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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:erythromycin
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Accession:CHEBI:48923 term browser browse the term
Definition:Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).
Synonyms:related_synonym: eritromicina;   erthromycin;   erythromycine
 xref: DrugBank:DB00199;   HMDB:HMDB0014344;   Patent:US2653899;   Wikipedia:Erythromycin
 cyclic_relationship: is_conjugate_acid_of CHEBI:64290


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(E)-roxithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Roxithromycin results in decreased expression of BCL2 protein CTD PMID:12921874 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Roxithromycin results in decreased activity of CYP2B6 protein CTD PMID:17164692 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity		 ISO Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]
Roxithromycin results in decreased expression of CYP3A4 mRNA
Roxithromycin results in decreased activity of CYP3A4 protein		 CTD PMID:16416302 PMID:16837568 PMID:17164692 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Faslg Fas ligand increases expression ISO Roxithromycin results in increased expression of FASLG protein CTD PMID:12921874 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Roxithromycin results in increased expression of FOS mRNA; Roxithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]		 CTD PMID:17524151 PMID:18197913 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 protein] CTD PMID:17524151 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Roxithromycin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO Roxithromycin results in decreased expression of LAMC2 protein CTD PMID:14687228 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein] CTD PMID:18197913 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of NOS2 protein]
Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein]		 CTD PMID:16061884 PMID:17524151 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:17524151 PMID:18197913 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
erythromycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity		 ISO Erythromycin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Erythromycin results in decreased activity of ABCB11 protein		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects transport		 ISO
EXP		 Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein affects the transport of Erythromycin		 CTD PMID:12235267 PMID:15304119 PMID:25268938 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression		 ISO [Penicillin G co-treated with Erythromycin] results in increased expression of ACACA mRNA
Erythromycin results in increased expression of ACACA mRNA		 CTD PMID:27503388 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acly ATP citrate lyase increases expression
multiple interactions		 ISO Erythromycin results in increased expression of ACLY mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of ACLY mRNA		 CTD PMID:27503388 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Erythromycin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Erythromycin results in decreased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions ISO [Benzoyl Peroxide co-treated with Erythromycin] results in decreased activity of CAT protein CTD PMID:11809596 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of CCL2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCL2 mRNA		 CTD PMID:27503388 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of CCR2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCR2 mRNA		 CTD PMID:27503388 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd34 CD34 molecule increases expression ISO Erythromycin results in increased expression of CD34 protein CTD PMID:16297520 NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO Erythromycin results in increased expression of CD36 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CD36 mRNA		 CTD PMID:27503388 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression		 ISO [Penicillin G co-treated with Erythromycin] results in increased expression of CPT1A mRNA
Erythromycin results in increased expression of CPT1A mRNA		 CTD PMID:27503388 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crp C-reactive protein increases expression
multiple interactions		 ISO Erythromycin results in increased expression of CRP mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CRP mRNA		 CTD PMID:27503388 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cs citrate synthase increases expression
multiple interactions		 ISO Erythromycin results in increased expression of CS mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CS mRNA		 CTD PMID:27503388 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Erythromycin results in increased expression of CXCR4 protein CTD PMID:19502290 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO Erythromycin results in increased expression of CYP11B2 CTD PMID:17822730 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO Erythromycin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases methylation
increases metabolic processing
affects metabolic processing
decreases activity
increases expression
multiple interactions		 ISO CYP3A4 protein results in decreased methylation of Erythromycin
CYP3A4 protein results in increased metabolism of Erythromycin
CYP3A4 protein affects the metabolism of Erythromycin
Erythromycin results in decreased activity of CYP3A4 protein
Erythromycin results in increased expression of CYP3A4 mRNA; Erythromycin results in increased expression of CYP3A4 protein
Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Etoposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide]; Erythromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; Erythromycin inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; IFNA protein inhibits the reaction [CYP3A4 protein results in increased metabolism of Erythromycin]		 CTD PMID:2271712 PMID:8114683 PMID:15383492 PMID:15466163 PMID:15845683 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Erythromycin CTD PMID:15383492 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Defb1 defensin beta 1 decreases expression
multiple interactions		 ISO Erythromycin results in decreased expression of DEFB1 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of DEFB1 mRNA		 CTD PMID:27503388 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Erythromycin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT1 mRNA CTD PMID:27503388 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT2 mRNA CTD PMID:27503388 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of FABP1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FABP1 mRNA		 CTD PMID:17175557 PMID:27503388 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions		 ISO Erythromycin results in increased expression of FASN mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FASN mRNA		 CTD PMID:27503388 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 decreases expression ISO Erythromycin results in decreased expression of FNDC4 mRNA CTD PMID:17175557 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Erythromycin results in increased expression of FOS mRNA; Erythromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression
multiple interactions		 ISO Erythromycin results in increased expression of GPAM mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of GPAM mRNA		 CTD PMID:27503388 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of HMOX1 mRNA] CTD PMID:23291319 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpn hepsin increases expression ISO Erythromycin results in increased expression of HPN mRNA CTD PMID:17175557 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin CTD PMID:12856827 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of ICAM1 protein CTD PMID:14729754 PMID:16297520 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO [Penicillin G co-treated with Erythromycin] results in increased expression of IFNG mRNA
Erythromycin results in increased expression of IFNG mRNA		 CTD PMID:27503388 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions		 ISO Erythromycin results in increased expression of IL1A mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of IL1A mRNA		 CTD PMID:27503388 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of IL6 mRNA
[Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of IL6 mRNA		 CTD PMID:27503388 PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Erythromycin results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding
decreases activity
multiple interactions		 ISO Erythromycin binds to KCNH2 protein
Erythromycin results in decreased activity of KCNH2 protein
Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin]; Erythromycin binds to and results in decreased activity of KCNH2 protein		 CTD PMID:15272206 PMID:16086867 PMID:18701618 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of LBP mRNA CTD PMID:27503388 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lss lanosterol synthase increases expression ISO Erythromycin results in increased expression of LSS mRNA CTD PMID:17175557 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of MTTP mRNA CTD PMID:27503388 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression
multiple interactions		 ISO Erythromycin results in decreased expression of MUC2 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of MUC2 mRNA		 CTD PMID:27503388 NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased activity of NFE2L2 protein]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased activity of NFE2L2 protein] CTD PMID:23291319 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of NFKB1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of NFKB1 mRNA		 CTD PMID:27503388 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of NQO1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of NQO1 mRNA] CTD PMID:23291319 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression
decreases expression		 ISO Erythromycin results in increased expression of NUPR1 mRNA
Erythromycin results in decreased expression of NUPR1 mRNA		 CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Erythromycin results in decreased expression of PLA2G2A mRNA CTD PMID:27503388 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions
decreases expression		 ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of REG3G mRNA
Erythromycin results in decreased expression of REG3G mRNA		 CTD PMID:27503388 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Retnlb resistin like beta multiple interactions
decreases expression		 ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of RETNLB mRNA
Erythromycin results in decreased expression of RETNLB mRNA		 CTD PMID:27503388 NCBI chr11:51,983,482...51,985,368
Ensembl chr11:51,983,483...51,985,368 		JBrowse link
G RT1-CE16 RT1 class I, locus CE16 affects expression ISO Erythromycin affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Erythromycin affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression		 ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SCD1 mRNA
Erythromycin results in increased expression of SCD1 mRNA		 CTD PMID:27503388 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sele selectin E increases expression ISO Erythromycin results in increased expression of SELE protein CTD PMID:16297520 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L increases expression ISO Erythromycin results in increased expression of SELL protein CTD PMID:16297520 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
Erythromycin inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]		 CTD PMID:12065749 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SLC27A2 mRNA CTD PMID:27503388 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of SREBF1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of SREBF1 mRNA		 CTD PMID:27503388 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tagln transgelin decreases expression ISO Erythromycin results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions		 ISO Erythromycin results in increased expression of TLR4 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of TLR4 mRNA		 CTD PMID:27503388 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Erythromycin results in increased expression of TNF mRNA
[Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of TNF mRNA		 CTD PMID:27503388 PMID:30876886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of VCAM1 protein CTD PMID:16297520 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Erythromycin results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
erythromycin estolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
decreases activity		 EXP
ISO		 Erythromycin Estolate results in decreased expression of ABCB11 mRNA
Erythromycin Estolate results in decreased activity of ABCB11 protein		 CTD PMID:17522070 PMID:20829430 PMID:23956101 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Erythromycin Estolate results in increased expression of ABCB1 mRNA; Erythromycin Estolate results in increased expression of ABCB1A mRNA CTD PMID:17522070 PMID:24412560 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Erythromycin Estolate results in increased expression of ABCC3 mRNA CTD PMID:17522070 PMID:24412560 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Erythromycin Estolate results in increased expression of ABCG5 mRNA CTD PMID:24412560 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Erythromycin Estolate results in increased expression of ABCG8 mRNA CTD PMID:24412560 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Erythromycin Estolate results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acly ATP citrate lyase decreases expression EXP Erythromycin Estolate results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Erythromycin Estolate results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Erythromycin Estolate results in increased expression of ALDH1A1 mRNA CTD PMID:24412560 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Erythromycin Estolate results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Erythromycin Estolate results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of ASPM mRNA
Erythromycin Estolate results in increased expression of ASPM mRNA		 CTD PMID:24412560 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755 		JBrowse link
G Aurkb aurora kinase B increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of AURKB mRNA
Erythromycin Estolate results in decreased expression of AURKB mRNA		 CTD PMID:24412560 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Erythromycin Estolate results in decreased expression of BAX mRNA CTD PMID:12883083 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Erythromycin Estolate results in increased expression of BCL2 mRNA CTD PMID:12883083 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Erythromycin Estolate results in increased expression of BTG2 mRNA CTD PMID:17522070 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression EXP Erythromycin Estolate results in decreased expression of CACNA1I mRNA CTD PMID:24412560 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688 		JBrowse link
G Calu calumenin increases expression EXP Erythromycin Estolate results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593 		JBrowse link
G Car1 carbonic anhydrase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CAR1 mRNA CTD PMID:24412560 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Cat catalase decreases expression EXP Erythromycin Estolate results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Erythromycin Estolate results in decreased expression of CCN2 mRNA CTD PMID:24412560 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of CCNA2 mRNA
Erythromycin Estolate results in decreased expression of CCNA2 mRNA		 CTD PMID:24412560 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of CCNB1 mRNA
Erythromycin Estolate results in increased expression of CCNB1 mRNA		 CTD PMID:24412560 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of CDCA3 mRNA
Erythromycin Estolate results in increased expression of CDCA3 mRNA		 CTD PMID:24412560 NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of CDK1 mRNA
Erythromycin Estolate results in decreased expression of CDK1 mRNA		 CTD PMID:24412560 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cenpw centromere protein W increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of CENPW mRNA
Erythromycin Estolate results in decreased expression of CENPW mRNA		 CTD PMID:24412560 NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464 		JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Erythromycin Estolate results in increased expression of CES2 mRNA CTD PMID:24412560 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of CHD2 mRNA CTD PMID:24412560 NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502 		JBrowse link
G Ctsl cathepsin L increases expression EXP Erythromycin Estolate results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP1A1 mRNA CTD PMID:24412560 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:12883083 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A9 mRNA CTD PMID:24412560 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP8B1 mRNA CTD PMID:24412560 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Erythromycin Estolate results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP Erythromycin Estolate results in increased expression of DUT mRNA CTD PMID:24412560 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771 		JBrowse link
G Ect2 epithelial cell transforming 2 decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of ECT2 mRNA
Erythromycin Estolate results in increased expression of ECT2 mRNA		 CTD PMID:24412560 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734 		JBrowse link
G Fam111a FAM111 trypsin like peptidase A increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of FAM111A mRNA
Erythromycin Estolate results in decreased expression of FAM111A mRNA		 CTD PMID:24412560 NCBI chr 1:209,640,865...209,656,551
Ensembl chr 1:209,640,953...209,656,547 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Erythromycin Estolate results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Erythromycin Estolate results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Erythromycin Estolate results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Erythromycin Estolate results in decreased expression of G6PC1 mRNA CTD PMID:24412560 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Erythromycin Estolate results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gck glucokinase decreases expression EXP Erythromycin Estolate results in decreased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Erythromycin Estolate results in increased expression of GPX2 mRNA CTD PMID:24412560 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Erythromycin Estolate results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Erythromycin Estolate results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of HMMR mRNA
Erythromycin Estolate results in decreased expression of HMMR mRNA		 CTD PMID:24412560 NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor increases expression EXP Erythromycin Estolate results in increased expression of IGF2R mRNA CTD PMID:24412560 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP1 mRNA CTD PMID:17522070 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP2 mRNA CTD PMID:24412560 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 decreases expression EXP Erythromycin Estolate results in decreased expression of IP6K2 mRNA CTD PMID:24412560 NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166 		JBrowse link
G Isy1 ISY1 splicing factor homolog increases expression EXP Erythromycin Estolate results in increased expression of ISY1 mRNA CTD PMID:24412560 NCBI chr 4:120,276,535...120,297,227
Ensembl chr 4:120,276,292...120,297,188 		JBrowse link
G Kif20b kinesin family member 20B increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of KIF20B mRNA
Erythromycin Estolate results in decreased expression of KIF20B mRNA		 CTD PMID:24412560 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787 		JBrowse link
G Kif23 kinesin family member 23 increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of KIF23 mRNA
Erythromycin Estolate results in decreased expression of KIF23 mRNA		 CTD PMID:24412560 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072 		JBrowse link
G Kif2c kinesin family member 2C decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of KIF2C mRNA
Erythromycin Estolate results in increased expression of KIF2C mRNA		 CTD PMID:24412560 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637 		JBrowse link
G Krt18 keratin 18 increases expression EXP Erythromycin Estolate results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Erythromycin Estolate results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lgals3 galectin 3 increases expression EXP Erythromycin Estolate results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Erythromycin Estolate results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpin1 lipin 1 decreases expression EXP Erythromycin Estolate results in decreased expression of LPIN1 mRNA CTD PMID:24412560 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP Erythromycin Estolate results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Maob monoamine oxidase B decreases expression EXP Erythromycin Estolate results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Mir16 microRNA 16 increases expression EXP Erythromycin Estolate results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of MYC mRNA
Erythromycin Estolate results in decreased expression of MYC mRNA		 CTD PMID:17522070 PMID:24412560 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of NCAPH mRNA
Erythromycin Estolate results in increased expression of NCAPH mRNA		 CTD PMID:24412560 NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180 		JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression EXP Erythromycin Estolate results in decreased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Noct nocturnin decreases expression EXP Erythromycin Estolate results in decreased expression of NOCT mRNA CTD PMID:24412560 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of NUSAP1 mRNA
Erythromycin Estolate results in decreased expression of NUSAP1 mRNA		 CTD PMID:24412560 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624 		JBrowse link
G Obp3 alpha-2u globulin PGCL4 decreases expression EXP Erythromycin Estolate results in decreased expression of OBP3 mRNA CTD PMID:24412560 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757 		JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Erythromycin Estolate results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918 		JBrowse link
G Pclaf PCNA clamp associated factor increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of PCLAF mRNA
Erythromycin Estolate results in decreased expression of PCLAF mRNA		 CTD PMID:24412560 NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994 		JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PCMTD1 mRNA CTD PMID:24412560 NCBI chr 5:12,284,711...12,355,680
Ensembl chr 5:12,284,711...12,354,899 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Erythromycin Estolate results in decreased expression of PDK4 mRNA CTD PMID:24412560 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PER1 mRNA CTD PMID:24412560 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of PFKFB3 mRNA CTD PMID:24412560 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Erythromycin Estolate results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Erythromycin Estolate results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Rad51 RAD51 recombinase increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of RAD51 mRNA
Erythromycin Estolate results in decreased expression of RAD51 mRNA		 CTD PMID:24412560 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of RRM2 mRNA
Erythromycin Estolate results in increased expression of RRM2 mRNA		 CTD PMID:24412560 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Erythromycin Estolate results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Erythromycin Estolate results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP Erythromycin Estolate results in increased expression of SERPINA7 mRNA CTD PMID:24412560 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Sertad3 SERTA domain containing 3 increases expression EXP Erythromycin Estolate results in increased expression of SERTAD3 mRNA CTD PMID:24412560 NCBI chr 1:82,763,535...82,767,271
Ensembl chr 1:82,763,149...82,769,001 		JBrowse link
G Shcbp1 SHC binding and spindle associated 1 decreases expression
increases expression		 EXP Erythromycin Estolate results in decreased expression of SHCBP1 mRNA
Erythromycin Estolate results in increased expression of SHCBP1 mRNA		 CTD PMID:24412560 NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLC38A2 mRNA CTD PMID:24412560 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Erythromycin Estolate results in increased expression of SLCO1A4 mRNA CTD PMID:24412560 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLCO1B2 mRNA CTD PMID:17522070 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression
decreases expression		 EXP Erythromycin Estolate results in increased expression of SPC25 mRNA
Erythromycin Estolate results in decreased expression of SPC25 mRNA		 CTD PMID:24412560 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959 		JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Erythromycin Estolate results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,573...17,192,351
Ensembl chr  X:17,180,474...17,192,351 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Erythromycin Estolate results in increased expression of SPINK1 mRNA CTD PMID:24412560 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Erythromycin Estolate results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Erythromycin Estolate results in increased expression of STAT3 mRNA CTD PMID:17522070 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP Erythromycin Estolate results in increased expression of STYXL1 mRNA CTD PMID:24412560 NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752 		JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone increases expression EXP Erythromycin Estolate results in increased expression of SUGT1 mRNA CTD PMID:24412560 NCBI chr15:54,991,419...55,032,244
Ensembl chr15:54,990,672...55,069,150 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TGFB3 mRNA CTD PMID:24412560 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Erythromycin Estolate results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Erythromycin Estolate results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tmcc1 transmembrane and coiled-coil domain family 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TMCC1 mRNA CTD PMID:24412560 NCBI chr 4:149,069,252...149,239,585
Ensembl chr 4:149,069,260...149,239,620 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TNFAIP3 mRNA CTD PMID:24412560 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Erythromycin Estolate results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Erythromycin Estolate results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TSC22D3 mRNA CTD PMID:24412560 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
G Ttr transthyretin decreases expression EXP Erythromycin Estolate results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP Erythromycin Estolate results in increased expression of UGT2A1 mRNA CTD PMID:24412560 NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531 		JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Erythromycin Estolate results in increased expression of ZC3H13 mRNA CTD PMID:24412560 NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802 		JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP Erythromycin Estolate results in decreased expression of ZFP354A mRNA CTD PMID:24412560 NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068 		JBrowse link
G Zfp574 zinc finger protein 574 increases expression EXP Erythromycin Estolate results in increased expression of ZFP574 mRNA CTD PMID:24412560 NCBI chr 1:80,667,984...80,678,257
Ensembl chr 1:80,664,259...80,679,427 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          erythromycin 177
            erythromycin A + 177
            erythromycin B 0
            erythromycin C 0
            erythromycin D 0
            erythromycin E 0
            erythromycin-[N-methyl-(14)C] 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  ester 17332
                                    carboxylic ester 16714
                                      lactone 13224
                                        macrocyclic lactone 7575
                                          macrolide 7523
                                            erythronolide 177
                                              erythromycins 177
                                                erythromycin 177
                                                  erythromycin A + 177
                                                  erythromycin B 0
                                                  erythromycin C 0
                                                  erythromycin D 0
                                                  erythromycin E 0
                                                  erythromycin-[N-methyl-(14)C] 0
paths to the root