Spin2b (spindlin family member 2B) - Rat Genome Database

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Gene: Spin2b (spindlin family member 2B) Rattus norvegicus
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Symbol: Spin2b
Name: spindlin family member 2B
RGD ID: 1584901
Description: Predicted to enable methylated histone binding activity. Predicted to be involved in gamete generation. Predicted to be located in cytosol and nucleoplasm; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC367746; similar to Spindlin-like protein 2 (SPIN-2); spindlin-2; spindlin-2B; uncharacterized protein LOC367746
RGD Orthologs
Human
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X19,923,341 - 19,925,119 (+)NCBIGRCr8
mRatBN7.2X17,190,573 - 17,192,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,180,474 - 17,192,351 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X18,160,267 - 18,164,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X18,926,845 - 18,930,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,887,062 - 27,889,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX17,267,565 - 17,271,443 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,ISO)
nucleoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Spin2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X19,923,341 - 19,925,119 (+)NCBIGRCr8
mRatBN7.2X17,190,573 - 17,192,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX17,180,474 - 17,192,351 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X18,160,267 - 18,164,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X18,926,845 - 18,930,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,887,062 - 27,889,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX17,267,565 - 17,271,443 (+)NCBICelera
Cytogenetic MapXq12NCBI
SPIN2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X57,119,682 - 57,121,548 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX57,118,551 - 57,121,548 (-)EnsemblGRCh38hg38GRCh38
GRCh37X57,146,115 - 57,147,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X57,162,840 - 57,164,704 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX61,000,501 - 61,002,365 (-)NCBICelera
Cytogenetic MapXp11.21NCBI
HuRefX54,209,485 - 54,211,348 (-)NCBIHuRef
CHM1_1X57,136,254 - 57,138,118 (-)NCBICHM1_1
T2T-CHM13v2.0X56,418,555 - 56,420,421 (-)NCBIT2T-CHM13v2.0
LOC100991305
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X58,547,714 - 58,549,583 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X58,551,320 - 58,553,189 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X49,388,786 - 49,390,647 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X57,550,921 - 57,552,788 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX57,551,092 - 57,551,867 (-)Ensemblpanpan1.1panPan2
LOC100855689
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X48,089,452 - 48,091,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX39,281,187 - 39,295,210 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X48,387,467 - 48,400,722 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.0X48,346,687 - 48,360,724 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X49,765,114 - 49,779,143 (+)NCBIUU_Cfam_GSD_1.0
SPIN2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X49,494,288 - 49,506,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X55,631,324 - 55,643,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Spin2b
1 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
DXWox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X17,186,508 - 17,186,697 (+)MAPPERmRatBN7.2
Rnor_6.0X18,158,303 - 18,158,491NCBIRnor6.0
Rnor_5.0X18,924,881 - 18,925,069UniSTSRnor5.0
RGSC_v3.4X27,892,716 - 27,892,904UniSTSRGSC3.4
CeleraX17,265,601 - 17,265,789UniSTS
Cytogenetic MapXq13UniSTS
AI175792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X17,189,436 - 17,189,681 (+)MAPPERmRatBN7.2
Rnor_6.0X18,161,231 - 18,161,475NCBIRnor6.0
Rnor_5.0X18,927,809 - 18,928,053UniSTSRnor5.0
RGSC_v3.4X27,889,732 - 27,889,976UniSTSRGSC3.4
CeleraX17,268,529 - 17,268,773UniSTS
RH 3.4 MapX170.3UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000042670   ⟹   ENSRNOP00000043186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,180,474 - 17,192,349 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113757   ⟹   ENSRNOP00000086459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,187,074 - 17,192,351 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114926   ⟹   ENSRNOP00000086832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX17,180,484 - 17,192,351 (+)Ensembl
RefSeq Acc Id: NM_001408862   ⟹   NP_001395791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X19,923,341 - 19,925,119 (+)NCBI
mRatBN7.2X17,190,573 - 17,192,351 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395791 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043186.4
  ENSRNOP00000086459.1
  ENSRNOP00000086832.1
Ensembl Acc Id: ENSRNOP00000043186   ⟸   ENSRNOT00000042670
Ensembl Acc Id: ENSRNOP00000086832   ⟸   ENSRNOT00000114926
Ensembl Acc Id: ENSRNOP00000086459   ⟸   ENSRNOT00000113757
RefSeq Acc Id: NP_001395791   ⟸   NM_001408862
- UniProtKB: F1LUT3 (UniProtKB/TrEMBL)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-2845 BioCyc
Ensembl Genes ENSRNOG00000062360 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042670.4 UniProtKB/TrEMBL
  ENSRNOT00000113757.1 UniProtKB/TrEMBL
  ENSRNOT00000114926.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7300876 IMAGE-MGC_LOAD
InterPro SPIN/Ssty UniProtKB/TrEMBL
  SPIN/Ssty_sf UniProtKB/TrEMBL
MGC_CLONE MGC:105648 IMAGE-MGC_LOAD
NCBI Gene 367746 ENTREZGENE
PANTHER PTHR10405 UniProtKB/TrEMBL
  PTHR10405:SF13 UniProtKB/TrEMBL
Pfam Spin-Ssty UniProtKB/TrEMBL
PhenoGen Spin2b PhenoGen
RatGTEx ENSRNOG00000062360 RatGTEx
UniProt F1LUT3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Spin2b  spindlin family member 2B  LOC367746  similar to Spindlin-like protein 2 (SPIN-2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC367746  similar to Spindlin-like protein 2 (SPIN-2)      Symbol and Name status set to provisional 70820 PROVISIONAL