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Gene: Sesn1 (sestrin 1) Mus musculus
Symbol: Sesn1
Name: sestrin 1
Description: Predicted to have leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of cell growth; and regulation of intracellular signal transduction. Predicted to colocalize with the GATOR2 complex; TORC2 complex; and cytoplasm. Is expressed in cortical plate. Orthologous to human SESN1 (sestrin 1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110002G11Rik; AU044290; MGC118148; p53 regulated Pa26 nuclear protein; p53-regulated protein PA26; Pa26; Sest1; sestrin-1
Homo sapiens (human) : SESN1 (sestrin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sesn1 (sestrin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sesn1 (sestrin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SESN1 (sestrin 1)
Canis lupus familiaris (dog) : SESN1 (sestrin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sesn1 (sestrin 1)
Sus scrofa (pig) : SESN1 (sestrin 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381041,810,574 - 41,908,436 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371041,530,380 - 41,628,242 (+)NCBIGRCm37mm9NCBIm37
MGSCv361041,575,864 - 41,596,839 (+)NCBImm8
Celera1042,690,911 - 42,787,751 (+)NCBICelera
Cytogenetic Map10 B2NCBI
cM Map1022.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sesn1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1316758
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.