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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:8630
Term: pterostilbene
Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Chemical ID: MESH:C107773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDpterostilbene results in increased expression of DDIT3 mRNA; pterostilbene results in increased expression of DDIT3 proteinPMID:22450950 PMID:25341683
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTD2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; CAT protein inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]PMID:25341683
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