SLC22A6 (solute carrier family 22 member 6) - Rat Genome Database

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Gene: SLC22A6 (solute carrier family 22 member 6) Homo sapiens
Analyze
Symbol: SLC22A6
Name: solute carrier family 22 member 6
RGD ID: 619572
HGNC Page HGNC
Description: Enables inorganic anion exchanger activity and sodium-independent organic anion transmembrane transporter activity. Involved in alpha-ketoglutarate transport; renal tubular secretion; and sodium-independent organic anion transport. Located in basolateral plasma membrane. Is integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ55736; HOAT1; hPAHT; hROAT1; MGC45260; OAT1; organic anion transporter 1; PAH transporter; PAHT; para-aminohippurate transporter; renal organic anion transporter 1; ROAT1; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22, member 6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1162,936,385 - 62,984,967 (-)EnsemblGRCh38hg38GRCh38
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBINCBI36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBI
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-D  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (EXP)
5-azaorotic acid  (ISO)
5-formyltetrahydrofolic acid  (EXP,ISO)
6-carboxyfluorescein  (EXP)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
9-[2-(phosphonomethoxy)ethyl]guanine  (EXP)
acetylsalicylic acid  (EXP)
adefovir  (EXP,ISO)
adipic acid  (EXP)
aflatoxin B1  (EXP)
allopurinol  (ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
angelicin  (ISO)
aristolochic acid  (EXP)
aurantio-obtusin  (EXP)
bacitracin  (ISO)
baicalein  (EXP)
bendroflumethiazide  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP)
benzylpenicillin  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromosulfophthalein  (EXP)
cadmium dichloride  (EXP,ISO)
cefaclor  (EXP)
cefaloridine  (EXP,ISO)
cefdinir  (EXP)
cefoselis sulfate  (EXP)
cefotiam  (EXP)
ceftibuten  (EXP)
ceftizoxime  (EXP)
chlorpyrifos-methyl  (EXP)
chrysophanol  (EXP)
cidofovir anhydrous  (EXP)
ciguatoxin CTX1B  (ISO)
cimetidine  (EXP)
cisplatin  (ISO)
clothianidin  (EXP)
cyazofamid  (EXP)
D-gluconic acid  (EXP)
diazepam  (EXP)
diclofenac  (EXP)
diethyl hydrogen phosphate  (ISO)
doxycycline  (EXP)
emodin  (EXP)
estrone 3-sulfate  (EXP)
fenitrothion  (EXP)
fluorescein (lactone form)  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (ISO)
furosemide  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glutaric acid  (EXP)
glutathione  (EXP)
glycidol  (ISO)
GW 4064  (ISO)
herbicide  (ISO)
hydrochlorothiazide  (ISO)
ibuprofen  (EXP)
imperatorin  (ISO)
indometacin  (EXP)
isoimperatorin  (ISO)
ketoprofen  (EXP)
linoleic acid  (EXP)
luteolin  (EXP)
malathion  (EXP)
mefenamic acid  (EXP)
Mercuric oxide  (EXP)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (ISO)
mianserin  (EXP)
minocycline  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naproxen  (EXP)
Nonylphenol  (ISO)
Obtusifolin  (EXP)
ochratoxin A  (EXP,ISO)
octanoic acid  (ISO)
oroxylin A  (EXP)
oxytetracycline  (EXP)
p-aminohippuric acid  (EXP,ISO)
paracetamol  (EXP)
paraquat  (ISO)
PCB138  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenacetin  (EXP)
PhIP  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prostaglandin E2  (ISO)
pyrazine-2-carboxylic acid  (EXP)
quercetin  (EXP,ISO)
quercetin 3-sulfate  (EXP)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
riddelliine  (ISO)
rutin  (ISO)
salicylates  (EXP)
salicylic acid  (EXP)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sodium hydrogencarbonate  (ISO)
streptozocin  (ISO)
sulindac  (EXP)
taurocholic acid  (EXP)
tenofovir disoproxil fumarate  (EXP)
testosterone  (ISO)
tetracycline  (EXP)
trans-piceid  (ISO)
triazolam  (EXP)
vancomycin  (ISO)
wedelolactone  (EXP)
wogonin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:9762842   PMID:9887087   PMID:9950961   PMID:10049739   PMID:10462545   PMID:10964714   PMID:11855680   PMID:12429554   PMID:12472777   PMID:12477932   PMID:12874449   PMID:14644751  
PMID:14702039   PMID:14749323   PMID:14984259   PMID:15037815   PMID:15039295   PMID:15145940   PMID:15200431   PMID:15284288   PMID:15864112   PMID:15914676   PMID:16024787   PMID:16046403  
PMID:16164645   PMID:16189514   PMID:16344560   PMID:16648942   PMID:16920720   PMID:17038320   PMID:17344191   PMID:17353191   PMID:17502342   PMID:17585018   PMID:18365245   PMID:18818201  
PMID:19034961   PMID:19056867   PMID:19060904   PMID:19082692   PMID:19088254   PMID:19308960   PMID:19343046   PMID:19400747   PMID:19403644   PMID:19854166   PMID:19892921   PMID:21164499  
PMID:21832049   PMID:21865262   PMID:21873635   PMID:21945944   PMID:22108572   PMID:22169006   PMID:23255614   PMID:23376485   PMID:23630107   PMID:23640180   PMID:23832370   PMID:24185403  
PMID:24530383   PMID:25234312   PMID:25354943   PMID:26823285   PMID:27053689   PMID:27226107   PMID:28371506   PMID:28472795   PMID:28514442   PMID:28572241   PMID:29273507   PMID:29285751  
PMID:29422382   PMID:29795395   PMID:30653465   PMID:31691080   PMID:31724834   PMID:32100958   PMID:32818533   PMID:33961781  


Genomics

Comparative Map Data
SLC22A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1162,936,385 - 62,984,967 (-)EnsemblGRCh38hg38GRCh38
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBINCBI36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBI
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
Slc22a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,595,360 - 8,605,663 (+)NCBIGRCm39mm39
GRCm39 Ensembl198,595,403 - 8,605,663 (+)Ensembl
GRCm38198,617,996 - 8,628,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,618,039 - 8,628,299 (+)EnsemblGRCm38mm10GRCm38
MGSCv37198,692,486 - 8,702,789 (+)NCBIGRCm37mm9NCBIm37
MGSCv36198,685,086 - 8,693,568 (+)NCBImm8
Celera198,376,155 - 8,386,458 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.44NCBI
Slc22a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)Ensembl
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Celera1203,036,078 - 203,044,298 (+)NCBICelera
Cytogenetic Map1q43NCBI
Slc22a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599301,981 - 311,447 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599302,026 - 307,503 (+)NCBIChiLan1.0ChiLan1.0
SLC22A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11161,680,016 - 61,688,223 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,680,016 - 61,688,223 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01158,328,476 - 58,336,887 (-)NCBIMhudiblu_PPA_v0panPan3
SLC22A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,736,669 - 53,745,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,736,959 - 53,744,396 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,342,543 - 52,350,303 (+)NCBI
ROS_Cfam_1.01854,782,055 - 54,789,820 (+)NCBI
UMICH_Zoey_3.11853,884,029 - 53,891,784 (+)NCBI
UNSW_CanFamBas_1.01853,458,362 - 53,466,122 (+)NCBI
UU_Cfam_GSD_1.01854,245,739 - 54,253,490 (+)NCBI
Slc22a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,235,014 - 10,242,500 (+)NCBI
SpeTri2.0NW_004936581348,719 - 356,246 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,802,349 - 8,817,338 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,809,547 - 8,817,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,152,459 - 8,160,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,918,081 - 10,926,790 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl110,918,770 - 10,925,983 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038108,270,857 - 108,278,591 (+)NCBIVero_WHO_p1.0
Slc22a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249261,363,322 - 1,368,768 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH78059  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371162,744,176 - 62,744,352UniSTSGRCh37
Build 361162,500,752 - 62,500,928RGDNCBI36
Celera1160,068,221 - 60,068,397RGD
Cytogenetic Map11q12.3UniSTS
HuRef1159,073,225 - 59,073,401UniSTS
GeneMap99-GB4 RH Map11230.54UniSTS
NCBI RH Map11563.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1802
Count of miRNA genes:667
Interacting mature miRNAs:777
Transcripts:ENST00000360421, ENST00000377871, ENST00000421062, ENST00000458333, ENST00000537349, ENST00000540654
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage
High
Medium 5 1 1 48 186 2
Low 3 41 9 11 9 8 2 2240 60 16 6 5 4
Below cutoff 942 1131 670 155 485 91 2040 845 1110 57 680 580 66 1 504 1429

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB009697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB009698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF057039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF097490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF104038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF124373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI017670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK091879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA628191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA629600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB320467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU567146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360421   ⟹   ENSP00000353597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,976,597 - 62,984,967 (-)Ensembl
RefSeq Acc Id: ENST00000377871   ⟹   ENSP00000367102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,976,602 - 62,984,957 (-)Ensembl
RefSeq Acc Id: ENST00000421062   ⟹   ENSP00000404441
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,976,794 - 62,984,690 (-)Ensembl
RefSeq Acc Id: ENST00000458333   ⟹   ENSP00000396401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,976,794 - 62,984,690 (-)Ensembl
RefSeq Acc Id: ENST00000537349
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,979,868 - 62,983,892 (-)Ensembl
RefSeq Acc Id: ENST00000540654   ⟹   ENSP00000445946
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,936,385 - 62,984,824 (-)Ensembl
RefSeq Acc Id: NM_004790   ⟹   NP_004781
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153276   ⟹   NP_695008
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153277   ⟹   NP_695009
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153278   ⟹   NP_695010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,967 (-)NCBI
GRCh371162,744,069 - 62,752,495 (-)ENTREZGENE
Build 361162,500,645 - 62,509,045 (-)NCBI Archive
HuRef1159,073,118 - 59,081,543 (-)ENTREZGENE
CHM1_11162,626,827 - 62,635,253 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018562   ⟹   XP_016874051
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,976,597 - 62,984,897 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_695009   ⟸   NM_153277
- Peptide Label: isoform c
- UniProtKB: Q4U2R8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_695010   ⟸   NM_153278
- Peptide Label: isoform d
- UniProtKB: Q4U2R8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_695008   ⟸   NM_153276
- Peptide Label: isoform b
- UniProtKB: Q4U2R8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_004781   ⟸   NM_004790
- Peptide Label: isoform a
- UniProtKB: Q4U2R8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016874051   ⟸   XM_017018562
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000353597   ⟸   ENST00000360421
RefSeq Acc Id: ENSP00000367102   ⟸   ENST00000377871
RefSeq Acc Id: ENSP00000396401   ⟸   ENST00000458333
RefSeq Acc Id: ENSP00000404441   ⟸   ENST00000421062
RefSeq Acc Id: ENSP00000445946   ⟸   ENST00000540654

Promoters
RGD ID:7220749
Promoter ID:EPDNEW_H16120
Type:initiation region
Name:SLC22A6_1
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16121  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,984,789 - 62,984,849EPDNEW
RGD ID:7220753
Promoter ID:EPDNEW_H16121
Type:multiple initiation site
Name:SLC22A6_2
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16120  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,984,967 - 62,985,027EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.3(chr11:62433886-63096003)x3 copy number gain See cases [RCV000053620] Chr11:62433886..63096003 [GRCh38]
Chr11:62201358..62863475 [GRCh37]
Chr11:61957934..62620051 [NCBI36]
Chr11:11q12.3
pathogenic
NM_004790.4(SLC22A6):c.794C>T (p.Ser265Phe) single nucleotide variant Malignant melanoma [RCV000069573] Chr11:62981845 [GRCh38]
Chr11:62749317 [GRCh37]
Chr11:62505893 [NCBI36]
Chr11:11q12.3
not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q12.3-13.1(chr11:62893226-64335043)x1 copy number loss See cases [RCV000140879] Chr11:62893226..64335043 [GRCh38]
Chr11:62660698..64102515 [GRCh37]
Chr11:62417274..63859091 [NCBI36]
Chr11:11q12.3-13.1
likely pathogenic
GRCh37/hg19 11q12.3(chr11:61840997-62987330)x1 copy number loss See cases [RCV000448355] Chr11:61840997..62987330 [GRCh37]
Chr11:11q12.3
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_153276.3(SLC22A6):c.1470C>T (p.Tyr490=) single nucleotide variant not provided [RCV000965839] Chr11:62977279 [GRCh38]
Chr11:62744751 [GRCh37]
Chr11:11q12.3
benign
GRCh37/hg19 11q12.3(chr11:62314663-62788240)x3 copy number gain not provided [RCV000849841] Chr11:62314663..62788240 [GRCh37]
Chr11:11q12.3
uncertain significance
GRCh37/hg19 11q12.3(chr11:62487052-62788240)x3 copy number gain not provided [RCV000846292] Chr11:62487052..62788240 [GRCh37]
Chr11:11q12.3
uncertain significance
GRCh37/hg19 11q12.3(chr11:62714816-63383226)x3 copy number gain not provided [RCV001260131] Chr11:62714816..63383226 [GRCh37]
Chr11:11q12.3
uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Epilepsy, familial temporal lobe, 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10970 AgrOrtholog
COSMIC SLC22A6 COSMIC
Ensembl Genes ENSG00000197901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000353597 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000367102 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000396401 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404441 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000445946 UniProtKB/TrEMBL
Ensembl Transcript ENST00000360421 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000377871 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000421062 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000458333 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000540654 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
GTEx ENSG00000197901 GTEx
HGNC ID HGNC:10970 ENTREZGENE
Human Proteome Map SLC22A6 Human Proteome Map
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
KEGG Report hsa:9356 UniProtKB/Swiss-Prot
NCBI Gene 9356 ENTREZGENE
OMIM 607582 OMIM
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB PA388 PharmGKB, RGD
PROSITE MFS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGRFAMs 2A0119 UniProtKB/Swiss-Prot
UniProt F5H0T7_HUMAN UniProtKB/TrEMBL
  Q4U2R8 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A8MY93 UniProtKB/Swiss-Prot
  B2D0R6 UniProtKB/Swiss-Prot
  O95187 UniProtKB/Swiss-Prot
  O95742 UniProtKB/Swiss-Prot
  Q7LDA0 UniProtKB/Swiss-Prot
  Q8N192 UniProtKB/Swiss-Prot
  Q9NQA6 UniProtKB/Swiss-Prot
  Q9NQC2 UniProtKB/Swiss-Prot
  Q9UBG6 UniProtKB/Swiss-Prot
  Q9UEQ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-23 SLC22A6  solute carrier family 22 member 6    solute carrier family 22 (organic anion transporter), member 6  Symbol and/or name change 5135510 APPROVED
2011-08-16 SLC22A6  solute carrier family 22 (organic anion transporter), member 6  SLC22A6  solute carrier family 22 (organic anion transporter), member 6  Symbol and/or name change 5135510 APPROVED