Trim38 (tripartite motif-containing 38)

Gene: Trim38 (tripartite motif-containing 38) Mus musculus

Analyze

Symbol:

Trim38

Name:

tripartite motif-containing 38

RGD ID:

1616586

MGI Page

MGI

Description:

Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including negative regulation of defense response to virus; positive regulation of viral genome replication; and protein K48-linked ubiquitination. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM38 (tripartite motif containing 38).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 SUMO-protein ligase TRIM38; E3 ubiquitin-protein ligase TRIM38; Gm23; RING finger protein 15; tripartite motif-containing protein 38; zinc finger protein RoRet

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRIM38 (tripartite motif containing 38)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OrthoDB, PhylomeDB
Rattus norvegicus (Norway rat):	Trim38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRIM38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRIM38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trim38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRIM38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRIM38 (tripartite motif containing 38)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TRIM38 (tripartite motif containing 38)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:194990	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-219e21.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-18p12.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-114c12.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-120g10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	B0281.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	Y47G6A.14	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.5	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	nhl-3	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	C28G1.6	Alliance	DIOPT (Ensembl Compara\|InParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	23,962,483 - 23,975,721 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	23,953,896 - 23,975,511 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	23,778,500 - 23,791,731 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	23,769,913 - 23,791,528 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	23,874,441 - 23,883,364 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	23,790,037 - 23,798,960 (+)	NCBI		MGSCv36	mm8
Celera	13	24,014,284 - 24,023,174 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	9.92	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-colchicine (ISO)

1,2-dichloroethane (EXP)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

adenine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

butanal (ISO)

calcitriol (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crotonaldehyde (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

glycidyl methacrylate (ISO)

hydroxyurea (ISO)

indometacin (ISO)

leflunomide (ISO)

mercury dibromide (ISO)

methyl methanesulfonate (ISO)

mitomycin C (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenylmercury acetate (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (EXP)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune system process (IEA)

innate immune response (IBA)

negative regulation of defense response to virus (IMP)

positive regulation of autophagy (IBA)

positive regulation of canonical NF-kappaB signal transduction (IBA,ISO)

positive regulation of viral entry into host cell (ISO)

positive regulation of viral genome replication (IDA,IMP)

proteasome-mediated ubiquitin-dependent protein catabolic process (IDA,IMP)

protein K48-linked ubiquitination (IDA,IMP)

protein polyubiquitination (IBA)

regulation of interferon-beta production (IDA,IMP)

regulation of protein localization (IBA)

regulation of viral entry into host cell (IBA)

Cellular Component

cytoplasm (IBA)

cytosol (IBA)

nucleoplasm (IBA)

Molecular Function

metal ion binding (IEA)

protein binding (IPI)

protein homodimerization activity (IBA)

protein kinase binding (IBA)

transcription coactivator activity (ISO)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IDA)

zinc ion binding (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased circulating interferon-alpha level (IAGP)

increased circulating interferon-beta level (IAGP)

increased circulating interleukin-6 level (IAGP)

increased circulating tumor necrosis factor level (IAGP)

increased susceptibility to bacterial infection (IAGP)

increased susceptibility to bacterial infection induced morbidity/mortality (IAGP)

increased susceptibility to infection induced morbidity/mortality (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12466851	PMID:12477932	PMID:21267068	PMID:21873635	PMID:22323536	PMID:22539786	PMID:26392463	PMID:27637147	PMID:28250012	PMID:29753717	PMID:32994318

Genomics

Comparative Map Data

Trim38
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	23,962,483 - 23,975,721 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	23,953,896 - 23,975,511 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	23,778,500 - 23,791,731 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	23,769,913 - 23,791,528 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	23,874,441 - 23,883,364 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	23,790,037 - 23,798,960 (+)	NCBI		MGSCv36	mm8
Celera	13	24,014,284 - 24,023,174 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	9.92	NCBI

TRIM38
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	25,962,802 - 25,991,231 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	25,962,802 - 25,991,231 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	25,963,030 - 25,991,459 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	26,071,050 - 26,093,337 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	26,071,049 - 26,093,329	NCBI
Celera	6	27,190,286 - 27,212,582 (+)	NCBI		Celera
Cytogenetic Map	6	p22.2	NCBI
HuRef	6	25,905,972 - 25,930,614 (+)	NCBI		HuRef
CHM1_1	6	25,965,160 - 25,989,826 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	25,828,703 - 25,857,166 (+)	NCBI		T2T-CHM13v2.0

Trim38
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	41,774,419 - 41,787,709 (-)	NCBI		GRCr8
mRatBN7.2	17	41,351,857 - 41,365,021 (-)	NCBI	mRatBN7.2	mRatBN7.2
Rnor_6.0	17	43,600,006 - 43,607,879 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	17	45,454,492 - 45,462,066 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	48,533,590 - 48,541,164 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	40,983,646 - 40,991,519 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

TRIM38
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	40,608,603 - 40,630,341 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	36,610,178 - 36,647,480 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	25,796,278 - 25,818,610 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	26,454,051 - 26,475,842 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	26,454,051 - 26,475,842 (+)	Ensembl	panpan1.1		panPan2

TRIM38
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	23,894,521 - 23,939,392 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	35	23,926,287 - 23,939,466 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	23,805,035 - 23,818,264 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	24,010,055 - 24,054,777 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	24,041,848 - 24,054,577 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	23,826,346 - 23,871,192 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	23,876,839 - 23,913,812 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	25,310,095 - 25,354,827 (+)	NCBI		UU_Cfam_GSD_1.0

Trim38
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	1,769,006 - 1,779,866 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936671	1,841,662 - 1,854,306 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936671	1,841,722 - 1,853,804 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM38
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	20,682,652 - 20,704,192 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	20,682,536 - 20,694,340 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TRIM38
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	46,269,498 - 46,292,050 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	46,268,289 - 46,292,092 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	25,899,176 - 25,922,157 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Trim38
525 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	118
Count of miRNA genes:	107
Interacting mature miRNAs:	108
Transcripts:	ENSMUST00000074067
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301255	Cd4ts6_m	CD4 T cell subset 6 (mouse)			Not determined		13	168545	34168684	Mouse
10449140	Eosn2_m	eosinophil differential 2 (mouse)					13	221311	34221311	Mouse
15039338	Nmrs34_m	NAFLD-associated magnetic resonance shift 34 (mouse)					13	221311	34221311	Mouse
1301455	Bmd3_m	bone mineral density 3 (mouse)			Not determined		13	3477612	37477820	Mouse
10045624	Heal24_m	wound healing/regeneration (mouse)			Not determined		13	3477612	37477820	Mouse
10045625	Heal23_m	wound healing/regeneration 23 (mouse)			Not determined		13	3477612	37477820	Mouse
1301367	Twq1_m	testis weight QTL 1 (mouse)			Not determined		13	3615512	37615672	Mouse
1301733	Heal3_m	wound healing/regeneration 3 (mouse)			Not determined		13	3680200	37680343	Mouse
26884393	Humsd7_m	humerus midshaft diameter 7, 16 week (mouse)					13	3950000	76048119	Mouse
1558898	Hpi1_m	hapatic PMN infiltration 1 (mouse)			Not determined		13	4414025	53101640	Mouse
10402494	Igmsc1_m	immunoglobulin M secreting cells 1 (mouse)			Not determined		13	17168545	44918560	Mouse
1301984	Pbd2_m	peak bone density 2 (mouse)			Not determined		13	17189508	38947406	Mouse
1301880	Hypt_m	hypertension (mouse)			Not determined		13	18156792	52156924	Mouse
13463469	Gssq1_m	glomerulosclerosis severity QTL 1 (mouse)					13	19060908	53061050	Mouse
12880423	V25Dq7_m	vitamin D inactive form serum level QTL 7 (mouse)					13	19583983	53583983	Mouse
1301015	Sysbp2_m	systolic blood pressure 2 (mouse)			Not determined		13	20477612	59821605	Mouse
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
1357591	Tesq1_m	testis weight QTL 1 (mouse)			Not determined		13	20615512	55720517	Mouse
4142009	Pregq3_m	pregnancy QTL 3 (mouse)			Not determined		13	20615512	72385189	Mouse
10045618	Heal17_m	wound healing/regeneration 17 (mouse)			Not determined		13	20746939	54747056	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001029935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006516637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011244303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL590388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC150836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC171998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000074067 ⟹ ENSMUSP00000073709

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	23,966,524 - 23,975,511 (+)	Ensembl
GRCm38.p6 Ensembl	13	23,782,541 - 23,791,528 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000223911 ⟹ ENSMUSP00000153540

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	23,966,524 - 23,975,511 (+)	Ensembl
GRCm38.p6 Ensembl	13	23,782,541 - 23,791,528 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000226039 ⟹ ENSMUSP00000153240

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	23,953,896 - 23,975,511 (+)	Ensembl
GRCm38.p6 Ensembl	13	23,769,913 - 23,791,528 (+)	Ensembl

RefSeq Acc Id:

NM_001029935 ⟹ NP_001025106

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	23,966,524 - 23,975,511 (+)	NCBI
GRCm38	13	23,782,541 - 23,791,528 (+)	NCBI
MGSCv37	13	23,874,441 - 23,883,364 (+)	RGD
Celera	13	24,014,253 - 24,023,207 (+)	NCBI
cM Map	13		ENTREZGENE

Sequence:

show sequence

TGCCACATTTGGAAACTTCTCAGAAAAAGCCATGGGCTCAGACTTTAGCACGGTGAAGATAAGA
AAGGTCACTTCTTGCTCCATCTGCAAGGCCATGATGTCTCACCCAGTGAGCATCAACTGTGGAC
ACAGCTACTGCAAATCCTGCATACAGAGCTATTATTGCAATGTCAGCCCAAAAACAGGGTGGAA
GATGTTGGGCTGTCCTTTGTGTAGTAGTCCATTTAGCTTAGAGAACCTCAGGCCCAACAAGGAG
CTAGAAACCATAATTGATATGATCAAGGGGATGGAAGAGCAGGATCAAGACATGGTGTGTGAGG
AACATGAAGAGAAGTTCAATCGCTTTTGTGAAGATGACGGTCAACTCCTCTGCTGGCGCTGTTA
TTGGGAAGATCGGCACAAAGGTCATACCTTGGCTCATGTGAAAGATGTGTACCAGAACTACAAG
GAAAAACTCCAGAACACCATGACAAAATTGCGTGAACTCCAAGAGAATCACGAAGTTCAGATAC
ATTTCATAACACACCAAATAAATGCCTGGAAGGATGCTGTAGAGGATCGTCGGCAAACAATCAA
GTCAAACTTCAAGAATCTCCAGAGTTTTCTACAGGAAGAAGAGAAGTTTTATCTTTGGAGGTTG
GAAAATGAGGAAAAGGAGATGCTGGTGCAGCTGGAAGGCAGCGAGGCCAATCTACAGCAGACGT
TTGAGAGAGCTCAATGCCAAATTCAGGAACTGGAGGCAAAATGTCAGGGCTCAGCCCAGAAATT
GCTACAGGACGTGAAAAACACTTTGAGCAGGTGTGAGGCCATGAAGCGAAACCCACTGAAGGCT
GATCCCCTGAAGGTTCACACTAAATGTAATGTGTCTGAGCTGTACTTCGATGTGAAGACGATAT
TACGACGTCACCAAGTCAGCGTGATCCTGGACCCCAGCACAGCCCACCTTGACCTAGCTCTGAC
TAAAGGTGGAAGATTAGTGACTTACAAAAGATGCCCCAGGGATCTTCAGGCAAGATCTTCAGCC
AAGAGGTTTTATGGTTTACCCTGTGTCCTGGGCTGTGAGGGCTTTACTTCGGGGAGATATTACT
TTGAAGTCTCTGTTGAGAATGCAACCAGTTGGGATTTGGGAGTCTGTGTAGAGAATGTGCACAG
GGGCTTTAACATGAAGAAGGAGCCTGAGTCTGGATTCTGGACCATCAAGATGTCTGAAGAGGAC
GGCCTTGAAGCTCTTACTTCTACCCCTACTCCTCCCCTTCATCTGATTGAAAAGCCCCAGATTC
TGGGAGTTTTCCTAGACTATGAGGCTGGAGCTGTATCGTTTTACAGTGTAACTACTGGCTCTCA
TATCTTCACCTTCCCTAAGGCTTCCTTCCAGGATACTCTGAGGCCCTTTTTCCAGGTTTATCAA
TATTCTCCTTTGTTCCTGCCTGCCATAAATAATCAATGAAAGAAGTAAGTCCCTATGCCTTAAG
TAGCCTCA

hide sequence

RefSeq Acc Id:

XM_006516637 ⟹ XP_006516700

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	23,962,483 - 23,975,721 (+)	NCBI
GRCm38	13	23,778,500 - 23,791,731 (+)	NCBI

Sequence:

show sequence

TTTCAAAAGACCAGAGCGACTTCATTGGCTATGGATTGGCCTCCTGCAGTGCTCTCACCCAGAT
GACTCAGCAGAGTCTTCTAGGTTTCCGGAAGTGGCAAGTGCTCAGCAGAGCACAACTGGATCCA
CGATTGTCTCCAGAGCTCTGGAAAGACTCAGGACTGGGGCAGCTCTCACATTGGCATCTGCTTT
TGCTTCTCGAATGGCACAAGCAATCTCAGATAATCCAGAATATAGAGACTACAAACCTCTAAAC
CCAGTAGCCGTCAGTTGATTGTATTTAAGTTTAGGTGAGGTGTACATCTACCACTGTGGGAAAC
ATTTCTCTACTTCTGATTGCCACATTTGGAAACTTCTCAGAAAAAGCCATGGGCTCAGACTTTA
GCACGGTGAAGATAAGAAAGGTCACTTCTTGCTCCATCTGCAAGGCCATGATGTCTCACCCAGT
GAGCATCAACTGTGGACACAGCTACTGCAAATCCTGCATACAGAGCTATTATTGCAATGTCAGC
CCAAAAACAGGGTGGAAGATGTTGGGCTGTCCTTTGTGTAGTAGTCCATTTAGCTTAGAGAACC
TCAGGCCCAACAAGGAGCTAGAAACCATAATTGATATGATCAAGGGGATGGAAGAGCAGGATCA
AGACATGGTGTGTGAGGAACATGAAGAGAAGTTCAATCGCTTTTGTGAAGATGACGGTCAACTC
CTCTGCTGGCGCTGTTATTGGGAAGATCGGCACAAAGGTCATACCTTGGCTCATGTGAAAGATG
TGTACCAGAACTACAAGGAAAAACTCCAGAACACCATGACAAAATTGCGTGAACTCCAAGAGAA
TCACGAAGTTCAGATACATTTCATAACACACCAAATAAATGCCTGGAAGGATGCTGTAGAGGAT
CGTCGGCAAACAATCAAGTCAAACTTCAAGAATCTCCAGAGTTTTCTACAGGAAGAAGAGAAGT
TTTATCTTTGGAGGTTGGAAAATGAGGAAAAGGAGATGCTGGTGCAGCTGGAAGGCAGCGAGGC
CAATCTACAGCAGACGTTTGAGAGAGCTCAATGCCAAATTCAGGAACTGGAGGCAAAATGTCAG
GGCTCAGCCCAGAAATTGCTACAGGACGTGAAAAACACTTTGAGCAGGTGTGAGGCCATGAAGC
GAAACCCACTGAAGGCTGATCCCCTGAAGGTTCACACTAAATGTAATGTGTCTGAGCTGTACTT
CGATGTGAAGACGATATTACGACGTCACCAAGTCAGCGTGATCCTGGACCCCAGCACAGCCCAC
CTTGACCTAGCTCTGACTAAAGGTGGAAGATTAGTGACTTACAAAAGATGCCCCAGGGATCTTC
AGGCAAGATCTTCAGCCAAGAGGTTTTATGGTTTACCCTGTGTCCTGGGCTGTGAGGGCTTTAC
TTCGGGGAGATATTACTTTGAAGTCTCTGTTGAGAATGCAACCAGTTGGGATTTGGGAGTCTGT
GTAGAGAATGTGCACAGGGGCTTTAACATGAAGAAGGAGCCTGAGTCTGGATTCTGGACCATCA
AGATGTCTGAAGAGGACGGCCTTGAAGCTCTTACTTCTACCCCTACTCCTCCCCTTCATCTGAT
TGAAAAGCCCCAGATTCTGGGAGTTTTCCTAGACTATGAGGCTGGAGCTGTATCGTTTTACAGT
GTAACTACTGGCTCTCATATCTTCACCTTCCCTAAGGCTTCCTTCCAGGATACTCTGAGGCCCT
TTTTCCAGGTTTATCAATATTCTCCTTTGTTCCTGCCTGCCATAAATAATCAATGAAAGAAGTA
AGTCCCTATGCCTTAAGTAGCCTCATAGAAAACCCATAAATATCACAAGGCAGAAACTTTATCT
TCACTGCTATCCCAATTCTTTTAGTGAACTTTCAATAAATATGCATTGAATTAATAACCCTTTC
AAATGTGTTGAATATTGAATGACTCAAAACATATTGCACGATCCCTGTGTTTGAAGGTAATTAT
TGTTTTCTGTTTATAGTGGGCACAGCTGTGAGGGATGTTTTTC

hide sequence

RefSeq Acc Id:

XM_011244303 ⟹ XP_011242605

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	23,963,014 - 23,975,721 (+)	NCBI
GRCm38	13	23,779,055 - 23,791,731 (+)	NCBI

Sequence:

show sequence

CCCTACTTATTATTTAATCATCTATCTAGGAAATCCCCAATAGTTATGGCTCCCAGGACTGTGT
GGTTCTGGCTCCACTTCCTCTCCTACAAGTTTCCACCATCTTGTCTCCTCATCTCTGTACTCTC
TAACTCTCCGCCCACCTTCTTTTTCCACTGCCCAGTTACAGGCTCTAGCCTTATCTTGTGCCCT
GCCCTCACCTGCTCATAGACCGCAATCCACAGGGTGGGACCTCCGTGGAAAGTGTCTCCAGATA
ACAGAGTCCTCTCCCCTACAGCTCTGGAAAGACTCAGGACTGGGGCAGCTCTCACATTGGCATC
TGCTTTTGCTTCTCGAATGGCACAAGCAATCTCAGATAATCCAGAATATAGAGACTACAAACCT
CTAAACCCAGTAGCCGTCAGTTGATTGTATTTAAGTTTAGGTGAGGTGTACATCTACCACTGTG
GGAAACATTTCTCTACTTCTGATTGCCACATTTGGAAACTTCTCAGAAAAAGCCATGGGCTCAG
ACTTTAGCACGGTGAAGATAAGAAAGGTCACTTCTTGCTCCATCTGCAAGGCCATGATGTCTCA
CCCAGTGAGCATCAACTGTGGACACAGCTACTGCAAATCCTGCATACAGAGCTATTATTGCAAT
GTCAGCCCAAAAACAGGGTGGAAGATGTTGGGCTGTCCTTTGTGTAGTAGTCCATTTAGCTTAG
AGAACCTCAGGCCCAACAAGGAGCTAGAAACCATAATTGATATGATCAAGGGGATGGAAGAGCA
GGATCAAGACATGGTGTGTGAGGAACATGAAGAGAAGTTCAATCGCTTTTGTGAAGATGACGGT
CAACTCCTCTGCTGGCGCTGTTATTGGGAAGATCGGCACAAAGGTCATACCTTGGCTCATGTGA
AAGATGTGTACCAGAACTACAAGGAAAAACTCCAGAACACCATGACAAAATTGCGTGAACTCCA
AGAGAATCACGAAGTTCAGATACATTTCATAACACACCAAATAAATGCCTGGAAGGATGCTGTA
GAGGATCGTCGGCAAACAATCAAGTCAAACTTCAAGAATCTCCAGAGTTTTCTACAGGAAGAAG
AGAAGTTTTATCTTTGGAGGTTGGAAAATGAGGAAAAGGAGATGCTGGTGCAGCTGGAAGGCAG
CGAGGCCAATCTACAGCAGACGTTTGAGAGAGCTCAATGCCAAATTCAGGAACTGGAGGCAAAA
TGTCAGGGCTCAGCCCAGAAATTGCTACAGGACGTGAAAAACACTTTGAGCAGGTGTGAGGCCA
TGAAGCGAAACCCACTGAAGGCTGATCCCCTGAAGGTTCACACTAAATGTAATGTGTCTGAGCT
GTACTTCGATGTGAAGACGATATTACGACGTCACCAAGTCAGCGTGATCCTGGACCCCAGCACA
GCCCACCTTGACCTAGCTCTGACTAAAGGTGGAAGATTAGTGACTTACAAAAGATGCCCCAGGG
ATCTTCAGGCAAGATCTTCAGCCAAGAGGTTTTATGGTTTACCCTGTGTCCTGGGCTGTGAGGG
CTTTACTTCGGGGAGATATTACTTTGAAGTCTCTGTTGAGAATGCAACCAGTTGGGATTTGGGA
GTCTGTGTAGAGAATGTGCACAGGGGCTTTAACATGAAGAAGGAGCCTGAGTCTGGATTCTGGA
CCATCAAGATGTCTGAAGAGGACGGCCTTGAAGCTCTTACTTCTACCCCTACTCCTCCCCTTCA
TCTGATTGAAAAGCCCCAGATTCTGGGAGTTTTCCTAGACTATGAGGCTGGAGCTGTATCGTTT
TACAGTGTAACTACTGGCTCTCATATCTTCACCTTCCCTAAGGCTTCCTTCCAGGATACTCTGA
GGCCCTTTTTCCAGGTTTATCAATATTCTCCTTTGTTCCTGCCTGCCATAAATAATCAATGAAA
GAAGTAAGTCCCTATGCCTTAAGTAGCCTCATAGAAAACCCATAAATATCACAAGGCAGAAACT
TTATCTTCACTGCTATCCCAATTCTTTTAGTGAACTTTCAATAAATATGCATTGAATTAATAAC
CCTTTCAAATGTGTTGAATATTGAATGACTCAAAACATATTGCACGATCCCTGTGTTTGAAGGT
AATTATTGTTTTCTGTTTATAGTGGGCACAGCTGTGAGGGATGTTTTTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001025106	(Get FASTA)	NCBI Sequence Viewer
	XP_006516700	(Get FASTA)	NCBI Sequence Viewer
	XP_011242605	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI50837	(Get FASTA)	NCBI Sequence Viewer
	EDL32533	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000073709
	ENSMUSP00000073709.3
	ENSMUSP00000153240
	ENSMUSP00000153240.2
	ENSMUSP00000153540.2
GenBank Protein	Q5SZ99	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001025106 ⟸ NM_001029935

- UniProtKB:

B9EKD3 (UniProtKB/Swiss-Prot), Q5SZ99 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYYCNVSPKTGWKMLGCPLCSSP
FSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKFNRFCEDDGQLLCWRCYWEDRHKGHTL
AHVKDVYQNYKEKLQNTMTKLRELQENHEVQIHFITHQINAWKDAVEDRRQTIKSNFKNLQSFL
QEEEKFYLWRLENEEKEMLVQLEGSEANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSR
CEAMKRNPLKADPLKVHTKCNVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKR
CPRDLQARSSAKRFYGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPES
GFWTIKMSEEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQ
DTLRPFFQVYQYSPLFLPAINNQ

hide sequence

RefSeq Acc Id:	XP_006516700 ⟸ XM_006516637
- Peptide Label:	isoform X1
- UniProtKB:	B9EKD3 (UniProtKB/Swiss-Prot), Q5SZ99 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYYCNVSPKTGWKMLGCPLCSSP FSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKFNRFCEDDGQLLCWRCYWEDRHKGHTL AHVKDVYQNYKEKLQNTMTKLRELQENHEVQIHFITHQINAWKDAVEDRRQTIKSNFKNLQSFL QEEEKFYLWRLENEEKEMLVQLEGSEANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSR CEAMKRNPLKADPLKVHTKCNVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKR CPRDLQARSSAKRFYGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPES GFWTIKMSEEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQ DTLRPFFQVYQYSPLFLPAINNQ hide sequence

RefSeq Acc Id:	XP_011242605 ⟸ XM_011244303
- Peptide Label:	isoform X1
- UniProtKB:	B9EKD3 (UniProtKB/Swiss-Prot), Q5SZ99 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSDFSTVKIRKVTSCSICKAMMSHPVSINCGHSYCKSCIQSYYCNVSPKTGWKMLGCPLCSSP FSLENLRPNKELETIIDMIKGMEEQDQDMVCEEHEEKFNRFCEDDGQLLCWRCYWEDRHKGHTL AHVKDVYQNYKEKLQNTMTKLRELQENHEVQIHFITHQINAWKDAVEDRRQTIKSNFKNLQSFL QEEEKFYLWRLENEEKEMLVQLEGSEANLQQTFERAQCQIQELEAKCQGSAQKLLQDVKNTLSR CEAMKRNPLKADPLKVHTKCNVSELYFDVKTILRRHQVSVILDPSTAHLDLALTKGGRLVTYKR CPRDLQARSSAKRFYGLPCVLGCEGFTSGRYYFEVSVENATSWDLGVCVENVHRGFNMKKEPES GFWTIKMSEEDGLEALTSTPTPPLHLIEKPQILGVFLDYEAGAVSFYSVTTGSHIFTFPKASFQ DTLRPFFQVYQYSPLFLPAINNQ hide sequence

RefSeq Acc Id:

ENSMUSP00000153540 ⟸ ENSMUST00000223911

RefSeq Acc Id:

ENSMUSP00000073709 ⟸ ENSMUST00000074067

RefSeq Acc Id:

ENSMUSP00000153240 ⟸ ENSMUST00000226039

Protein Domains

B box-type B30.2/SPRY RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5SZ99-F1-model_v2	AlphaFold	Q5SZ99	1-471	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2684869	AgrOrtholog
Ensembl Genes	ENSMUSG00000064140	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000074067	ENTREZGENE
	ENSMUST00000074067.4	UniProtKB/Swiss-Prot
	ENSMUST00000223911.2	UniProtKB/TrEMBL
	ENSMUST00000226039	ENTREZGENE
	ENSMUST00000226039.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.120.920	UniProtKB/Swiss-Prot
	3.30.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/Swiss-Prot
	B30.2/SPRY_sf	UniProtKB/Swiss-Prot
	Butyrophylin_SPRY	UniProtKB/Swiss-Prot
	ConA-like_dom_sf	UniProtKB/Swiss-Prot
	PRY	UniProtKB/Swiss-Prot
	SPRY/PRY_TRIM38	UniProtKB/Swiss-Prot
	SPRY_dom	UniProtKB/Swiss-Prot
	Znf_B-box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:214158	UniProtKB/Swiss-Prot
MGD	MGI:2684869	ENTREZGENE
NCBI Gene	214158	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE TRIM38	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PRY	UniProtKB/Swiss-Prot
	SPRY	UniProtKB/Swiss-Prot
	zf-B_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Trim38	PhenoGen
PRINTS	BUTYPHLNCDUF	UniProtKB/Swiss-Prot
PROSITE	B302_SPRY	UniProtKB/Swiss-Prot
	ZF_BBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	BBOX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PRY	UniProtKB/Swiss-Prot
	RING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPRY	UniProtKB/Swiss-Prot
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RING/U-box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49899	UniProtKB/Swiss-Prot
UniProt	A0A286YDR5_MOUSE	UniProtKB/TrEMBL
	B9EKD3	ENTREZGENE
	Q5SZ99	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	B9EKD3	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype