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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62335
Species: Mus musculus
RGD Object: Gene
Symbol: Xdh
Name: xanthine dehydrogenase
Acc ID: CHEBI:47612
Term: bezafibrate
Definition: A monocarboxylic acid amide obtained by the formal condensation of the carboxy group of 4-chlorobenzoic acid with the amino group of 2-[4-(2-aminoethyl)phenoxy]-2-methylpropanoic acid. Benafibrate is used for the treatment of hyperlipidaemia.
Chemical ID: MESH:D001629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xdhdecreases activityISOXdh (Rattus norvegicus)6480464CTDBezafibrate results in decreased activity of XDH proteinPMID:8373410
Xdhdecreases expressionISOXdh (Rattus norvegicus)6480464CTDBezafibrate results in decreased expression of XDH proteinPMID:8373410
Xdhmultiple interactionsISOXdh (Rattus norvegicus)6480464CTDBezafibrate results in increased degradation of and results in decreased expression of XDH mRNAPMID:8373410
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