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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bezafibrate
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Accession:CHEBI:47612 term browser browse the term
Definition:A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Synonyms:exact_synonym: 2-{4-[2-(4-chlorobenzamido)ethyl]phenoxy}-2-methylpropanoic acid
 related_synonym: 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID;   Befizal;   Bezalip;   Bezatol SR (TN);   Cedur;   Formula=C19H20ClNO4;   InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24);   InChIKey=IIBYAHWJQTYFKB-UHFFFAOYSA-N;   SMILES=CC(C)(OC1=CC=C(CCNC(=O)C2=CC=C(Cl)C=C2)C=C1)C(O)=O;   bezafibrato;   bezafibratum
 alt_id: CHEBI:31284;   CHEBI:47611
 xref: CAS:41859-67-0;   Chemspider:35728;   DrugBank:DB01393;   Drug_Central:362;   HMDB:HMDB0015465;   KEGG:D01366;   LINCS:LSM-3015
 xref_mesh: MESH:D001629
 xref: PDBeChem:PEM;   PMID:12122004;   PMID:12782154;   PMID:17379010;   PMID:18787029;   PMID:19131462;   PMID:23603800;   PMID:28931607;   PMID:32107855;   PMID:32509533;   PMID:32721217;   PMID:32798077;   PMID:32976735;   PMID:33205029;   PMID:33549744;   PMID:34447954;   Patent:DE2149070;   Patent:US3781328;   Reaxys:4267656;   Wikipedia:Bezafibrate


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bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
increases expression		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA
Bezafibrate results in increased expression of ABCA1 mRNA; Bezafibrate results in increased expression of ABCA1 protein		 CTD PMID:12595494 PMID:19201410 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases expression
affects localization
increases expression		 EXP
ISO		 Bezafibrate results in decreased expression of ABCB11 mRNA
Bezafibrate affects the localization of ABCB11 protein
Bezafibrate results in increased expression of ABCB11 mRNA		 CTD PMID:15258199 PMID:15447978 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 affects localization
multiple interactions
increases expression		 ISO
EXP		 Bezafibrate affects the localization of ABCB4 protein
[Bezafibrate co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB4 mRNA; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein]
Bezafibrate results in increased expression of ABCB4 mRNA
Bezafibrate results in increased expression of ABCB4 mRNA; Bezafibrate results in increased expression of ABCB4 protein		 CTD PMID:15242490 PMID:15258199 PMID:15588777 PMID:17118139 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 affects localization
increases expression
multiple interactions		 ISO
EXP		 Bezafibrate affects the localization of ABCC2 protein
Bezafibrate results in increased expression of ABCC2 mRNA
[Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ABCC2 mRNA		 CTD PMID:15258199 PMID:21549692 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 increases transport ISO ABCC4 protein results in increased transport of Bezafibrate CTD PMID:17939016 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Abcd3 ATP-binding cassette, sub-family D member 3 increases expression EXP Bezafibrate results in increased expression of ABCD3 protein CTD PMID:19124612 PMID:20594415 NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Bezafibrate results in increased expression of ABCG5 mRNA CTD PMID:14685799 NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439 		JBrowse link
G Acaa1a acetyl-Coenzyme A acyltransferase 1A multiple interactions
increases expression		 EXP PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA] CTD PMID:19124612 NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365 		JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha decreases expression
increases expression
multiple interactions		 EXP Bezafibrate results in decreased expression of ACACA mRNA; Bezafibrate results in decreased expression of ACACA protein
Bezafibrate results in increased expression of ACACA mRNA; Bezafibrate results in increased expression of ACACA protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]		 CTD PMID:19124612 NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477 		JBrowse link
G Acacb acetyl-Coenzyme A carboxylase beta decreases expression
multiple interactions
increases expression		 EXP Bezafibrate results in decreased expression of ACACB mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA]		 CTD PMID:17118139 PMID:19124612 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Acadl acyl-Coenzyme A dehydrogenase, long-chain multiple interactions
increases expression		 EXP PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein]
Bezafibrate results in increased expression of ACADL mRNA; Bezafibrate results in increased expression of ACADL protein		 CTD PMID:12782154 NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions
increases expression		 EXP
ISO		 Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]		 CTD PMID:11929713 PMID:19124612 PMID:26190035 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain affects response to substance
increases activity
increases expression
multiple interactions		 ISO
EXP		 ACADVL protein affects the susceptibility to Bezafibrate; ACADVL protein mutant form affects the susceptibility to Bezafibrate
Bezafibrate results in increased activity of ACADVL protein
Bezafibrate results in increased expression of ACADVL mRNA
Butyrates promotes the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein]
Bezafibrate inhibits the reaction [ACADVL protein mutant form results in decreased oxidation of Fatty Acids]
Bezafibrate results in increased expression of ACADVL mRNA; Bezafibrate results in increased expression of ACADVL protein		 CTD PMID:12782154 PMID:17118139 PMID:17999356 PMID:20060901 PMID:22338096 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein] CTD PMID:16979161 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl increases expression
multiple interactions
increases activity		 ISO
EXP		 Bezafibrate results in increased expression of ACOX1 mRNA
Bezafibrate results in increased expression of ACOX1 mRNA; Bezafibrate results in increased expression of ACOX1 protein
[Sodium Glutamate co-treated with Bezafibrate] results in increased expression of ACOX1 mRNA; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]
Bezafibrate results in increased activity of ACOX1 protein		 CTD PMID:2399535 PMID:11172741 PMID:11216866 PMID:11473052 PMID:11519881 More... NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions
increases expression		 EXP
ISO		 Butyrates promotes the reaction [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA] CTD PMID:17118139 PMID:19124612 PMID:19682441 PMID:21640707 PMID:22338096 NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 increases expression EXP Bezafibrate results in increased expression of ACSL4 mRNA CTD PMID:17118139 NCBI chr  X:141,100,989...141,173,792
Ensembl chr  X:141,100,989...141,173,531 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 increases expression EXP Bezafibrate results in increased expression of ACSL5 mRNA CTD PMID:17118139 NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 affects expression ISO Bezafibrate affects the expression of ACSS2 mRNA CTD PMID:17719200 NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
decreases expression		 EXP
ISO		 Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of ACTA2 mRNA]
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]
Bezafibrate results in decreased expression of ACTA2 protein		 CTD PMID:12657956 PMID:18513333 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of ADIPOQ protein
Bezafibrate results in increased expression of ADIPOQ mRNA; Bezafibrate results in increased expression of ADIPOQ protein
Bezafibrate results in increased secretion of ADIPOQ protein
Bezafibrate inhibits the reaction [Sodium Glutamate results in decreased expression of ADIPOQ protein]		 CTD PMID:16574099 PMID:17190905 PMID:18513333 PMID:21324916 PMID:21411093 More... NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adipor1 adiponectin receptor 1 increases expression EXP Bezafibrate results in increased expression of ADIPOR1 mRNA CTD PMID:16574099 NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Bezafibrate results in increased expression of ADIPOR2 mRNA CTD PMID:16574099 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665 		JBrowse link
G Adora2a adenosine A2a receptor increases expression EXP Bezafibrate results in increased expression of ADORA2A mRNA CTD PMID:18787029 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP
ISO		 Bezafibrate inhibits the reaction [AKT1 protein mutant form results in increased susceptibility to Glucose deficiency]
[Bezafibrate co-treated with 3-methylglutaric acid] results in decreased expression of AKT1 protein		 CTD PMID:15806154 PMID:32169667 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 increases expression EXP Bezafibrate results in increased expression of ALDH1A2 mRNA CTD PMID:17118139 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 increases activity
increases expression
affects response to substance		 ISO Bezafibrate results in increased activity of ALDH3A2 protein
Bezafibrate results in increased expression of ALDH3A2 mRNA
ALDH3A2 protein affects the susceptibility to Bezafibrate		 CTD PMID:16837225 NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney decreases activity
multiple interactions
increases expression		 ISO
EXP		 Bezafibrate results in decreased activity of ALPL protein
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of ALPL mRNA]		 CTD PMID:8102192 PMID:21499286 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression EXP Bezafibrate results in increased expression of ANGPTL4 mRNA CTD PMID:17118139 NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression EXP Bezafibrate results in increased expression of APEX1 mRNA CTD PMID:15447978 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; Bezafibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]
Bezafibrate results in decreased expression of APOA1 mRNA; Bezafibrate results in decreased expression of APOA1 protein
Bezafibrate results in increased expression of APOA1 protein		 CTD PMID:1323073 PMID:7893284 PMID:7983038 PMID:8017468 PMID:9678787 More... NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa2 apolipoprotein A-II increases expression ISO Bezafibrate results in increased expression of APOA2 protein CTD PMID:7893284 PMID:8017468 NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948 		JBrowse link
G Apob apolipoprotein B multiple interactions
decreases secretion
decreases expression
increases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of APOB protein]
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]
Bezafibrate results in decreased secretion of APOB protein
[Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOB protein alternative form
Bezafibrate results in increased expression of APOB protein
Bezafibrate results in decreased expression of APOB protein		 CTD PMID:1323073 PMID:3084275 PMID:7893284 PMID:8017468 PMID:8944747 More... NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G Apoc2 apolipoprotein C2 decreases expression
multiple interactions		 EXP Bezafibrate results in decreased expression of APOC2 mRNA
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]		 CTD PMID:12782154 NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866 		JBrowse link
G Apoc3 apolipoprotein C-III decreases expression
multiple interactions		 EXP
ISO		 Bezafibrate results in decreased expression of APOC3 mRNA
PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]
Bezafibrate results in decreased expression of APOC3 mRNA; Bezafibrate results in decreased expression of APOC3 protein		 CTD PMID:8847480 PMID:9041378 PMID:11164425 PMID:12782154 PMID:19124612 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934 		JBrowse link
G Apoe apolipoprotein E multiple interactions
decreases expression
increases expression		 ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
[Bezafibrate co-treated with Ethanolamine] results in decreased secretion of APOE protein
Bezafibrate results in decreased expression of APOE protein
Bezafibrate results in increased expression of APOE protein		 CTD PMID:8017468 PMID:8944747 PMID:9006809 PMID:19603250 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Arpp21 cyclic AMP-regulated phosphoprotein, 21 increases expression EXP Bezafibrate results in increased expression of ARPP21 mRNA CTD PMID:18787029 NCBI chr 9:111,894,159...112,065,356
Ensembl chr 9:111,894,159...112,065,006 		JBrowse link
G Ascl2 achaete-scute family bHLH transcription factor 2 decreases expression ISO Bezafibrate results in decreased expression of ASCL2 mRNA CTD PMID:15708366 NCBI chr 7:142,520,559...142,523,001
Ensembl chr 7:142,520,566...142,523,001 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of BCL2 mRNA
Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein]		 CTD PMID:12704018 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bglap2 bone gamma-carboxyglutamate protein 2 increases expression EXP Bezafibrate results in increased expression of BGLAP2 mRNA CTD PMID:21499286 NCBI chr 3:88,285,043...88,286,008
Ensembl chr 3:88,285,043...88,286,006 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 multiple interactions EXP [CLOCK protein binds to BMAL1 protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] CTD PMID:20400680 NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of BMP2 mRNA
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of BMP2 mRNA]		 CTD PMID:21499286 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 increases expression EXP Bezafibrate results in increased expression of BNIP3 mRNA CTD PMID:17118139 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Btbd9 BTB domain containing 9 increases expression EXP Bezafibrate results in increased expression of BTBD9 mRNA CTD PMID:18787029 NCBI chr17:30,434,498...30,801,595
Ensembl chr17:30,434,498...30,795,462 		JBrowse link
G Car9 carbonic anhydrase 9 multiple interactions ISO Bezafibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:34520103 NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729 		JBrowse link
G Cat catalase increases activity
multiple interactions
increases expression		 ISO
EXP		 Bezafibrate results in increased activity of CAT protein
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of CAT mRNA]
Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Bezafibrate promotes the reaction [3-methylglutaric acid results in increased activity of CAT protein]
Bezafibrate results in increased expression of CAT protein		 CTD PMID:2399535 PMID:17145126 PMID:18513333 PMID:20594415 PMID:32169667 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 EXP
ISO		 Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CCL2 mRNA]
Bezafibrate results in decreased expression of CCL2 mRNA
Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]		 CTD PMID:16574099 PMID:18513333 PMID:32613381 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] CTD PMID:21745629 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein] CTD PMID:12126966 PMID:12586603 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] CTD PMID:19429239 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP Bezafibrate results in increased expression of CCNB1 mRNA CTD PMID:15447978 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of CD36 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA]		 CTD PMID:11473052 PMID:12759900 PMID:12782154 PMID:17118139 PMID:19124612 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases activity		 ISO [Bezafibrate co-treated with Medroxyprogesterone Acetate] results in decreased activity of CD40LG protein
Bezafibrate results in decreased activity of CD40LG protein		 CTD PMID:18923439 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cdk4 cyclin dependent kinase 4 increases expression EXP Bezafibrate results in increased expression of CDK4 mRNA CTD PMID:15447978 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Chmp4b charged multivesicular body protein 4B increases expression EXP Bezafibrate results in increased expression of CHMP4B mRNA CTD PMID:18787029 NCBI chr 2:154,498,949...154,536,703
Ensembl chr 2:154,493,625...154,536,705 		JBrowse link
G Clock clock circadian regulator multiple interactions EXP [CLOCK protein binds to BMAL1 protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA] CTD PMID:20400680 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Clps colipase, pancreatic increases expression EXP Bezafibrate results in increased expression of CLPS mRNA CTD PMID:18787029 NCBI chr17:28,777,184...28,779,740
Ensembl chr17:28,777,123...28,779,740 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression		 EXP
ISO		 Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of COL1A1 mRNA]
Bezafibrate results in increased expression of COL1A1 mRNA
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]		 CTD PMID:18513333 PMID:21499286 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver decreases expression
multiple interactions
increases expression		 EXP
ISO		 Bezafibrate results in decreased expression of CPT1A mRNA
[Butyrates co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; [Sodium Glutamate co-treated with Bezafibrate] results in increased expression of CPT1A mRNA; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA]
Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA]
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA]		 CTD PMID:11527545 PMID:16123366 PMID:16574099 PMID:18787029 PMID:19124612 More... NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1b, muscle increases expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased expression of CPT1B mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA]		 CTD PMID:11056218 PMID:11473052 PMID:21324916 NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression
increases activity
multiple interactions		 ISO Bezafibrate results in increased expression of CPT2 mRNA
Bezafibrate results in increased activity of CPT2 protein
[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate; [Oleic Acid co-treated with Bezafibrate] results in increased expression of CPT2 mRNA; Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate]		 CTD PMID:16707586 PMID:21816645 PMID:24534255 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Crat carnitine acetyltransferase multiple interactions
increases activity		 ISO etomoxir inhibits the reaction [Bezafibrate results in increased activity of CRAT protein] CTD PMID:3421940 PMID:8075222 PMID:9920142 NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825 		JBrowse link
G Crebbp CREB binding protein multiple interactions ISO Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein] CTD PMID:19263263 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Bezafibrate results in decreased expression of CREM mRNA CTD PMID:18787029 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Crot carnitine O-octanoyltransferase increases expression ISO Bezafibrate results in increased expression of CROT mRNA CTD PMID:17719200 NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324 		JBrowse link
G Crp C-reactive protein, pentraxin-related decreases expression ISO Bezafibrate results in decreased expression of CRP protein CTD PMID:11893366 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CXCL8 mRNA] CTD PMID:21745629 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 affects expression ISO Bezafibrate affects the expression of CYB5R3 mRNA CTD PMID:17719200 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793 		JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions
decreases expression		 ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]
Bezafibrate results in decreased expression of CYBA mRNA
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]		 CTD PMID:11172467 PMID:12967931 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide increases expression EXP Bezafibrate results in increased expression of CYBB protein CTD PMID:20594415 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased activity of CYP19A1 protein
Bezafibrate results in decreased expression of CYP19A1 mRNA
Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACADM mRNA]; Bezafibrate inhibits the reaction [CYP19A1 gene mutant form results in decreased expression of ACOX1 mRNA]		 CTD PMID:11929713 PMID:19539015 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity		 ISO Bezafibrate results in increased expression of CYP1A1 mRNA
Bezafibrate results in increased activity of CYP1A1 protein		 CTD PMID:9007043 PMID:15521013 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions ISO Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:19667161 NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases expression ISO Bezafibrate results in decreased expression of CYP2C8 protein CTD PMID:29960002 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 affects expression ISO Bezafibrate affects the expression of CYP2J2 protein CTD PMID:29960002 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of CYP4A10 mRNA
PPARA protein promotes the reaction [Bezafibrate results in increased expression of CYP4A10 mRNA]		 CTD PMID:20854792 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B multiple interactions
increases expression		 ISO Acetylcysteine promotes the reaction [Bezafibrate results in increased expression of CYP4A1 mRNA] CTD PMID:19647067 NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
increases expression		 EXP PPARA protein affects the reaction [Bezafibrate results in increased expression of CYP4A14 mRNA] CTD PMID:12782154 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339 		JBrowse link
G Cyp4a31 cytochrome P450, family 4, subfamily a, polypeptide 31 increases expression EXP Bezafibrate results in increased expression of CYP4A22 mRNA CTD PMID:15447978 NCBI chr 4:115,420,824...115,436,212
Ensembl chr 4:115,420,846...115,436,212 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression ISO Bezafibrate affects the expression of CYP4B1 mRNA CTD PMID:17719200 NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression ISO Bezafibrate results in decreased expression of CYP51 mRNA CTD PMID:17719200 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Bezafibrate results in decreased activity of CYP7A1 protein
Bezafibrate results in decreased expression of CYP7A1 mRNA		 CTD PMID:2044640 PMID:14685799 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Dbi diazepam binding inhibitor increases expression EXP Bezafibrate results in increased expression of DBI mRNA CTD PMID:17118139 NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression ISO Bezafibrate affects the expression of DHCR7 mRNA CTD PMID:17719200 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 increases expression ISO Bezafibrate results in increased expression of DLK1 mRNA CTD PMID:11473052 NCBI chr12:109,418,411...109,429,262
Ensembl chr12:109,418,749...109,429,262 		JBrowse link
G Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 decreases expression EXP Bezafibrate results in decreased expression of DNAJB6 mRNA CTD PMID:18787029 NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO [Bezafibrate co-treated with 3-methylglutaric acid] results in increased expression of DNM1L protein CTD PMID:32169667 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Dtnb dystrobrevin, beta decreases expression EXP Bezafibrate results in decreased expression of DTNB mRNA CTD PMID:18787029 NCBI chr12:3,622,372...3,834,070
Ensembl chr12:3,622,381...3,831,796 		JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal increases expression EXP Bezafibrate results in increased expression of ECH1 mRNA CTD PMID:17118139 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672 		JBrowse link
G Eci2 enoyl-Coenzyme A delta isomerase 2 increases expression ISO Bezafibrate results in increased expression of ECI2 mRNA CTD PMID:16707586 NCBI chr13:35,161,731...35,211,098
Ensembl chr13:35,161,731...35,211,079 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of EDN1 protein
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]		 CTD PMID:11330878 PMID:12967931 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase increases expression
multiple interactions
affects expression		 EXP
ISO		 Bezafibrate results in increased expression of EHHADH mRNA; Bezafibrate results in increased expression of EHHADH protein
PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]
Bezafibrate affects the expression of EHHADH mRNA		 CTD PMID:12782154 PMID:17118139 PMID:17719200 PMID:19124612 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [Oleic Acid co-treated with Bezafibrate] results in increased expression of ELOVL6 mRNA CTD PMID:24534255 NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144 		JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic affects expression ISO Bezafibrate affects the expression of EPHX2 protein CTD PMID:29960002 NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver multiple interactions
decreases expression
increases expression		 ISO
EXP		 [Cisplatin co-treated with Bezafibrate] results in increased expression of FABP1 mRNA; Bezafibrate affects the localization of and results in increased expression of FABP1 protein; Bezafibrate inhibits the reaction [Cisplatin results in decreased expression of FABP1 protein]
Bezafibrate results in decreased expression of FABP1 mRNA
Bezafibrate results in increased expression of FABP1 mRNA
Bezafibrate results in increased expression of FABP1 mRNA; Bezafibrate results in increased expression of FABP1 protein
Butyrates promotes the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]
2-tetradecylglycidic acid inhibits the reaction [Bezafibrate results in increased expression of FABP1 protein]; Bezafibrate inhibits the reaction [Oleic Acid binds to FABP1 protein]		 CTD PMID:2328261 PMID:10191295 PMID:12782154 PMID:15708366 PMID:16574099 More... NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007 		JBrowse link
G Fabp2 fatty acid binding protein 2, intestinal increases expression EXP Bezafibrate results in increased expression of FABP2 mRNA CTD PMID:17118139 NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart decreases expression ISO Bezafibrate results in decreased expression of FABP3 mRNA CTD PMID:15708366 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of FABP4 mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA]		 CTD PMID:11473052 PMID:12759900 PMID:21324916 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fads1 fatty acid desaturase 1 increases activity ISO Bezafibrate results in increased activity of FADS1 protein CTD PMID:7606338 PMID:9032088 NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241 		JBrowse link
G Fads2 fatty acid desaturase 2 increases activity ISO Bezafibrate results in increased activity of FADS2 protein CTD PMID:7606338 NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110 		JBrowse link
G Fas Fas cell surface death receptor increases expression
multiple interactions		 ISO Bezafibrate results in increased expression of FAS mRNA
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]		 CTD PMID:16712844 PMID:26190035 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand affects expression ISO Bezafibrate affects the expression of FASLG protein modified form CTD PMID:15063428 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fasn fatty acid synthase increases expression
decreases expression
affects expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased expression of FASN mRNA; Bezafibrate results in increased expression of FASN protein
Bezafibrate results in decreased expression of FASN mRNA; Bezafibrate results in decreased expression of FASN protein
Bezafibrate affects the expression of FASN mRNA
[Oleic Acid co-treated with Bezafibrate] results in increased expression of FASN mRNA		 CTD PMID:17118139 PMID:17719200 PMID:19124612 PMID:24534255 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
increases expression		 EXP
ISO		 [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]; Butyrates promotes the reaction [Bezafibrate results in increased expression of FGF21 protein]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]
Bezafibrate results in increased expression of FGF21 mRNA; Bezafibrate results in increased expression of FGF21 protein		 CTD PMID:18787029 PMID:20854792 PMID:21720023 PMID:22338096 NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA] CTD PMID:18513333 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein] CTD PMID:17360982 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein] CTD PMID:21734263 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO Bezafibrate inhibits the reaction [3-methylglutaric acid results in decreased activity of G6PD protein]; Bezafibrate inhibits the reaction [etomoxir results in increased activity of G6PD protein] CTD PMID:3421940 PMID:32169667 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression
increases expression
multiple interactions		 EXP Bezafibrate results in decreased expression of GPAM mRNA; Bezafibrate results in decreased expression of GPAM protein
Bezafibrate results in increased expression of GPAM mRNA; Bezafibrate results in increased expression of GPAM protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA]		 CTD PMID:19124612 NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of GPD1 mRNA
Bucladesine promotes the reaction [Bezafibrate results in increased expression of GPD1 mRNA]		 CTD PMID:1976021 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Bezafibrate promotes the reaction [Sodium Glutamate results in increased expression of GPT protein] CTD PMID:21549692 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gsr glutathione reductase multiple interactions
decreases activity		 ISO Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]
Bezafibrate results in decreased activity of GSR protein		 CTD PMID:17145126 PMID:17710547 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression EXP Bezafibrate results in increased expression of HADHA mRNA CTD PMID:17118139 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP Bezafibrate results in increased expression of HADHB mRNA CTD PMID:17118139 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591 		JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions EXP [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein CTD PMID:22338096 NCBI chr18:38,070,024...38,088,073
Ensembl chr18:38,068,897...38,088,069 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase decreases activity
increases activity		 ISO Bezafibrate results in decreased activity of HMGCR protein
Bezafibrate results in increased activity of HMGCR protein		 CTD PMID:2044640 PMID:2907502 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 multiple interactions
increases expression		 EXP Butyrates promotes the reaction [Bezafibrate results in increased expression of HMGCS2 mRNA] CTD PMID:18787029 PMID:22338096 NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity
decreases expression		 EXP Bezafibrate results in decreased activity of HSD11B1 protein
Bezafibrate results in decreased expression of HSD11B1 mRNA		 CTD PMID:17190905 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP Bezafibrate results in increased expression of HSD17B4 mRNA CTD PMID:17118139 NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Vitamin E co-treated with Bezafibrate] results in decreased expression of ICAM1 protein modified form CTD PMID:14602771 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein] CTD PMID:20631892 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Bezafibrate results in decreased expression of IGF1 protein CTD PMID:10716467 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Bezafibrate inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases expression		 ISO
EXP		 Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate promotes the reaction [IL1B protein results in increased expression of NPHS1 mRNA]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]
Bezafibrate results in decreased expression of IL1B mRNA
Bezafibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein]
Bezafibrate results in decreased expression of IL1B protein
Bezafibrate results in increased expression of IL1B protein		 CTD PMID:12657956 PMID:12704018 PMID:16288986 PMID:16574099 PMID:18513333 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]; Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]
Bezafibrate results in decreased expression of IL6 mRNA
Bezafibrate results in decreased expression of IL6 protein		 CTD PMID:11893366 PMID:12657956 PMID:16574099 PMID:17360982 PMID:18513333 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I decreases expression
multiple interactions		 ISO Bezafibrate results in decreased expression of INS1 mRNA
Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of INS1 mRNA]		 CTD PMID:11527545 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II multiple interactions
decreases expression		 ISO [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]
Bezafibrate results in decreased expression of INS protein		 CTD PMID:2209320 PMID:11292061 PMID:20404010 PMID:32613381 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insig1 insulin induced gene 1 increases expression EXP Bezafibrate results in increased expression of INSIG1 mRNA CTD PMID:17118139 PMID:19124612 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Jun jun proto-oncogene multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN protein] CTD PMID:17360982 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Ldha lactate dehydrogenase A increases expression ISO Bezafibrate results in increased expression of LDHA protein CTD PMID:8632003 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Lep leptin decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased expression of LEP
Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein]
Bezafibrate results in decreased expression of LEP mRNA
Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein]		 CTD PMID:10726910 PMID:11216866 PMID:11473052 PMID:17379010 PMID:21549692 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 increases expression EXP Bezafibrate results in increased expression of LGALS3 mRNA CTD PMID:17118139 NCBI chr14:47,611,317...47,623,624
Ensembl chr14:47,605,208...47,623,617 		JBrowse link
G Lipc lipase, hepatic increases activity ISO Bezafibrate results in increased activity of LIPC protein CTD PMID:3084275 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lpl lipoprotein lipase increases expression
multiple interactions
increases activity		 EXP
ISO		 Bezafibrate results in increased expression of LPL mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA]
Bezafibrate results in increased activity of LPL protein
[Bezafibrate results in increased activity of LPL protein] which results in decreased abundance of Triglycerides; Bezafibrate inhibits the reaction [Lipopolysaccharides results in decreased expression of LPL mRNA]		 CTD PMID:2907502 PMID:8147947 PMID:8593127 PMID:9006809 PMID:11164425 More... NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression EXP Bezafibrate results in increased expression of LY6D mRNA CTD PMID:17118139 NCBI chr15:74,633,905...74,635,416
Ensembl chr15:74,633,905...74,635,469 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK1 protein CTD PMID:11687581 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO Bezafibrate results in decreased phosphorylation of and results in decreased activity of MAPK3 protein CTD PMID:11687581 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO Bezafibrate inhibits the reaction [3-methylglutaric acid results in increased expression of MFN1 protein] CTD PMID:32169667 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mgll monoglyceride lipase increases expression EXP Bezafibrate results in increased expression of MGLL mRNA CTD PMID:17118139 NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression EXP Bezafibrate results in increased expression of MGMT mRNA CTD PMID:15447978 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mpeg1 macrophage expressed gene 1 decreases expression EXP Bezafibrate results in decreased expression of MPEG1 mRNA CTD PMID:18787029 NCBI chr19:12,438,134...12,442,649
Ensembl chr19:12,438,143...12,442,649 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression EXP Bezafibrate results in increased expression of MPG mRNA CTD PMID:15447978 NCBI chr11:32,176,505...32,182,702
Ensembl chr11:32,176,505...32,182,700 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression
decreases expression
multiple interactions		 EXP Bezafibrate results in increased expression of MTTP mRNA
Bezafibrate results in decreased expression of MTTP mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]		 CTD PMID:19124612 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NCF1 protein] CTD PMID:11172467 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein] CTD PMID:19263263 NCBI chr12:4,297,362...4,569,452
Ensembl chr12:4,297,362...4,527,182 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein] CTD PMID:19263263 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases activity EXP Bezafibrate results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions
decreases expression		 EXP Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of NFKB1 mRNA]
Bezafibrate results in decreased expression of NFKB1 mRNA		 CTD PMID:16574099 PMID:18513333 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
increases phosphorylation		 EXP [Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide; dorsomorphin inhibits the reaction [[Bezafibrate results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; dorsomorphin inhibits the reaction [Bezafibrate results in increased phosphorylation of NOS3 protein] CTD PMID:21499286 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased expression of NOX4 protein
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of NOX4 mRNA]		 CTD PMID:16979161 PMID:20594415 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Npy neuropeptide Y increases expression EXP Bezafibrate results in increased expression of NPY mRNA CTD PMID:18787029 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of NR0B2 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]		 CTD PMID:19124612 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases expression ISO Bezafibrate results in increased expression of NR1H2 mRNA CTD PMID:19201410 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]
Bezafibrate results in increased expression of NR1H3 mRNA
NR1H3 protein affects the susceptibility to Bezafibrate
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of NR1H3 mRNA]		 CTD PMID:12595494 PMID:19124612 PMID:19201410 PMID:26190035 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases expression		 EXP
ISO		 PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA]
[Oleic Acid co-treated with Bezafibrate] results in increased expression of NR1H4 mRNA		 CTD PMID:15447978 PMID:19124612 PMID:24534255 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Bezafibrate binds to and results in increased activity of NR1I2 protein CTD PMID:20024649 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Bezafibrate results in increased expression of NR1I3 mRNA CTD PMID:20208394 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nthl1 nth (endonuclease III)-like 1 (E.coli) increases expression EXP Bezafibrate results in increased expression of NTHL1 mRNA CTD PMID:15447978 NCBI chr17:24,851,656...24,857,812
Ensembl chr17:24,851,654...24,857,811 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 increases expression EXP Bezafibrate results in increased expression of OGG1 mRNA CTD PMID:15447978 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions EXP [Sodium Glutamate co-treated with Bezafibrate] results in decreased expression of PCK1 mRNA CTD PMID:21549692 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP
ISO		 Bezafibrate results in increased expression of PCNA mRNA
Bezafibrate results in increased expression of PCNA protein		 CTD PMID:9007043 PMID:15447978 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression ISO Bezafibrate results in increased expression of PCSK9 protein CTD PMID:21411093 NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526 		JBrowse link
G Pcx pyruvate carboxylase increases expression ISO Bezafibrate results in increased expression of PC mRNA CTD PMID:11527545 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 increases expression ISO Bezafibrate results in increased expression of PDHA1 mRNA CTD PMID:11527545 NCBI chr  X:158,905,215...158,921,426
Ensembl chr  X:158,905,205...158,921,409 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of PDK2 mRNA
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]		 CTD PMID:19124612 NCBI chr11:94,917,084...94,932,197
Ensembl chr11:94,917,084...94,932,180 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of PDK4 mRNA; Bezafibrate results in increased expression of PDK4 protein
MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 mRNA]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PDK4 protein]
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA]		 CTD PMID:17118139 PMID:19124612 PMID:19683050 PMID:21720023 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
decreases expression		 ISO Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of PDX1 mRNA] CTD PMID:11527545 NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658 		JBrowse link
G Plin2 perilipin 2 multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN2 mRNA] CTD PMID:24534255 NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297 		JBrowse link
G Plin4 perilipin 4 multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in increased expression of PLIN4 mRNA] CTD PMID:24534255 NCBI chr17:56,407,587...56,416,947
Ensembl chr17:56,407,591...56,416,803 		JBrowse link
G Pltp phospholipid transfer protein decreases activity
multiple interactions		 ISO Bezafibrate results in decreased activity of PLTP protein
[Bezafibrate results in decreased activity of PLTP protein] affects the reaction [Bezafibrate results in decreased abundance of Fatty Acids, Nonesterified]		 CTD PMID:12754275 NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631 		JBrowse link
G Pnliprp2 pancreatic lipase-related protein 2 increases expression EXP Bezafibrate results in increased expression of PNLIPRP2 mRNA CTD PMID:18787029 NCBI chr19:58,748,155...58,765,966
Ensembl chr19:58,748,151...58,765,966 		JBrowse link
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A multiple interactions EXP [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein CTD PMID:22338096 NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463 		JBrowse link
G Pomc pro-opiomelanocortin-alpha decreases expression EXP Bezafibrate results in decreased expression of POMC mRNA CTD PMID:18787029 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Por cytochrome p450 oxidoreductase increases activity ISO Bezafibrate results in increased activity of POR protein CTD PMID:7606338 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases response to substance
increases activity
increases expression
affects binding
decreases expression
affects response to substance		 ISO
EXP		 [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Glucose; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of 3-Hydroxybutyric Acid; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Ketones; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of ABCA1 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of NR1H3 mRNA; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Bezafibrate affects the reaction [PPARA protein binds to CREBBP protein]; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate promotes the reaction [PPARA protein binds to NCOA1 protein]; Bezafibrate promotes the reaction [PPARA protein binds to NCOA2 protein]; Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARA mRNA]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; MK-886 inhibits the reaction [Bezafibrate results in increased expression of PPARA mRNA]; NR1H3 protein affects the reaction [Bezafibrate results in increased expression of PPARA mRNA]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [Bezafibrate affects the localization of ABCB4 protein]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
PPARA protein results in increased susceptibility to Bezafibrate
[[Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids] which results in decreased abundance of Triglycerides; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Fatty Acids; [Bezafibrate co-treated with Sodium Glutamate] results in increased expression of PPARA mRNA; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in decreased expression of HDAC3 protein; [Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]] which results in increased expression of POLR2A protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in increased uptake of and results in increased oxidation of Fatty Acids; Bezafibrate promotes the reaction [PPARA protein binds to FGF21 promoter]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased abundance of Lipid Peroxides]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACADVL protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of ACOX1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CPT1B mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of CYP4A14 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of EHHADH protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP1 protein]; PPARA protein affects the reaction [Bezafibrate results in increased expression of FABP4 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACAA1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACA protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACACB mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of ACSL1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CD36 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of CPT1A mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of EHHADH mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of GPAM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of LPL mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of MTTP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR0B2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H3 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of NR1H4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK4 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of CYP4A10 mRNA]; PPARA protein promotes the reaction [Bezafibrate results in increased expression of FGF21 mRNA]
Bezafibrate results in increased expression of PPARA; Bezafibrate results in increased expression of PPARA mRNA; Bezafibrate results in increased expression of PPARA protein
Bezafibrate binds to PPARA protein
Bezafibrate results in decreased expression of PPARA mRNA
[Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein; Bezafibrate results in increased activity of PPARA protein
PPARA protein affects the susceptibility to Bezafibrate
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased susceptibility to Palmitates; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased abundance of Nitric Oxide; [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate; [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein; [Bezafibrate results in increased activity of PPARA protein] which results in increased abundance of Ceramides; Bezafibrate binds to and results in increased activity of PPARA protein; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]		 CTD PMID:9836514 PMID:10585473 PMID:11056218 PMID:11172467 PMID:11341955 More... NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta affects binding
increases expression
multiple interactions
decreases expression
increases activity		 ISO
EXP		 Bezafibrate binds to PPARB protein; Bezafibrate binds to PPARD protein
Bezafibrate results in increased expression of PPARD mRNA; Bezafibrate results in increased expression of PPARD protein
Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Calcitriol promotes the reaction [Bezafibrate results in increased expression of PPARD mRNA]
PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOB mRNA alternative form]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]; PPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC3 mRNA]; PPARD protein affects the reaction [Bezafibrate results in increased expression of CD36 mRNA]
Bezafibrate results in increased expression of PPARD; Bezafibrate results in increased expression of PPARD mRNA
Bezafibrate results in decreased expression of PPARD mRNA
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARB mRNA]
Bezafibrate results in increased activity of PPARD protein		 CTD PMID:10585473 PMID:11172467 PMID:11779144 PMID:12782154 PMID:19124612 More... NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
increases activity
increases expression
affects binding		 ISO
EXP		 [2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein]
Bezafibrate results in decreased expression of PPARG mRNA
Bezafibrate results in increased activity of PPARG protein
PPARA protein affects the reaction [Bezafibrate results in increased expression of PPARG mRNA]
Bezafibrate inhibits the reaction [3-methylglutaric acid results in increased expression of PPARG protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]
Bezafibrate binds to PPARG protein		 CTD PMID:11473052 PMID:11779144 PMID:12401884 PMID:12967931 PMID:15708366 More... NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression EXP Bezafibrate results in increased expression of PPARGC1A mRNA CTD PMID:17275789 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Psmc3ip proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein decreases expression EXP Bezafibrate results in decreased expression of PSMC3IP mRNA CTD PMID:18787029 NCBI chr11:100,981,238...100,986,261
Ensembl chr11:100,982,649...100,986,262 		JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO Bezafibrate results in decreased expression of RARB mRNA CTD PMID:11519881 PMID:11579993 NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Bezafibrate inhibits the reaction [Aldosterone results in increased activity of RELA protein] CTD PMID:18660453 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Reln reelin increases expression EXP Bezafibrate results in increased expression of RELN mRNA CTD PMID:18787029 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G Rida reactive intermediate imine deaminase A homolog multiple interactions ISO [Bezafibrate co-treated with Sunflower Oil] results in increased expression of RIDA protein CTD PMID:16843601 NCBI chr15:34,484,168...34,495,392
Ensembl chr15:34,484,167...34,495,401 		JBrowse link
G Rmnd1 required for meiotic nuclear division 1 homolog decreases expression EXP Bezafibrate results in decreased expression of RMND1 mRNA CTD PMID:18787029 NCBI chr10:4,353,168...4,382,583
Ensembl chr10:4,351,915...4,382,388 		JBrowse link
G Runx2 runt related transcription factor 2 increases expression
multiple interactions		 EXP Bezafibrate results in increased expression of RUNX2 mRNA
dorsomorphin inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA]; GSK0660 inhibits the reaction [Bezafibrate results in increased expression of RUNX2 mRNA]		 CTD PMID:21499286 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
affects binding		 ISO Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARD protein binds to RXRA protein]; Bezafibrate results in increased activity of [PPARG protein alternative form binds to RXRA protein]; cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; Cholesterol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; fluvastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; geranylgeraniol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]; pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
Bezafibrate binds to RXRA protein		 CTD PMID:11779144 PMID:23843199 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Rxrb retinoid X receptor beta affects binding ISO Bezafibrate binds to RXRB protein CTD PMID:23843199 NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373 		JBrowse link
G Rxrg retinoid X receptor gamma affects binding ISO Bezafibrate binds to RXRG protein CTD PMID:23843199 NCBI chr 1:167,425,902...167,467,191
Ensembl chr 1:167,425,953...167,467,192 		JBrowse link
G Scap SREBF chaperone decreases expression
increases expression
multiple interactions		 EXP Bezafibrate results in decreased expression of SCAP mRNA; Bezafibrate results in decreased expression of SCAP protein
Bezafibrate results in increased expression of SCAP mRNA; Bezafibrate results in increased expression of SCAP protein
PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SCAP protein]		 CTD PMID:19124612 NCBI chr 9:110,162,356...110,214,017
Ensembl chr 9:110,162,356...110,214,018 		JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 decreases expression
multiple interactions
increases expression
increases activity		 EXP
ISO		 Bezafibrate results in decreased expression of SCD1 mRNA
PPARA protein affects the reaction [Bezafibrate results in increased expression of SCD1 mRNA]
Bezafibrate results in increased activity of SCD protein; Bezafibrate results in increased activity of SCD1 protein		 CTD PMID:7606338 PMID:11172741 PMID:12782154 PMID:19124612 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased expression of SCD mRNA
[Oleic Acid co-treated with Bezafibrate] results in increased expression of SCD1 mRNA; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]
Bezafibrate results in increased expression of SCD1 mRNA		 CTD PMID:11172741 PMID:17118139 PMID:24534255 PMID:32613381 NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303 		JBrowse link
G Sco2 SCO2 cytochrome c oxidase assembly protein increases activity
multiple interactions		 ISO Bezafibrate results in increased activity of SCO2 protein mutant form
cupric chloride promotes the reaction [Bezafibrate results in increased activity of SCO2 protein mutant form]		 CTD PMID:22515166 NCBI chr15:89,255,833...89,258,094
Ensembl chr15:89,255,840...89,258,049 		JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO [Vitamin E co-treated with Bezafibrate] results in decreased expression of SELE protein modified form CTD PMID:14602771 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 multiple interactions
increases expression
increases activity
increases secretion		 EXP
ISO		 [CLOCK protein binds to BMAL1 protein] promotes the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; Bezafibrate promotes the reaction [PPARA protein binds to SERPINE1 promoter]; CLOCK protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein affects the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]; PPARA protein inhibits the reaction [Bezafibrate results in increased expression of SERPINE1 mRNA]
Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 protein]
Bezafibrate results in increased activity of SERPINE1 protein
Bezafibrate results in increased secretion of SERPINE1 protein		 CTD PMID:9678787 PMID:10364093 PMID:11292061 PMID:17118139 PMID:20400680 More... NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Bezafibrate inhibits the reaction [3-methylglutaric acid results in decreased expression of SIRT1 protein] CTD PMID:32169667 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 multiple interactions
increases expression		 EXP PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A1 mRNA] CTD PMID:19124612 NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946 		JBrowse link
G Slc27a2 solute carrier family 27 (fatty acid transporter), member 2 multiple interactions
increases expression		 EXP Bezafibrate inhibits the reaction [SLC27A2 gene mutant form results in decreased expression of ACADM mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SLC27A2 mRNA] CTD PMID:11929713 PMID:17118139 PMID:19124612 NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163 		JBrowse link
G Slc2a2 solute carrier family 2 (facilitated glucose transporter), member 2 multiple interactions
decreases expression		 ISO Bezafibrate inhibits the reaction [Oleic Acid results in increased expression of SLC2A2 mRNA]
Bezafibrate results in decreased expression of SLC2A2 mRNA
Diazoxide inhibits the reaction [Bezafibrate results in decreased expression of SLC2A2 mRNA]		 CTD PMID:11527545 PMID:12048068 NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions EXP Bezafibrate inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal increases activity ISO [Bezafibrate results in increased activity of PPARA protein] which results in increased activity of SMPD1 protein CTD PMID:18024222 NCBI chr 7:105,203,567...105,207,596
Ensembl chr 7:105,203,567...105,207,596 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2, neutral multiple interactions ISO [Bezafibrate results in increased activity of PPARA protein] which results in decreased activity of SMPD2 protein CTD PMID:18024222 NCBI chr10:41,363,168...41,366,410
Ensembl chr10:41,361,638...41,366,365 		JBrowse link
G Soat1 sterol O-acyltransferase 1 decreases activity ISO Bezafibrate results in decreased activity of SOAT1 protein CTD PMID:2044640 NCBI chr 1:156,255,678...156,301,898
Ensembl chr 1:156,252,095...156,301,901 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in increased expression of SOD1 mRNA; Bezafibrate results in increased expression of SOD1 protein
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in decreased expression of SOD1 mRNA]		 CTD PMID:11172467 PMID:18513333 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
decreases expression		 ISO Bezafibrate inhibits the reaction [IL6 protein results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [[FOS protein binds to JUN protein modified form] which binds to SPP1 promoter]]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]; Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; PPARA protein affects the reaction [Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]
Bezafibrate results in decreased expression of SPP1 protein		 CTD PMID:17360982 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 SREBF1 protein inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]]
Bezafibrate results in decreased expression of SREBF1 mRNA; Bezafibrate results in decreased expression of SREBF1 protein
[Bezafibrate results in decreased expression of SREBF1] which results in decreased abundance of Triglycerides; PPARA protein affects the susceptibility to [Bezafibrate results in decreased expression of SREBF1 mRNA]; PPARA protein affects the susceptibility to [Bezafibrate results in increased expression of SREBF1 protein]
Bezafibrate results in increased expression of SREBF1 mRNA; Bezafibrate results in increased expression of SREBF1 protein
Bezafibrate inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]		 CTD PMID:11779144 PMID:19124612 PMID:26190035 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Srebf2 sterol regulatory element binding factor 2 increases expression ISO Bezafibrate results in increased expression of SREBF2 mRNA CTD PMID:14685799 NCBI chr15:82,031,455...82,089,580
Ensembl chr15:82,031,382...82,089,580 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity EXP Bezafibrate results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550 		JBrowse link
G Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit increases expression ISO Bezafibrate results in increased expression of SUCLG1 mRNA CTD PMID:16707586 NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894 		JBrowse link
G Syp synaptophysin multiple interactions ISO Bezafibrate affects the reaction [3-nitropropionic acid affects the expression of SYP protein] CTD PMID:37116597 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tdg thymine DNA glycosylase increases expression EXP Bezafibrate results in increased expression of TDG mRNA CTD PMID:15447978 NCBI chr10:82,465,649...82,486,633
Ensembl chr10:82,465,662...82,486,633 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TGFB1 mRNA]
Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Bezafibrate inhibits the reaction [TGFB1 protein results in increased expression of TGFB1 mRNA]
Bezafibrate results in decreased expression of TGFB1 mRNA		 CTD PMID:16574099 PMID:18513333 PMID:19429239 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO Bezafibrate results in decreased expression of THRA mRNA CTD PMID:11519881 PMID:11579993 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta decreases expression ISO Bezafibrate results in decreased expression of THRB mRNA CTD PMID:11519881 PMID:11579993 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Thrsp thyroid hormone responsive multiple interactions ISO Bezafibrate promotes the reaction [Oleic Acid results in decreased expression of THRSP mRNA] CTD PMID:24534255 NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions EXP Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP1 mRNA] CTD PMID:18513333 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 multiple interactions EXP Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TIMP2 mRNA] CTD PMID:18513333 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tnf tumor necrosis factor decreases response to substance
increases response to substance
decreases expression
multiple interactions		 ISO
EXP		 Bezafibrate results in decreased susceptibility to TNF protein
Bezafibrate results in increased susceptibility to TNF protein
Bezafibrate results in decreased expression of TNF mRNA; Bezafibrate results in decreased expression of TNF protein
[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Bezafibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of SCD mRNA]; Bezafibrate affects the susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Bezafibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CXCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Bezafibrate inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; Bezafibrate promotes the reaction [TNF protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; Bezafibrate promotes the reaction [TNF protein results in decreased susceptibility to FSHB protein]; PPARG protein affects the reaction [Bezafibrate results in increased susceptibility to TNF protein]
Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]		 CTD PMID:11473052 PMID:11893366 PMID:12586603 PMID:12657956 PMID:16574099 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA CTD PMID:19593819 NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) increases expression
affects expression
multiple interactions		 EXP
ISO		 Bezafibrate results in increased expression of UCP2 mRNA
Bezafibrate affects the expression of UCP2 mRNA
[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; Triiodothyronine promotes the reaction [Bezafibrate results in increased expression of UCP2 mRNA]		 CTD PMID:10933891 PMID:11056218 PMID:11341955 PMID:11473052 PMID:12588052 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) increases expression
decreases expression		 ISO
EXP		 Bezafibrate results in increased expression of UCP3 mRNA
Bezafibrate results in decreased expression of UCP3 mRNA		 CTD PMID:10342807 PMID:10403804 PMID:10909982 PMID:10933891 PMID:11473052 More... NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 increases response to substance ISO UGT1A9 results in increased susceptibility to Bezafibrate CTD PMID:17880178 NCBI chr 1:87,998,501...88,147,724
Ensembl chr 1:87,998,522...88,146,719 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B1 protein results in increased glucuronidation of Bezafibrate CTD PMID:8302279 NCBI chr 5:87,064,498...87,074,362
Ensembl chr 5:87,064,497...87,074,389 		JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 increases response to substance ISO UGT2B7 results in increased susceptibility to Bezafibrate CTD PMID:17880178 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G Vbp1 von Hippel-Lindau binding protein 1 increases expression EXP Bezafibrate results in increased expression of VBP1 mRNA CTD PMID:18787029 NCBI chr  X:74,557,903...74,578,552
Ensembl chr  X:74,557,905...74,578,548 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Bezafibrate inhibits the reaction [Streptozocin results in increased expression of VCAM1 mRNA]
[Vitamin E co-treated with Bezafibrate] results in decreased expression of VCAM1 protein modified form		 CTD PMID:14602771 PMID:16979161 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vcan versican decreases expression ISO Bezafibrate results in decreased expression of VCAN mRNA CTD PMID:11522680 NCBI chr13:89,803,429...89,891,146
Ensembl chr13:89,803,431...89,890,628 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor multiple interactions ISO [Calcitriol co-treated with Bezafibrate] results in increased expression of VDR mRNA CTD PMID:19667161 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
G Xdh xanthine dehydrogenase decreases activity
decreases expression
multiple interactions		 ISO Bezafibrate results in decreased activity of XDH protein
Bezafibrate results in decreased expression of XDH protein
Bezafibrate results in increased degradation of and results in decreased expression of XDH mRNA		 CTD PMID:8373410 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Zfp704 zinc finger protein 704 increases expression EXP Bezafibrate results in increased expression of ZFP704 mRNA CTD PMID:18787029 NCBI chr 3:9,492,070...9,675,145
Ensembl chr 3:9,492,080...9,675,145 		JBrowse link
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  CHEBI ontology 22210
    role 22195
      biological role 22194
        xenobiotic 19703
          bezafibrate 229
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21005
                                organooxygen compound 20846
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      carboacyl group 18296
                                        univalent carboacyl group 18296
                                          carbamoyl group 18108
                                            carboxamide 18108
                                              monocarboxylic acid amide 15839
                                                bezafibrate 229
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