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Gene: Cln8 (CLN8 transmembrane ER and ERGIC protein) Mus musculus
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Symbol: Cln8
Name: CLN8 transmembrane ER and ERGIC protein
Description: Predicted to have ceramide binding activity. Involved in several processes, including adult walking behavior; glutamate reuptake; and neurofilament cytoskeleton organization. Localizes to endoplasmic reticulum. Is expressed in several structures, including adrenal gland; gonad; hemolymphoid system gland; nervous system; and retina. Used to study neuronal ceroid lipofuscinosis 8. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 8 and neuronal ceroid lipofuscinosis 8 northern epilepsy variant. Orthologous to human CLN8 (CLN8 transmembrane ER and ERGIC protein); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ceroid-lipofuscinosis, neuronal 8; mnd; motor neuron degeneration; Tlcd6
Orthologs:
Homo sapiens (human) : CLN8 (CLN8 transmembrane ER and ERGIC protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cln8 (CLN8, transmembrane ER and ERGIC protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cln8 (CLN8 transmembrane ER and ERGIC protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CLN8 (CLN8 transmembrane ER and ERGIC protein)
Canis lupus familiaris (dog) : CLN8 (CLN8 transmembrane ER and ERGIC protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cln8 (CLN8 transmembrane ER and ERGIC protein)
Sus scrofa (pig) : CLN8 (CLN8 transmembrane ER and ERGIC protein)
Chlorocebus sabaeus (African green monkey) : CLN8 (CLN8 transmembrane ER and ERGIC protein)
Heterocephalus glaber (naked mole-rat) : Cln8 (CLN8 transmembrane ER and ERGIC protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl814,881,335 - 14,901,720 (+)EnsemblGRCm38mm10GRCm38
GRCm38814,881,335 - 14,901,720 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37814,888,536 - 14,901,720 (+)NCBIGRCm37mm9NCBIm37
MGSCv36814,888,866 - 14,900,339 (+)NCBImm8
Celera815,052,911 - 15,066,094 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map87.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Cln8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552276
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.