Lhx2 (LIM homeobox protein 2) - Rat Genome Database

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Gene: Lhx2 (LIM homeobox protein 2) Mus musculus
Analyze
Symbol: Lhx2
Name: LIM homeobox protein 2
RGD ID: 733850
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including nervous system development; positive regulation of neural precursor cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including hair follicle development; maintenance of epithelial cell apical/basal polarity; and nervous system development. Located in nucleus. Is expressed in several structures, including branchial arch; future brain; limb primordium; nervous system; and sensory organ. Orthologous to human LHX2 (LIM homeobox 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ap; apt; apterous; homeobox protein LH-2; LH; Lh-; Lh-2; LH2A; LIM homeo box protein 2; LIM/homeobox protein Lhx2; Lim2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,229,282 - 38,259,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,229,293 - 38,259,745 (+)EnsemblGRCm39 Ensembl
GRCm38238,339,271 - 38,369,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,339,281 - 38,369,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,206,828 - 38,225,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,173,317 - 38,191,737 (+)NCBIMGSCv36mm8
Celera240,107,977 - 40,108,866 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
amosite asbestos  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
dexamethasone  (ISO)
diclofenac  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
flusilazole  (EXP)
fulvestrant  (ISO)
glyphosate  (ISO)
hydroxyurea  (ISO)
imidacloprid  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (TAS)
nucleus  (IBA,IDA,IMP)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Porter FD, etal., Development 1997 Aug;124(15):2935-44.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Xu Y, etal., Proc Natl Acad Sci U S A 1993 Jan 1;90(1):227-31.
Additional References at PubMed
PMID:7513049   PMID:8565076   PMID:8817562   PMID:8872459   PMID:9078439   PMID:9192866   PMID:9230312   PMID:9247261   PMID:9315901   PMID:9449674   PMID:9697309   PMID:9808626  
PMID:9876181   PMID:9880598   PMID:10021340   PMID:10049573   PMID:10051612   PMID:10325223   PMID:10330499   PMID:10349636   PMID:10399918   PMID:10431247   PMID:10433919   PMID:10482234  
PMID:10518547   PMID:10593900   PMID:10594069   PMID:10693795   PMID:10693804   PMID:11003833   PMID:11042159   PMID:11071781   PMID:11076861   PMID:11091089   PMID:11124115   PMID:11165475  
PMID:11217851   PMID:11306624   PMID:11395003   PMID:11502253   PMID:11502254   PMID:11641222   PMID:11719201   PMID:11877374   PMID:11934853   PMID:11944941   PMID:12010792   PMID:12023301  
PMID:12062038   PMID:12091317   PMID:12118260   PMID:12351192   PMID:12354394   PMID:12397111   PMID:12466851   PMID:12477932   PMID:12561075   PMID:12619132   PMID:12642482   PMID:12717732  
PMID:12724834   PMID:12741987   PMID:12895419   PMID:12925582   PMID:14566948   PMID:14610273   PMID:14627641   PMID:14681479   PMID:14687986   PMID:14758363   PMID:14960494   PMID:15053981  
PMID:15147765   PMID:15173589   PMID:15183721   PMID:15226823   PMID:15229646   PMID:15261829   PMID:15294144   PMID:15295034   PMID:15385160   PMID:15456728   PMID:15469980   PMID:15489334  
PMID:15496443   PMID:15536133   PMID:15618518   PMID:15691760   PMID:15758185   PMID:15769945   PMID:15858069   PMID:15917450   PMID:16141072   PMID:16141073   PMID:16226707   PMID:16234809  
PMID:16284245   PMID:16527264   PMID:16597514   PMID:16600034   PMID:16602821   PMID:16790481   PMID:16809539   PMID:16818446   PMID:16855091   PMID:16957084   PMID:17086203   PMID:17122047  
PMID:17329426   PMID:17350283   PMID:17470284   PMID:17475798   PMID:17493606   PMID:17694053   PMID:17804629   PMID:17880938   PMID:17913911   PMID:17914453   PMID:17953485   PMID:17991461  
PMID:18076286   PMID:18094027   PMID:18184563   PMID:18202285   PMID:18243104   PMID:18270576   PMID:18272594   PMID:18287559   PMID:18431502   PMID:18547559   PMID:18565323   PMID:18577233  
PMID:18579678   PMID:18590716   PMID:18593557   PMID:18701067   PMID:18854508   PMID:18940588   PMID:19020026   PMID:19027001   PMID:19029045   PMID:19030180   PMID:19036983   PMID:19088088  
PMID:19109910   PMID:19135992   PMID:19146846   PMID:19244520   PMID:19304889   PMID:19386638   PMID:19542352   PMID:19571125   PMID:19668217   PMID:19718027   PMID:19741146   PMID:19820705  
PMID:19887680   PMID:19900438   PMID:19906857   PMID:19923199   PMID:20025935   PMID:20059953   PMID:20080794   PMID:20081193   PMID:20206242   PMID:20211142   PMID:20364121   PMID:20386748  
PMID:20392740   PMID:20436479   PMID:20498066   PMID:20503368   PMID:20599664   PMID:20599893   PMID:20610746   PMID:20696379   PMID:20808958   PMID:20890044   PMID:20943929   PMID:20960561  
PMID:21060110   PMID:21060113   PMID:21192082   PMID:21262812   PMID:21267068   PMID:21302255   PMID:21307096   PMID:21343610   PMID:21490064   PMID:21525287   PMID:21539826   PMID:21558380  
PMID:21690374   PMID:21731673   PMID:21857657   PMID:21862448   PMID:21873635   PMID:21886788   PMID:21940705   PMID:21991391   PMID:22028024   PMID:22077982   PMID:22115758   PMID:22159578  
PMID:22174793   PMID:22307612   PMID:22371696   PMID:22393024   PMID:22457488   PMID:22492355   PMID:22581782   PMID:22609550   PMID:22658483   PMID:22689450   PMID:22734700   PMID:22745311  
PMID:22923088   PMID:22984456   PMID:22988430   PMID:23024056   PMID:23036195   PMID:23112163   PMID:23136391   PMID:23178882   PMID:23193182   PMID:23223288   PMID:23250207   PMID:23271346  
PMID:23300826   PMID:23307637   PMID:23454273   PMID:23575831   PMID:23595746   PMID:23638021   PMID:23648511   PMID:23674600   PMID:23863479   PMID:23884928   PMID:23922318   PMID:24012369  
PMID:24014668   PMID:24128663   PMID:24146773   PMID:24148613   PMID:24154525   PMID:24262147   PMID:24324671   PMID:24333658   PMID:24360543   PMID:24376126   PMID:24403153   PMID:24423492  
PMID:24463367   PMID:24523460   PMID:24553291   PMID:24643061   PMID:24705356   PMID:24715462   PMID:24781987   PMID:24902903   PMID:24906954   PMID:24948604   PMID:24952961   PMID:24982158  
PMID:24995995   PMID:25460335   PMID:25505333   PMID:25631876   PMID:25794677   PMID:25916825   PMID:25927996   PMID:25971728   PMID:25989023   PMID:26013465   PMID:26176759   PMID:26204903  
PMID:26311466   PMID:26339946   PMID:26371318   PMID:26527010   PMID:26661907   PMID:26671461   PMID:26721689   PMID:26795843   PMID:26814967   PMID:26830346   PMID:26911688   PMID:26952977  
PMID:26988119   PMID:26992132   PMID:27117402   PMID:27178193   PMID:27349434   PMID:27384060   PMID:27521061   PMID:27605455   PMID:27611684   PMID:27633990   PMID:27655933   PMID:27697904  
PMID:27822500   PMID:27871306   PMID:27957530   PMID:28031177   PMID:28053041   PMID:28122236   PMID:28219675   PMID:28467430   PMID:28579317   PMID:28625870   PMID:28885142   PMID:28933695  
PMID:29025924   PMID:29137925   PMID:29141678   PMID:29229772   PMID:29361558   PMID:29420689   PMID:29485116   PMID:29513653   PMID:29650591   PMID:29867344   PMID:29899403   PMID:30084950  
PMID:30127719   PMID:30329130   PMID:30470704   PMID:30470893   PMID:30485816   PMID:30509557   PMID:30529950   PMID:30626972   PMID:30638933   PMID:30692221   PMID:30843071   PMID:30846445  
PMID:30872278   PMID:30873428   PMID:30884041   PMID:31044167   PMID:31152445   PMID:31475747   PMID:31708105   PMID:31758234   PMID:31814023   PMID:31825820   PMID:31845732   PMID:32049024  
PMID:32169553   PMID:32471461   PMID:32571845   PMID:32701653   PMID:32737167   PMID:32737294   PMID:32840212   PMID:32845239   PMID:32950463   PMID:32994168   PMID:33238113   PMID:33302058  
PMID:33492553   PMID:33500475   PMID:33723039   PMID:33863910   PMID:33933312   PMID:34011608   PMID:34040115   PMID:34108685   PMID:34193558   PMID:34287339   PMID:34321999   PMID:34432485  
PMID:34616069   PMID:34718219   PMID:34822715   PMID:34906895   PMID:34921112   PMID:34994686   PMID:35179492   PMID:35247020   PMID:35337816   PMID:35377797   PMID:35501157   PMID:35762573  
PMID:35942939   PMID:35951005   PMID:36007540   PMID:36070393   PMID:36074819   PMID:36198802   PMID:36263009   PMID:36395107   PMID:36459481   PMID:36476860   PMID:36537580   PMID:36630508  
PMID:36649236   PMID:36737666   PMID:36796745   PMID:36924502   PMID:37048108   PMID:37071993   PMID:37073980   PMID:37125418   PMID:37139782   PMID:37298722   PMID:37348506   PMID:37435631  
PMID:37524711   PMID:37594984   PMID:38159590   PMID:38488687   PMID:38729157   PMID:39157903   PMID:39348458   PMID:39351282   PMID:39362030   PMID:39413781   PMID:39547237  


Genomics

Comparative Map Data
Lhx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,229,282 - 38,259,747 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,229,293 - 38,259,745 (+)EnsemblGRCm39 Ensembl
GRCm38238,339,271 - 38,369,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,339,281 - 38,369,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,206,828 - 38,225,248 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,173,317 - 38,191,737 (+)NCBIMGSCv36mm8
Celera240,107,977 - 40,108,866 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.31NCBI
LHX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,011,768 - 124,033,301 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,001,670 - 124,033,301 (+)EnsemblGRCh38hg38GRCh38
GRCh379126,774,047 - 126,795,580 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,813,710 - 125,835,263 (+)NCBINCBI36Build 36hg18NCBI36
Build 349123,853,442 - 123,874,996NCBI
Celera997,421,143 - 97,442,696 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,387,559 - 96,409,113 (+)NCBIHuRef
CHM1_19126,922,665 - 126,944,218 (+)NCBICHM1_1
T2T-CHM13v2.09136,209,686 - 136,231,219 (+)NCBIT2T-CHM13v2.0
Lhx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,523,345 - 42,553,646 (+)NCBIGRCr8
mRatBN7.2322,113,619 - 22,143,909 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,126,007 - 22,143,908 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,594,877 - 25,612,777 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,179,870 - 34,197,771 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,991,800 - 32,009,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,628,674 - 22,658,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,640,545 - 22,658,446 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,870,008 - 27,887,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,129,455 - 18,147,357 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,025,179 - 18,043,730 (+)NCBI
Celera320,559,471 - 20,577,366 (+)NCBICelera
Cytogenetic Map3q12NCBI
Lhx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,998,242 - 4,018,875 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,999,364 - 4,019,543 (-)NCBIChiLan1.0ChiLan1.0
LHX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,322,198 - 15,343,933 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,324,546 - 15,346,290 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,132,445 - 95,154,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,655,845 - 123,676,803 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,655,845 - 123,676,796 (+)Ensemblpanpan1.1panPan2
LHX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,825,505 - 58,859,311 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,825,492 - 58,845,883 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha958,022,250 - 58,042,687 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0959,745,814 - 59,766,310 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,745,801 - 59,766,240 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1958,502,870 - 58,523,325 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,819,702 - 58,840,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,910,400 - 58,930,871 (-)NCBIUU_Cfam_GSD_1.0
Lhx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,627,290 - 192,645,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,395,812 - 12,414,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,395,817 - 12,413,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1264,900,591 - 264,920,890 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11264,900,931 - 264,920,888 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21298,708,264 - 298,728,222 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LHX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11214,110,122 - 14,133,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1214,110,068 - 14,132,026 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660791,939,043 - 1,961,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476010,951,837 - 10,982,592 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lhx2
1158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1173
Count of miRNA genes:590
Interacting mature miRNAs:724
Transcripts:ENSMUST00000000253, ENSMUST00000133661, ENSMUST00000143783, ENSMUST00000149664, ENSMUST00000155964, ENSMUST00000175896, ENSMUST00000176229
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse

Markers in Region
Lhx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2BUniSTS
cM Map2 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF124734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB674460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX813320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000253   ⟹   ENSMUSP00000000253
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,240,771 - 38,259,745 (+)Ensembl
GRCm38.p6 Ensembl238,350,759 - 38,369,733 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133661   ⟹   ENSMUSP00000115179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,231,104 - 38,244,837 (+)Ensembl
GRCm38.p6 Ensembl238,341,092 - 38,354,825 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143783   ⟹   ENSMUSP00000114797
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,229,293 - 38,259,211 (+)Ensembl
GRCm38.p6 Ensembl238,339,281 - 38,369,199 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149664
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,229,500 - 38,243,705 (+)Ensembl
GRCm38.p6 Ensembl238,339,488 - 38,353,693 (+)Ensembl
Ensembl Acc Id: ENSMUST00000155964   ⟹   ENSMUSP00000121462
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,242,544 - 38,244,585 (+)Ensembl
GRCm38.p6 Ensembl238,352,532 - 38,354,573 (+)Ensembl
Ensembl Acc Id: ENSMUST00000175896
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,243,814 - 38,250,101 (+)Ensembl
GRCm38.p6 Ensembl238,353,802 - 38,360,089 (+)Ensembl
Ensembl Acc Id: ENSMUST00000176229   ⟹   ENSMUSP00000135402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl238,241,780 - 38,244,643 (+)Ensembl
GRCm38.p6 Ensembl238,351,768 - 38,354,631 (+)Ensembl
RefSeq Acc Id: NM_001290646   ⟹   NP_001277575
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,229,282 - 38,259,747 (+)NCBI
GRCm38238,339,281 - 38,369,737 (+)NCBI
Celera240,107,977 - 40,108,875 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001420354   ⟹   NP_001407283
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,241,243 - 38,259,747 (+)NCBI
RefSeq Acc Id: NM_001420355   ⟹   NP_001407284
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,229,282 - 38,259,747 (+)NCBI
RefSeq Acc Id: NM_001420356   ⟹   NP_001407285
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,231,086 - 38,259,747 (+)NCBI
RefSeq Acc Id: NM_001420357   ⟹   NP_001407286
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,241,958 - 38,259,747 (+)NCBI
RefSeq Acc Id: NM_001420359   ⟹   NP_001407288
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,229,282 - 38,259,747 (+)NCBI
RefSeq Acc Id: NM_010710   ⟹   NP_034840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,241,243 - 38,259,747 (+)NCBI
GRCm38238,351,308 - 38,369,737 (+)NCBI
MGSCv37238,206,828 - 38,225,248 (+)RGD
Celera240,107,977 - 40,108,875 (+)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497735   ⟹   XP_006497798
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,231,075 - 38,259,747 (+)NCBI
GRCm38238,341,062 - 38,369,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006497736   ⟹   XP_006497799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39238,240,776 - 38,259,747 (+)NCBI
GRCm38238,351,898 - 38,369,736 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034840   ⟸   NM_010710
- Peptide Label: isoform a
- UniProtKB: Q9Z0S2 (UniProtKB/Swiss-Prot),   Q543C6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497798   ⟸   XM_006497735
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006497799   ⟸   XM_006497736
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001277575   ⟸   NM_001290646
- Peptide Label: isoform b
- UniProtKB: F6Z9H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000114797   ⟸   ENSMUST00000143783
Ensembl Acc Id: ENSMUSP00000000253   ⟸   ENSMUST00000000253
Ensembl Acc Id: ENSMUSP00000115179   ⟸   ENSMUST00000133661
Ensembl Acc Id: ENSMUSP00000135402   ⟸   ENSMUST00000176229
Ensembl Acc Id: ENSMUSP00000121462   ⟸   ENSMUST00000155964
RefSeq Acc Id: NP_001407284   ⟸   NM_001420355
- Peptide Label: isoform d
RefSeq Acc Id: NP_001407288   ⟸   NM_001420359
- Peptide Label: isoform e
RefSeq Acc Id: NP_001407285   ⟸   NM_001420356
- Peptide Label: isoform b
- UniProtKB: F6Z9H5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001407283   ⟸   NM_001420354
- Peptide Label: isoform c
RefSeq Acc Id: NP_001407286   ⟸   NM_001420357
- Peptide Label: isoform b
- UniProtKB: F6Z9H5 (UniProtKB/TrEMBL)
Protein Domains
Homeobox   LIM zinc-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0S2-F1-model_v2 AlphaFold Q9Z0S2 1-406 view protein structure

Promoters
RGD ID:6831691
Promoter ID:MM_KWN:29008
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Lung
Transcripts:OTTMUST00000030849
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36238,206,311 - 38,207,227 (+)MPROMDB
RGD ID:6877200
Promoter ID:EPDNEW_M2051
Type:single initiation site
Name:Lhx2_2
Description:Mus musculus LIM homeobox protein 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2052  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38238,351,068 - 38,351,128EPDNEW
RGD ID:6877202
Promoter ID:EPDNEW_M2052
Type:multiple initiation site
Name:Lhx2_1
Description:Mus musculus LIM homeobox protein 2 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2051  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38238,351,231 - 38,351,291EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96785 AgrOrtholog
Ensembl Genes ENSMUSG00000000247 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000253 ENTREZGENE
  ENSMUST00000000253.6 UniProtKB/Swiss-Prot
  ENSMUST00000133661.8 UniProtKB/TrEMBL
  ENSMUST00000143783 ENTREZGENE
  ENSMUST00000143783.9 UniProtKB/TrEMBL
  ENSMUST00000155964.3 UniProtKB/TrEMBL
  ENSMUST00000176229.2 UniProtKB/TrEMBL
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_Homeobox_TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96785 ENTREZGENE
NCBI Gene 16870 ENTREZGENE
PANTHER LIM/HOMEOBOX PROTEIN LHX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM/HOMEOBOX PROTEIN LHX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lhx2 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MQK9_MOUSE UniProtKB/TrEMBL
  F6SM03_MOUSE UniProtKB/TrEMBL
  F6Z9H5 ENTREZGENE, UniProtKB/TrEMBL
  H3BKI3_MOUSE UniProtKB/TrEMBL
  LHX2_MOUSE UniProtKB/Swiss-Prot
  Q543C6 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z0S2 ENTREZGENE