Pelo (pelota mRNA surveillance and ribosome rescue factor) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pelo (pelota mRNA surveillance and ribosome rescue factor) Mus musculus
Analyze
Symbol: Pelo
Name: pelota mRNA surveillance and ribosome rescue factor
RGD ID: 1552813
MGI Page MGI
Description: Predicted to have endonuclease activity and metal ion binding activity. Involved in several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to localize to cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor); PARTICIPATES IN translation termination pathway; mRNA decay pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA409897; AI852218; pelota homolog; pelota homolog (Drosophila); protein pelota homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913115,224,891 - 115,226,694 (-)NCBIGRCm39mm39
GRCm3813115,088,355 - 115,090,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13115,088,355 - 115,090,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,878,563 - 115,880,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613116,209,242 - 116,211,703 (-)NCBImm8
Celera13119,447,710 - 119,449,318 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-colchicine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
hydroxyurea  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
mitomycin C  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sodium dichromate  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,TAS)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16919269  
PMID:17093407   PMID:18287559   PMID:21267068   PMID:21873635   PMID:21905163   PMID:24835669   PMID:25061210   PMID:25661254   PMID:26410627   PMID:27164299   PMID:29643507   PMID:30707697  
PMID:32098917   PMID:32325033   PMID:32968282  


Genomics

Comparative Map Data
Pelo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913115,224,891 - 115,226,694 (-)NCBIGRCm39mm39
GRCm3813115,088,355 - 115,090,158 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13115,088,355 - 115,090,186 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,878,563 - 115,880,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613116,209,242 - 116,211,703 (-)NCBImm8
Celera13119,447,710 - 119,449,318 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
PELO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl552,787,916 - 52,804,044 (+)EnsemblGRCh38hg38GRCh38
GRCh38552,787,916 - 52,804,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,083,750 - 52,099,878 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37552,083,774 - 52,098,451 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,531 - 52,134,208 (+)NCBINCBI36hg18NCBI36
Build 34552,119,530 - 52,134,206NCBI
Celera549,037,324 - 49,052,004 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,055,620 - 49,070,302 (+)NCBIHuRef
CHM1_1552,086,424 - 52,101,104 (+)NCBICHM1_1
Pelo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,797,853 - 46,799,621 (-)NCBI
Rnor_6.0 Ensembl247,266,738 - 47,268,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0247,266,758 - 47,268,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0271,808,491 - 71,810,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4245,900,723 - 45,902,491 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1245,828,956 - 45,830,724 (-)NCBI
Celera242,545,596 - 42,547,364 (-)NCBICelera
Cytogenetic Map2q14NCBI
Pelo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,564,366 - 14,566,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,564,366 - 14,566,178 (-)NCBIChiLan1.0ChiLan1.0
PELO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1562,851,499 - 62,865,786 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,851,099 - 62,865,786 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0561,229,841 - 61,247,565 (-)NCBIMhudiblu_PPA_v0panPan3
PELO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,440,923 - 62,443,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pelo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648014,578,718 - 14,580,690 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PELO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,142,034 - 32,148,335 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,130,254 - 32,146,114 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21633,953,117 - 33,955,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PELO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,094,330 - 49,097,545 (+)NCBI
ChlSab1.1 Ensembl449,094,528 - 49,100,838 (+)Ensembl
Pelo
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247596,525,529 - 6,527,320 (-)NCBI

Position Markers
RH124904  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813115,088,459 - 115,088,658UniSTSGRCm38
MGSCv3713115,878,667 - 115,878,866UniSTSGRCm37
Celera13119,447,814 - 119,448,013UniSTS
Cytogenetic Map13D2.2UniSTS
PMC141158P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813115,090,430 - 115,090,641UniSTSGRCm38
MGSCv3713115,880,638 - 115,880,849UniSTSGRCm37
Cytogenetic Map13D2.2UniSTS
AI852218  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813115,088,564 - 115,088,687UniSTSGRCm38
MGSCv3713115,878,772 - 115,878,895UniSTSGRCm37
Celera13119,447,919 - 119,448,042UniSTS
Cytogenetic Map13D2.2UniSTS
Whitehead/MRC_RH13994.85UniSTS
Pelo  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map13 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382603460116603598Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383739552117739748Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386000000120000000Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386205109120205250Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391247158120421639Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391828769120421639Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393738733120421639Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394391865120421639Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1394900290120421639Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395365596120421639Mouse
14746974Manh75_mmandible shape 75 (mouse)1399250111120421639Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100604983120421639Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102466094120421639Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103205109116906680Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107477080119339836Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110272953119339836Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSMUST00000109226
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000109226   ⟹   ENSMUSP00000104849
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl13115,088,355 - 115,090,186 (-)Ensembl
RefSeq Acc Id: NM_134058   ⟹   NP_598819
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913115,224,891 - 115,226,694 (-)NCBI
GRCm3813115,088,355 - 115,090,158 (-)ENTREZGENE
MGSCv3713115,878,563 - 115,880,366 (-)RGD
Celera13119,447,710 - 119,449,318 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598819   ⟸   NM_134058
- UniProtKB: Q80X73 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000104849   ⟸   ENSMUST00000109226
Protein Domains
eRF1_1

Promoters
RGD ID:8681356
Promoter ID:EPDNEW_M18709
Type:initiation region
Name:Pelo_1
Description:Mus musculus pelota mRNA surveillance and ribosome rescue factor, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18710  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813115,090,179 - 115,090,239EPDNEW
RGD ID:6824236
Promoter ID:MM_KWN:15328
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC007RYB.1,   UC007RYC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613115,879,706 - 115,880,617 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2145154 AgrOrtholog
Ensembl Genes ENSMUSG00000042275 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000104849 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000109226 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.30.870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1330.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro eFR1_2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_1_Pelota UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L30e-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pelota/DOM34_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transl-rel_pelota UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105083 UniProtKB/Swiss-Prot
MGD MGI:2145154 ENTREZGENE
NCBI Gene 105083 ENTREZGENE
PANTHER PTHR10853 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eRF1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eRF1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pelo PhenoGen
SMART eRF1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF159065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55315 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs pelota UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PELO_MOUSE UniProtKB/Swiss-Prot
  Q3THL5_MOUSE UniProtKB/TrEMBL
  Q80X73 ENTREZGENE
UniProt Secondary Q3TCN0 UniProtKB/Swiss-Prot
  Q6PG91 UniProtKB/Swiss-Prot
  Q91UZ2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-05 Pelo  pelota mRNA surveillance and ribosome rescue factor    pelota homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED