Mpeg1 (macrophage expressed gene 1) - Rat Genome Database

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Gene: Mpeg1 (macrophage expressed gene 1) Mus musculus
Analyze
Symbol: Mpeg1
Name: macrophage expressed gene 1
RGD ID: 736356
MGI Page MGI
Description: Enables pore-forming activity and wide pore channel activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I; defense response to bacterium; and dendritic cell antigen processing and presentation. Located in phagocytic vesicle. Is active in endolysosome and phagocytic vesicle membrane. Is expressed in several structures, including blood vessel; central nervous system; genital tubercle; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: macrophage expressed 1; macrophage gene 1 protein; macrophage-expressed gene 1 protein; MGC150002; MGC150003; MP; mPFN2; Mpg-; Mpg-1; MPS1; P-2; Perf; perforin-2; PFN2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,438,134 - 12,442,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,438,143 - 12,442,647 (+)EnsemblGRCm39 Ensembl
GRCm381912,460,770 - 12,465,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,460,779 - 12,465,283 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,535,269 - 12,539,775 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,527,824 - 12,532,330 (+)NCBIMGSCv36mm8
Celera1913,124,779 - 13,129,283 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7888681   PMID:10349636   PMID:11005868   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:16141072   PMID:16141073   PMID:21267068  
PMID:21308776   PMID:21862448   PMID:21873635   PMID:23257510   PMID:23753625   PMID:24952961   PMID:25753484   PMID:26402460   PMID:26418746   PMID:26831467   PMID:27173853   PMID:27480124  
PMID:28378742   PMID:30249808   PMID:30409884   PMID:30635555   PMID:32064340   PMID:32161097   PMID:32180773   PMID:33082323   PMID:33188058   PMID:34321999   PMID:34730110   PMID:35471730  
PMID:36245269   PMID:37347855  


Genomics

Comparative Map Data
Mpeg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391912,438,134 - 12,442,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1912,438,143 - 12,442,647 (+)EnsemblGRCm39 Ensembl
GRCm381912,460,770 - 12,465,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1912,460,779 - 12,465,283 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,535,269 - 12,539,775 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,527,824 - 12,532,330 (+)NCBIMGSCv36mm8
Celera1913,124,779 - 13,129,283 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.72NCBI
MPEG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,208,510 - 59,212,927 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,208,510 - 59,212,927 (-)EnsemblGRCh38hg38GRCh38
GRCh371158,975,983 - 58,980,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,732,559 - 58,737,070 (-)NCBINCBI36Build 36hg18NCBI36
Celera1156,335,080 - 56,339,591 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1155,321,954 - 55,326,538 (-)NCBIHuRef
CHM1_11158,841,473 - 58,846,067 (-)NCBICHM1_1
T2T-CHM13v2.01159,157,683 - 59,162,100 (-)NCBIT2T-CHM13v2.0
Mpeg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81218,876,848 - 218,881,364 (+)NCBIGRCr8
mRatBN7.21209,452,176 - 209,456,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1209,452,133 - 209,458,855 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,826,816 - 217,831,286 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,758,435 - 224,762,905 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,581,271 - 217,585,741 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01228,724,559 - 228,729,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1228,724,900 - 228,727,160 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,886,584 - 235,891,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,387,912 - 215,390,172 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,546,341 - 215,548,602 (+)NCBI
Celera1206,869,012 - 206,873,482 (+)NCBICelera
Cytogenetic Map1q43NCBI
Mpeg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555113,785,019 - 3,787,154 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555113,783,200 - 3,787,300 (-)NCBIChiLan1.0ChiLan1.0
MPEG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2960,330,295 - 60,335,842 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11161,373,648 - 61,377,986 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,425,904 - 54,442,631 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11157,877,944 - 57,882,409 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1157,880,109 - 57,882,259 (-)Ensemblpanpan1.1panPan2
MPEG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11837,530,895 - 37,535,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1837,531,032 - 37,533,179 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1837,065,693 - 37,070,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01838,181,524 - 38,185,954 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11837,780,626 - 37,785,058 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01837,349,846 - 37,354,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01837,973,828 - 37,978,258 (+)NCBIUU_Cfam_GSD_1.0
Mpeg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494713,306,779 - 13,319,480 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365813,421,256 - 3,431,706 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365813,428,515 - 3,436,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259471
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1212,472,927 - 12,475,116 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Mpeg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,470,887 - 1,473,046 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,470,862 - 1,474,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpeg1
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:568
Count of miRNA genes:378
Interacting mature miRNAs:420
Transcripts:ENSMUST00000081035
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse

Markers in Region
Mpeg1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381912,464,188 - 12,464,280UniSTSGRCm38
MGSCv371912,538,678 - 12,538,770UniSTSGRCm37
Celera1913,128,186 - 13,128,278UniSTS
Cytogenetic Map19AUniSTS
cM Map19 UniSTS
UniSTS:224979  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381912,465,005 - 12,465,160UniSTSGRCm38
MGSCv371912,539,495 - 12,539,650UniSTSGRCm37
Celera1913,129,003 - 13,129,158UniSTS
Cytogenetic Map19AUniSTS
PMC27130P3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381912,464,188 - 12,464,280UniSTSGRCm38
MGSCv371912,538,678 - 12,538,770UniSTSGRCm37
Celera1913,128,186 - 13,128,278UniSTS
Cytogenetic Map19AUniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000081035   ⟹   ENSMUSP00000108573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1912,438,143 - 12,442,647 (+)Ensembl
GRCm38.p6 Ensembl1912,460,779 - 12,465,283 (+)Ensembl
RefSeq Acc Id: NM_001374668   ⟹   NP_001361597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391912,438,134 - 12,442,644 (+)NCBI
GRCm381912,460,770 - 12,465,280 (+)NCBI
Sequence:
RefSeq Acc Id: NM_010821   ⟹   NP_034951
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391912,438,134 - 12,442,649 (+)NCBI
GRCm381912,460,770 - 12,465,285 (+)NCBI
MGSCv371912,535,269 - 12,539,775 (+)RGD
Celera1913,124,779 - 13,129,283 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034951   ⟸   NM_010821
- Peptide Label: precursor
- UniProtKB: E9QN37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001361597   ⟸   NM_001374668
- Peptide Label: precursor
- UniProtKB: E9QN37 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000108573   ⟸   ENSMUST00000081035
Protein Domains
MACPF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L314-F1-model_v2 AlphaFold A1L314 1-713 view protein structure

Promoters
RGD ID:13679006
Promoter ID:EPDNEW_M23652
Type:initiation region
Name:Mpeg1_1
Description:Mus musculus macrophage expressed gene 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23653  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381912,460,775 - 12,460,835EPDNEW
RGD ID:13679008
Promoter ID:EPDNEW_M23653
Type:initiation region
Name:Mpeg1_2
Description:Mus musculus macrophage expressed gene 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23652  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381912,461,149 - 12,461,209EPDNEW
RGD ID:6830211
Promoter ID:MM_KWN:26484
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Spleen
Transcripts:ENSMUST00000081035,   NM_010821
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361912,534,691 - 12,535,757 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333743 AgrOrtholog
Ensembl Genes ENSMUSG00000046805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081035 ENTREZGENE
  ENSMUST00000081035.9 UniProtKB/TrEMBL
InterPro MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPEG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17476 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333743 ENTREZGENE
NCBI Gene 17476 ENTREZGENE
PANTHER MACROPHAGE-EXPRESSED GENE 1 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR31463 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpeg1 PhenoGen
PROSITE MACPF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART MACPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L314 ENTREZGENE
  E9QN37 ENTREZGENE, UniProtKB/TrEMBL
  MPEG1_MOUSE UniProtKB/Swiss-Prot
  Q80VB7_MOUSE UniProtKB/TrEMBL
UniProt Secondary A1L315 UniProtKB/Swiss-Prot
  Q61889 UniProtKB/Swiss-Prot