Orai3 (ORAI calcium release-activated calcium modulator 3)

Gene: Orai3 (ORAI calcium release-activated calcium modulator 3) Mus musculus

Analyze

Symbol:

Orai3

Name:

ORAI calcium release-activated calcium modulator 3

RGD ID:

1315211

MGI Page

MGI

Description:

Predicted to enable store-operated calcium channel activity. Acts upstream of or within store-operated calcium entry. Located in membrane. Orthologous to human ORAI3 (ORAI calcium release-activated calcium modulator 3).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

9930124N15; BC061259; calcium release-activated calcium channel 3; protein orai-3; Tmem142c; transmembrane protein 142C

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,368,987 - 127,374,322 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,368,987 - 127,374,322 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,769,815 - 127,775,150 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,769,815 - 127,775,150 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	134,913,329 - 134,918,664 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,560,993 - 127,566,152 (+)	NCBI		MGSCv36	mm8
Celera	7	127,605,006 - 127,610,345 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.73	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

branched-chain keto acid dehydrogenase kinase deficiency (ISO)

generalized epilepsy with febrile seizures plus 9 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-colchicine (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

acrylamide (ISO)

adenine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium dichloride (ISO)

chloroacetaldehyde (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clodronic acid (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (ISO)

ethyl methanesulfonate (ISO)

fenofibrate (ISO)

fenthion (EXP)

folic acid (EXP)

formaldehyde (ISO)

glyphosate (ISO)

hydrogen peroxide (ISO)

imidacloprid (ISO)

lead(0) (ISO)

metformin (ISO)

methyl methanesulfonate (ISO)

mitomycin C (ISO)

niclosamide (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thiabendazole (ISO)

trichostatin A (ISO)

triptonide (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

store-operated calcium entry (IBA,IMP,ISO)

Cellular Component

membrane (IBA,IDA)

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

store-operated calcium channel activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal retina outer nuclear layer morphology (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	STIM proteins: dynamic calcium signal transducers.	Soboloff J, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):549-65. doi: 10.1038/nrm3414.

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12466851	PMID:12477932	PMID:14610273	PMID:15489334	PMID:15782199	PMID:16141072	PMID:16141073	PMID:17343823
PMID:17463004	PMID:18059270	PMID:18799693	PMID:21677750	PMID:21873635	PMID:26160956	PMID:26764049	PMID:26956485	PMID:28294127	PMID:33849280	PMID:35861698	PMID:36803766

Genomics

Comparative Map Data

Orai3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	127,368,987 - 127,374,322 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	127,368,987 - 127,374,322 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,769,815 - 127,775,150 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,769,815 - 127,775,150 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	134,913,329 - 134,918,664 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,560,993 - 127,566,152 (+)	NCBI		MGSCv36	mm8
Celera	7	127,605,006 - 127,610,345 (+)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.73	NCBI

ORAI3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	30,949,068 - 30,954,938 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	30,949,068 - 30,956,461 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	30,960,389 - 30,966,259 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	30,867,916 - 30,873,760 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	29,331,449 - 29,337,301 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,523,075 - 28,528,912 (+)	NCBI		HuRef
CHM1_1	16	32,277,415 - 32,283,267 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	31,336,531 - 31,342,399 (+)	NCBI		T2T-CHM13v2.0

Orai3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,811,671 - 191,816,530 (+)	NCBI		GRCr8
mRatBN7.2	1	182,381,196 - 182,386,055 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	182,344,293 - 182,386,052 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,731,737 - 190,736,596 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	197,917,832 - 197,922,691 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,588,302 - 190,593,161 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	199,217,504 - 199,222,363 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	199,217,016 - 199,222,851 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	206,239,787 - 206,244,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	187,054,514 - 187,059,373 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	187,204,394 - 187,209,253 (+)	NCBI
Celera	1	180,032,317 - 180,037,176 (+)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

Orai3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	7,799,738 - 7,806,590 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	7,799,738 - 7,806,590 (+)	NCBI	ChiLan1.0	ChiLan1.0

ORAI3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	34,154,764 - 34,160,896 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	38,956,223 - 38,962,309 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	24,014,018 - 24,019,889 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	31,314,878 - 31,321,562 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	31,314,922 - 31,323,320 (+)	Ensembl	panpan1.1		panPan2

ORAI3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,248,900 - 17,253,935 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	17,248,884 - 17,274,850 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	18,823,980 - 18,829,005 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,379,252 - 17,384,277 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,379,685 - 17,384,254 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	17,179,607 - 17,184,632 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	17,098,744 - 17,103,769 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,411,301 - 17,416,327 (-)	NCBI		UU_Cfam_GSD_1.0

Orai3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	125,234,885 - 125,240,976 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	13,332,757 - 13,339,324 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	13,332,859 - 13,338,838 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ORAI3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,490,528 - 17,497,063 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,490,524 - 17,497,391 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	17,807,162 - 17,814,006 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ORAI3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,637,919 - 27,644,585 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	27,638,731 - 27,644,829 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	1,826,773 - 1,832,820 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Orai3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	14,020,791 - 14,030,867 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	14,020,815 - 14,028,055 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Orai3
151 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1268
Count of miRNA genes:	521
Interacting mature miRNAs:	628
Transcripts:	ENSMUST00000061587, ENSMUST00000118865, ENSMUST00000121504
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25314307	Mlh1fc2_m	MLH1 foci count 2 (mouse)					7	6502999	133501729	Mouse
12792978	Fbmd3_m	femoral bone mineral density 3, females only (mouse)					7	7050288	142367832	Mouse
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19147398	141919804	Mouse
27226751	Femd5_m	femur midshaft diameter 5, 10 week (mouse)					7	53249748	143153737	Mouse
27226778	Femd11_m	femur midshaft diameter 11, 16 week (mouse)					7	56949748	134001729	Mouse
27095933	Ulnl3_m	ulna length 3, 5 week (mouse)					7	73149748	143153737	Mouse
26884398	Humsd6_m	humerus midshaft diameter 6, 16 week (mouse)					7	78649748	136901729	Mouse
1300528	Ssial3_m	susceptibility to sialadenitis 3 (mouse)			Not determined		7	93391848	127392041	Mouse
1301478	Eae26_m	susceptibility to experimental allergic encephalomyelitis 26 (mouse)			Not determined		7	98164922	132165010	Mouse
13524850	Asrq7_m	acoustic startle response 7 (mouse)					7	98394974	132394974	Mouse
10412104	Tons2_m	tongue size 2 (mouse)			Not determined		7	99837716	133837716	Mouse
11039524	Tbbr3_m	Trypanosoma brucei brucei response 3 (mouse)					7	100750722	134750843	Mouse
1301447	Fembm3_m	femoral bone morphometry 3 (mouse)			Not determined		7	100993261	134993342	Mouse
1357460	Vtbt4_m	vertebral trabecular bone trait 4 (mouse)			Not determined		7	101693381	135693530	Mouse
1301105	Cfld4_m	cystic fibrosis lung disease 4 (mouse)			Not determined		7	101693381	135693530	Mouse
1300721	Cfbw3_m	cystic fibrosis body weight 3 (mouse)			Not determined		7	101693381	135693530	Mouse
4142312	Nilac4_m	nicotine induced locomotor activity 4 (mouse)			Not determined		7	102485219	136485380	Mouse
5491192	Mobq1_m	multigenic obesity QTL 1 (mouse)			Not determined		7	105250663	139250811	Mouse
13524852	Asrq7a_m	acoustic startle response 7a (mouse)					7	105350008	139350008	Mouse
14700684	Civq1_m	cerebral infarct volume QTL 1 (mouse)					7	109707335	143707335	Mouse
14700687	Civq5_m	cerebral infarct volume QTL 5 (mouse)					7	109707335	143707335	Mouse
14700688	Civq6_m	cerebral infarct volume QTL 6 (mouse)					7	109707335	143707335	Mouse
11059562	Lmr21b_m	leishmaniasis resistance 21b (mouse)					7	110967235	144967336	Mouse
10402499	Lmr21_m	leishmaniasis resistance 21 (mouse)			Not determined		7	110967235	144967336	Mouse
1302032	Alcp12_m	alcohol preference locus 12 (mouse)			Not determined		7	111166122	144995196	Mouse
1301898	Alcp14_m	alcohol preference locus 14 (mouse)			Not determined		7	111166122	144995196	Mouse
1300670	Sluc19_m	susceptibility to lung cancer 19 (mouse)			Not determined		7	111166122	144995196	Mouse
4142444	Femwf5_m	femur work to failure 5 (mouse)			Not determined			112552248	144995196	Mouse
1300747	Skts2_m	skin tumor susceptibility 2 (mouse)			Not determined		7	112922733	144995196	Mouse
38501072	Stsl7_m	Salmonella typhimurium susceptibility locus 7 (mouse)					7	115699235	128501724	Mouse
1300677	Bmd9_m	bone mineral density 9 (mouse)			Not determined		7	116634089	144995196	Mouse
15092059	Wogrme1_m	week one growth rate, maternal effect 1 (mouse)					7	117199227	134101729	Mouse
11059561	Lmr21a_m	leishmaniasis resistance 21a (mouse)					7	117750722	127967336	Mouse
1357711	Adbg1_m	adult body growth 1 (mouse)			Not determined		7	118693381	144398314	Mouse
1301773	Stheal7_m	soft tissue heal 7 (mouse)			Not determined		7	119132573	144995196	Mouse
1357613	Bsbob2_m	BSB obesity 2 (mouse)			Not determined		7	122250663	128819324	Mouse
1301903	Tlsm1_m	thymic lymphoma susceptible 1 (mouse)			Not determined		7	122250663	135170901	Mouse
4141945	Il4ppq_m	IL-4 producing potential QTL (mouse)			Not determined		7	124513662	128819324	Mouse
1301590	Pbwg3_m	postnatal body weight growth 3 (mouse)			Not determined		7	127311241	144995196	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB271216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC149222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK037138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK136955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK184874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK185889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK193998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK208652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK217284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AM712358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000061587 ⟹ ENSMUSP00000050279

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	127,368,987 - 127,374,322 (+)	Ensembl
GRCm38.p6 Ensembl	7	127,769,815 - 127,775,150 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000118865 ⟹ ENSMUSP00000112382

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	127,368,987 - 127,373,864 (+)	Ensembl
GRCm38.p6 Ensembl	7	127,769,815 - 127,774,692 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000121504 ⟹ ENSMUSP00000113142

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	127,368,987 - 127,374,322 (+)	Ensembl
GRCm38.p6 Ensembl	7	127,769,815 - 127,775,150 (+)	Ensembl

RefSeq Acc Id:

NM_198424 ⟹ NP_940816

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	127,368,987 - 127,374,322 (+)	NCBI
GRCm38	7	127,769,815 - 127,775,150 (+)	NCBI
MGSCv37	7	134,913,329 - 134,918,664 (+)	RGD
Celera	7	127,605,006 - 127,610,345 (+)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

CCAGTTCCTGTTTCGGCCCCTGGGCCTTCTAGACGCGTCCGTAACTGTTCCCGCTGGGTCTGCC
TTGCCACCCAGGATGGGGTCCCACCCGCGCTTGGGCCGTCCCTTCTTGGGGATACAAGGCGCCT
CGGCCCCTCCTTGACCATCTGCGCTTGTGGTGTAACTGCTCTCAGGATGAAGGGCGGCGAGGGG
GACACGGGCGAACAGGCCCCGCTGAACCCGGAGGTGGACAGCCCCGCGGGCTCAGCCACGTACC
GGGAGTTCGTGCACCGCGGCTACCTGGACCTTATGGGGGCCAGTCAGCACTCTCTGCGGGCGCT
CAGCTGGCGCCGCCTCTACCTCAGCCGGGCTAAGCTCAAAGCCTCCAGCCGCACATCTGCTCTG
CTGTCGGGCTTCGCCATGGTGGCCATGGTGGAGGTACAGCTGGAGAACGATCATGAATACCCAC
CAGGCCTGCTGGTGGCATTTAGTGCCTGCACCACTGTGTTAGTAGCTGTGCACCTCTTTGCACT
GATGGTCTCCACATGTCTGCTGCCCCATATTGAAGCCGTGAGCAACATCCACAATCTCAACTCT
GTCCACCAGTCACCACACCAACGACTGCACAGATACGTGGAGCTTGCCTGGGGCTTCTCTACTG
CCTTGGGTACCTTTCTCTTCCTGGCTGAAGTTGTTCTGGTGGGCTGGGTCAAGTTTGTGCCCAT
TGGGGCACCCATGGGTAAACCAGCTCCTGTTGTACCTATGTCCCAGGTGCCACCTGTGACTGTC
TCCCTTAGTTTAGCTTCTAACCTCACACCATCCTCTGCTTCTATTACCACATCACAACAGCCTT
CCAAAGCCTGTCCACCCCGGCAAGTGTGTGATAGTGCTCATGGACCAGGCTGGCAGGCAGCTAT
GGCCTCCACGGCAATCATGGTACCTGTGGGACTAGTGTTTATGGCCTTTGCCCTACATTTCTAC
CGATCCTTGGTTGCCCACAAGACAGACCGCCACAAGCAGGAGCTGGAGGAGCTCAGTCGCCTGC
AGGGGGAGCTGCAGGCTGTGTAAGCCTGGCTTTAGACTGTTGCAAGCATTGCCTCAGAAACCCC
AGGGATCGACAGACCTCCTTCCTTGCCCTAGGCTGGAGCCACCTCCTGTAAGCTCTGAGGTAGA
GGCCAAGTACCTGCCCAGCAGCATCCCACACTCCCAGGGATGATCCCTGTCATCATGTTCTGGT
GGGTTTTGTAAATTCTGCTCTGCTTGGGGAACTGTTTCAGCCTAAGGATCCTGGGTTAAATGAG
AGGAAAGAGGCCCGCCTGCCTTAGTGAGATCCCTGGTGGTGCTGAGCAGTTGTTTGCTCCTCCA
GGAAGGTGACATGTCTGCACAACTGTCCTCAAGGCAATCAGCCCTTGCTTATCTGTATAATCTG
CTTTGCAGTTGGCATCCTGGGAGAGATTTTACAGGGCTCCTCAGATGAGCCACTTCACCCTTGG
TGACTTGTGGTGGTCGTTCCACTGCCCTAGGCACTGACTGTCTGGCCAGAACTGGGAGAGGAGG
AAGTATTGACGAGTGGGAGATTGTGCAGCTACTTGACAAGGGTTGGTGAGTTGGTAAGGGAGAA
GATTCAGCCCTTAGAATGCAGAACTCTTCTTCAGACACTGATTTTTTTTCTTTTGTTTTGTTTT
TCAAGCCAGAGTTTCACTATGTCTGTTGCTCTGGCTGTCCTGGAACACTCTCTGTAGACCAGGC
TGGCCTTGAGCTCAGAGATGTACCTGCCTCTGCCTCCCATGTACAGGGATTAAAGGCATGCACC
ACCACCACCTGACACTGAGTTTTTGATGCACCTTGTTTTGTAAATAAAGTGTGTCTCACATATG
TTCCTATGGCTATGAATGGGATGAAGGTGAAACCTTGGGTATGGTTCTTTGTTCCTAAGGGCCA
GATGGAGGTAATATGCTTGATAGATGGTATGAGTCCATCAGGTGCTGACAAGATCTGATAAACT
TCTGAATGTGGT

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Protein Sequences


Protein RefSeqs	NP_940816	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61259	(Get FASTA)	NCBI Sequence Viewer
	BAE23186	(Get FASTA)	NCBI Sequence Viewer
	BAF47907	(Get FASTA)	NCBI Sequence Viewer
	CAN36429	(Get FASTA)	NCBI Sequence Viewer
	EDL17582	(Get FASTA)	NCBI Sequence Viewer
	EDL17583	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000050279
	ENSMUSP00000050279.7
	ENSMUSP00000112382.2
	ENSMUSP00000113142.2
GenBank Protein	Q6P8G8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_940816 ⟸ NM_198424

- UniProtKB:

Q6P8G8 (UniProtKB/Swiss-Prot), A3KCG3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKGGEGDTGEQAPLNPEVDSPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKAS
SRTSALLSGFAMVAMVEVQLENDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSN
IHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPMGKPAPVVPMSQ
VPPVTVSLSLASNLTPSSASITTSQQPSKACPPRQVCDSAHGPGWQAAMASTAIMVPVGLVFMA
FALHFYRSLVAHKTDRHKQELEELSRLQGELQAV

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RefSeq Acc Id:

ENSMUSP00000112382 ⟸ ENSMUST00000118865

RefSeq Acc Id:

ENSMUSP00000113142 ⟸ ENSMUST00000121504

RefSeq Acc Id:

ENSMUSP00000050279 ⟸ ENSMUST00000061587

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P8G8-F1-model_v2	AlphaFold	Q6P8G8	1-290	view protein structure

Promoters

RGD ID:

8665711

Promoter ID:

EPDNEW_M10886

Type:

initiation region

Name:

Orai3_1

Description:

Mus musculus ORAI calcium release-activated calcium modulator3 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	127,769,817 - 127,769,877	EPDNEW

RGD ID:

6841684

Promoter ID:

MM_KWN:52807

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000118865, ENSMUST00000121504, NM_198424

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	134,912,481 - 134,913,512 (+)	MPROMDB

RGD ID:

6848185

Promoter ID:

MM_ACW:46162

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, MEF_B6

Transcripts:

ORAI3.ESEP07-UNSPLICED

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	134,914,739 - 134,915,239 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:3039586	AgrOrtholog
Ensembl Genes	ENSMUSG00000043964	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000061587	ENTREZGENE
	ENSMUST00000061587.13	UniProtKB/Swiss-Prot
	ENSMUST00000118865.8	UniProtKB/TrEMBL
	ENSMUST00000121504.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.140.140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CRAC_channel	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Orai_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:269999	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:3039586	ENTREZGENE
NCBI Gene	269999	ENTREZGENE
PANTHER	PTHR31501	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR31501:SF6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Orai-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Orai3	PhenoGen
UniProt	A3KCG3	ENTREZGENE, UniProtKB/TrEMBL
	D3YX58_MOUSE	UniProtKB/TrEMBL
	D3Z6X8_MOUSE	UniProtKB/TrEMBL
	ORAI3_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

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