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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732911
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin dependent kinase inhibitor 1A
Acc ID: CHEBI:27882
Term: (S)-colchicine
Definition: A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.
Chemical ID: MESH:D003078
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDColchicine results in decreased expression of CDKN1A mRNAPMID:24211769
Cdkn1aincreases expressionISOCdkn1a (Rattus norvegicus)6480464CTDColchicine results in increased expression of CDKN1A mRNAPMID:20624997
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDColchicine results in increased expression of CDKN1A proteinPMID:27358234
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