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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:8630
Term: pterostilbene
Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Chemical ID: MESH:C107773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDpterostilbene results in decreased expression of CCND1 protein

PMID:20398797
decreases expressionISORGD:685566480464CTDpterostilbene results in decreased expression of CCND1 protein

PMID:19549798
multiple interactionsISORGD:685576480464CTDpterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 mRNA], pterostilbene inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]

PMID:20681671
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.