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Gene: Lhx2 (LIM homeobox protein 2) Mus musculus
Symbol: Lhx2
Name: LIM homeobox protein 2
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including maintenance of epithelial cell apical/basal polarity; nervous system development; and regulation of gene expression. Localizes to nucleus. Is expressed in several structures, including branchial arch; limb; nervous system; sensory organ; and septum transversum. Orthologous to human LHX2 (LIM homeobox 2); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ap; apterous; homeobox protein LH-2; Lh-2; LH2A; LIM homeo box protein 2; LIM/homeobox protein Lhx2; Lim2
Homo sapiens (human) : LHX2 (LIM homeobox 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lhx2 (LIM homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lhx2 (LIM homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LHX2 (LIM homeobox 2)
Canis lupus familiaris (dog) : LHX2 (LIM homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lhx2 (LIM homeobox 2)
Sus scrofa (pig) : LHX2 (LIM homeobox 2)
Chlorocebus sabaeus (African green monkey) : LHX2 (LIM homeobox 2)
Heterocephalus glaber (naked mole-rat) : Lhx2 (LIM homeobox 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl238,339,281 - 38,369,733 (+)EnsemblGRCm38mm10GRCm38
GRCm38238,339,271 - 38,369,737 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37238,206,828 - 38,225,248 (+)NCBIGRCm37mm9NCBIm37
MGSCv36238,173,317 - 38,191,737 (+)NCBImm8
Celera240,107,977 - 40,108,866 (+)NCBICelera
Cytogenetic Map2BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lhx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733850
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.