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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10468
Species: Mus musculus
RGD Object: Gene
Symbol: Ace
Name: angiotensin I converting enzyme
Acc ID: CHEBI:27882
Term: (S)-colchicine
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Chemical ID: MESH:D003078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acedecreases activityISOAce (Rattus norvegicus)6480464CTDColchicine results in decreased activity of ACE proteinPMID:17135773 PMID:18980205 PMID:18992766
Acedecreases expressionISOAce (Rattus norvegicus)6480464CTDColchicine results in decreased expression of ACE proteinPMID:17652827
Acemultiple interactionsISOAce (Rattus norvegicus)6480464CTDcarvedilol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Quercetin inhibits the reaction [Colchicine results in decreased activity of ACE protein]; resveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein]PMID:17135773 PMID:17652827 PMID:18980205 PMID:18992766
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