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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:27882
Term: (S)-colchicine
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Chemical ID: MESH:D003078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein affects the transport of ColchicinePMID:16007523
Abcb1adecreases response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in decreased susceptibility to ColchicinePMID:15112361 PMID:15725475 PMID:7905786
Abcb1aincreases exportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased export of ColchicinePMID:15112361
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDColchicine results in increased expression of ABCB1; Colchicine results in increased expression of ABCB1 mRNAPMID:15342794 PMID:24759273
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Colchicine; Colchicine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]PMID:11792417 PMID:12711602
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