Crot (carnitine O-octanoyltransferase) - Rat Genome Database
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Gene: Crot (carnitine O-octanoyltransferase) Mus musculus
Analyze
Symbol: Crot
Name: carnitine O-octanoyltransferase
RGD ID: 732198
MGI Page MGI
Description: Exhibits carnitine O-octanoyltransferase activity. Involved in several processes, including carnitine metabolic process; coenzyme A metabolic process; and fatty acid transport. Localizes to peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1200003H03Rik; COT; peroxisomal carnitine O-octanoyltransferase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3959,016,033 - 9,047,926 (-)NCBIGRCm39mm39
GRCm3858,966,033 - 8,997,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,966,033 - 8,997,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv3758,966,048 - 8,997,146 (-)NCBIGRCm37mm9NCBIm37
MGSCv3658,972,054 - 9,003,152 (-)NCBImm8
Celera58,885,457 - 8,916,553 (-)NCBICelera
Cytogenetic Map5A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dibenz[a,h]anthracene  (EXP)
dichloroacetic acid  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
indometacin  (ISO)
lithocholic acid  (EXP)
maneb  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
O-octanoylcarnitine  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
Tesaglitazar  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:6436243   PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11452036   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15492013  
PMID:16141072   PMID:16141073   PMID:16916647   PMID:18614015   PMID:21267068   PMID:21873635   PMID:23375831   PMID:25124681   PMID:28335007  


Genomics

Comparative Map Data
Crot
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3959,016,033 - 9,047,926 (-)NCBIGRCm39mm39
GRCm3858,966,033 - 8,997,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,966,033 - 8,997,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv3758,966,048 - 8,997,146 (-)NCBIGRCm37mm9NCBIm37
MGSCv3658,972,054 - 9,003,152 (-)NCBImm8
Celera58,885,457 - 8,916,553 (-)NCBICelera
Cytogenetic Map5A1NCBI
CROT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl787,345,681 - 87,399,795 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl787,345,664 - 87,399,794 (+)EnsemblGRCh38hg38GRCh38
GRCh38787,345,646 - 87,399,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37786,974,980 - 87,029,110 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37786,974,951 - 87,029,112 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,812,947 - 86,867,045 (+)NCBINCBI36hg18NCBI36
Build 34786,619,661 - 86,673,760NCBI
Celera781,679,821 - 81,733,990 (+)NCBI
Cytogenetic Map7q21.12NCBI
HuRef781,585,930 - 81,640,108 (+)NCBIHuRef
CHM1_1786,905,052 - 86,959,218 (+)NCBICHM1_1
CRA_TCAGchr7v2786,306,455 - 86,360,622 (+)NCBI
Crot
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2425,068,270 - 25,133,111 (+)NCBI
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0422,079,837 - 22,116,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0422,018,106 - 22,053,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,023,913 - 22,067,029 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1422,023,912 - 22,067,029 (-)NCBI
Celera420,575,938 - 20,626,257 (+)NCBICelera
Cytogenetic Map4q12NCBI
Crot
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955607378,439 - 413,394 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955607379,121 - 413,394 (-)NCBIChiLan1.0ChiLan1.0
CROT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1792,989,868 - 93,043,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl792,989,868 - 93,043,832 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0779,339,498 - 79,393,676 (+)NCBIMhudiblu_PPA_v0panPan3
CROT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1413,475,235 - 13,532,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11413,475,130 - 13,532,536 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Crot
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367631,425,394 - 1,462,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CROT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl993,258,619 - 93,308,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1993,263,606 - 93,308,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,743,699 - 102,788,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CROT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,531,263 - 61,584,448 (-)NCBI
ChlSab1.1 Ensembl2161,531,060 - 61,584,447 (-)Ensembl
Crot
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473934,696,516 - 34,738,143 (+)NCBI

Position Markers
UniSTS:235128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3858,966,108 - 8,966,353UniSTSGRCm38
MGSCv3758,966,108 - 8,966,353UniSTSGRCm37
Celera58,885,517 - 8,885,762UniSTS
Cytogenetic Map5A1UniSTS
UniSTS:224977  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3858,996,570 - 8,996,720UniSTSGRCm38
MGSCv3758,996,570 - 8,996,720UniSTSGRCm37
Celera58,915,977 - 8,916,127UniSTS
Cytogenetic Map5A1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5884069387693978Mouse
1301468Eye1_meye weight 1 (mouse)Not determined5121879650Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5517952239179654Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5791911941919241Mouse
4141234Pbwg14_mpostnatal body weight growth 14 (mouse)Not determined5121223552Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5886594940372526Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5879767233318293Mouse
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined561814634618282Mouse
10412081Bwq13_mbody weight QTL 13 (mouse)Not determined5123556323Mouse
12904958Gmmq8_mgastrocnemius muscle mass QTL 8 (mouse)5129371157Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5329982537299825Mouse
13442491Mecth1_mmechanosensation threshold 1 (mouse)5446800019630000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:277
Interacting mature miRNAs:295
Transcripts:ENSMUST00000003720, ENSMUST00000146115, ENSMUST00000157024
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000003720   ⟹   ENSMUSP00000003720
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,966,033 - 8,997,324 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146115
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,973,603 - 8,982,144 (-)Ensembl
RefSeq Acc Id: ENSMUST00000157024
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl58,986,181 - 8,997,042 (-)Ensembl
RefSeq Acc Id: NM_023733   ⟹   NP_076222
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3959,016,048 - 9,047,146 (-)NCBI
GRCm3858,966,048 - 8,997,146 (-)NCBI
MGSCv3758,966,048 - 8,997,146 (-)RGD
Celera58,885,457 - 8,916,553 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503610   ⟹   XP_006503673
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3959,016,033 - 9,047,926 (-)NCBI
GRCm3858,966,033 - 8,983,682 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165551   ⟹   XP_036021444
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3959,016,033 - 9,047,087 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_076222   ⟸   NM_023733
- UniProtKB: Q9DC50 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503673   ⟸   XM_006503610
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000003720   ⟸   ENSMUST00000003720
RefSeq Acc Id: XP_036021444   ⟸   XM_036165551
- Peptide Label: isoform X1
Protein Domains
Carn_acyltransf

Promoters
RGD ID:6885972
Promoter ID:EPDNEW_M6437
Type:initiation region
Name:Crot_2
Description:Mus musculus carnitine O-octanoyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6438  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3858,996,625 - 8,996,685EPDNEW
RGD ID:6837309
Promoter ID:MM_KWN:41344
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000059513,   OTTMUST00000059514
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3658,996,756 - 8,997,467 (-)MPROMDB
RGD ID:6885974
Promoter ID:EPDNEW_M6438
Type:multiple initiation site
Name:Crot_1
Description:Mus musculus carnitine O-octanoyltransferase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6437  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3858,997,146 - 8,997,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921364 AgrOrtholog
Ensembl Genes ENSMUSG00000003623 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000003720 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000003720 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.275.20 UniProtKB/TrEMBL
  3.30.559.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carn_acyl_trans_N UniProtKB/TrEMBL
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74114 UniProtKB/Swiss-Prot
MGD MGI:1921364 ENTREZGENE
NCBI Gene 74114 ENTREZGENE
PANTHER PTHR22589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carn_acyltransf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crot PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot
UniProt OCTC_MOUSE UniProtKB/Swiss-Prot
  Q3V3N1_MOUSE UniProtKB/TrEMBL
  Q9DC50 ENTREZGENE
  Q9QZZ3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q921I4 UniProtKB/Swiss-Prot