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Gene: Polr2a (polymerase (RNA) II (DNA directed) polypeptide A) Mus musculus
Symbol: Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
RGD ID: 1557071
Description: Exhibits core promoter sequence-specific DNA binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in DNA-templated transcription, termination; positive regulation of RNA splicing; and transcription by RNA polymerase II. Localizes to nuclear euchromatin. Predicted to colocalize with Prp19 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human POLR2A (RNA polymerase II subunit A); PARTICIPATES IN RNA polymerase II transcription pathway; Huntington's disease pathway; purine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,2-naphthoquinone; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 220kD; 220kDa; DNA-directed RNA polymerase II A; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; RNA polymerase II 1; RNA polymerase II subunit B1; Rpb1; Rpo; Rpo2-1
Homo sapiens (human) : POLR2A (RNA polymerase II subunit A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Polr2a (RNA polymerase II subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Polr2a (RNA polymerase II subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : POLR2A (RNA polymerase II subunit A)
Canis lupus familiaris (dog) : POLR2A (RNA polymerase II subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Polr2a (RNA polymerase II subunit A)
Sus scrofa (pig) : POLR2A (RNA polymerase II subunit A)
Chlorocebus sabaeus (African green monkey) : POLR2A (RNA polymerase II subunit A)
Heterocephalus glaber (naked mole-rat) : Polr2a (RNA polymerase II subunit A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391169,624,823 - 69,649,459 (-)NCBI
GRCm381169,733,997 - 69,758,633 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,733,997 - 69,758,637 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,547,912 - 69,571,725 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,550,605 - 69,574,418 (-)NCBImm8
MGSCv361170,318,517 - 70,342,330 (-)NCBImm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Polr2a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557071
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.