Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pterostilbene
go back to main search page
Accession:CHEBI:8630 term browser browse the term
Definition:A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Synonyms:exact_synonym: 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
 related_synonym: (E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene;   (E)-3',5'-dimethoxy-4-stilbenol;   (E)-4'-hydroxy-3,5-dimethoxystilbene;   3',5'-Dimethoxy-4-stilbenol;   3',5'-dimethoxy-resveratrol;   3,5-Dimethoxy-4'-hydroxy-trans-stilbene;   4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol;   4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol;   Formula=C16H16O3;   InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+;   InChIKey=VLEUZFDZJKSGMX-ONEGZZNKSA-N;   SMILES=COc1cc(OC)cc(c1)\\C=C\\c1ccc(O)cc1;   trans-pterostilbene
 xref: CAS:537-42-8;   KEGG:C10287;   KNApSAcK:C00002902;   LIPID_MAPS_instance:LMPK13090015
 xref_mesh: MESH:C107773
 xref: MetaCyc:CPD-6959;   PMID:11312782;   PMID:15264904;   PMID:17726731;   PMID:20499322;   PMID:21084102;   PMID:21116625;   PMID:21482204;   PMID:21838877;   PMID:21902799;   PMID:21928089;   PMID:21936500;   PMID:21944294;   PMID:21982274;   PMID:22038118;   PMID:22094440;   PMID:22099605;   PMID:22273805;   Patent:CN101912377;   Patent:EP2445488;   Patent:KR20120000824;   Patent:US2011224290;   Reaxys:2054316;   Wikipedia:Pterostilbene


show annotations for term's descendants           Sort by:
 
pterostilbene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO pterostilbene results in increased expression of ACADM mRNA CTD PMID:26443543 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of ACOX1 protein CTD PMID:25083823 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity
ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [pterostilbene results in increased activity of AHR protein]; pterostilbene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:28279696, PMID:31004704 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 protein] CTD PMID:21355597 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
ISO pterostilbene results in decreased expression of AKT1 mRNA
pterostilbene results in decreased phosphorylation of and results in decreased activity of AKT1 protein
CTD PMID:20152895, PMID:24154491 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO pterostilbene results in decreased expression of AMACR mRNA CTD PMID:20152895 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form] CTD PMID:19549798 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO pterostilbene results in increased expression of BAD protein CTD PMID:20681671 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pterostilbene results in increased expression of BAK1 protein CTD PMID:23313376 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects response to substance
increases expression
ISO BAX protein affects the susceptibility to pterostilbene
pterostilbene results in increased expression of BAX mRNA; pterostilbene results in increased expression of BAX protein
CTD PMID:20152895, PMID:20681671, PMID:22572619, PMID:23313376, PMID:24936659 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
ISO [pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein; RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]
pterostilbene results in decreased expression of BCL2 mRNA; pterostilbene results in decreased expression of BCL2 protein
pterostilbene results in increased expression of BCL2 protein
CTD PMID:18852136, PMID:20152895, PMID:20681671, PMID:24936659 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
ISO pterostilbene results in increased expression of BCL2L1 protein
pterostilbene results in decreased expression of BCL2L1 protein
CTD PMID:20681671, PMID:23313376 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO pterostilbene results in increased expression of BID protein modified form CTD PMID:20681671 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression
ISO calcipotriene promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP protein]; paricalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP protein]
pterostilbene results in increased expression of CAMP mRNA; pterostilbene results in increased expression of CAMP protein
CTD PMID:24039193 NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
increases activity
multiple interactions
ISO pterostilbene results in increased cleavage of CASP3 protein
pterostilbene results in increased expression of CASP3 mRNA
pterostilbene results in increased activity of CASP3 protein
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP3 protein]
CTD PMID:20152895, PMID:20681671, PMID:23313376, PMID:24936659, PMID:25341683 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions
increases activity
ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP4 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions ISO pterostilbene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:20681671 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases expression
multiple interactions
increases activity
increases cleavage
ISO pterostilbene results in increased expression of CASP9 protein
Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein]
pterostilbene results in increased cleavage of CASP9 protein
CTD PMID:20152895, PMID:20681671, PMID:25341683 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
increases expression
ISO CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]
pterostilbene inhibits the reaction [Streptozocin results in decreased expression of CAT]
pterostilbene results in increased expression of CAT mRNA
CTD PMID:25341683, PMID:26700463 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
pterostilbene results in decreased expression of CCND1 protein
pterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]
CTD PMID:19549798, PMID:20398797, PMID:20681671 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression EXP pterostilbene results in decreased expression of CCNE1 protein CTD PMID:20398797 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression
ISO pterostilbene inhibits the reaction [Azoxymethane results in decreased expression of CDH1 protein]
pterostilbene results in increased expression of CDH1 protein
CTD PMID:20681671, PMID:23921149 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP pterostilbene results in decreased expression of CDK2 protein CTD PMID:20398797 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP pterostilbene results in decreased expression of CDK4 protein CTD PMID:20398797 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO pterostilbene results in increased expression of CDKN1A protein CTD PMID:23313376 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pterostilbene results in increased expression of CDKN1B protein CTD PMID:23313376 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of CPT1A protein CTD PMID:25083823 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein multiple interactions ISO [resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein CTD PMID:24319627 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression
ISO pterostilbene affects the localization of CYCS protein
pterostilbene results in increased expression of CYCS mRNA; pterostilbene results in increased expression of CYCS protein
CTD PMID:22450950, PMID:22572619, PMID:26443543 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
increases expression
multiple interactions
ISO pterostilbene results in decreased expression of CYP1A1 mRNA
pterostilbene results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [pterostilbene results in increased expression of CYP1A1 protein]
CTD PMID:22450950, PMID:31004704 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pterostilbene results in decreased activity of CYP1A2 protein CTD PMID:16684708, PMID:30394306 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pterostilbene results in increased expression of CYP2B6 mRNA CTD PMID:30394306 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO pterostilbene results in decreased activity of CYP2C19 protein CTD PMID:30394306 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]
pterostilbene results in increased expression of DDIT3 mRNA; pterostilbene results in increased expression of DDIT3 protein
CTD PMID:22450950, PMID:25341683 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO pterostilbene results in increased cleavage of DFFA protein CTD PMID:20681671 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO pterostilbene results in increased expression of DHRS2 mRNA; pterostilbene results in increased expression of DHRS2 protein CTD PMID:24936659 NCBI chr15:33,876,701...33,891,559
Ensembl chr15:33,885,106...33,891,539
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
affects localization
ISO pterostilbene results in increased expression of DIABLO protein
pterostilbene affects the localization of DIABLO protein
CTD PMID:22450950, PMID:22572619 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of DNMT1 mRNA CTD PMID:26459286 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of DNMT3A mRNA CTD PMID:26459286 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO pterostilbene promotes the reaction [resveratrol results in decreased expression of DNMT3B mRNA] CTD PMID:26459286 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Egf epidermal growth factor multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein] CTD PMID:19447859 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO pterostilbene results in increased phosphorylation of EIF2A protein CTD PMID:25341683 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form] CTD PMID:19549798 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions
ISO pterostilbene results in increased expression of ESR1 protein
[resveratrol co-treated with pterostilbene] results in increased expression of ESR1 mRNA; [resveratrol co-treated with pterostilbene] results in increased expression of ESR1 protein
CTD PMID:27159275 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ESR2 gene mutant form inhibits the reaction [pterostilbene results in increased expression of SOD2 protein] CTD PMID:24361291 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pterostilbene results in increased expression of FAS protein CTD PMID:20681671 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO pterostilbene results in increased expression of FASL protein CTD PMID:20681671 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of FASN protein CTD PMID:25083823 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of FOS protein] CTD PMID:18551458 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fut1 fucosyltransferase 1 increases expression ISO pterostilbene results in increased expression of FUT1 mRNA CTD PMID:22450950 NCBI chr 1:101,599,018...101,602,440
Ensembl chr 1:101,599,018...101,602,436
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO pterostilbene results in increased expression of GDF15 mRNA CTD PMID:22450950 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA] CTD PMID:25341683 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of GSK3B protein] CTD PMID:20681671 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases expression
ISO NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]
pterostilbene results in decreased expression of GSR mRNA
CTD PMID:21355597, PMID:25341683 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Resveratrol co-treated with pterostilbene] results in decreased expression of H2AX protein modified form CTD PMID:26459286 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions
increases phosphorylation
ISO HDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]; pterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter] CTD PMID:26443543 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO pterostilbene results in increased expression of HMOX1 mRNA
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA
NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 protein]
CTD PMID:21355597, PMID:22450950, PMID:25111660 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression ISO pterostilbene results in increased expression of HNRNPM mRNA CTD PMID:22450950 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]
pterostilbene results in increased expression of HSPA5 mRNA; pterostilbene results in increased expression of HSPA5 protein
CTD PMID:25341683 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO pterostilbene results in increased expression of HSPA9 mRNA CTD PMID:22450950 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression ISO pterostilbene results in decreased expression of HSPE1 protein CTD PMID:24936659 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
JBrowse link
G Ifng interferon gamma multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein] CTD PMID:19549798, PMID:22698256 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:19549798, PMID:22698256 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:22698256 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb8 integrin subunit beta 8 decreases expression
increases expression
ISO pterostilbene results in decreased expression of ITGB8 mRNA
pterostilbene results in increased expression of ITGB8 mRNA
CTD PMID:22450950 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO pterostilbene results in decreased phosphorylation of JAK2 protein CTD PMID:23313376 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:18551458 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:26700463 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Klf2 Kruppel-like factor 2 multiple interactions
increases expression
ISO MAPK7 protein affects the reaction [pterostilbene results in increased expression of KLF2 mRNA]; pterostilbene promotes the reaction [KLF2 protein binds to SOD2 promoter]
pterostilbene results in increased expression of KLF2 mRNA; pterostilbene results in increased expression of KLF2 protein
CTD PMID:26443543 NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO pterostilbene results in decreased expression of LDLR mRNA CTD PMID:22153697 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pterostilbene results in increased phosphorylation of MAPK1 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; pterostilbene results in increased phosphorylation of and results in increased activity of MAPK1 protein
pterostilbene results in decreased phosphorylation of MAPK1 protein
CTD PMID:19447859, PMID:24154491, PMID:26138072 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]] CTD PMID:19549798 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pterostilbene results in increased phosphorylation of MAPK3 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; pterostilbene results in increased phosphorylation of and results in increased activity of MAPK3 protein
pterostilbene results in decreased phosphorylation of MAPK3 protein
CTD PMID:19447859, PMID:24154491, PMID:26138072 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions
increases phosphorylation
ISO MAPK7 protein affects the reaction [pterostilbene results in increased expression of KLF2 mRNA]; MAPK7 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of MAPK7 protein] CTD PMID:26443543 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]; pterostilbene results in decreased phosphorylation of and results in decreased activity of MAPK8 protein CTD PMID:19447859, PMID:24154491 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; pterostilbene results in decreased phosphorylation of and results in decreased activity of MAPK9 protein CTD PMID:19447859, PMID:24154491 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO pterostilbene results in decreased expression of MCL1 protein CTD PMID:23313376 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP2 protein] CTD PMID:20681671 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp28 matrix metallopeptidase 28 multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP26 protein] CTD PMID:20681671 NCBI chr10:70,660,691...70,681,672
Ensembl chr10:70,660,691...70,681,672
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP7 protein]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]; pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP2 protein]; pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP9 protein] CTD PMID:20681671 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
decreases activity
multiple interactions
ISO pterostilbene results in decreased expression of MMP9 mRNA
pterostilbene results in decreased activity of MMP9 protein
pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP9 protein]
pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
CTD PMID:19447859, PMID:19617202, PMID:20152895, PMID:20681671 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO pterostilbene results in decreased expression of MYC protein CTD PMID:19549798 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases phosphorylation
ISO NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]]; NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]]; pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased phosphorylation of and affects the localization of NFE2L2 protein]; pterostilbene results in increased expression of and results in increased localization of NFE2L2 protein; pterostilbene results in increased phosphorylation of and affects the localization of NFE2L2 protein
pterostilbene results in increased expression of NFE2L2 protein
pterostilbene results in increased phosphorylation of NFE2L2 protein
2-tert-butylhydroquinone promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]
CTD PMID:21355597, PMID:25341683, PMID:26700463 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:18852136 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [pterostilbene co-treated with Quercetin] results in decreased degradation of NFKBIA protein; [pterostilbene co-treated with Quercetin] results in decreased phosphorylation of NFKBIA protein
pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKBIA protein]
CTD PMID:18551458, PMID:18852136 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NOS2 protein]
CTD PMID:18551458, PMID:19549798, PMID:20681671, PMID:21355597, PMID:22698256, PMID:22842666, PMID:23731018 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO pterostilbene results in increased expression of NQO1 mRNA
[pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [pterostilbene co-treated with Quercetin] results in increased expression of NQO1 protein; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]
CTD PMID:25111660, PMID:25341683 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 increases expression ISO pterostilbene results in increased expression of NQO2 mRNA; pterostilbene results in increased expression of NQO2 protein CTD PMID:24936659 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects binding
ISO pterostilbene binds to and results in increased activity of NR1I2 protein
pterostilbene binds to NR1I2 protein
CTD PMID:20869355, PMID:30394306 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO pterostilbene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO pterostilbene results in increased expression of PARP1 protein modified form CTD PMID:19549798 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP pterostilbene results in decreased expression of PCNA protein CTD PMID:20398797 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO pterostilbene results in increased expression of PDK4 mRNA CTD PMID:26443543 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO pterostilbene results in decreased expression of PGAM1 protein CTD PMID:24936659 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Pgr progesterone receptor multiple interactions ISO [resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]; [resveratrol co-treated with pterostilbene] promotes the reaction [Estradiol results in increased expression of PGR mRNA] CTD PMID:27159275 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP pterostilbene binds to and results in increased activity of PPARA protein CTD PMID:15853379 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO pterostilbene results in increased expression of PPARGC1A mRNA CTD PMID:26443543 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions
increases phosphorylation
ISO PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of MAPK7 protein]
pterostilbene results in increased phosphorylation of PRKAA1 protein
CTD PMID:26443543 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of and results in increased activity of PRKCB protein] CTD PMID:21355597 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO pterostilbene results in decreased expression of PSME3 protein CTD PMID:24936659 NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]
pterostilbene inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein]
CTD PMID:18551458, PMID:19549798, PMID:20681671, PMID:21355597, PMID:22842666, PMID:23731018 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP pterostilbene results in decreased expression of RB1 protein CTD PMID:20398797 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [pterostilbene co-treated with Quercetin] affects the localization of RELA protein; [pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein]; RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]
pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of RELA protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]
CTD PMID:18551458, PMID:18852136, PMID:21355597 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps12 ribosomal protein S12 decreases expression ISO pterostilbene results in decreased expression of RPS12 protein CTD PMID:24936659 NCBI chr 1:22,758,214...22,760,370
Ensembl chr 1:22,758,212...22,760,370
JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO pterostilbene results in increased expression of SARS1 mRNA CTD PMID:22450950 NCBI chr 2:211,219,743...211,235,475
Ensembl chr 2:211,219,750...211,235,467
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA; [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein CTD PMID:26459286 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO pterostilbene results in decreased expression of SNAI1 protein CTD PMID:23921149 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [pterostilbene co-treated with Quercetin] results in increased expression of SOD1 protein
pterostilbene results in increased expression of SOD1 protein
CTD PMID:25111660 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity
ISO [pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein; HDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; MAPK7 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; pterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter]; pterostilbene promotes the reaction [KLF2 protein binds to SOD2 promoter]; pterostilbene results in increased expression of and results in increased activity of SOD2 protein; SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]
pterostilbene results in increased expression of SOD2 protein
ESR2 gene mutant form inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]
pterostilbene results in increased activity of SOD2 protein
CTD PMID:18852136, PMID:22450950, PMID:22572619, PMID:24361291, PMID:26443543 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein] CTD PMID:18852136 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
decreases phosphorylation
decreases activity
ISO pterostilbene results in decreased expression of STAT3 protein modified form
pterostilbene results in decreased phosphorylation of STAT3 protein
pterostilbene results in decreased activity of STAT3 protein
CTD PMID:22450950, PMID:23313376, PMID:26138072 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO pterostilbene results in increased phosphorylation of STK11 protein CTD PMID:26443543 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tert telomerase reverse transcriptase decreases expression
multiple interactions
ISO pterostilbene results in decreased expression of TERT mRNA; pterostilbene results in decreased expression of TERT protein
Resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT mRNA]; Resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT protein]
CTD PMID:26459286 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19549798, PMID:22698256, PMID:23731018 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression ISO pterostilbene results in increased expression of TP53 mRNA CTD PMID:20152895 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO pterostilbene results in decreased expression of TPT1 protein CTD PMID:24936659 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
decreases activity
multiple interactions
ISO UGT1A1 protein results in increased glucuronidation of pterostilbene
pterostilbene results in decreased activity of UGT1A1 protein
pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:23965644, PMID:31812603 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
multiple interactions
decreases activity
ISO UGT1A3 protein results in increased glucuronidation of pterostilbene
pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
pterostilbene results in decreased activity of UGT1A3 protein
CTD PMID:23965644, PMID:31812603 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
decreases activity
ISO pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
pterostilbene results in decreased activity of UGT1A6 protein
CTD PMID:31812603 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 affects glucuronidation
decreases activity
multiple interactions
ISO UGT1A8 protein affects the glucuronidation of pterostilbene
pterostilbene results in decreased activity of UGT1A8 protein
pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:23965644, PMID:31812603 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects glucuronidation
multiple interactions
decreases activity
ISO UGT1A9 protein affects the glucuronidation of pterostilbene
pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
pterostilbene results in decreased activity of UGT1A9 protein
CTD PMID:23965644, PMID:31812603 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity
multiple interactions
ISO pterostilbene results in decreased activity of UGT2B7 protein
pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:31812603 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Umod uromodulin multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein] CTD PMID:22865646 NCBI chr 1:189,186,027...189,199,939
Ensembl chr 1:189,186,026...189,199,376
JBrowse link
G Zfp488 zinc finger protein 488 decreases expression ISO pterostilbene results in decreased expression of ZNF488 mRNA CTD PMID:22450950 NCBI chr16:10,292,964...10,304,794
Ensembl chr16:10,294,931...10,296,341
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          pterostilbene 128
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  olefin 7183
                                    acyclic olefin 7164
                                      stilbene 3343
                                        trans-stilbene 225
                                          pterostilbene 128
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.