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Gene: Rfc1 (replication factor C (activator 1) 1) Mus musculus
Symbol: Rfc1
Name: replication factor C (activator 1) 1
Description: ENCODES a protein that exhibits DNA clamp unloader activity (ortholog); double-stranded DNA binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN DNA clamp unloading (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); negative regulation of transcription, DNA-templated (ortholog); PARTICIPATES IN FasL mediated signaling pathway; mismatch repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH Bilateral Vestibulopathy (ortholog); cerebellar ataxia (ortholog); CEREBELLAR ATAXIA, NEUROPATHY, AND VESTIBULAR AREFLEXIA SYNDROME (ortholog); FOUND IN nucleus; cytoplasm (ortholog); DNA replication factor C complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 140kDa; A1 140 kDa subunit; A1-P145; activator 1 140 kDa subunit; activator 1 large subunit; activator 1 subunit 1; Alp145; differentiation-specific element-binding protein; ISRE-binding protein; MGC96526; Recc1; replication factor C 1; replication factor C 140 kDa subunit; replication factor C large subunit; replication factor C subunit 1; replication factor C, 140 kDa; RF-C 140 kDa subunit; RFC140
Homo sapiens (human) : RFC1 (replication factor C subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rfc1 (replication factor C subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rfc1 (replication factor C subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RFC1 (replication factor C subunit 1)
Canis lupus familiaris (dog) : RFC1 (replication factor C subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfc1 (replication factor C subunit 1)
Sus scrofa (pig) : RFC1 (replication factor C subunit 1)
more info ...
Related Pseudogenes: Gm18719  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38565,261,852 - 65,338,617 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37565,653,091 - 65,726,878 (-)NCBIGRCm37mm9NCBIm37
MGSCv36565,540,993 - 65,614,740 (-)NCBImm8
Celera562,539,065 - 62,612,753 (-)NCBICelera
Cytogenetic Map5 C3.1NCBI
cM Map533.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rfc1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550066
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.