Abcd3 (ATP-binding cassette, sub-family D member 3) - Rat Genome Database

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Gene: Abcd3 (ATP-binding cassette, sub-family D member 3) Mus musculus
Analyze
Symbol: Abcd3
Name: ATP-binding cassette, sub-family D member 3
RGD ID: 10051
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and protein homodimerization activity. Involved in bile acid and bile salt transport; bile acid biosynthetic process; and phytanic acid metabolic process. Located in peroxisomal membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study congenital bile acid synthesis defect 5. Human ortholog(s) of this gene implicated in Zellweger syndrome and congenital bile acid synthesis defect 5. Orthologous to human ABCD3 (ATP binding cassette subfamily D member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 68 kDa peroxisomal membrane protein; 70 kDa peroxisomal membrane protein; AI313901; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; AU018866; AW146054; peroxisomal membrane protein 1; peroxisomal membrane protein, 70 kDa; PMP; PMP68; PMP70; Pxm; Pxmp1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,552,553 - 121,609,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,552,423 - 121,608,951 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383121,758,904 - 121,815,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,758,774 - 121,815,302 (-)Ensemblmm10GRCm38
MGSCv373121,461,828 - 121,518,133 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363121,750,933 - 121,807,238 (-)NCBIMGSCv36mm8
Celera3128,155,294 - 128,218,276 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-bromohexadecanoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
7-ketocholesterol  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldrin  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
chloroethene  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enilconazole  (EXP)
epoxiconazole  (EXP)
fenofibrate  (EXP)
finasteride  (ISO)
fluoranthene  (ISO)
folic acid  (EXP)
fomesafen  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
MeIQx  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Muraglitazar  (ISO)
nickel atom  (ISO)
oleic acid  (EXP)
Oxyfluorfen  (EXP)
ozone  (EXP)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium chromate  (ISO)
pravastatin  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sulindac  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
topotecan  (ISO)
triacsin C  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
mitochondrial inner membrane  (HDA)
mitochondrion  (HDA,IEA,ISO)
peroxisomal matrix  (IEA,ISO)
peroxisomal membrane  (IBA,IDA,IEA,ISO)
peroxisome  (IDA,IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Restoration of peroxisome biogenesis in a peroxisome-deficient mammalian cell line by expression of either the 35 kDa or the 70 kDa peroxisomal membrane proteins. Gartner J, etal., J Inherit Metab Dis 1994;17(3):327-9.
2. Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome. Gartner J, etal., Nat Genet. 1992 Apr;1(1):16-23.
3. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Hu B, etal., Biochem Biophys Res Commun 2001 Aug 3;285(5):1369-76.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7544098   PMID:7551822   PMID:7772082   PMID:8034329   PMID:8404042   PMID:8449508   PMID:9195160   PMID:9288097   PMID:9521874   PMID:10349636   PMID:10504404   PMID:10551832  
PMID:10708515   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12865426   PMID:12870272   PMID:12915479   PMID:14561759   PMID:14610273   PMID:14681479  
PMID:15276650   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16916647   PMID:17208939   PMID:17978498   PMID:18614015   PMID:18799693   PMID:19010322   PMID:20007743   PMID:21460186  
PMID:21502359   PMID:21613372   PMID:21677750   PMID:21873635   PMID:24457600   PMID:25044020   PMID:25168382   PMID:25737280   PMID:27458135   PMID:28209736   PMID:28378742   PMID:28930673  
PMID:30540494   PMID:30550785   PMID:32325033   PMID:32581705   PMID:33230847   PMID:33378226   PMID:34321999   PMID:34564857   PMID:35681537   PMID:36114006   PMID:36184612   PMID:36417873  
PMID:36504079   PMID:37142655   PMID:38187761   PMID:38355793  


Genomics

Comparative Map Data
Abcd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393121,552,553 - 121,609,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3121,552,423 - 121,608,951 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383121,758,904 - 121,815,302 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3121,758,774 - 121,815,302 (-)Ensemblmm10GRCm38
MGSCv373121,461,828 - 121,518,133 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363121,750,933 - 121,807,238 (-)NCBIMGSCv36mm8
Celera3128,155,294 - 128,218,276 (-)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
ABCD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38194,385,131 - 94,518,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl194,418,389 - 94,518,666 (+)Ensemblhg38GRCh38
GRCh37194,883,945 - 94,984,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,656,599 - 94,756,672 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34194,596,031 - 94,696,105NCBI
Celera193,137,599 - 93,238,680 (+)NCBICelera
Cytogenetic Map1p21.3ENTREZGENE
HuRef193,005,619 - 93,105,917 (+)NCBIHuRef
CHM1_1194,998,783 - 95,099,070 (+)NCBICHM1_1
T2T-CHM13v2.0194,233,380 - 94,366,700 (+)NCBIT2T-CHM13v2.0
Abcd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82212,536,791 - 212,590,379 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2212,536,791 - 212,590,504 (-)EnsemblGRCr8
mRatBN7.22209,852,087 - 209,905,763 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2209,852,087 - 209,906,020 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2217,515,099 - 217,568,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,422,840 - 215,476,397 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,264,674 - 210,318,230 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,335,708 - 225,389,120 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,335,718 - 225,389,120 (-)Ensemblrn6Rnor6.0
Rnor_5.02243,374,189 - 243,409,604 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42218,396,071 - 218,432,172 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2202,282,471 - 202,317,962 (-)NCBICelera
RGSC_v3.12218,359,132 - 218,395,230 (-)NCBI
RH 3.4 Map21501.0RGD
Cytogenetic Map2q42NCBI
Abcd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423280,497 - 359,711 (-)Ensembl
ChiLan1.0NW_004955423280,497 - 359,711 (-)NCBIChiLan1.0ChiLan1.0
ABCD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21132,505,970 - 132,606,599 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11131,660,847 - 131,761,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,079,326 - 97,179,886 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,808,027 - 95,907,864 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,808,027 - 95,907,864 (+)EnsemblpanPan2panpan1.1
ABCD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1654,740,704 - 54,816,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl654,742,111 - 54,817,235 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha657,449,009 - 57,525,742 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0655,116,365 - 55,193,330 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,116,488 - 55,193,330 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1654,797,137 - 54,873,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0654,781,385 - 54,858,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,234,335 - 55,310,979 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Abcd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058104,201,915 - 104,288,290 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365374,659,484 - 4,746,616 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365374,659,685 - 4,745,992 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4122,847,927 - 122,953,257 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14122,847,925 - 122,929,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24134,491,144 - 134,572,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12038,750,147 - 38,846,011 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2038,748,787 - 38,845,989 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603379,200,937 - 79,302,556 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,142,570 - 3,236,728 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247423,146,000 - 3,236,473 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcd3
3355 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:422
Count of miRNA genes:323
Interacting mature miRNAs:363
Transcripts:ENSMUST00000029770, ENSMUST00000161742, ENSMUST00000162262, ENSMUST00000162299
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119057332153057456Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
12910796Pwbwq6_mpost-weaning body weight QTL 6 (mouse)3110084357135715812Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
12910793Pwbwq7_mpost-weaning body weight QTL 7 (mouse)3110084357135715812Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119318586153318586Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3120772078154772078Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119318586153318586Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3119778857153779044Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111133243145133417Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119057332153057456Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3109834882143835005Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
12910815Ogrq1_moverall growth rate QTL 1 (mouse)3110084357135715812Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107376936147304689Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
8655599Cia5c_mcollagen induced arthritis QTL 5c (mouse)Not determined3107376936125316237Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3114736617148736784Mouse

Markers in Region
RH136505  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383121,759,126 - 121,759,325UniSTSGRCm38
MGSCv373121,462,044 - 121,462,243UniSTSGRCm37
Celera3128,155,510 - 128,155,709UniSTS
Cytogenetic Map3G-H1UniSTS
AW146054  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383121,759,054 - 121,759,142UniSTSGRCm38
MGSCv373121,461,972 - 121,462,060UniSTSGRCm37
Celera3128,155,438 - 128,155,526UniSTS
Cytogenetic Map3G-H1UniSTS
Whitehead/MRC_RH31408.54UniSTS
AI313901  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383121,759,078 - 121,759,359UniSTSGRCm38
MGSCv373121,461,996 - 121,462,277UniSTSGRCm37
Celera3128,155,462 - 128,155,743UniSTS
Cytogenetic Map3G-H1UniSTS
Whitehead/MRC_RH31408.54UniSTS
UniSTS:234814  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383121,787,506 - 121,787,746UniSTSGRCm38
MGSCv373121,490,424 - 121,490,664UniSTSGRCm37
Celera3128,190,686 - 128,190,926UniSTS
Cytogenetic Map3G-H1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001355756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001409851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC129311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF028806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB622401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY123916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB245413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L28836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X89569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029770   ⟹   ENSMUSP00000029770
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,552,556 - 121,608,951 (-)Ensembl
GRCm38.p6 Ensembl3121,758,907 - 121,815,302 (-)Ensembl
Ensembl Acc Id: ENSMUST00000195965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,579,658 - 121,608,558 (-)Ensembl
GRCm38.p6 Ensembl3121,786,009 - 121,814,909 (-)Ensembl
Ensembl Acc Id: ENSMUST00000196340
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,560,013 - 121,562,501 (-)Ensembl
GRCm38.p6 Ensembl3121,766,364 - 121,768,852 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197383   ⟹   ENSMUSP00000142387
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,552,423 - 121,608,815 (-)Ensembl
GRCm38.p6 Ensembl3121,758,774 - 121,815,166 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197662   ⟹   ENSMUSP00000143487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,553,405 - 121,608,815 (-)Ensembl
GRCm38.p6 Ensembl3121,759,756 - 121,815,166 (-)Ensembl
Ensembl Acc Id: ENSMUST00000199593
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3121,589,686 - 121,608,846 (-)Ensembl
GRCm38.p6 Ensembl3121,796,037 - 121,815,197 (-)Ensembl
RefSeq Acc Id: NM_001355756   ⟹   NP_001342685
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,595 (-)NCBI
GRCm383121,758,904 - 121,814,909 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001409848   ⟹   NP_001396777
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,845 (-)NCBI
RefSeq Acc Id: NM_001409849   ⟹   NP_001396778
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,845 (-)NCBI
RefSeq Acc Id: NM_001409850   ⟹   NP_001396779
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,845 (-)NCBI
RefSeq Acc Id: NM_001409851   ⟹   NP_001396780
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,845 (-)NCBI
RefSeq Acc Id: NM_008991   ⟹   NP_033017
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,845 (-)NCBI
GRCm383121,758,904 - 121,815,302 (-)NCBI
MGSCv373121,461,828 - 121,518,133 (-)RGD
Celera3128,155,294 - 128,218,276 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036162959   ⟹   XP_036018852
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,609,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162960   ⟹   XP_036018853
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393121,552,553 - 121,608,821 (-)NCBI
Sequence:
RefSeq Acc Id: NP_033017   ⟸   NM_008991
- Peptide Label: isoform 1
- UniProtKB: P55096 (UniProtKB/Swiss-Prot),   Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001342685   ⟸   NM_001355756
- Peptide Label: isoform 2
- UniProtKB: Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000142387   ⟸   ENSMUST00000197383
Ensembl Acc Id: ENSMUSP00000143487   ⟸   ENSMUST00000197662
Ensembl Acc Id: ENSMUSP00000029770   ⟸   ENSMUST00000029770
RefSeq Acc Id: XP_036018852   ⟸   XM_036162959
- Peptide Label: isoform X1
- UniProtKB: Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036018853   ⟸   XM_036162960
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001396780   ⟸   NM_001409851
- Peptide Label: isoform 2
- UniProtKB: Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396778   ⟸   NM_001409849
- Peptide Label: isoform 4
- UniProtKB: Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396779   ⟸   NM_001409850
- Peptide Label: isoform 5
- UniProtKB: A0A0G2JDI9 (UniProtKB/TrEMBL),   Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001396777   ⟸   NM_001409848
- Peptide Label: isoform 3
- UniProtKB: Q3U645 (UniProtKB/TrEMBL),   Q3UNS0 (UniProtKB/TrEMBL),   Q91VT3 (UniProtKB/TrEMBL),   Q9DBZ6 (UniProtKB/TrEMBL)
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55096-F1-model_v2 AlphaFold P55096 1-659 view protein structure

Promoters
RGD ID:6833264
Promoter ID:MM_KWN:35951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver
Transcripts:OTTMUST00000077014
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363121,471,511 - 121,472,011 (-)MPROMDB
RGD ID:6833261
Promoter ID:MM_KWN:35953
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000077011,   OTTMUST00000077012,   OTTMUST00000077013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363121,517,711 - 121,518,757 (-)MPROMDB
RGD ID:6882240
Promoter ID:EPDNEW_M4571
Type:initiation region
Name:Abcd3_1
Description:Mus musculus ATP-binding cassette, sub-family D , member 3 ,transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383121,815,196 - 121,815,256EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1349216 AgrOrtholog
Ensembl Genes ENSMUSG00000028127 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029770 ENTREZGENE
  ENSMUST00000029770.8 UniProtKB/Swiss-Prot
  ENSMUST00000197383 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABC_transporter_sub-D UniProtKB/Swiss-Prot
  FA_transporter UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report mmu:19299 UniProtKB/Swiss-Prot
MGD MGI:1349216 ENTREZGENE
NCBI Gene 19299 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 3 UniProtKB/Swiss-Prot
  ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER UniProtKB/Swiss-Prot
Pfam ABC_membrane_2 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PhenoGen Abcd3 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A0G2JDI9 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JGA4_MOUSE UniProtKB/TrEMBL
  ABCD3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U645 ENTREZGENE, UniProtKB/TrEMBL
  Q3UNS0 ENTREZGENE, UniProtKB/TrEMBL
  Q91VT3 ENTREZGENE, UniProtKB/TrEMBL
  Q9DBZ6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Abcd3  ATP-binding cassette, sub-family D member 3  Abcd3  ATP-binding cassette, sub-family D (ALD), member 3  Symbol and/or name change 5135510 APPROVED