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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-colchicine
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Accession:CHEBI:27882 term browser browse the term
Definition:A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Synonyms:exact_synonym: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
 related_synonym: (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;   7alphaH-colchicine;   Colchicin;   Colchicine;   Colchisol;   Colcin;   Colcrys;   Colsaloid;   Condylon;   Formula=C22H25NO6;   Goutnil;   InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1;   InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N;   Kolkicin;   Mitigare;   SMILES=COC1=CC2=C(C(OC)=C1OC)C1=CC=C(OC)C(=O)C=C1[C@H](CC2)NC(C)=O;   colchicina;   colchicinum
 alt_id: CHEBI:3811
 xref: Beilstein:2228813;   CAS:64-86-8;   Chemspider:5933;   DrugBank:DB01394;   Drug_Central:726;   KEGG:C07592;   KEGG:D00570;   KNApSAcK:C00002327;   LINCS:LSM-5199
 xref_mesh: MESH:D003078
 xref: MetaCyc:CPD-9785;   PDBeChem:LOC;   PMID:16188942;   PMID:17619668;   PMID:18787557;   PMID:24530796;   PMID:28832953;   PMID:28912485;   PMID:28959419;   PMID:30565859;   PMID:32025680;   PMID:32426001;   PMID:32511763;   PMID:32837853;   PMID:32865380;   PMID:33100196;   PMID:33166069;   Wikipedia:Colchicine
 cyclic_relationship: is_enantiomer_of CHEBI:51074


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(S)-colchicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca13 ATP-binding cassette, sub-family A member 13 affects response to substance ISO ABCA13 gene SNP affects the susceptibility to Colchicine CTD PMID:25622337 NCBI chr11:9,141,942...9,634,871
Ensembl chr11:9,141,942...9,634,259 		JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 affects localization ISO Colchicine affects the localization of ABCB11 protein CTD PMID:12702492 PMID:15304119 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects transport
increases export
increases expression
multiple interactions
decreases response to substance		 ISO ABCB1 protein affects the transport of Colchicine
ABCB1 protein results in increased export of Colchicine
Colchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNA
[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]
ABCB1 protein results in decreased susceptibility to Colchicine		 CTD PMID:7905786 PMID:11792417 PMID:12711602 PMID:15112361 PMID:15342794 More... NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 decreases response to substance ISO ABCC1 protein results in decreased susceptibility to Colchicine CTD PMID:12067707 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions ISO [Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein] CTD PMID:31300867 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcc3 ATP-binding cassette, sub-family C member 3 affects localization ISO Colchicine affects the localization of ABCC3 protein CTD PMID:12702492 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823 		JBrowse link
G Abcc4 ATP-binding cassette, sub-family C member 4 multiple interactions EXP Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein] CTD PMID:18468992 NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
decreases activity		 ISO carvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] CTD PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Colchicine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Ache acetylcholinesterase increases activity
multiple interactions		 ISO Colchicine results in increased activity of ACHE protein
amyloid beta-protein (25-35) inhibits the reaction [Colchicine results in increased activity of ACHE protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of ACHE protein]		 CTD PMID:33617922 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO
EXP		 Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]		 CTD PMID:14726149 PMID:22446813 PMID:37573684 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ahr aryl-hydrocarbon receptor decreases activity ISO Colchicine results in decreased activity of AHR protein CTD PMID:16611024 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression ISO Colchicine results in decreased expression of AIF1 mRNA CTD PMID:20624997 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Colchicine results in decreased expression of AK1 mRNA CTD PMID:20624997 NCBI chr 2:32,511,770...32,525,070
Ensembl chr 2:32,511,770...32,525,070 		JBrowse link
G Alb albumin affects expression
multiple interactions		 ISO Colchicine affects the expression of ALB protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of ALB protein]		 CTD PMID:8574231 PMID:23146695 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of ALPL protein] CTD PMID:37573684 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Apln apelin decreases expression ISO Colchicine results in decreased expression of APLN mRNA CTD PMID:20624997 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730 		JBrowse link
G Arg1 arginase, liver multiple interactions ISO Colchicine promotes the reaction [Uric Acid results in increased expression of ARG1 protein] CTD PMID:33894285 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Colchicine results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484 		JBrowse link
G Aurkb aurora kinase B increases expression ISO Colchicine results in increased expression of AURKB mRNA CTD PMID:21472861 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490 		JBrowse link
G Avp arginine vasopressin decreases transport ISO Colchicine results in decreased transport of AVP protein CTD PMID:2453250 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO Colchicine results in increased expression of BAX protein
dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of BAX protein]		 CTD PMID:22342440 PMID:33617922 PMID:33684465 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression		 ISO Colchicine inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA]
Colchicine results in decreased expression of BCL2 protein
dihydroactinidiolide inhibits the reaction [Colchicine results in decreased expression of BCL2 protein]		 CTD PMID:22342440 PMID:22446813 PMID:33617922 PMID:33684465 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [Diethylnitrosamine co-treated with Colchicine] results in decreased expression of BCL2L1 protein CTD PMID:11749691 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bdnf brain derived neurotrophic factor decreases transport ISO Colchicine results in decreased transport of BDNF protein CTD PMID:21310905 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Blm Bloom syndrome, RecQ like helicase decreases expression ISO Colchicine results in decreased expression of BLM mRNA CTD PMID:24211769 NCBI chr 7:80,104,839...80,184,896
Ensembl chr 7:80,104,481...80,184,867 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Colchicine results in decreased expression of BTG1 mRNA CTD PMID:24211769 NCBI chr10:96,452,863...96,458,675
Ensembl chr10:96,452,868...96,458,671 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression ISO Colchicine results in decreased expression of BTG2 mRNA CTD PMID:24211769 NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Colchicine results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080 		JBrowse link
G C3 complement component 3 increases expression ISO Colchicine results in increased expression of C3 mRNA CTD PMID:20624997 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Capn1 calpain 1 decreases expression ISO Colchicine results in decreased expression of CAPN1 mRNA CTD PMID:18255150 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity		 ISO alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; alvocidib inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; Lithium inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; SB 216763 inhibits the reaction [Colchicine results in increased activity of CASP3 protein]
Colchicine results in increased cleavage of CASP3 protein
Colchicine results in increased expression of CASP3 mRNA
Colchicine results in increased expression of CASP3 protein
dihydroactinidiolide inhibits the reaction [Colchicine results in increased activity of CASP3 protein]; dihydroactinidiolide inhibits the reaction [Colchicine results in increased expression of CASP3 protein]		 CTD PMID:12941380 PMID:15005753 PMID:16478524 PMID:18255150 PMID:19815060 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases expression ISO Colchicine results in increased expression of CASP8 mRNA CTD PMID:18255150 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity ISO Colchicine results in increased activity of CASP9 protein CTD PMID:22342440 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase increases expression ISO Colchicine results in increased expression of CAT mRNA CTD PMID:18255150 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Colchicine results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 9:108,911,564...108,922,431
Ensembl chr 9:108,911,561...108,921,557 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Colchicine results in increased expression of CCL2 mRNA CTD PMID:3119359 PMID:20624997 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Colchicine results in increased expression of CCNB1 mRNA; Colchicine results in increased expression of CCNB1 protein CTD PMID:21472861 PMID:27769712 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP
ISO		 Colchicine results in increased expression of CCND1 protein
Colchicine results in increased expression of CCND1 mRNA		 CTD PMID:16495211 PMID:18255150 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Colchicine results in decreased expression of CCNE2 mRNA CTD PMID:24211769 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779 		JBrowse link
G Cd14 CD14 antigen increases expression ISO Colchicine results in increased expression of CD14 mRNA CTD PMID:20624997 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd44 CD44 antigen increases expression ISO Colchicine results in increased expression of CD44 mRNA CTD PMID:20624997 NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010 		JBrowse link
G Cd59b CD59b antigen increases mutagenesis ISO Colchicine results in increased mutagenesis of CD59 protein CTD PMID:17045307 NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534 		JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Colchicine results in decreased expression of CDC25A mRNA CTD PMID:24211769 NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963 		JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Colchicine results in decreased expression of CDC6 mRNA CTD PMID:24211769 NCBI chr11:98,798,627...98,814,768
Ensembl chr11:98,798,627...98,814,766 		JBrowse link
G Cdh1 cadherin 1 affects activity ISO Colchicine affects the activity of CDH1 protein CTD PMID:10413674 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO Colchicine results in increased expression of CDK2 mRNA CTD PMID:18255150 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk5 cyclin dependent kinase 5 increases expression
multiple interactions		 ISO Colchicine results in increased expression of CDK5 protein
alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]		 CTD PMID:12941380 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression
decreases expression		 ISO Colchicine results in increased expression of CDKN1A mRNA
Colchicine results in decreased expression of CDKN1A mRNA
Colchicine results in increased expression of CDKN1A protein		 CTD PMID:20624997 PMID:24211769 PMID:27358234 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn3 cyclin dependent kinase inhibitor 3 decreases expression ISO Colchicine results in decreased expression of CDKN3 mRNA CTD PMID:20624997 NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 multiple interactions
increases expression		 ISO 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased expression of CELF2 mRNA] CTD PMID:11478917 NCBI chr 2:6,544,505...7,401,345
Ensembl chr 2:6,544,505...7,514,374 		JBrowse link
G Chaf1a chromatin assembly factor 1, subunit A decreases expression ISO Colchicine results in decreased expression of CHAF1A mRNA CTD PMID:24211769 NCBI chr17:56,347,404...56,375,027
Ensembl chr17:56,347,439...56,379,289 		JBrowse link
G Chaf1b chromatin assembly factor 1, subunit B decreases expression ISO Colchicine results in decreased expression of CHAF1B mRNA CTD PMID:24211769 NCBI chr16:93,680,801...93,703,003
Ensembl chr16:93,680,789...93,703,003 		JBrowse link
G Cldn1 claudin 1 decreases expression EXP Colchicine results in decreased expression of CLDN1 mRNA CTD PMID:33002524 NCBI chr16:26,175,395...26,190,589
Ensembl chr16:26,175,392...26,190,591 		JBrowse link
G Cln8 CLN8 transmembrane ER and ERGIC protein decreases expression ISO Colchicine results in decreased expression of CLN8 mRNA CTD PMID:24211769 NCBI chr 8:14,931,335...14,951,720
Ensembl chr 8:14,931,335...14,951,720 		JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Colchicine results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 4:108,185,349...108,197,915
Ensembl chr 4:108,185,337...108,198,741 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA] CTD PMID:37573684 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased secretion of COL3A1 protein]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA] CTD PMID:37573684 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cp ceruloplasmin increases expression ISO Colchicine results in increased expression of CP mRNA CTD PMID:20624997 NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Colchicine results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Crh corticotropin releasing hormone decreases expression
increases expression		 ISO Colchicine results in decreased expression of CRH protein
Colchicine results in increased expression of CRH mRNA		 CTD PMID:1850078 PMID:2453250 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) multiple interactions ISO Colchicine inhibits the reaction [kaempferol results in increased secretion of CSF2 protein]; Colchicine inhibits the reaction [Quercetin results in increased secretion of CSF2 protein] CTD PMID:18346843 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Colchicine results in increased expression of CXCL1 mRNA CTD PMID:3119359 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
increases expression		 ISO [Colchicine co-treated with lipopolysaccharide, E. coli O26-B6] results in increased expression of CXCL8 mRNA
Colchicine results in increased expression of CXCL8 mRNA		 CTD PMID:29594315 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Colchicine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] CTD PMID:16611024 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Colchicine results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO Colchicine results in decreased expression of DDIT4 mRNA CTD PMID:24211769 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Drd3 dopamine receptor D3 decreases expression ISO Colchicine results in decreased expression of DRD3 mRNA CTD PMID:7878047 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Dusp14 dual specificity phosphatase 14 decreases expression ISO Colchicine results in decreased expression of DUSP14 mRNA CTD PMID:24211769 NCBI chr11:83,938,859...83,960,016
Ensembl chr11:83,938,867...83,960,087 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Colchicine results in decreased expression of E2F1 mRNA CTD PMID:24211769 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Ednrb endothelin receptor type B increases expression ISO Colchicine results in increased expression of EDNRB mRNA CTD PMID:20624997 NCBI chr14:104,052,055...104,081,764
Ensembl chr14:104,052,061...104,081,838 		JBrowse link
G Enc1 ectodermal-neural cortex 1 decreases expression ISO Colchicine results in decreased expression of ENC1 mRNA CTD PMID:24211769 NCBI chr13:97,377,613...97,389,548
Ensembl chr13:97,377,613...97,389,542 		JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 increases expression ISO Colchicine results in increased expression of EPRS1 mRNA CTD PMID:20624997 NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557 		JBrowse link
G Esm1 endothelial cell-specific molecule 1 decreases expression ISO Colchicine results in decreased expression of ESM1 mRNA CTD PMID:20624997 NCBI chr13:113,346,193...113,354,638
Ensembl chr13:113,346,193...113,354,632 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Colchicine binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G F2 coagulation factor II affects activity ISO Colchicine affects the activity of F2 protein CTD PMID:8574231 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F3 coagulation factor III increases expression ISO Colchicine results in increased expression of F3 mRNA CTD PMID:20624997 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Fas Fas cell surface death receptor increases expression
decreases expression		 EXP Colchicine results in increased expression of FAS mRNA
Colchicine results in decreased expression of FAS protein		 CTD PMID:10675359 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb increases expression ISO Colchicine results in increased expression of FCGR2B mRNA CTD PMID:20624997 NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G Fdxr ferredoxin reductase decreases expression ISO Colchicine results in decreased expression of FDXR mRNA CTD PMID:24211769 NCBI chr11:115,158,850...115,167,925
Ensembl chr11:115,158,850...115,167,876 		JBrowse link
G Fgf2 fibroblast growth factor 2 affects expression ISO Colchicine affects the expression of FGF2 protein CTD PMID:7714246 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA] CTD PMID:37573684 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression		 ISO Colchicine results in increased expression of and affects the localization of FOS protein
Colchicine results in increased expression of FOS mRNA		 CTD PMID:3119359 PMID:7537689 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Colchicine results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 6:122,797,143...122,822,325
Ensembl chr 6:122,796,873...122,822,325 		JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Colchicine results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 5:4,803,839...4,808,216
Ensembl chr 5:4,803,839...4,808,035 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases expression ISO Colchicine results in increased expression of GADD45A mRNA CTD PMID:20624997 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression ISO Colchicine results in increased expression of GADD45B mRNA CTD PMID:20624997 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma increases expression ISO Colchicine results in increased expression of GADD45G mRNA CTD PMID:20624997 NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504 		JBrowse link
G Gas7 growth arrest specific 7 decreases expression ISO Colchicine results in decreased expression of GAS7 mRNA CTD PMID:20624997 NCBI chr11:67,344,083...67,579,818
Ensembl chr11:67,345,917...67,575,800 		JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression ISO Colchicine results in decreased expression of GCH1 mRNA CTD PMID:24211769 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA] CTD PMID:37573684 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA] CTD PMID:37573684 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdf15 growth differentiation factor 15 decreases expression ISO Colchicine results in decreased expression of GDF15 mRNA CTD PMID:24211769 NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Colchicine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form] CTD PMID:8824497 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GOT1 protein] CTD PMID:37573684 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:37573684 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Colchicine results in increased expression of GPX1 mRNA CTD PMID:18255150 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) decreases expression ISO Colchicine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Colchicine results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr 5:36,622,529...36,631,421
Ensembl chr 5:36,622,342...36,631,424 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression ISO Colchicine results in decreased expression of GSK3B mRNA CTD PMID:18255150 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] CTD PMID:37573684 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hal histidine ammonia lyase decreases expression ISO Colchicine results in decreased expression of HAL mRNA CTD PMID:32741898 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
multiple interactions		 ISO Colchicine results in increased expression of HMOX1 mRNA
Colchicine affects the expression of HMOX1 mRNA
[dihydroactinidiolide co-treated with Colchicine] results in increased expression of HMOX1 mRNA		 CTD PMID:20624997 PMID:22954530 PMID:33617922 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hspa5 heat shock protein 5 increases expression ISO Colchicine results in increased expression of HSPA5 protein CTD PMID:27358234 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Colchicine results in increased expression of ICAM1 mRNA CTD PMID:20624997 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Id3 inhibitor of DNA binding 3 decreases expression ISO Colchicine results in decreased expression of ID3 mRNA CTD PMID:24211769 NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 [Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]		 CTD PMID:29594315 PMID:37573684 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta increases phosphorylation
multiple interactions
affects response to substance		 ISO
EXP		 Colchicine results in increased phosphorylation of IKBKB protein
Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
IKBKB protein affects the susceptibility to Colchicine		 CTD PMID:17029595 PMID:20159942 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Colchicine co-treated with Uric Acid] results in increased expression of IL10 protein CTD PMID:33894285 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein] CTD PMID:11154858 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
multiple interactions		 ISO
EXP		 Colchicine results in increased expression of IL1B mRNA
Colchicine results in decreased expression of IL1B mRNA
Colchicine results in increased expression of IL1B protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]
Colchicine inhibits the reaction [Uric Acid results in increased expression of IL1B protein]		 CTD PMID:20624997 PMID:29594315 PMID:33002524 PMID:33894285 PMID:34453961 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 ISO Colchicine results in decreased expression of IL2 protein
[Colchicine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA		 CTD PMID:1553933 PMID:29594315 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Colchicine results in increased expression of IL6 mRNA
Colchicine inhibits the reaction [Ethanol results in increased expression of IL6 protein]
Colchicine results in decreased expression of IL6 mRNA
Colchicine results in increased expression of IL6 protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]		 CTD PMID:20624997 PMID:22446813 PMID:33002524 PMID:34453961 PMID:37573684 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Inha inhibin alpha decreases expression ISO Colchicine results in decreased expression of INHA mRNA CTD PMID:20624997 NCBI chr 1:75,483,872...75,487,010
Ensembl chr 1:75,483,721...75,487,010 		JBrowse link
G Ins1 insulin I multiple interactions ISO Colchicine inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:19070612 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ints15 integrator complex subunit 15 decreases expression ISO Colchicine results in decreased expression of INTS15 mRNA CTD PMID:24211769 NCBI chr 5:143,286,827...143,301,147
Ensembl chr 5:143,286,950...143,301,115 		JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Colchicine results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 3:87,837,602...87,847,994
Ensembl chr 3:87,837,621...87,847,993 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of JAK2 protein] CTD PMID:33894285 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jun jun proto-oncogene increases phosphorylation
increases activity
multiple interactions		 ISO
EXP		 Colchicine results in increased phosphorylation of JUN protein
Colchicine results in increased activity of JUN protein
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased activity of JUN protein]; Colchicine results in increased phosphorylation of and results in increased localization of JUN protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]
3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased phosphorylation of JUN protein]; Colchicine results in increased expression of and results in increased phosphorylation of JUN protein		 CTD PMID:12221076 PMID:16478524 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Colchicine results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330 		JBrowse link
G Klf6 Kruppel-like transcription factor 6 increases expression ISO Colchicine results in increased expression of KLF6 mRNA CTD PMID:24211769 NCBI chr13:5,911,488...5,920,392
Ensembl chr13:5,911,481...5,920,393 		JBrowse link
G Krt18 keratin 18 decreases expression ISO Colchicine results in decreased expression of KRT18 protein CTD PMID:11259854 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased activity of LDHA protein] CTD PMID:37573684 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Lhx2 LIM homeobox protein 2 decreases expression ISO Colchicine results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 2:38,229,282...38,259,747
Ensembl chr 2:38,229,293...38,259,745 		JBrowse link
G Lpo lactoperoxidase decreases expression ISO Colchicine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr11:87,697,254...87,716,750
Ensembl chr11:87,697,254...87,719,115 		JBrowse link
G Lrp2 low density lipoprotein receptor-related protein 2 affects localization ISO Colchicine affects the localization of LRP2 protein CTD PMID:25588984 NCBI chr 2:69,254,679...69,416,373
Ensembl chr 2:69,254,684...69,416,409 		JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Colchicine results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 4:154,096,260...154,105,969
Ensembl chr 4:154,096,188...154,105,970 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression ISO Colchicine results in decreased expression of MAP2 mRNA CTD PMID:34748853 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of MAPK8 protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]		 CTD PMID:12221076 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of MAPK9 protein
TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein]		 CTD PMID:12221076 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Colchicine results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO Colchicine results in decreased expression of MCM10 mRNA CTD PMID:24211769 NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions ISO [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine CTD PMID:11792417 NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995 		JBrowse link
G Mir130b microRNA 130b decreases expression ISO Colchicine results in decreased expression of MIR130B CTD PMID:35134991 NCBI chr16:16,941,925...16,942,006
Ensembl chr16:16,941,925...16,942,006 		JBrowse link
G Mir185 microRNA 185 decreases expression ISO Colchicine results in decreased expression of MIR185 CTD PMID:35134991 NCBI chr16:18,145,265...18,145,329
Ensembl chr16:18,145,265...18,145,329 		JBrowse link
G Mir190b microRNA 190b increases expression ISO Colchicine results in increased expression of MIR190B CTD PMID:35134991 NCBI chr 3:89,977,327...89,977,406
Ensembl chr 3:89,977,327...89,977,406 		JBrowse link
G Mir20a microRNA 20a decreases expression ISO Colchicine results in decreased expression of MIR20A CTD PMID:35134991 NCBI chr14:115,281,589...115,281,695
Ensembl chr14:115,281,589...115,281,695 		JBrowse link
G Mir501 microRNA 501 decreases expression ISO Colchicine results in decreased expression of MIR501 CTD PMID:35134991 NCBI chr  X:7,107,482...7,107,590
Ensembl chr  X:7,107,482...7,107,590 		JBrowse link
G Mir9-1 microRNA 9-1 decreases expression ISO Colchicine results in decreased expression of MIR9-1 CTD PMID:35134991 NCBI chr 3:88,122,905...88,122,993
Ensembl chr 3:88,122,905...88,122,993 		JBrowse link
G Mir9-2 microRNA 9-2 decreases expression ISO Colchicine results in decreased expression of MIR9-2 CTD PMID:35134991 NCBI chr13:83,886,933...83,887,004
Ensembl chr13:83,886,933...83,887,004 		JBrowse link
G Mir9-3 microRNA 9-3 decreases expression ISO Colchicine results in decreased expression of MIR9-3 CTD PMID:35134991 NCBI chr 7:79,155,012...79,155,101
Ensembl chr 7:79,155,012...79,155,101 		JBrowse link
G Mirlet7d microRNA let7d decreases expression ISO Colchicine results in decreased expression of MIRLET7D CTD PMID:35134991 NCBI chr13:48,689,488...48,689,590
Ensembl chr13:48,689,488...48,689,590 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Colchicine results in decreased expression of MMP9 mRNA CTD PMID:33684465 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Colchicine inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Colchicine results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr 5:140,313,429...140,317,653
Ensembl chr 5:140,313,429...140,317,653 		JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Colchicine results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr17:88,282,478...88,298,320
Ensembl chr17:88,282,490...88,298,320 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Colchicine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Colchicine results in increased expression of MYC mRNA CTD PMID:3119359 PMID:20624997 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Myt1 myelin transcription factor 1 increases phosphorylation ISO Colchicine results in increased phosphorylation of MYT1 protein CTD PMID:16611024 NCBI chr 2:181,405,099...181,469,579
Ensembl chr 2:181,405,125...181,469,590 		JBrowse link
G Nbn nibrin increases expression ISO Colchicine results in increased expression of NBN mRNA CTD PMID:20624997 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]] CTD PMID:25257666 NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase core subunit S4 affects response to substance EXP NDUFS4 protein affects the susceptibility to Colchicine CTD PMID:21383081 NCBI chr13:114,424,331...114,524,630
Ensembl chr13:114,424,331...114,524,794 		JBrowse link
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 decreases localization ISO Colchicine results in decreased localization of NFATC4 protein CTD PMID:17044076 NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP		 [dihydroactinidiolide co-treated with Colchicine] results in increased expression of NFE2L2 mRNA
Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFE2L2 mRNA]		 CTD PMID:33617922 PMID:37573684 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha increases phosphorylation
multiple interactions		 ISO Colchicine results in increased phosphorylation of NFKBIA protein
Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]
Colchicine inhibits the reaction [Uric Acid results in decreased expression of NFKBIA protein]		 CTD PMID:17029595 PMID:33894285 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO Colchicine results in increased expression of NOS1 protein CTD PMID:7537689 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Colchicine inhibits the reaction [Uric Acid results in increased expression of NOS2 protein] CTD PMID:23146695 PMID:33894285 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nptx1 neuronal pentraxin 1 increases expression ISO Colchicine results in increased expression of NPTX1 mRNA CTD PMID:18255150 NCBI chr11:119,429,545...119,438,646
Ensembl chr11:119,429,545...119,438,579 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Colchicine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Colchicine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
increases degradation		 ISO Colchicine results in decreased localization of and results in decreased activity of NR3C1 protein
Colchicine results in increased activity of NR3C1 protein
Colchicine results in increased degradation of NR3C1 protein		 CTD PMID:15744361 PMID:20448266 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Nts neurotensin increases expression ISO Colchicine results in increased expression of NTS mRNA CTD PMID:1850078 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Ocln occludin decreases expression EXP Colchicine results in decreased expression of OCLN mRNA CTD PMID:33002524 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
increases expression		 EXP
ISO		 Colchicine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Colchicine results in increased expression of ODC1 mRNA		 CTD PMID:3119359 PMID:9270009 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Colchicine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr16:91,016,745...91,025,567
Ensembl chr16:91,022,345...91,025,565 		JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression ISO Colchicine results in decreased expression of ORAI3 mRNA CTD PMID:24211769 NCBI chr 7:127,368,987...127,374,322
Ensembl chr 7:127,368,987...127,374,322 		JBrowse link
G Palb2 partner and localizer of BRCA2 decreases expression ISO Colchicine results in decreased expression of PALB2 mRNA CTD PMID:24211769 NCBI chr 7:121,706,485...121,732,203
Ensembl chr 7:121,706,485...121,732,208 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Colchicine results in increased cleavage of PARP1 protein CTD PMID:33684465 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator increases expression
multiple interactions		 ISO Colchicine results in increased expression of PAWR protein
alvocidib inhibits the reaction [Colchicine results in increased expression of PAWR protein]		 CTD PMID:12941380 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pax6 paired box 6 multiple interactions ISO Colchicine promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA] CTD PMID:32949729 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Colchicine results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr13:115,224,891...115,226,694
Ensembl chr13:115,224,891...115,226,722 		JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 decreases expression ISO Colchicine results in decreased expression of PHLDA3 mRNA CTD PMID:24211769 NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874 		JBrowse link
G Pidd1 p53 induced death domain protein 1 decreases expression ISO Colchicine results in decreased expression of PIDD1 mRNA CTD PMID:24211769 NCBI chr 7:141,018,026...141,027,477
Ensembl chr 7:141,018,026...141,023,938 		JBrowse link
G Plagl1 pleiomorphic adenoma gene-like 1 increases expression ISO Colchicine results in increased expression of PLAGL1 mRNA CTD PMID:20624997 NCBI chr10:12,966,576...13,007,438
Ensembl chr10:12,936,248...13,007,438 		JBrowse link
G Plat plasminogen activator, tissue increases expression ISO Colchicine results in increased expression of PLAT mRNA CTD PMID:20624997 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Colchicine results in increased expression of PLAUR mRNA CTD PMID:20624997 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393 		JBrowse link
G Plekhf1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 decreases expression ISO Colchicine results in decreased expression of PLEKHF1 mRNA CTD PMID:24211769 NCBI chr 7:37,920,078...37,927,418
Ensembl chr 7:37,916,396...37,927,440 		JBrowse link
G Plxnb2 plexin B2 decreases expression ISO Colchicine results in decreased expression of PLXNB2 mRNA CTD PMID:24211769 NCBI chr15:89,039,752...89,064,960
Ensembl chr15:89,039,752...89,064,991 		JBrowse link
G Pomc pro-opiomelanocortin-alpha increases secretion ISO Colchicine results in increased secretion of POMC protein CTD PMID:2453250 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform decreases expression ISO Colchicine results in decreased expression of PPM1D mRNA CTD PMID:24211769 NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha increases expression EXP Colchicine results in increased expression of PPP1CA protein CTD PMID:16495211 NCBI chr19:4,242,173...4,245,418
Ensembl chr19:4,242,064...4,245,419 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Colchicine results in increased expression of PPP1R15A mRNA CTD PMID:20624997 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit decreases expression ISO Colchicine results in decreased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567 		JBrowse link
G Psmc3ip proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein decreases expression ISO Colchicine results in decreased expression of PSMC3IP mRNA CTD PMID:24211769 NCBI chr11:100,981,238...100,986,261
Ensembl chr11:100,982,649...100,986,262 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:37573684 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation		 ISO 2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole inhibits the reaction [Colchicine results in increased phosphorylation of PTK2B protein] CTD PMID:11478917 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4a1 decreases expression ISO Colchicine results in decreased expression of PTP4A1 mRNA CTD PMID:24211769 NCBI chr 1:30,979,384...30,988,838
Ensembl chr 1:30,979,383...30,988,390
Ensembl chr 1:30,979,383...30,988,390 		JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Colchicine results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 9:35,469,856...35,478,697
Ensembl chr 9:35,469,891...35,478,697 		JBrowse link
G Rad51c RAD51 paralog C decreases expression ISO Colchicine results in decreased expression of RAD51C mRNA CTD PMID:24211769 NCBI chr11:87,267,471...87,295,780
Ensembl chr11:87,267,471...87,295,780 		JBrowse link
G Ralbp1 ralA binding protein 1 multiple interactions
affects transport		 ISO Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4]
RALBP1 protein affects the transport of Colchicine		 CTD PMID:15386349 NCBI chr17:66,155,410...66,192,750
Ensembl chr17:66,155,413...66,192,793 		JBrowse link
G Rap2b RAP2B, member of RAS oncogene family decreases expression ISO Colchicine results in decreased expression of RAP2B mRNA CTD PMID:24211769 NCBI chr 3:61,271,928...61,276,124
Ensembl chr 3:61,269,059...61,275,851 		JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 increases expression ISO Colchicine results in increased expression of RASSF1 mRNA CTD PMID:20624997 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions EXP Colchicine results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:16495211 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbm34 RNA binding motif protein 34 decreases expression ISO Colchicine results in decreased expression of RBM34 mRNA CTD PMID:24211769 NCBI chr 8:127,673,922...127,697,799
Ensembl chr 8:127,673,922...127,697,821 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Colchicine inhibits the reaction [Uric Acid results in increased phosphorylation of RELA protein] CTD PMID:33894285 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rfc1 replication factor C (activator 1) 1 decreases expression ISO Colchicine results in decreased expression of RFC1 mRNA CTD PMID:24211769 NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Colchicine results in decreased expression of RGS16 mRNA CTD PMID:24211769 NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214 		JBrowse link
G Rnf113a1 ring finger protein 113A1 decreases expression ISO Colchicine results in decreased expression of RNF113A mRNA CTD PMID:24211769 NCBI chr  X:36,454,875...36,456,120
Ensembl chr  X:36,454,898...36,456,120 		JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Colchicine results in decreased expression of RNF19B mRNA CTD PMID:24211769 NCBI chr 4:128,951,871...128,978,319
Ensembl chr 4:128,952,064...128,979,679 		JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression ISO Colchicine results in increased expression of S100A8 mRNA CTD PMID:20624997 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Colchicine results in increased expression of S100A9 mRNA CTD PMID:20624997 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028 		JBrowse link
G Sac3d1 SAC3 domain containing 1 decreases expression ISO Colchicine results in decreased expression of SAC3D1 mRNA CTD PMID:24211769 NCBI chr19:6,166,025...6,168,689
Ensembl chr19:6,166,030...6,168,680 		JBrowse link
G Sct secretin multiple interactions ISO Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 7:140,858,243...140,859,082
Ensembl chr 7:140,858,243...140,859,046 		JBrowse link
G Sdc1 syndecan 1 decreases expression ISO Colchicine results in decreased expression of SDC1 mRNA CTD PMID:24211769 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Colchicine results in decreased expression of SDHAF1 mRNA CTD PMID:24211769 NCBI chr 7:30,020,834...30,021,800
Ensembl chr 7:30,020,831...30,023,320 		JBrowse link
G Sele selectin, endothelial cell increases expression ISO Colchicine results in increased expression of SELE mRNA CTD PMID:20624997 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 decreases transport ISO Colchicine results in decreased transport of SERPINA6 protein CTD PMID:16700006 NCBI chr12:103,612,889...103,623,477
Ensembl chr12:103,612,889...103,623,471 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases expression ISO Colchicine results in increased expression of SERPINE1 mRNA CTD PMID:20624997 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sesn1 sestrin 1 increases expression
decreases expression		 ISO Colchicine results in increased expression of SESN1 mRNA
Colchicine results in decreased expression of SESN1 mRNA		 CTD PMID:20624997 PMID:24211769 NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO Colchicine results in decreased expression of SGK1 mRNA CTD PMID:24211769 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Colchicine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 7:143,531,819...143,979,780
Ensembl chr 7:143,555,665...143,978,231 		JBrowse link
G Slbp stem-loop binding protein decreases expression ISO Colchicine results in decreased expression of SLBP mRNA CTD PMID:24211769 NCBI chr 5:33,797,399...33,809,918
Ensembl chr 5:33,792,296...33,809,918 		JBrowse link
G Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 decreases expression ISO Colchicine results in decreased expression of SLC1A5 mRNA CTD PMID:24211769 NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199 		JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 decreases expression ISO Colchicine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein] CTD PMID:37573684 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Spon1 spondin 1, (f-spondin) extracellular matrix protein increases expression ISO Colchicine results in increased expression of SPON1 mRNA CTD PMID:20624997 NCBI chr 7:113,365,235...113,642,610
Ensembl chr 7:113,365,235...113,642,605 		JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 multiple interactions
increases cleavage		 EXP 3,9-bis((ethylthio)methyl)-K-252a inhibits the reaction [Colchicine results in increased cleavage of SPTAN1 protein] CTD PMID:16478524 NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463 		JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression EXP Colchicine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Colchicine deficiency results in decreased activity of and affects the localization of STAT1 protein CTD PMID:28086195 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Colchicine promotes the reaction [Uric Acid results in increased phosphorylation of STAT3 protein] CTD PMID:33894285 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tat tyrosine aminotransferase multiple interactions
decreases expression		 ISO pyrazolanthrone inhibits the reaction [Colchicine results in decreased expression of TAT mRNA] CTD PMID:15744361 NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435 		JBrowse link
G Tbc1d4 TBC1 domain family, member 4 multiple interactions
affects phosphorylation		 ISO Colchicine inhibits the reaction [Oligomycins results in increased phosphorylation of TBC1D4 protein]
Colchicine affects the phosphorylation of TBC1D4 protein		 CTD PMID:18063688 NCBI chr14:101,679,800...101,846,717
Ensembl chr14:101,679,796...101,846,627 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO Colchicine results in increased expression of TFPI2 mRNA CTD PMID:20624997 NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:14726149 PMID:22446813 PMID:23146695 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Thbd thrombomodulin increases expression ISO Colchicine results in increased expression of THBD mRNA CTD PMID:20624997 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Colchicine results in increased expression of THBS1 mRNA CTD PMID:20624997 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Colchicine binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr11:98,631,539...98,659,832
Ensembl chr11:98,631,464...98,659,832 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Colchicine binds to and results in decreased activity of THRB protein CTD PMID:25752796 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
G Tigar Trp53 induced glycolysis regulatory phosphatase decreases expression ISO Colchicine results in decreased expression of TIGAR mRNA CTD PMID:24211769 NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Colchicine results in increased expression of TIMP1 mRNA CTD PMID:20624997 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tipin timeless interacting protein decreases expression ISO Colchicine results in decreased expression of TIPIN mRNA CTD PMID:24211769 NCBI chr 9:64,188,776...64,212,704
Ensembl chr 9:64,188,863...64,212,706 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Colchicine results in decreased expression of TJP1 mRNA CTD PMID:33002524 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Colchicine results in decreased expression of TMEM185B mRNA CTD PMID:24211769 NCBI chr 1:119,453,884...119,456,713
Ensembl chr 1:119,453,890...119,456,713 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
increases expression		 ISO
EXP		 Colchicine results in decreased expression of TNF protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]
Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]
Colchicine results in decreased expression of TNF mRNA
Colchicine results in increased expression of TNF protein
Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]		 CTD PMID:1553933 PMID:11154858 PMID:22446813 PMID:23146695 PMID:33002524 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a affects response to substance EXP TNFRSF1A protein affects the susceptibility to Colchicine CTD PMID:20159942 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfsf9 tumor necrosis factor (ligand) superfamily, member 9 decreases expression ISO Colchicine results in decreased expression of TNFSF9 mRNA CTD PMID:24211769 NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757 		JBrowse link
G Tnni3 troponin I, cardiac 3 increases expression ISO Colchicine results in increased expression of TNNI3 protein CTD PMID:20624997 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
G Top3a topoisomerase (DNA) III alpha decreases expression ISO Colchicine results in decreased expression of TOP3A mRNA CTD PMID:24211769 NCBI chr11:60,629,014...60,668,099
Ensembl chr11:60,630,884...60,668,191 		JBrowse link
G Tor1a torsin family 1, member A (torsin A) decreases expression ISO Colchicine results in decreased expression of TOR1A mRNA CTD PMID:24211769 NCBI chr 2:30,850,573...30,857,930
Ensembl chr 2:30,850,639...30,857,945 		JBrowse link
G Tpd52l1 tumor protein D52-like 1 increases expression ISO Colchicine results in increased expression of TPD52L1 mRNA CTD PMID:20624997 NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954 		JBrowse link
G Traf2 TNF receptor-associated factor 2 affects response to substance EXP TRAF2 protein affects the susceptibility to Colchicine CTD PMID:20159942 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 decreases expression ISO Colchicine results in decreased expression of TRIAP1 mRNA CTD PMID:24211769 NCBI chr 5:115,479,290...115,481,612
Ensembl chr 5:115,479,284...115,481,628 		JBrowse link
G Trim26 tripartite motif-containing 26 decreases expression ISO Colchicine results in decreased expression of TRIM26 mRNA CTD PMID:24211769 NCBI chr17:37,148,016...37,170,290
Ensembl chr17:37,148,026...37,170,290 		JBrowse link
G Trim30a tripartite motif-containing 30A decreases expression ISO Colchicine results in decreased expression of TRIM22 mRNA CTD PMID:24211769 NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400 		JBrowse link
G Trim32 tripartite motif-containing 32 decreases expression ISO Colchicine results in decreased expression of TRIM32 mRNA CTD PMID:24211769 NCBI chr 4:65,523,223...65,534,477
Ensembl chr 4:65,523,223...65,534,475 		JBrowse link
G Trim38 tripartite motif-containing 38 decreases expression ISO Colchicine results in decreased expression of TRIM38 mRNA CTD PMID:24211769 NCBI chr13:23,962,483...23,975,721
Ensembl chr13:23,953,896...23,975,511 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO TP53 protein affects the reaction [Colchicine results in increased phosphorylation of JUN protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK8 protein]; TP53 protein affects the reaction [Colchicine results in increased phosphorylation of MAPK9 protein] CTD PMID:12221076 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tuba1b tubulin, alpha 1B decreases expression ISO Colchicine results in decreased expression of TUBA1B mRNA CTD PMID:20624997 NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446 		JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO Colchicine results in decreased expression of TUBA4A mRNA CTD PMID:20624997 NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509 		JBrowse link
G Tubb4b tubulin, beta 4B class IVB decreases expression ISO Colchicine results in decreased expression of TUBB4B mRNA CTD PMID:20624997 NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714 		JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO Colchicine results in decreased expression of TUBB5 mRNA CTD PMID:20624997 NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198 		JBrowse link
G Tubg1 tubulin, gamma 1 decreases expression ISO Colchicine results in decreased expression of TUBG1 mRNA CTD PMID:20624997 NCBI chr11:101,010,725...101,017,249
Ensembl chr11:101,010,764...101,017,245 		JBrowse link
G Utp3 UTP3 small subunit processome component decreases expression ISO Colchicine results in decreased expression of UTP3 mRNA CTD PMID:24211769 NCBI chr 5:88,702,321...88,703,949
Ensembl chr 5:88,702,321...88,703,949 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression
multiple interactions		 ISO Colchicine results in increased expression of VCAM1 mRNA
Colchicine inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Colchicine inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]		 CTD PMID:11154858 PMID:20624997 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vip vasoactive intestinal polypeptide increases expression ISO Colchicine results in increased expression of VIP mRNA; Colchicine results in increased expression of VIP protein CTD PMID:1850078 PMID:8837219 NCBI chr10:5,589,131...5,597,617
Ensembl chr10:5,589,218...5,597,617 		JBrowse link
G Xpc xeroderma pigmentosum, complementation group C decreases expression ISO Colchicine results in decreased expression of XPC mRNA CTD PMID:24211769 NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870 		JBrowse link
G Zbtb24 zinc finger and BTB domain containing 24 decreases expression ISO Colchicine results in decreased expression of ZBTB24 mRNA CTD PMID:24211769 NCBI chr10:41,326,354...41,341,578
Ensembl chr10:41,326,379...41,341,570 		JBrowse link
G Zfp202 zinc finger protein 202 decreases expression ISO Colchicine results in decreased expression of ZNF202 mRNA CTD PMID:24211769 NCBI chr 9:40,103,612...40,124,900
Ensembl chr 9:40,103,612...40,124,900 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression ISO Colchicine results in decreased expression of ZFP36L1 mRNA CTD PMID:24211769 NCBI chr12:80,154,534...80,159,787
Ensembl chr12:80,154,528...80,159,787 		JBrowse link
G Zfp94 zinc finger protein 94 decreases expression ISO Colchicine results in decreased expression of ZNF45 mRNA CTD PMID:24211769 NCBI chr 7:24,001,129...24,016,091
Ensembl chr 7:24,001,129...24,016,091 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22210
    role 22195
      application 21776
        anti-inflammatory agent 17353
          (S)-colchicine 259
Path 2
Term Annotations click to browse term
  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    p-block element atom 22136
                      carbon group element atom 21936
                        carbon atom 21861
                          organic molecular entity 21861
                            heteroorganic entity 21517
                              organochalcogen compound 21005
                                organooxygen compound 20846
                                  carbon oxoacid 19634
                                    carboxylic acid 19630
                                      carboacyl group 18296
                                        univalent carboacyl group 18296
                                          carbamoyl group 18108
                                            carboxamide 18108
                                              acetamides 14672
                                                colchicine 259
                                                  (S)-colchicine 259
paths to the root