 ENTREZGENE
  F1RGH2 ENTREZGENE, UniProtKB/TrEMBL
  K7GKX5_PIG UniProtKB/TrEMBL
  S5R6U6_PIG UniProtKB/TrEMBL
  STING_PIG UniProtKB/Swiss-Prot
UniProt Secondary A0A8D0I9S8 UniProtKB/TrEMBL
VGNC ID VGNC:93547 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 STING1  stimulator of interferon response cGAMP interactor 1  TMEM173  transmembrane protein 173  Symbol and/or name change 5135510 APPROVED