Tmem185b (transmembrane protein 185B) - Rat Genome Database

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Gene: Tmem185b (transmembrane protein 185B) Mus musculus
Analyze
Symbol: Tmem185b
Name: transmembrane protein 185B
RGD ID: 1320028
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human TMEM185B (transmembrane protein 185B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2500001K11Rik; ee3_2; erythropoietin-induced EST 3-2; MGC25511
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,453,884 - 119,456,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,453,890 - 119,456,713 (+)EnsemblGRCm39 Ensembl
GRCm381119,526,154 - 119,528,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,526,160 - 119,528,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371121,422,744 - 121,424,803 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,353,713 - 121,355,772 (+)NCBIMGSCv36mm8
Celera1122,184,964 - 122,187,094 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334   PMID:15525354   PMID:16141072   PMID:16141073  
PMID:27899360   PMID:32554809  


Genomics

Comparative Map Data
Tmem185b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,453,884 - 119,456,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,453,890 - 119,456,713 (+)EnsemblGRCm39 Ensembl
GRCm381119,526,154 - 119,528,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,526,160 - 119,528,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371121,422,744 - 121,424,803 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,353,713 - 121,355,772 (+)NCBIMGSCv36mm8
Celera1122,184,964 - 122,187,094 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.31NCBI
TMEM185B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382120,217,479 - 120,223,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2120,217,479 - 120,223,400 (-)EnsemblGRCh38hg38GRCh38
GRCh372120,975,055 - 120,980,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362120,695,324 - 120,697,454 (-)NCBINCBI36Build 36hg18NCBI36
Celera2114,305,701 - 114,307,831 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2113,298,822 - 113,304,759 (-)NCBIHuRef
CHM1_12120,979,441 - 120,985,378 (-)NCBICHM1_1
T2T-CHM13v2.02120,652,239 - 120,658,160 (-)NCBIT2T-CHM13v2.0
Tmem185b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,200,329 - 33,203,660 (+)NCBIGRCr8
mRatBN7.21330,647,533 - 30,650,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,647,482 - 30,650,858 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,228,893 - 33,232,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,516,732 - 34,520,065 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,790,854 - 31,794,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,554,621 - 35,557,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,554,964 - 35,556,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01340,669,220 - 40,672,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41332,276,974 - 32,279,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11332,280,108 - 32,281,829 (+)NCBI
Celera1330,543,175 - 30,546,506 (+)NCBICelera
Cytogenetic Map13q11NCBI
Tmem185b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554599,610,905 - 9,613,405 (+)NCBIChiLan1.0ChiLan1.0
TMEM185B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21322,219,290 - 22,225,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B22,238,267 - 22,240,349 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B7,149,925 - 7,155,857 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,725,913 - 120,731,687 (-)NCBIpanpan1.1PanPan1.1panPan2
TMEM185B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11929,892,735 - 29,894,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1930,149,219 - 30,151,009 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01931,268,313 - 31,270,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1931,268,280 - 31,270,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11929,954,584 - 29,956,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,123,872 - 30,125,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01931,309,974 - 31,311,768 (+)NCBIUU_Cfam_GSD_1.0
Tmem185b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530391,308,751 - 91,314,210 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,303,976 - 50,305,028 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,303,513 - 50,306,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM185B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1531,141,126 - 31,142,181 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11531,140,283 - 31,146,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21536,617,474 - 36,619,775 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM185B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11010,068,817 - 10,070,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1010,069,244 - 10,070,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606112,616,649 - 12,619,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem185b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473224,869,529 - 24,872,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:495
Count of miRNA genes:363
Interacting mature miRNAs:404
Transcripts:ENSMUST00000069755, ENSMUST00000183607, ENSMUST00000183952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879492Ecgnq1_meccrine gland number QTL 1 (mouse)1103278062120535225Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
15039333Nmrs1_mNAFLD-associated magnetic resonance shift 1 (mouse)189786512123786512Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
10045976Tir6_mtrypanosome infection response 6 (mouse)Not determined193536855120529678Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
4141627Bwq7_mbody weight, QTL 7 (mouse)Not determined192940909124497796Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12879491Hfnq1_mhair follicle number QTL 1 (mouse)193310310123636759Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
12790991Aath1_maortic arch atherosclerosis 1 (mouse)186483929120483929Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139132808126445310Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1301123Cd8mts2_mCD8 memory T cell subset 2 (mouse)Not determined196618386130618557Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
1357760Synch3_msynechia 3 (mouse)Not determined192901442126901550Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
13452398Leusq5_mleucocytosis susceptibility QTL 5 (mouse)198474785126386517Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
13452395Leusq2_mleucocytosis susceptibility QTL 2 (mouse)180245593126386517Mouse
27095931Pglq1_mpelvic girdle length QTL 1, 5 week (mouse)175976637128527737Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162946755120529678Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
4141329Mleu1_mmyeloid leukemia survival 1 (mouse)Not determined89786512123786512Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167339159129727737Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse

Markers in Region
UniSTS:234194  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381119,527,480 - 119,527,724UniSTSGRCm38
MGSCv371121,424,057 - 121,424,301UniSTSGRCm37
Celera1122,186,348 - 122,186,592UniSTS
Cytogenetic Map1E2.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000183607
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,453,903 - 119,454,959 (+)Ensembl
GRCm38.p6 Ensembl1119,526,173 - 119,527,229 (+)Ensembl
Ensembl Acc Id: ENSMUST00000183952   ⟹   ENSMUSP00000139021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1119,453,890 - 119,456,713 (+)Ensembl
GRCm38.p6 Ensembl1119,526,160 - 119,528,983 (+)Ensembl
RefSeq Acc Id: NM_146103   ⟹   NP_666215
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391119,453,884 - 119,456,713 (+)NCBI
GRCm381119,526,154 - 119,528,983 (+)ENTREZGENE
MGSCv371121,422,744 - 121,424,803 (+)RGD
Celera1122,184,951 - 122,187,851 (+)ENTREZGENE
cM Map1 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_666215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH24712 (Get FASTA)   NCBI Sequence Viewer  
  BAC25317 (Get FASTA)   NCBI Sequence Viewer  
  BAC27267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000139021
  ENSMUSP00000139021.2
GenBank Protein Q8R3R5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_666215   ⟸   NM_146103
- UniProtKB: Q8R3R5 (UniProtKB/Swiss-Prot),   Q8BSP3 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000139021   ⟸   ENSMUST00000183952

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R3R5-F1-model_v2 AlphaFold Q8R3R5 1-350 view protein structure

Promoters
RGD ID:6874710
Promoter ID:EPDNEW_M806
Type:initiation region
Name:KY467405_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381119,526,143 - 119,526,203EPDNEW
RGD ID:6874712
Promoter ID:EPDNEW_M807
Type:initiation region
Name:Tmem185b_1
Description:Mus musculus transmembrane protein 185B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381119,526,174 - 119,526,234EPDNEW
RGD ID:6818604
Promoter ID:MM_KWN:1880
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_146103
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361121,421,896 - 121,424,227 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917634 AgrOrtholog
Ensembl Genes ENSMUSG00000098923 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000183952 ENTREZGENE
  ENSMUST00000183952.2 UniProtKB/Swiss-Prot
InterPro TM_Fragile-X-F-assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:226351 UniProtKB/Swiss-Prot
MGD MGI:1917634 ENTREZGENE
NCBI Gene Tmem185b ENTREZGENE
PANTHER PTHR13568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 185B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tmemb_185A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem185b PhenoGen
UniProt Q8BSP3 ENTREZGENE
  Q8CEW0_MOUSE UniProtKB/TrEMBL
  Q8R3R5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8BSP3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Tmem185b  transmembrane protein 185B  2500001K11Rik  RIKEN cDNA 2500001K11 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 2500001K11Rik  RIKEN cDNA 2500001K11 gene  Tmem185b  transmembrane protein 185B  Symbol and/or name change 5135510 APPROVED