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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pterostilbene
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Accession:CHEBI:8630 term browser browse the term
Definition:A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Synonyms:exact_synonym: 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
 related_synonym: (E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene;   (E)-3',5'-dimethoxy-4-stilbenol;   (E)-4'-hydroxy-3,5-dimethoxystilbene;   3',5'-dimethoxy-4-stilbenol;   3',5'-dimethoxy-resveratrol;   3,5-dimethoxy-4'-hydroxy-trans-stilbene;   4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol;   4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol;   Formula=C16H16O3;   InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+;   InChIKey=VLEUZFDZJKSGMX-ONEGZZNKSA-N;   SMILES=COC1=CC(\\C=C\\C2=CC=C(O)C=C2)=CC(OC)=C1;   trans-pterostilbene
 xref: CAS:537-42-8;   Chemspider:4445042;   FooDB:FDB012375;   HMDB:HMDB0130987;   KEGG:C10287;   KNApSAcK:C00002902;   LINCS:LSM-43245;   LIPID_MAPS_instance:LMPK13090015
 xref_mesh: MESH:C107773
 xref: MetaCyc:CPD-6959;   PDBeChem:3RL;   PMID:11312782;   PMID:15264904;   PMID:17726731;   PMID:18366703;   PMID:20499322;   PMID:21084102;   PMID:21116625;   PMID:21482204;   PMID:21838877;   PMID:21902799;   PMID:21928089;   PMID:21936500;   PMID:21944294;   PMID:21982274;   PMID:22038118;   PMID:22094440;   PMID:22099605;   PMID:22273805;   PMID:26249340;   PMID:30570862;   PMID:32125846;   PMID:32525309;   PMID:33737656;   PMID:33801098;   PMID:33849700;   Patent:CN101912377;   Patent:EP2445488;   Patent:KR20120000824;   Patent:US2011224290;   Reaxys:2054316;   Wikipedia:Pterostilbene


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pterostilbene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO pterostilbene results in increased expression of ACADM mRNA CTD PMID:26443543 NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of ACOX1 protein CTD PMID:25083823 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [pterostilbene results in increased activity of AHR protein]; pterostilbene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:28279696 PMID:31004704 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B1 protein] CTD PMID:21355597 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
increases phosphorylation		 ISO pterostilbene results in decreased expression of AKT1 mRNA
pterostilbene results in decreased phosphorylation of and results in decreased activity of AKT1 protein
pterostilbene results in increased phosphorylation of AKT1 protein		 CTD PMID:20152895 PMID:24154491 PMID:31139082 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO pterostilbene results in decreased expression of AMACR mRNA CTD PMID:20152895 NCBI chr 2:61,673,291...61,685,381
Ensembl chr 2:59,946,153...59,958,255 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form] CTD PMID:19549798 NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]] CTD PMID:34405320 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO ATG7 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]] CTD PMID:34405320 NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions		 ISO pterostilbene results in increased expression of BAD protein
pterostilbene inhibits the reaction [sodium arsenite results in increased expression of BAD protein]		 CTD PMID:20681671 PMID:31139082 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO pterostilbene results in increased expression of BAK1 protein CTD PMID:23313376 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects response to substance
increases expression
multiple interactions		 ISO BAX protein affects the susceptibility to pterostilbene
pterostilbene results in increased expression of BAX protein
pterostilbene results in increased expression of BAX mRNA; pterostilbene results in increased expression of BAX protein
pterostilbene inhibits the reaction [sodium arsenite results in increased expression of BAX protein]		 CTD PMID:20152895 PMID:20681671 PMID:22572619 PMID:23313376 PMID:24936659 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO [pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein; pterostilbene inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]
pterostilbene results in increased expression of BCL2 protein
pterostilbene results in decreased expression of BCL2 mRNA; pterostilbene results in decreased expression of BCL2 protein		 CTD PMID:18852136 PMID:20152895 PMID:20681671 PMID:24936659 PMID:31139082 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
multiple interactions		 ISO pterostilbene results in increased expression of BCL2L1 protein
pterostilbene results in decreased expression of BCL2L1 protein
pterostilbene inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]		 CTD PMID:20681671 PMID:23313376 PMID:31139082 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]] CTD PMID:34405320 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO pterostilbene results in increased expression of BID protein modified form CTD PMID:20681671 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Camp cathelicidin antimicrobial peptide multiple interactions
increases expression		 ISO calcipotriene promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; Calcitriol promotes the reaction [pterostilbene results in increased expression of CAMP protein]; paricalcitol promotes the reaction [pterostilbene results in increased expression of CAMP mRNA]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]; pterostilbene promotes the reaction [Calcitriol results in increased expression of CAMP protein]
pterostilbene results in increased expression of CAMP mRNA; pterostilbene results in increased expression of CAMP protein		 CTD PMID:24039193 NCBI chr 8:118,720,184...118,721,998
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased expression of CASP1 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CASP1 protein]] CTD PMID:34474091 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
increases expression		 ISO pterostilbene results in increased cleavage of CASP3 protein
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]; pterostilbene inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP3 protein]
pterostilbene results in increased expression of CASP3 mRNA		 CTD PMID:20152895 PMID:20681671 PMID:23313376 PMID:24936659 PMID:25341683 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions
increases activity		 ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP4 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP7 protein] CTD PMID:33930484 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO pterostilbene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:20681671 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression
increases cleavage
increases activity
multiple interactions		 ISO pterostilbene results in increased expression of CASP9 protein
pterostilbene results in increased cleavage of CASP9 protein
pterostilbene results in increased activity of CASP9 protein
pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP9 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein]		 CTD PMID:20152895 PMID:20681671 PMID:25341683 PMID:33930484 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase multiple interactions
increases expression		 ISO CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased activity of CASP4 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; pterostilbene inhibits the reaction [Ethanol results in decreased activity of CAT protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased activity of CAT protein]]
pterostilbene results in increased expression of CAT mRNA
pterostilbene inhibits the reaction [Streptozocin results in decreased expression of CAT]		 CTD PMID:25341683 PMID:26700463 PMID:34474091 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1A mRNA]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]
3-methyladenine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; Ammonium Chloride inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; ATG7 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; BECN1 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]]; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]]; Chloroquine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]		 CTD PMID:34405320 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 pterostilbene results in decreased expression of CCND1 protein
pterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]		 CTD PMID:19549798 PMID:20398797 PMID:20681671 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression EXP pterostilbene results in decreased expression of CCNE1 protein CTD PMID:20398797 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO pterostilbene inhibits the reaction [Azoxymethane results in decreased expression of CDH1 protein]
pterostilbene results in increased expression of CDH1 protein		 CTD PMID:20681671 PMID:23921149 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression EXP pterostilbene results in decreased expression of CDK2 protein CTD PMID:20398797 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression EXP pterostilbene results in decreased expression of CDK4 protein CTD PMID:20398797 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO pterostilbene results in increased expression of CDKN1A protein
CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN1A protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN1A protein]]		 CTD PMID:23313376 PMID:34405320 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO pterostilbene results in increased expression of CDKN1B protein CTD PMID:23313376 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of CDKN2A protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN2A protein]] CTD PMID:34405320 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of CPT1A protein CTD PMID:25083823 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein CTD PMID:24319627 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression		 ISO pterostilbene affects the localization of CYCS protein
pterostilbene results in increased expression of CYCS mRNA; pterostilbene results in increased expression of CYCS protein		 CTD PMID:22450950 PMID:22572619 PMID:26443543 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression
multiple interactions
increases expression		 ISO pterostilbene results in decreased expression of CYP1A1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [pterostilbene results in increased expression of CYP1A1 protein]		 CTD PMID:22450950 PMID:31004704 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pterostilbene results in decreased activity of CYP1A2 protein CTD PMID:16684708 PMID:30394306 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO pterostilbene results in increased expression of CYP2B6 mRNA CTD PMID:30394306 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO pterostilbene results in decreased activity of CYP2C19 protein CTD PMID:30394306 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]
pterostilbene results in increased expression of DDIT3 mRNA; pterostilbene results in increased expression of DDIT3 protein		 CTD PMID:22450950 PMID:25341683 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases cleavage ISO pterostilbene results in increased cleavage of DFFA protein CTD PMID:20681671 NCBI chr 5:164,823,807...164,836,729
Ensembl chr 5:159,540,715...159,553,633 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 increases expression ISO pterostilbene results in increased expression of DHRS2 mRNA; pterostilbene results in increased expression of DHRS2 protein CTD PMID:24936659 NCBI chr15:32,658,855...32,673,591
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
affects localization		 ISO pterostilbene results in increased expression of DIABLO protein
pterostilbene affects the localization of DIABLO protein		 CTD PMID:22450950 PMID:22572619 NCBI chr12:38,716,668...38,731,285
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of DNMT1 mRNA CTD PMID:26459286 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of DNMT3A mRNA CTD PMID:26459286 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO pterostilbene promotes the reaction [resveratrol results in decreased expression of DNMT3B mRNA] CTD PMID:26459286 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein] CTD PMID:19447859 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO pterostilbene results in increased phosphorylation of EIF2A protein CTD PMID:25341683 NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form] CTD PMID:19549798 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
multiple interactions		 ISO pterostilbene results in increased expression of ESR1 protein
[resveratrol co-treated with pterostilbene] results in increased expression of ESR1 mRNA; [resveratrol co-treated with pterostilbene] results in increased expression of ESR1 protein		 CTD PMID:27159275 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO ESR2 gene mutant form inhibits the reaction [pterostilbene results in increased expression of SOD2 protein] CTD PMID:24361291 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO pterostilbene results in increased expression of FAS protein CTD PMID:20681671 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression ISO pterostilbene results in increased expression of FASL protein CTD PMID:20681671 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase multiple interactions EXP [Dietary Sucrose co-treated with Dietary Fats co-treated with pterostilbene] affects the activity of FASN protein CTD PMID:25083823 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of FOS protein] CTD PMID:18551458 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fut1 fucosyltransferase 1 increases expression ISO pterostilbene results in increased expression of FUT1 mRNA CTD PMID:22450950 NCBI chr 1:105,223,399...105,226,817
Ensembl chr 1:96,086,635...96,090,616 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO pterostilbene results in increased expression of GDF15 mRNA CTD PMID:22450950 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of GLO1 protein] CTD PMID:33930484 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,662,801...8,681,649 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of GPX1 mRNA] CTD PMID:25341683 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of GSK3B protein] CTD PMID:20681671 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases expression		 ISO NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]
pterostilbene results in decreased expression of GSR mRNA		 CTD PMID:21355597 PMID:25341683 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Resveratrol co-treated with pterostilbene] results in decreased expression of H2AX protein modified form; CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of H2AX protein modified form]] CTD PMID:26459286 PMID:34405320 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions
increases phosphorylation		 ISO HDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]; pterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter] CTD PMID:26443543 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hmga1 high mobility group AT-hook 1 multiple interactions ISO CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of HMGA1 protein]; pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMGA1 protein]]
CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of HMGA1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMGA1 protein]]		 CTD PMID:34405320 PMID:34474091 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]] CTD PMID:34474091 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO pterostilbene results in increased expression of HMOX1 mRNA; pterostilbene results in increased expression of HMOX1 protein
NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]; pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 protein]
[pterostilbene co-treated with kaempferol] results in increased expression of HMOX1 mRNA; pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 mRNA]; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]]		 CTD PMID:21355597 PMID:22450950 PMID:25111660 PMID:31139082 PMID:33930484 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression ISO pterostilbene results in increased expression of HNRNPM mRNA CTD PMID:22450950 NCBI chr 7:15,140,877...15,178,871
Ensembl chr 7:14,438,688...14,476,762 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression		 ISO 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of HSPA5 protein]
pterostilbene results in increased expression of HSPA5 mRNA; pterostilbene results in increased expression of HSPA5 protein		 CTD PMID:25341683 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO pterostilbene results in increased expression of HSPA9 mRNA CTD PMID:22450950 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression ISO pterostilbene results in decreased expression of HSPE1 protein CTD PMID:24936659 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Ifng interferon gamma multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IFNG protein]
pterostilbene inhibits the reaction [Ethanol results in increased secretion of IFNG protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of IFNG protein]]		 CTD PMID:19549798 PMID:22698256 PMID:34405320 PMID:34474091 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased expression of IL18 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL18 protein]] CTD PMID:34474091 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of IL1A protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of IL1A protein]
CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1A mRNA]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1A mRNA]		 CTD PMID:34405320 PMID:34474091 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1B protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1B protein]]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]		 CTD PMID:19549798 PMID:22698256 PMID:34474091 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]]; pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased secretion of IL6 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]]		 CTD PMID:22698256 PMID:34405320 PMID:34474091 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions ISO pterostilbene inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein] CTD PMID:26700463 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Itgb8 integrin subunit beta 8 decreases expression
increases expression		 ISO pterostilbene results in decreased expression of ITGB8 mRNA
pterostilbene results in increased expression of ITGB8 mRNA		 CTD PMID:22450950 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO pterostilbene results in decreased phosphorylation of JAK2 protein CTD PMID:23313376 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of JUN protein] CTD PMID:18551458 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:26700463 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Klf2 KLF transcription factor 2 multiple interactions
increases expression		 ISO MAPK7 protein affects the reaction [pterostilbene results in increased expression of KLF2 mRNA]; pterostilbene promotes the reaction [KLF2 protein binds to SOD2 promoter]
pterostilbene results in increased expression of KLF2 mRNA; pterostilbene results in increased expression of KLF2 protein		 CTD PMID:26443543 NCBI chr16:17,555,136...17,557,768
Ensembl chr16:17,514,552...17,523,944 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in decreased expression of LAMP1 protein] CTD PMID:34405320 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO pterostilbene results in decreased expression of LDLR mRNA CTD PMID:22153697 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in decreased expression of MAP1LC3B protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of MAP1LC3B protein]] CTD PMID:34405320 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pterostilbene results in increased phosphorylation of MAPK1 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; pterostilbene results in increased phosphorylation of and results in increased activity of MAPK1 protein
pterostilbene results in decreased phosphorylation of MAPK1 protein		 CTD PMID:19447859 PMID:24154491 PMID:26138072 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]] CTD PMID:19549798 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [pterostilbene results in increased phosphorylation of MAPK3 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; pterostilbene results in increased phosphorylation of and results in increased activity of MAPK3 protein
pterostilbene results in decreased phosphorylation of MAPK3 protein		 CTD PMID:19447859 PMID:24154491 PMID:26138072 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions
increases phosphorylation		 ISO MAPK7 protein affects the reaction [pterostilbene results in increased expression of KLF2 mRNA]; MAPK7 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of MAPK7 protein] CTD PMID:26443543 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK8 protein]; pterostilbene results in decreased phosphorylation of and results in decreased activity of MAPK8 protein CTD PMID:19447859 PMID:24154491 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; pterostilbene results in decreased phosphorylation of and results in decreased activity of MAPK9 protein CTD PMID:19447859 PMID:24154491 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO pterostilbene results in decreased expression of MCL1 protein CTD PMID:23313376 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased phosphorylation of MLKL protein] CTD PMID:34474091 NCBI chr19:56,186,860...56,213,886
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP2 protein] CTD PMID:20681671 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp28 matrix metallopeptidase 28 multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP26 protein] CTD PMID:20681671 NCBI chr10:68,738,651...68,762,377
Ensembl chr10:68,241,138...68,264,866 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP7 protein]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]; pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP2 protein]; pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP9 protein] CTD PMID:20681671 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
decreases activity		 ISO pterostilbene results in decreased expression of MMP9 mRNA
pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
pterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP9 protein]
pterostilbene results in decreased activity of MMP9 protein		 CTD PMID:19447859 PMID:19617202 PMID:20152895 PMID:20681671 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO pterostilbene results in decreased expression of MYC protein CTD PMID:19549798 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions ISO NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK1 protein]]; NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]]; NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]; NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of IL1A protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of and results in increased acetylation of NFATC4 protein]; SIRT2 protein affects the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of and results in increased acetylation of NFATC4 protein]]; SIRT2 protein affects the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of NFATC4 protein]] CTD PMID:34474091 NCBI chr15:33,256,912...33,284,522
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases phosphorylation
increases expression
affects localization		 ISO NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of GSR mRNA]]; NFE2L2 protein promotes the reaction [pterostilbene promotes the reaction [Azoxymethane results in increased expression of HMOX1 mRNA]]; pterostilbene inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased phosphorylation of and affects the localization of NFE2L2 protein]; pterostilbene results in increased expression of and results in increased localization of NFE2L2 protein; pterostilbene results in increased phosphorylation of and affects the localization of NFE2L2 protein
2-tert-butylhydroquinone promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]; pterostilbene inhibits the reaction [Pyruvaldehyde affects the localization of NFE2L2 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]]
pterostilbene results in increased expression of NFE2L2 protein
pterostilbene affects the localization of NFE2L2 protein		 CTD PMID:21355597 PMID:25341683 PMID:26700463 PMID:31139082 PMID:33930484 More... NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein] CTD PMID:18852136 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [pterostilbene co-treated with Quercetin] results in decreased degradation of NFKBIA protein; [pterostilbene co-treated with Quercetin] results in decreased phosphorylation of NFKBIA protein
pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of NFKBIA protein]		 CTD PMID:18551458 PMID:18852136 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]] CTD PMID:34474091 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NOS2 protein]		 CTD PMID:18551458 PMID:19549798 PMID:20681671 PMID:21355597 PMID:22698256 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions		 ISO pterostilbene results in increased expression of NQO1 mRNA; pterostilbene results in increased expression of NQO1 protein
[pterostilbene co-treated with kaempferol] results in increased expression of NQO1 protein; [pterostilbene co-treated with Quercetin] results in increased expression of NQO1 protein; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of NQO1 mRNA]; CAT protein inhibits the reaction [pterostilbene results in increased expression of NQO1 mRNA]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of NQO1 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of NQO1 protein]]		 CTD PMID:25111660 PMID:25341683 PMID:31139082 PMID:34474091 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 increases expression ISO pterostilbene results in increased expression of NQO2 mRNA; pterostilbene results in increased expression of NQO2 protein CTD PMID:24936659 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
affects binding		 ISO pterostilbene binds to and results in increased activity of NR1I2 protein
pterostilbene binds to NR1I2 protein		 CTD PMID:20869355 PMID:30394306 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO pterostilbene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
multiple interactions		 ISO pterostilbene results in increased expression of PARP1 protein modified form
pterostilbene inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]		 CTD PMID:19549798 PMID:33930484 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP pterostilbene results in decreased expression of PCNA protein CTD PMID:20398797 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO pterostilbene results in increased expression of PDK4 mRNA CTD PMID:26443543 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO pterostilbene results in decreased expression of PGAM1 protein CTD PMID:24936659 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO [resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA]; [resveratrol co-treated with pterostilbene] promotes the reaction [Estradiol results in increased expression of PGR mRNA] CTD PMID:27159275 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO		 pterostilbene binds to and results in increased activity of PPARA protein
pterostilbene inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]		 CTD PMID:15853379 PMID:34474091 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO pterostilbene results in increased expression of PPARGC1A mRNA CTD PMID:26443543 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions
increases phosphorylation		 ISO PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of MAPK7 protein]
pterostilbene results in increased phosphorylation of PRKAA1 protein		 CTD PMID:26443543 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of and results in increased activity of PRKCB protein] CTD PMID:21355597 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO pterostilbene results in decreased expression of PSME3 protein CTD PMID:24936659 NCBI chr10:86,757,933...86,765,719
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]
pterostilbene inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [Azoxymethane results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PTGS2 protein]		 CTD PMID:18551458 PMID:19549798 PMID:20681671 PMID:21355597 PMID:22842666 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased expression of PYCARD protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of PYCARD protein]] CTD PMID:34474091 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP pterostilbene results in decreased expression of RB1 protein CTD PMID:20398797 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [pterostilbene co-treated with Quercetin] affects the localization of RELA protein; [pterostilbene co-treated with Quercetin] results in decreased activity of [NFKB1 protein binds to RELA protein]; RELA protein affects the reaction [[pterostilbene co-treated with Quercetin] results in decreased expression of BCL2 protein]
pterostilbene inhibits the reaction [Azoxymethane results in increased phosphorylation of RELA protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of RELA protein]		 CTD PMID:18551458 PMID:18852136 PMID:21355597 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK1 protein]]; pterostilbene inhibits the reaction [Ethanol promotes the reaction [RIPK1 protein binds to RIPK3 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK1 protein] CTD PMID:34474091 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]]; pterostilbene inhibits the reaction [Ethanol promotes the reaction [RIPK1 protein binds to RIPK3 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK3 mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased expression of RIPK3 protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased activity of CAT protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMOX1 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of NFE2L2 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of NQO1 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CASP1 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL18 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL1B protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of NLRP3 protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of PYCARD protein]]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of TNF mRNA]] CTD PMID:34474091 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Rps12 ribosomal protein S12 decreases expression ISO pterostilbene results in decreased expression of RPS12 protein CTD PMID:24936659 NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression ISO pterostilbene results in increased expression of SARS1 mRNA CTD PMID:22450950 NCBI chr 2:198,753,673...198,769,411
Ensembl chr 2:196,065,430...196,081,277 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in decreased expression of SESN2 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of BECN1 protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN1A protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of CDKN2A protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of H2AX protein modified form]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of HMGA1 protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of MAP1LC3B protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in decreased expression of SESN2 protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of IFNG protein]]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]] CTD PMID:34405320 NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 mRNA; [resveratrol co-treated with pterostilbene] results in decreased expression of SIRT1 protein CTD PMID:26459286 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in decreased expression of SIRT2 protein]; SIRT2 protein affects the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of and results in increased acetylation of NFATC4 protein]]; SIRT2 protein affects the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of NFATC4 protein]] CTD PMID:34474091 NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 NCBI chr 1:213,274,266...213,282,793
Ensembl chr 1:203,845,048...203,853,555 		JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO pterostilbene results in decreased expression of SNAI1 protein CTD PMID:23921149 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 ISO [pterostilbene co-treated with kaempferol] results in increased expression of SOD1 protein; [pterostilbene co-treated with Quercetin] results in increased expression of SOD1 protein; pterostilbene inhibits the reaction [Pyruvaldehyde results in decreased expression of SOD1 mRNA]
pterostilbene results in increased expression of SOD1 protein		 CTD PMID:25111660 PMID:33930484 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
increases expression		 ISO [pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein; HDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; MAPK7 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; pterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter]; pterostilbene promotes the reaction [KLF2 protein binds to SOD2 promoter]; pterostilbene results in increased expression of and results in increased activity of SOD2 protein; SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein]
pterostilbene results in increased activity of SOD2 protein
ESR2 gene mutant form inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [pterostilbene results in increased expression of SOD2 protein]		 CTD PMID:18852136 PMID:22450950 PMID:22572619 PMID:24361291 PMID:26443543 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein] CTD PMID:18852136 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO bafilomycin A1 inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; Cycloheximide promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]] CTD PMID:34405320 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
decreases activity
decreases phosphorylation		 ISO pterostilbene results in decreased expression of STAT3 protein modified form
pterostilbene results in decreased activity of STAT3 protein
pterostilbene results in decreased phosphorylation of STAT3 protein		 CTD PMID:22450950 PMID:23313376 PMID:26138072 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO pterostilbene results in increased phosphorylation of STK11 protein CTD PMID:26443543 NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Terf1 telomeric repeat binding factor 1 multiple interactions ISO pterostilbene inhibits the reaction [Ethanol results in increased expression of TERF1 protein] CTD PMID:34405320 NCBI chr 5:8,226,345...8,255,614
Ensembl chr 5:3,443,106...3,472,340 		JBrowse link
G Tert telomerase reverse transcriptase decreases expression
multiple interactions		 ISO pterostilbene results in decreased expression of TERT mRNA; pterostilbene results in decreased expression of TERT protein
pterostilbene inhibits the reaction [Ethanol results in decreased expression of TERT mRNA]; pterostilbene inhibits the reaction [Ethanol results in decreased expression of TERT protein]; Resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT mRNA]; Resveratrol promotes the reaction [pterostilbene results in decreased expression of TERT protein]		 CTD PMID:26459286 PMID:34405320 NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]]; MAPK14 protein affects the reaction [pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ATF2 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of ELK1 protein modified form]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of NOS2 protein]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 mRNA]; pterostilbene inhibits the reaction [[TNF protein co-treated with IFNG protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of PTGS2 protein]; pterostilbene inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]
pterostilbene inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; pterostilbene inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]]		 CTD PMID:19549798 PMID:22698256 PMID:23731018 PMID:34405320 PMID:34474091 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO pterostilbene results in increased expression of TP53 mRNA CTD PMID:20152895 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 decreases expression ISO pterostilbene results in decreased expression of TPT1 protein CTD PMID:24936659 NCBI chr15:57,562,217...57,568,968
Ensembl chr15:51,146,154...51,159,625 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
multiple interactions
decreases activity		 ISO UGT1A1 protein results in increased glucuronidation of pterostilbene
pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
pterostilbene results in decreased activity of UGT1A1 protein		 CTD PMID:23965644 PMID:31812603 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
decreases activity
multiple interactions		 ISO UGT1A3 protein results in increased glucuronidation of pterostilbene
pterostilbene results in decreased activity of UGT1A3 protein
pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:23965644 PMID:31812603 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
decreases activity		 ISO pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
pterostilbene results in decreased activity of UGT1A6 protein		 CTD PMID:31812603 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects glucuronidation
decreases activity
multiple interactions		 ISO UGT1A9 protein affects the glucuronidation of pterostilbene
pterostilbene results in decreased activity of UGT1A9 protein
pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:23965644 PMID:31812603 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 decreases activity
multiple interactions		 ISO pterostilbene results in decreased activity of UGT2B7 protein
pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]		 CTD PMID:31812603 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Umod uromodulin multiple interactions ISO pterostilbene inhibits the reaction [potassium oxonate results in increased expression of UMOD protein] CTD PMID:22865646 NCBI chr 1:183,247,676...183,261,665
Ensembl chr 1:173,816,339...173,830,302 		JBrowse link
G Zfp488 zinc finger protein 488 decreases expression ISO pterostilbene results in decreased expression of ZNF488 mRNA CTD PMID:22450950 NCBI chr16:9,289,286...9,299,928
Ensembl chr16:9,283,043...9,293,671 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    role 19875
      chemical role 19504
        antioxidant 16191
          pterostilbene 152
Path 2
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  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            organic molecule 19730
                              organic cyclic compound 19522
                                carbocyclic compound 18625
                                  benzenoid aromatic compound 18092
                                    benzenes 17969
                                      stilbene 3407
                                        trans-stilbene 258
                                          pterostilbene 152
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