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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,6-di-tert-butyl-4-methylphenol
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Accession:CHEBI:34247 term browser browse the term
Definition:A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Synonyms:related_synonym: 1-hydroxy-4-methyl-2,6-di-tert-butylbenzene;   2,6-bis(1,1-dimethylethyl)-4-methylphenol;   2,6-di-t-butyl-4-methylphenol;   2,6-di-t-butyl-p-cresol;   2,6-di-tert-butyl-1-hydroxy-4-methylbenzene;   2,6-di-tert-butyl-4-cresol;   2,6-di-tert-butyl-4-hydroxytoluene;   2,6-di-tert-butyl-4-methylhydroxybenzene;   2,6-di-tert-butyl-p-cresol;   BHT;   FEMA 2184;   Formula=C15H24O;   InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3;   InChIKey=NLZUEZXRPGMBCV-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C;   butylated hydroxytoluene;   butylhydroxytoluene;   o-di-tert-butyl-p-methylphenol
 xref: Beilstein:1911640;   CAS:128-37-0;   Chemspider:13835296;   FooDB:FDB011992;   HMDB:HMDB0033826;   KEGG:C14693;   KEGG:D02413;   LINCS:LSM-19020
 xref_mesh: MESH:D002084
 xref: PMID:11837686;   PMID:24612426;   PMID:24617543;   PMID:29864697;   PMID:31029976;   PMID:31780362;   PMID:32304926;   PMID:32322261;   PMID:32387881;   PMID:32397407;   PMID:32963880;   PMID:33039371;   PMID:33091556;   PMID:33519739;   PMID:33792845;   PMID:34013795;   PMID:34041400;   PMID:34443068;   PMID:448040;   Reaxys:1911640;   Wikipedia:Butylated_hydroxytoluene


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2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression		 ISO [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]
Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA		 CTD PMID:17070507 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of ACTG1 mRNA CTD PMID:12082028 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232 		JBrowse link
G Agt angiotensinogen multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein] CTD PMID:14987999 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression
increases activity		 EXP Butylated Hydroxytoluene results in increased expression of AKR7A3 protein
Butylated Hydroxytoluene results in increased activity of AKR7A3 protein		 CTD PMID:8198522 PMID:9328168 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Butylated Hydroxytoluene results in increased phosphorylation of AKT1 protein CTD PMID:17604070 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects localization
multiple interactions		 ISO Butylated Hydroxytoluene affects the localization of ALOX5 protein
celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]		 CTD PMID:12376474 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] CTD PMID:12576517 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] CTD PMID:12576517 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP Butylated Hydroxytoluene results in increased expression of APOA4 mRNA CTD PMID:12082028 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Ar androgen receptor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:10696776 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arg1 arginase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of ARG1 mRNA CTD PMID:19925653 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]		 CTD PMID:12470298 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G C5 complement C5 increases expression EXP Butylated Hydroxytoluene results in increased expression of HC mRNA CTD PMID:12082028 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Capn2 calpain 2 affects expression ISO Butylated Hydroxytoluene affects the expression of CAPN2 protein CTD PMID:7716780 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA CTD PMID:19925653 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Butylated Hydroxytoluene results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity		 ISO
EXP		 [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein
Butylated Hydroxytoluene results in decreased activity of CASP3 protein
[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein; zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein]
Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]		 CTD PMID:10783138 PMID:14981915 PMID:16272459 PMID:27588890 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] CTD PMID:9306888 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCDC116 mRNA CTD PMID:19925653 NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCL17 mRNA CTD PMID:19925653 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion		 ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
Butylated Hydroxytoluene results in increased expression of CCL2 protein
Butylated Hydroxytoluene results in increased secretion of CCL2 protein		 CTD PMID:16443645 PMID:16822543 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CCL5 mRNA CTD PMID:19925653 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccna2 cyclin A2 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; Butylated Hydroxytoluene results in increased expression of CCNA2 mRNA CTD PMID:12867420 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA CTD PMID:12867420 PMID:19000923 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein CTD PMID:16272459 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA CTD PMID:12867420 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccnf cyclin F increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of CCNF mRNA CTD PMID:12867420 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Cd19 CD19 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD19 mRNA CTD PMID:19925653 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Cd37 CD37 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD37 mRNA CTD PMID:19925653 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD3D mRNA CTD PMID:19925653 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd81 Cd81 molecule increases expression EXP Butylated Hydroxytoluene results in increased expression of CD81 mRNA CTD PMID:12082028 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein CTD PMID:16272459 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA CTD PMID:12082028 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137 		JBrowse link
G Cfi complement factor I increases expression ISO Butylated Hydroxytoluene results in increased expression of CFI mRNA CTD PMID:19925653 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cldn2 claudin 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CLDN2 mRNA CTD PMID:19925653 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression ISO Butylated Hydroxytoluene results in increased expression of COL18A1 mRNA CTD PMID:19925653 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593 		JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 increases expression ISO Butylated Hydroxytoluene results in increased expression of COX6B2 mRNA CTD PMID:19925653 NCBI chr 1:69,094,009...69,095,312 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein; [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein CTD PMID:16272459 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol affects the localization of CYCS protein] CTD PMID:19121293 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Butylated Hydroxytoluene results in increased expression of CYP1A1 mRNA
Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]		 CTD PMID:19925653 PMID:21094198 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B1 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B2 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B2 protein CTD PMID:12082028 PMID:15110098 PMID:18539377 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2C6 mRNA CTD PMID:18539377 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNA CTD PMID:24021950 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP3A9 mRNA CTD PMID:18539377 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dcx doublecortin multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] CTD PMID:17067360 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein] CTD PMID:14987999 NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Butylated Hydroxytoluene results in increased expression of DNAJC3 mRNA CTD PMID:19925653 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181 		JBrowse link
G Dock2 dedicator of cytokinesis 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNA CTD PMID:19925653 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 affects localization ISO Butylated Hydroxytoluene affects the localization of ELAVL1 protein CTD PMID:10900464 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Eln elastin multiple interactions ISO [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA CTD PMID:10761639 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928 		JBrowse link
G Epor erythropoietin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of EPOR mRNA CTD PMID:19925653 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257 		JBrowse link
G Ereg epiregulin increases expression ISO Butylated Hydroxytoluene results in increased expression of EREG mRNA CTD PMID:19925653 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Evpl envoplakin increases expression ISO Butylated Hydroxytoluene results in increased expression of EVPL mRNA CTD PMID:19925653 NCBI chr10:101,458,227...101,474,778
Ensembl chr10:101,458,216...101,474,763 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of FOSL1 mRNA CTD PMID:19000923 PMID:19925653 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Foxf1 forkhead box F1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of FOXF1 mRNA CTD PMID:11238010 NCBI chr19:49,153,949...49,157,741
Ensembl chr19:49,153,699...49,157,738 		JBrowse link
G Foxm1 forkhead box M1 affects localization
increases expression
affects response to substance		 ISO Butylated Hydroxytoluene affects the localization of FOXM1 mRNA
[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 protein
FOXM1 protein affects the susceptibility to Butylated Hydroxytoluene		 CTD PMID:11238010 PMID:12867420 PMID:18345025 PMID:19672312 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of GFPT2 mRNA CTD PMID:19925653 NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329 		JBrowse link
G Ggta1 glycoprotein alpha-galactosyltransferase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of GGTA1 mRNA CTD PMID:19925653 NCBI chr 3:18,732,985...18,824,916
Ensembl chr 3:18,732,991...18,809,908 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases phosphorylation ISO
EXP		 Butylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein CTD PMID:7586169 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gnmt glycine N-methyltransferase increases expression EXP Butylated Hydroxytoluene results in increased expression of GNMT mRNA CTD PMID:12082028 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GPLD1 mRNA CTD PMID:12082028 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases activity		 EXP Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein
Butylated Hydroxytoluene results in increased activity of GSTA5 protein		 CTD PMID:8198522 PMID:9328168 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA CTD PMID:12082028 PMID:18539377 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 EXP
ISO		 Butylated Hydroxytoluene results in increased expression of GSTP1 mRNA
Butylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein		 CTD PMID:15110098 PMID:21536018 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gzma granzyme A decreases expression ISO Butylated Hydroxytoluene results in decreased expression of GZMA mRNA CTD PMID:19925653 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression EXP Butylated Hydroxytoluene affects the expression of HCK mRNA CTD PMID:18539377 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Butylated Hydroxytoluene results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity EXP Butylated Hydroxytoluene results in increased activity of HMGCR protein CTD PMID:9199277 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 affects expression
increases expression		 ISO
EXP		 Butylated Hydroxytoluene affects the expression of HMOX1 mRNA
Butylated Hydroxytoluene results in increased expression of HMOX1 mRNA		 CTD PMID:8743975 PMID:12420312 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA CTD PMID:16272459 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects localization
multiple interactions
increases expression		 ISO Butylated Hydroxytoluene affects the localization of HNRNPA1 protein
[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein
Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein		 CTD PMID:15390079 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions ISO [Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein CTD PMID:17477362 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects localization ISO Butylated Hydroxytoluene affects the localization of HNRNPD protein CTD PMID:10900464 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786 		JBrowse link
G Hras HRas proto-oncogene, GTPase decreases methylation
increases response to substance		 EXP
ISO		 Butylated Hydroxytoluene results in decreased methylation of HRAS gene
HRAS protein results in increased susceptibility to Butylated Hydroxytoluene		 CTD PMID:9780227 PMID:11599794 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Butylated Hydroxytoluene results in increased expression of HSPA9 mRNA CTD PMID:19925653 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] CTD PMID:16822543 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il15 interleukin 15 affects expression EXP Butylated Hydroxytoluene affects the expression of IL15 mRNA CTD PMID:18539377 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] CTD PMID:16822543 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Ilk integrin-linked kinase multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein CTD PMID:16272459 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kng1 kininogen 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of KNG1 mRNA CTD PMID:19925653 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene CTD PMID:20101149 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA CTD PMID:16272459 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lep leptin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Butylated Hydroxytoluene results in increased expression of MAPK14 mRNA CTD PMID:19925653 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mbp myelin basic protein increases expression ISO Butylated Hydroxytoluene results in increased expression of MBP mRNA CTD PMID:19925653 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]
Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]		 CTD PMID:12470298 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Myl3 myosin light chain 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MYL3 mRNA CTD PMID:19925653 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene CTD PMID:10535991 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15713255 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP		 Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased phosphorylation of NFKBIA protein]		 CTD PMID:16478757 PMID:17532611 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 EXP Butylated Hydroxytoluene results in increased activity of NQO1 protein
Butylated Hydroxytoluene results in increased expression of NQO1 mRNA		 CTD PMID:16045903 PMID:20308224 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] CTD PMID:17070507 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] CTD PMID:17070507 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Butylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form; Butylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nras NRAS proto-oncogene, GTPase increases activity EXP Butylated Hydroxytoluene results in increased activity of NRAS CTD PMID:3040652 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Nrbf2 nuclear receptor binding factor 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of NRBF2 mRNA CTD PMID:12082028 NCBI chr20:21,308,555...21,326,881
Ensembl chr20:21,308,576...21,326,818 		JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Butylated Hydroxytoluene results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028 		JBrowse link
G Parn poly(A)-specific ribonuclease decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PARN mRNA CTD PMID:19925653 NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein]; Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] CTD PMID:2126186 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Butylated Hydroxytoluene results in increased expression of PCNA protein CTD PMID:11238010 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PER2 mRNA CTD PMID:19925653 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Butylated Hydroxytoluene results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Butylated Hydroxytoluene results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNA CTD PMID:19925653 NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940 		JBrowse link
G Pla2g4a phospholipase A2 group 4A increases expression ISO Butylated Hydroxytoluene results in increased expression of PLA2G4A protein CTD PMID:16443645 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] CTD PMID:10856522 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pomp proteasome maturation protein increases expression EXP Butylated Hydroxytoluene results in increased expression of POMP mRNA CTD PMID:12082028 NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO
EXP		 Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] CTD PMID:17916643 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNA CTD PMID:19925653 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] CTD PMID:17070507 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 ISO Butylated Hydroxytoluene results in increased expression of PPARG mRNA
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA]		 CTD PMID:17070507 PMID:19925653 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PRKCA protein CTD PMID:7716780 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]		 CTD PMID:12470298 PMID:17532611 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of PTGS1 protein CTD PMID:11696405 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Butylated Hydroxytoluene results in increased expression of PTGS2 protein
Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]		 CTD PMID:11696405 PMID:17067360 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO Butylated Hydroxytoluene results in increased expression of PTHLH mRNA CTD PMID:19925653 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases expression ISO Butylated Hydroxytoluene results in decreased expression of RAB31 mRNA CTD PMID:19925653 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253 		JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15713255 PMID:16478757 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Rnf112 ring finger protein 112 affects expression EXP Butylated Hydroxytoluene affects the expression of RNF112 mRNA CTD PMID:18539377 NCBI chr10:46,121,146...46,126,691
Ensembl chr10:46,121,148...46,126,699 		JBrowse link
G Sell selectin L decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SELL mRNA CTD PMID:19925653 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] CTD PMID:10856522 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SERPINH1 mRNA CTD PMID:19925653 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Shisa2 shisa family member 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA CTD PMID:19925653 NCBI chr15:33,806,715...33,811,013
Ensembl chr15:33,805,958...33,811,013 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA CTD PMID:19925653 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNA CTD PMID:19925653 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295 		JBrowse link
G Slfn4 schlafen family member 4 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLFN4 mRNA CTD PMID:19925653 NCBI chr10:67,994,601...68,018,141
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA CTD PMID:14981915 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spib Spi-B transcription factor decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SPIB mRNA CTD PMID:19925653 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SPP1 mRNA CTD PMID:19925653 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 multiple interactions
affects localization
increases expression		 ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein
Butylated Hydroxytoluene affects the localization of SRSF1 protein
Butylated Hydroxytoluene results in increased expression of SRSF1 protein		 CTD PMID:15390079 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Stom stomatin increases expression ISO Butylated Hydroxytoluene results in increased expression of STOM mRNA CTD PMID:19925653 NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354 		JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression
increases expression		 EXP
ISO		 Butylated Hydroxytoluene affects the expression of TDO2 mRNA
Butylated Hydroxytoluene results in increased expression of TDO2 mRNA		 CTD PMID:18539377 PMID:19925653 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfa transforming growth factor alpha decreases response to substance EXP Butylated Hydroxytoluene results in decreased susceptibility to TGFA protein CTD PMID:7593635 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thpo thrombopoietin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Butylated Hydroxytoluene results in decreased expression of TMEM45B mRNA CTD PMID:19925653 NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453 		JBrowse link
G Tnc tenascin C increases expression ISO Butylated Hydroxytoluene results in increased expression of TNC mRNA CTD PMID:19925653 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases response to substance		 ISO
EXP		 Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene results in decreased expression of TNF protein
Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]]; Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased uptake of Excitatory Amino Acid Agents]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein]
Butylated Hydroxytoluene results in increased susceptibility to TNF protein		 CTD PMID:9721806 PMID:12470298 PMID:15713255 PMID:16822543 PMID:16910777 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression EXP Butylated Hydroxytoluene results in increased expression of TP53 mRNA CTD PMID:9780227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ttr transthyretin increases expression EXP Butylated Hydroxytoluene results in increased expression of TTR mRNA CTD PMID:12082028 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of UBE2G2 mRNA CTD PMID:19925653 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
Butylated Hydroxytoluene results in increased expression of VEGFA mRNA		 CTD PMID:16822543 PMID:19000923 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        food additive 16109
          2,6-di-tert-butyl-4-methylphenol 170
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic aromatic compound 19336
                                  phenols 18605
                                    phenol 1389
                                      2,6-di-tert-butyl-4-methylphenol 170
paths to the root