Msh6 (mutS homolog 6) - Rat Genome Database

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Gene: Msh6 (mutS homolog 6) Mus musculus
Analyze
Symbol: Msh6
Name: mutS homolog 6
RGD ID: 1321739
MGI Page MGI
Description: Enables chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU044881; AW550279; DNA mismatch repair protein Msh6; g/T mismatch-binding protein; GTB; GTBP; Gtmb; Gtmbp; Msh; mutS protein homolog 6; mutS-alpha 160 kDa subunit; p160
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm11855  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,282,478 - 88,298,320 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,282,490 - 88,298,320 (+)EnsemblGRCm39 Ensembl
GRCm381787,975,050 - 87,990,892 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,975,062 - 87,990,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,374,390 - 88,390,232 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,883,410 - 87,899,389 (+)NCBIMGSCv36mm8
Celera1792,385,348 - 92,401,193 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ataxia telangiectasia  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2B  (ISO)
autosomal recessive progressive external ophthalmoplegia 1  (ISO)
B-lymphoblastic leukemia/lymphoma with BCR-ABL1  (ISO)
bilateral breast cancer  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
CEREBELLAR ATAXIA INFANTILE WITH PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA  (ISO)
cerebellar medulloblastoma  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Digestive System Neoplasms  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
endometrial serous adenocarcinoma  (ISO)
Familial Prostate Cancer  (ISO)
Gaucher's disease  (ISO)
Gaucher's disease type I  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
hepatoblastoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hereditary nonpolyposis colorectal cancer type 4  (ISO)
hereditary nonpolyposis colorectal cancer type 5  (ISO)
INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES  (ISO)
lung adenocarcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
Lynch syndrome  (ISO)
Lynch syndrome 1  (ISO)
Microsatellite Instability  (ISO)
mismatch repair cancer syndrome  (ISO)
Mismatch Repair Cancer Syndrome 1  (ISO)
Mismatch Repair Cancer Syndrome 3  (ISO)
Neurodevelopmental Disorders  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Pitt-Hopkins-like syndrome 2  (ISO)
progressive myoclonus epilepsy 5  (ISO)
prostate cancer  (ISO)
rhabdomyosarcoma  (ISO)
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  (ISO)
sigmoid colon cancer  (ISO)
sigmoid neoplasm  (ISO)
stomach cancer  (ISO)
Thyroid Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urogenital Neoplasms  (ISO)
uterine corpus cancer  (ISO)
xeroderma pigmentosum group D  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carboplatin  (ISO)
celastrol  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
SB 431542  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
2. The expression of mismatched repair genes and their correlation with clinicopathological parameters and response to neo-adjuvant chemotherapy in breast cancer. Chintamani, etal., Int Semin Surg Oncol. 2007 Feb 14;4:5.
3. DNA mismatch repair defects: role in colorectal carcinogenesis. Jacob S and Praz F, Biochimie. 2002 Jan;84(1):27-47.
4. Expression of MSH2 and MSH6 on a tissue microarray in patients with osteosarcoma. Jentzsch T, etal., Anticancer Res. 2014 Dec;34(12):6961-72.
5. Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis. Karihtala P, etal., Eur J Cancer. 2006 Oct;42(15):2653-9. Epub 2006 Sep 22.
6. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
7. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
8. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
9. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Mongiat-Artus P, etal., Oncogene. 2006 Mar 30;25(14):2113-8.
13. Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder. Mylona E, etal., APMIS. 2008 Jan;116(1):59-65.
14. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Mutations of GTBP in genetically unstable cells. Papadopoulos N, etal., Science. 1995 Jun 30;268(5219):1915-7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer. Rey JM, etal., Cancer Genet Cytogenet. 2004 Dec;155(2):149-51.
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. van Boxtel R, etal., Carcinogenesis. 2008 Apr 15;.
23. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Yin J, etal., Hum Mutat. 1997;10(6):474-8.
Additional References at PubMed
PMID:8812455   PMID:8870641   PMID:9354786   PMID:9390556   PMID:9823302   PMID:10349636   PMID:10545954   PMID:10662804   PMID:10706084   PMID:10809667   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11223406   PMID:11691815   PMID:11809728   PMID:12370835   PMID:12477932   PMID:12520002   PMID:12612914   PMID:12904583   PMID:14610273   PMID:14632208   PMID:15166087  
PMID:15208683   PMID:15238604   PMID:15238605   PMID:15324697   PMID:15805259   PMID:16141072   PMID:16141073   PMID:16260499   PMID:16552576   PMID:16618598   PMID:16713580   PMID:16728433  
PMID:17015724   PMID:17142234   PMID:17615258   PMID:18413732   PMID:18538799   PMID:18799693   PMID:19029948   PMID:19124772   PMID:20362541   PMID:20362542   PMID:20412781   PMID:20567595  
PMID:20691478   PMID:20934970   PMID:21267068   PMID:21533166   PMID:21589869   PMID:21731673   PMID:21804017   PMID:21873635   PMID:22083510   PMID:22289650   PMID:22922362   PMID:23071719  
PMID:23603115   PMID:23892456   PMID:24013230   PMID:24040339   PMID:24457600   PMID:25737280   PMID:26206133   PMID:26365490   PMID:26590968   PMID:27427765   PMID:27441645   PMID:27886214  
PMID:28378742   PMID:30665938   PMID:31077711   PMID:32325033   PMID:33181035  


Genomics

Comparative Map Data
Msh6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391788,282,478 - 88,298,320 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1788,282,490 - 88,298,320 (+)EnsemblGRCm39 Ensembl
GRCm381787,975,050 - 87,990,892 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1787,975,062 - 87,990,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv371788,374,390 - 88,390,232 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361787,883,410 - 87,899,389 (+)NCBIMGSCv36mm8
Celera1792,385,348 - 92,401,193 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1757.87NCBI
MSH6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38247,783,145 - 47,810,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl247,695,530 - 47,810,063 (+)EnsemblGRCh38hg38GRCh38
GRCh37248,010,284 - 48,037,240 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36247,863,725 - 47,887,596 (+)NCBINCBI36Build 36hg18NCBI36
Build 34247,921,936 - 47,945,743NCBI
Celera247,849,755 - 47,873,614 (+)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef247,746,516 - 47,770,575 (+)NCBIHuRef
CHM1_1247,940,665 - 47,964,487 (+)NCBICHM1_1
T2T-CHM13v2.0247,789,083 - 47,816,050 (+)NCBIT2T-CHM13v2.0
Msh6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8612,316,190 - 12,333,505 (-)NCBIGRCr8
mRatBN7.266,562,631 - 6,579,995 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl66,562,632 - 6,579,956 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx66,844,774 - 6,862,085 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.067,154,179 - 7,171,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.066,681,324 - 6,698,635 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0611,644,565 - 11,662,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,644,578 - 11,662,499 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,616,672 - 21,634,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,525,292 - 11,542,592 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera66,326,162 - 6,343,370 (-)NCBICelera
Cytogenetic Map6q12NCBI
Msh6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544114,451,307 - 14,471,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544114,451,207 - 14,471,316 (+)NCBIChiLan1.0ChiLan1.0
MSH6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21278,578,235 - 78,603,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A78,582,203 - 78,607,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A47,901,591 - 47,926,662 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A48,824,469 - 48,849,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A48,824,350 - 48,849,779 (+)Ensemblpanpan1.1panPan2
MSH6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11049,825,330 - 49,838,036 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1049,803,898 - 49,838,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1049,669,446 - 49,693,588 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01050,687,723 - 50,711,873 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1050,687,741 - 50,711,873 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11050,394,939 - 50,419,090 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01050,681,795 - 50,705,920 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01050,869,560 - 50,893,685 (+)NCBIUU_Cfam_GSD_1.0
Msh6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629233,280,052 - 33,300,065 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365084,708,661 - 4,728,787 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365084,708,661 - 4,728,671 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl392,785,664 - 92,814,238 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1392,792,590 - 92,814,154 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2398,710,956 - 98,732,503 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSH6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11459,375,602 - 59,400,252 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1459,375,691 - 59,400,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604552,443,508 - 52,468,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msh6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,083,692 - 29,108,792 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473829,083,696 - 29,108,792 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Msh6
685 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSMUST00000005503
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
AW550279  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,990,227 - 87,990,340UniSTSGRCm38
MGSCv371788,389,567 - 88,389,680UniSTSGRCm37
Celera1792,400,528 - 92,400,641UniSTS
Cytogenetic Map17E4UniSTS
cM Map1747.0UniSTS
Whitehead/MRC_RH171098.04UniSTS
AU044881  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,990,428 - 87,990,801UniSTSGRCm38
MGSCv371788,389,768 - 88,390,141UniSTSGRCm37
Celera1792,400,729 - 92,401,102UniSTS
Cytogenetic Map17E4UniSTS
cM Map1747.0UniSTS
cM Map1750.0UniSTS
Whitehead/MRC_RH171095.95UniSTS
UniSTS:237725  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,986,581 - 87,986,783UniSTSGRCm38
MGSCv371788,385,921 - 88,386,123UniSTSGRCm37
Celera1792,396,882 - 92,397,084UniSTS
Cytogenetic Map17E4UniSTS
cM Map1747.0UniSTS
RH140511  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,991,119 - 87,991,298UniSTSGRCm38
MGSCv371788,390,459 - 88,390,638UniSTSGRCm37
Celera1792,401,420 - 92,401,599UniSTS
Cytogenetic Map17E4UniSTS
cM Map1750.0UniSTS
cM Map1747.0UniSTS
RH126790  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,990,881 - 87,991,098UniSTSGRCm38
MGSCv371788,390,221 - 88,390,438UniSTSGRCm37
Celera1792,401,182 - 92,401,399UniSTS
Cytogenetic Map17E4UniSTS
cM Map1747.0UniSTS
cM Map1750.0UniSTS
Whitehead/MRC_RH171092.91UniSTS
Gtmbp-rs  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,984,659 - 87,984,830UniSTSGRCm38
MGSCv371788,383,999 - 88,384,170UniSTSGRCm37
Celera1792,394,960 - 92,395,131UniSTS
Cytogenetic Map17E4UniSTS
cM Map45.4UniSTS
RH127753  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381787,989,463 - 87,990,347UniSTSGRCm38
MGSCv371788,388,803 - 88,389,687UniSTSGRCm37
Celera1792,399,764 - 92,400,648UniSTS
Cytogenetic Map17E4UniSTS
cM Map1747.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000005503   ⟹   ENSMUSP00000005503
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1788,282,490 - 88,298,320 (+)Ensembl
GRCm38.p6 Ensembl1787,975,062 - 87,990,892 (+)Ensembl
Ensembl Acc Id: ENSMUST00000234756   ⟹   ENSMUSP00000157173
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1788,287,131 - 88,291,986 (+)Ensembl
GRCm38.p6 Ensembl1787,979,703 - 87,984,558 (+)Ensembl
Ensembl Acc Id: ENSMUST00000234936
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1788,282,523 - 88,292,207 (+)Ensembl
GRCm38.p6 Ensembl1787,975,095 - 87,984,779 (+)Ensembl
RefSeq Acc Id: NM_010830   ⟹   NP_034960
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391788,282,478 - 88,298,320 (+)NCBI
GRCm381787,975,050 - 87,990,892 (+)ENTREZGENE
MGSCv371788,374,390 - 88,390,232 (+)RGD
Celera1792,385,348 - 92,401,193 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034960   ⟸   NM_010830
- UniProtKB: O54710 (UniProtKB/Swiss-Prot),   Q6GTK8 (UniProtKB/Swiss-Prot),   P54276 (UniProtKB/Swiss-Prot),   Q8C2N9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000005503   ⟸   ENSMUST00000005503
Ensembl Acc Id: ENSMUSP00000157173   ⟸   ENSMUST00000234756
Protein Domains
DNA mismatch repair proteins mutS family   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54276-F1-model_v2 AlphaFold P54276 1-1358 view protein structure

Promoters
RGD ID:13676964
Promoter ID:EPDNEW_M22631
Type:initiation region
Name:Msh6_1
Description:Mus musculus mutS homolog 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381787,975,062 - 87,975,122EPDNEW
RGD ID:6828389
Promoter ID:MM_KWN:24410
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000005503,   XM_917266_GM6720
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361788,374,096 - 88,374,596 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1343961 AgrOrtholog
Ensembl Genes ENSMUSG00000005370 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005503 ENTREZGENE
  ENSMUST00000005503.5 UniProtKB/Swiss-Prot
  ENSMUST00000234756.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.30.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS-lik_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS/MSH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_clamp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_family UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PWWP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZCWPW1/ZCWPW2 UniProtKB/TrEMBL
KEGG Report mmu:17688 UniProtKB/Swiss-Prot
MGD MGI:1343961 ENTREZGENE
NCBI Gene 17688 ENTREZGENE
PANTHER DNA MISMATCH REPAIR PROTEIN MSH6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15999 UniProtKB/TrEMBL
  ZINC FINGER CW-TYPE PWWP DOMAIN PROTEIN 1 UniProtKB/TrEMBL
Pfam MutS_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MutS_V UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PWWP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MSH6 RGD
PhenoGen Msh6 PhenoGen
PIRSF DNA_mis_repair_Msh6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PWWP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MUTSac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MUTSd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PWWP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tudor/PWWP/MBT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EGF1_MOUSE UniProtKB/TrEMBL
  MSH6_MOUSE UniProtKB/Swiss-Prot
  O54710 ENTREZGENE
  P54276 ENTREZGENE
  Q61061_MOUSE UniProtKB/TrEMBL
  Q6GTK8 ENTREZGENE
  Q8C2N9 ENTREZGENE, UniProtKB/TrEMBL
  Q9CRH0_MOUSE UniProtKB/TrEMBL
UniProt Secondary O54710 UniProtKB/Swiss-Prot
  Q6GTK8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Msh6  mutS homolog 6    mutS homolog 6 (E. coli)  Symbol and/or name change 5135510 APPROVED