Il20rb (interleukin 20 receptor subunit beta) - Rat Genome Database

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Gene: Il20rb (interleukin 20 receptor subunit beta) Rattus norvegicus
Analyze
Symbol: Il20rb
Name: interleukin 20 receptor subunit beta
RGD ID: 1566151
Description: Predicted to enable cytokine receptor activity and interleukin-20 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within several processes, including negative regulation of T cell proliferation; negative regulation of type IV hypersensitivity; and regulation of cytokine production. Predicted to be active in plasma membrane. Orthologous to human IL20RB (interleukin 20 receptor subunit beta); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH bisphenol A; gentamycin; mercury dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL20R2; interleukin 20 receptor beta; interleukin 20 receptor beta subunit; interleukin-20 receptor subunit beta; LOC501043; RGD1566151; similar to hypothetical protein MGC34923
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28100,979,085 - 101,010,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8100,980,383 - 101,009,942 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8106,651,028 - 106,680,558 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08104,850,343 - 104,879,875 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08102,692,883 - 102,722,416 (-)NCBIRnor_WKY
Rnor_6.08108,745,906 - 108,778,561 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8108,747,204 - 108,777,717 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,165,070 - 108,194,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48105,305,597 - 105,337,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8100,377,810 - 100,407,239 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. IL-19 is involved in the pathogenesis of endotoxic shock. Hsing CH, etal., Shock. 2008 Jan;29(1):7-15.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19124723   PMID:21844205  


Genomics

Comparative Map Data
Il20rb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28100,979,085 - 101,010,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8100,980,383 - 101,009,942 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8106,651,028 - 106,680,558 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.08104,850,343 - 104,879,875 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.08102,692,883 - 102,722,416 (-)NCBIRnor_WKY
Rnor_6.08108,745,906 - 108,778,561 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8108,747,204 - 108,777,717 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,165,070 - 108,194,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48105,305,597 - 105,337,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8100,377,810 - 100,407,239 (-)NCBICelera
Cytogenetic Map8q31NCBI
IL20RB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383136,957,983 - 137,011,085 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3136,946,230 - 137,011,085 (+)EnsemblGRCh38hg38GRCh38
GRCh373136,676,825 - 136,729,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,159,397 - 138,212,610 (+)NCBINCBI36Build 36hg18NCBI36
Celera3135,102,983 - 135,156,200 (+)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3134,052,492 - 134,105,781 (+)NCBIHuRef
CHM1_13136,640,346 - 136,693,509 (+)NCBICHM1_1
T2T-CHM13v2.03139,698,644 - 139,751,732 (+)NCBIT2T-CHM13v2.0
Il20rb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,339,772 - 100,368,526 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9100,339,772 - 100,368,841 (-)EnsemblGRCm39 Ensembl
GRCm389100,457,719 - 100,486,473 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9100,457,719 - 100,486,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv379100,358,138 - 100,386,892 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369100,267,073 - 100,295,737 (-)NCBIMGSCv36mm8
Celera999,996,528 - 100,025,243 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
Il20rb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555011,826,687 - 1,863,261 (-)NCBIChiLan1.0ChiLan1.0
IL20RB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13141,457,692 - 141,504,744 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3141,474,161 - 141,504,744 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03133,995,863 - 134,045,206 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL20RB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12333,384,057 - 33,421,619 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2333,384,486 - 33,420,016 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2333,368,707 - 33,406,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02333,914,041 - 33,951,404 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2333,914,195 - 33,950,582 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12333,596,433 - 33,633,821 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02333,661,858 - 33,699,150 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02333,906,877 - 33,944,149 (+)NCBIUU_Cfam_GSD_1.0
NCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,952,336 - 77,986,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11377,946,356 - 77,986,158 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21385,591,946 - 85,626,043 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL20RB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11553,446,410 - 53,493,827 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1553,448,034 - 53,493,618 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604126,489,282 - 26,536,106 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il20rb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473013,378,478 - 13,409,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473013,371,898 - 13,408,927 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il20rb
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:102
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000034188
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
AI013928  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28100,979,177 - 100,979,389 (+)MAPPERmRatBN7.2
Rnor_6.08108,745,999 - 108,746,210NCBIRnor6.0
Rnor_5.08108,163,865 - 108,164,076UniSTSRnor5.0
RGSC_v3.48105,305,690 - 105,305,901UniSTSRGSC3.4
Celera8100,376,605 - 100,376,816UniSTS
RH 3.4 Map81177.1UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 1 25 15 18 8 11 12 18 28 5 8
Below cutoff 2 18 26 25 1 25 58 17 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000034188   ⟹   ENSRNOP00000031089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8100,980,383 - 101,009,942 (-)Ensembl
Rnor_6.0 Ensembl8108,747,204 - 108,777,717 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112682   ⟹   ENSRNOP00000083540
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8100,988,468 - 101,009,942 (-)Ensembl
RefSeq Acc Id: NM_001173438   ⟹   NP_001166909
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28100,980,383 - 101,009,942 (-)NCBI
Rnor_6.08108,747,204 - 108,777,717 (-)NCBI
Rnor_5.08108,165,070 - 108,194,857 (-)NCBI
Celera8100,377,810 - 100,407,239 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595846   ⟹   XP_017451335
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28100,979,085 - 101,010,811 (-)NCBI
Rnor_6.08108,745,906 - 108,778,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081976   ⟹   XP_038937904
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28100,979,085 - 101,010,829 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001166909 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451335 (Get FASTA)   NCBI Sequence Viewer  
  XP_038937904 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB30153 (Get FASTA)   NCBI Sequence Viewer  
  EDL77426 (Get FASTA)   NCBI Sequence Viewer  
  EDL77427 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001166909   ⟸   NM_001173438
- UniProtKB: B8K1X9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451335   ⟸   XM_017595846
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000031089   ⟸   ENSRNOT00000034188
RefSeq Acc Id: XP_038937904   ⟸   XM_039081976
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000083540   ⟸   ENSRNOT00000112682
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B8K1X9-F1-model_v2 AlphaFold B8K1X9 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696216
Promoter ID:EPDNEW_R6741
Type:multiple initiation site
Name:Il20rb_1
Description:interleukin 20 receptor subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08108,777,758 - 108,777,818EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566151 AgrOrtholog
BioCyc Gene G2FUF-29374 BioCyc
Ensembl Genes ENSRNOG00000023214 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000031089 ENTREZGENE
  ENSRNOP00000031089.4 UniProtKB/TrEMBL
  ENSRNOP00000083540.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034188 ENTREZGENE
  ENSRNOT00000034188.5 UniProtKB/TrEMBL
  ENSRNOT00000112682.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon_alpha/beta_rcpt_bsu UniProtKB/TrEMBL
KEGG Report rno:501043 UniProtKB/TrEMBL
NCBI Gene 501043 ENTREZGENE
Pfam Interfer-bind UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PhenoGen Il20rb PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A0A8I5ZW17_RAT UniProtKB/TrEMBL
  B8K1X9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il20rb  interleukin 20 receptor subunit beta  Il20rb  interleukin 20 receptor beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Il20rb  interleukin 20 receptor beta subunit  Il20rb  interleukin 20 receptor beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Il20rb  interleukin 20 receptor beta  RGD1566151_predicted  similar to hypothetical protein MGC34923 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566151_predicted  similar to hypothetical protein MGC34923 (predicted)  LOC501043  similar to hypothetical protein MGC34923  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501043  similar to hypothetical protein MGC34923      Symbol and Name status set to provisional 70820 PROVISIONAL