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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:erythronolide
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Accession:CHEBI:23955 term browser browse the term


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(E)-roxithromycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Roxithromycin results in decreased expression of BCL2 protein CTD PMID:12921874 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity ISO Roxithromycin results in decreased activity of CYP2B6 protein CTD PMID:17164692 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Faslg Fas ligand increases expression ISO Roxithromycin results in increased expression of FASLG protein CTD PMID:12921874 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Roxithromycin results in increased expression of FOS mRNA; Roxithromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL1B protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD PMID:17524151, PMID:18197913 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of IL6 protein] CTD PMID:17524151 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Roxithromycin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression ISO Roxithromycin results in decreased expression of LAMC2 protein CTD PMID:14687228 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]; Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein] CTD PMID:18197913 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of NOS2 protein]
Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of NOS2 protein]
CTD PMID:16061884, PMID:17524151 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:16061884 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF mRNA]; Roxithromycin inhibits the reaction [Mustard Gas results in increased expression of TNF protein]
Roxithromycin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:17524151, PMID:18197913 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
erythromycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Erythromycin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Erythromycin results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects transport
ISO
EXP
Erythromycin inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Erythromycin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
ABCB1 protein affects the transport of Erythromycin
CTD PMID:12235267, PMID:15304119, PMID:25268938 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of ACACA mRNA
Erythromycin results in increased expression of ACACA mRNA
CTD PMID:27503388 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acly ATP citrate lyase increases expression
multiple interactions
ISO Erythromycin results in increased expression of ACLY mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of ACLY mRNA
CTD PMID:27503388 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Erythromycin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Erythromycin results in decreased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions ISO [Benzoyl Peroxide co-treated with Erythromycin] results in decreased activity of CAT protein CTD PMID:11809596 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Erythromycin results in increased expression of CCL2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCL2 mRNA
CTD PMID:27503388 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression
multiple interactions
ISO Erythromycin results in increased expression of CCR2 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CCR2 mRNA
CTD PMID:27503388
G Cd34 CD34 molecule increases expression ISO Erythromycin results in increased expression of CD34 protein CTD PMID:16297520 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO Erythromycin results in increased expression of CD36 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CD36 mRNA
CTD PMID:27503388 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of CPT1A mRNA
Erythromycin results in increased expression of CPT1A mRNA
CTD PMID:27503388 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Crp C-reactive protein increases expression
multiple interactions
ISO Erythromycin results in increased expression of CRP mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CRP mRNA
CTD PMID:27503388 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cs citrate synthase increases expression
multiple interactions
ISO Erythromycin results in increased expression of CS mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of CS mRNA
CTD PMID:27503388 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO Erythromycin results in increased expression of CXCR4 protein CTD PMID:19502290 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO Erythromycin results in increased expression of CYP11B2 CTD PMID:17822730 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Erythromycin results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases methylation ISO CYP3A5 protein results in decreased methylation of Erythromycin CTD PMID:15383492 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Defb1 defensin beta 1 decreases expression
multiple interactions
ISO Erythromycin results in decreased expression of DEFB1 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of DEFB1 mRNA
CTD PMID:27503388 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Erythromycin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT1 mRNA CTD PMID:27503388 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of DGAT2 mRNA CTD PMID:27503388 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of FABP1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FABP1 mRNA
CTD PMID:17175557, PMID:27503388 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fasn fatty acid synthase increases expression
multiple interactions
ISO Erythromycin results in increased expression of FASN mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of FASN mRNA
CTD PMID:27503388 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Erythromycin results in increased expression of FOS mRNA; Erythromycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression
multiple interactions
ISO Erythromycin results in increased expression of GPAM mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of GPAM mRNA
CTD PMID:27503388 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of HMOX1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of HMOX1 mRNA] CTD PMID:23291319 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpn hepsin increases expression ISO Erythromycin results in increased expression of HPN mRNA CTD PMID:17175557 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin CTD PMID:12856827 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of ICAM1 protein CTD PMID:14729754, PMID:16297520 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of IFNG mRNA
Erythromycin results in increased expression of IFNG mRNA
CTD PMID:27503388 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO Erythromycin results in increased expression of IL1A mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of IL1A mRNA
CTD PMID:27503388 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Erythromycin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Erythromycin results in increased expression of IL6 mRNA
[Erythromycin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of IL6 mRNA
CTD PMID:27503388, PMID:30876886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Erythromycin results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding
decreases activity
multiple interactions
ISO Erythromycin binds to KCNH2 protein
Erythromycin results in decreased activity of KCNH2 protein
Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin]; Erythromycin binds to and results in decreased activity of KCNH2 protein
CTD PMID:15272206, PMID:16086867, PMID:18701618, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of LBP mRNA CTD PMID:27503388 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO Erythromycin affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Lss lanosterol synthase increases expression ISO Erythromycin results in increased expression of LSS mRNA CTD PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of MTTP mRNA CTD PMID:27503388 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming decreases expression
multiple interactions
ISO Erythromycin results in decreased expression of MUC2 mRNA
[Penicillin G co-treated with Erythromycin] results in decreased expression of MUC2 mRNA
CTD PMID:27503388 NCBI chr 1:214,663,929...214,693,197 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased activity of NFE2L2 protein]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased activity of NFE2L2 protein] CTD PMID:23291319 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of NFKB1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of NFKB1 mRNA
CTD PMID:27503388 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Erythromycin inhibits the reaction [Particulate Matter results in increased expression of NQO1 mRNA]; Erythromycin inhibits the reaction [Vehicle Emissions results in increased expression of NQO1 mRNA] CTD PMID:23291319 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression
decreases expression
ISO Erythromycin results in increased expression of NUPR1 mRNA
Erythromycin results in decreased expression of NUPR1 mRNA
CTD PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Pla2g2a phospholipase A2 group IIA decreases expression ISO Erythromycin results in decreased expression of PLA2G2A mRNA CTD PMID:27503388 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions
decreases expression
ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of REG3G mRNA
Erythromycin results in decreased expression of REG3G mRNA
CTD PMID:27503388 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Retnlb resistin like beta multiple interactions
decreases expression
ISO [Penicillin G co-treated with Erythromycin] results in decreased expression of RETNLB mRNA
Erythromycin results in decreased expression of RETNLB mRNA
CTD PMID:27503388 NCBI chr11:54,565,471...54,567,578
Ensembl chr11:54,565,472...54,567,357
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
increases expression
ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SCD1 mRNA
Erythromycin results in increased expression of SCD1 mRNA
CTD PMID:27503388 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sele selectin E increases expression ISO Erythromycin results in increased expression of SELE protein CTD PMID:16297520 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L increases expression ISO Erythromycin results in increased expression of SELL protein CTD PMID:16297520 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
Erythromycin inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
CTD PMID:12065749, PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc27a2 solute carrier family 27 member 2 multiple interactions ISO [Penicillin G co-treated with Erythromycin] results in increased expression of SLC27A2 mRNA CTD PMID:27503388 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression
multiple interactions
ISO Erythromycin results in increased expression of SREBF1 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of SREBF1 mRNA
CTD PMID:27503388 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tagln transgelin decreases expression ISO Erythromycin results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tlr4 toll-like receptor 4 increases expression
multiple interactions
ISO Erythromycin results in increased expression of TLR4 mRNA
[Penicillin G co-treated with Erythromycin] results in increased expression of TLR4 mRNA
CTD PMID:27503388 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Erythromycin results in increased expression of TNF mRNA
[Erythromycin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] inhibits the reaction [Erythromycin results in increased activity of CASP3 protein]
[Penicillin G co-treated with Erythromycin] results in increased expression of TNF mRNA
CTD PMID:27503388, PMID:30876886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Erythromycin results in increased expression of VCAM1 protein CTD PMID:16297520 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Erythromycin results in increased expression of WIPI1 mRNA CTD PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
erythromycin estolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
decreases activity
EXP
ISO
Erythromycin Estolate results in decreased expression of ABCB11 mRNA
Erythromycin Estolate results in decreased activity of ABCB11 protein
CTD PMID:17522070, PMID:20829430, PMID:23956101, PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Erythromycin Estolate results in increased expression of ABCB1 mRNA; Erythromycin Estolate results in increased expression of ABCB1A mRNA CTD PMID:17522070, PMID:24412560 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Erythromycin Estolate results in increased expression of ABCC3 mRNA CTD PMID:17522070, PMID:24412560 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Erythromycin Estolate results in increased expression of ABCG5 mRNA CTD PMID:24412560 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Erythromycin Estolate results in increased expression of ABCG8 mRNA CTD PMID:24412560 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Erythromycin Estolate results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Erythromycin Estolate results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Erythromycin Estolate results in decreased expression of ACSL1 mRNA CTD PMID:17522070 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Erythromycin Estolate results in increased expression of ALDH1A1 mRNA CTD PMID:24412560 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Erythromycin Estolate results in decreased expression of ALDH3A2 mRNA CTD PMID:17522070 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Erythromycin Estolate results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of ASPM mRNA
Erythromycin Estolate results in increased expression of ASPM mRNA
CTD PMID:24412560 NCBI chr13:56,546,021...56,591,793
Ensembl chr13:56,546,021...56,591,793
JBrowse link
G Aurkb aurora kinase B increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of AURKB mRNA
Erythromycin Estolate results in decreased expression of AURKB mRNA
CTD PMID:24412560 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Erythromycin Estolate results in decreased expression of BAX mRNA CTD PMID:12883083 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Erythromycin Estolate results in increased expression of BCL2 mRNA CTD PMID:12883083 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Erythromycin Estolate results in increased expression of BTG2 mRNA CTD PMID:17522070 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I decreases expression EXP Erythromycin Estolate results in decreased expression of CACNA1I mRNA CTD PMID:24412560 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Calu calumenin increases expression EXP Erythromycin Estolate results in increased expression of CALU mRNA CTD PMID:17522070 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
JBrowse link
G Car1 carbonic anhydrase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CAR1 mRNA CTD PMID:24412560 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Cat catalase decreases expression EXP Erythromycin Estolate results in decreased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Erythromycin Estolate results in decreased expression of CCN2 mRNA CTD PMID:24412560 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccna2 cyclin A2 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CCNA2 mRNA
Erythromycin Estolate results in decreased expression of CCNA2 mRNA
CTD PMID:24412560 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of CCNB1 mRNA
Erythromycin Estolate results in increased expression of CCNB1 mRNA
CTD PMID:24412560 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdca3 cell division cycle associated 3 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of CDCA3 mRNA
Erythromycin Estolate results in increased expression of CDCA3 mRNA
CTD PMID:24412560 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CDK1 mRNA
Erythromycin Estolate results in decreased expression of CDK1 mRNA
CTD PMID:24412560 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP Erythromycin Estolate results in decreased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
G Cenpw centromere protein W increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of CENPW mRNA
Erythromycin Estolate results in decreased expression of CENPW mRNA
CTD PMID:24412560 NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP Erythromycin Estolate results in increased expression of CES2 mRNA CTD PMID:24412560 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of CHD2 mRNA CTD PMID:24412560 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167
JBrowse link
G Ctsl cathepsin L increases expression EXP Erythromycin Estolate results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr 7:124,024,003...124,041,564
Ensembl chr 7:124,023,995...124,041,594
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP1A1 mRNA CTD PMID:24412560 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Erythromycin Estolate results in decreased expression of CYP2D3 mRNA CTD PMID:17522070 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A23-3A1 mRNA CTD PMID:12883083 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Erythromycin Estolate results in increased expression of CYP3A9 mRNA CTD PMID:24412560 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP Erythromycin Estolate results in increased expression of CYP8B1 mRNA CTD PMID:24412560 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Erythromycin Estolate results in increased expression of DDIT3 mRNA CTD PMID:17522070 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dut deoxyuridine triphosphatase increases expression EXP Erythromycin Estolate results in increased expression of DUT mRNA CTD PMID:24412560 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Ect2 epithelial cell transforming 2 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of ECT2 mRNA
Erythromycin Estolate results in increased expression of ECT2 mRNA
CTD PMID:24412560 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of FABP1 mRNA CTD PMID:17522070 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FADS1 mRNA CTD PMID:17522070 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fam111a family with sequence similarity 111, member A increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of FAM111A mRNA
Erythromycin Estolate results in decreased expression of FAM111A mRNA
CTD PMID:24412560 NCBI chr 1:229,003,778...229,019,532
Ensembl chr 1:229,003,961...229,019,527
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Erythromycin Estolate results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Erythromycin Estolate results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Erythromycin Estolate results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of FMO1 mRNA CTD PMID:17522070 NCBI chr13:80,712,885...80,745,095
Ensembl chr13:80,712,882...80,745,347
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit decreases expression EXP Erythromycin Estolate results in decreased expression of G6PC mRNA CTD PMID:24412560 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Erythromycin Estolate results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gck glucokinase decreases expression EXP Erythromycin Estolate results in decreased expression of GCK mRNA CTD PMID:17522070 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of GPX1 mRNA CTD PMID:17522070 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP Erythromycin Estolate results in increased expression of GPX2 mRNA CTD PMID:24412560 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Erythromycin Estolate results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase decreases expression EXP Erythromycin Estolate results in decreased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hmmr hyaluronan-mediated motility receptor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of HMMR mRNA
Erythromycin Estolate results in decreased expression of HMMR mRNA
CTD PMID:24412560 NCBI chr10:25,861,490...25,890,639
Ensembl chr10:25,861,490...25,890,639
JBrowse link
G Igf2r insulin-like growth factor 2 receptor increases expression EXP Erythromycin Estolate results in increased expression of IGF2R mRNA CTD PMID:24412560 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP1 mRNA CTD PMID:17522070 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Erythromycin Estolate results in increased expression of IGFBP2 mRNA CTD PMID:24412560 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 decreases expression EXP Erythromycin Estolate results in decreased expression of IP6K2 mRNA CTD PMID:24412560 NCBI chr 8:117,574,136...117,599,849
Ensembl chr 8:117,574,161...117,599,848
JBrowse link
G Isy1 ISY1 splicing factor homolog increases expression EXP Erythromycin Estolate results in increased expression of ISY1 mRNA CTD PMID:24412560 NCBI chr 4:119,721,659...119,742,349
Ensembl chr 4:119,721,660...119,742,349
JBrowse link
G Kif20b kinesin family member 20B increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of KIF20B mRNA
Erythromycin Estolate results in decreased expression of KIF20B mRNA
CTD PMID:24412560 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Kif23 kinesin family member 23 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of KIF23 mRNA
Erythromycin Estolate results in decreased expression of KIF23 mRNA
CTD PMID:24412560 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kif2c kinesin family member 2C decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of KIF2C mRNA
Erythromycin Estolate results in increased expression of KIF2C mRNA
CTD PMID:24412560 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Krt18 keratin 18 increases expression EXP Erythromycin Estolate results in increased expression of KRT18 mRNA CTD PMID:17522070 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Erythromycin Estolate results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lgals3 galectin 3 increases expression EXP Erythromycin Estolate results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Erythromycin Estolate results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G LOC100909485 spindlin-2-like decreases expression EXP Erythromycin Estolate results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:18,340,413...18,342,492
Ensembl chr  X:18,340,688...18,341,467
JBrowse link
G Lpin1 lipin 1 decreases expression EXP Erythromycin Estolate results in decreased expression of LPIN1 mRNA CTD PMID:24412560 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lpl lipoprotein lipase increases expression EXP Erythromycin Estolate results in increased expression of LPL mRNA CTD PMID:17522070 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Erythromycin Estolate results in decreased expression of MAOB mRNA CTD PMID:17522070 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mir16 microRNA 16 increases expression EXP Erythromycin Estolate results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:165,606,072...165,606,166
Ensembl chr 2:165,606,072...165,606,166
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of MYC mRNA
Erythromycin Estolate results in decreased expression of MYC mRNA
CTD PMID:17522070, PMID:24412560 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncaph non-SMC condensin I complex, subunit H decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of NCAPH mRNA
Erythromycin Estolate results in increased expression of NCAPH mRNA
CTD PMID:24412560 NCBI chr 3:119,583,798...119,611,148
Ensembl chr 3:119,583,648...119,611,136
JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression EXP Erythromycin Estolate results in decreased expression of NFKBIB mRNA CTD PMID:17522070 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Noct nocturnin decreases expression EXP Erythromycin Estolate results in decreased expression of NOCT mRNA CTD PMID:24412560 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of NUSAP1 mRNA
Erythromycin Estolate results in decreased expression of NUSAP1 mRNA
CTD PMID:24412560 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971
JBrowse link
G Obp3 alpha-2u globulin PGCL4 decreases expression EXP Erythromycin Estolate results in decreased expression of OBP3 mRNA CTD PMID:24412560 NCBI chr 5:77,313,357...77,316,875 JBrowse link
G Otc ornithine carbamoyltransferase decreases expression EXP Erythromycin Estolate results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pclaf PCNA clamp associated factor increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of PCLAF mRNA
Erythromycin Estolate results in decreased expression of PCLAF mRNA
CTD PMID:24412560 NCBI chr 8:71,514,281...71,526,182
Ensembl chr 8:71,514,281...71,526,182
JBrowse link
G Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PCMTD1 mRNA CTD PMID:24412560 NCBI chr 5:12,132,657...12,204,376
Ensembl chr 5:12,132,657...12,199,283
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Erythromycin Estolate results in decreased expression of PDK4 mRNA CTD PMID:24412560 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Erythromycin Estolate results in decreased expression of PER1 mRNA CTD PMID:24412560 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression EXP Erythromycin Estolate results in decreased expression of PFKFB3 mRNA CTD PMID:24412560 NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Erythromycin Estolate results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Erythromycin Estolate results in decreased expression of PYGL mRNA CTD PMID:17522070 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rad51 RAD51 recombinase increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of RAD51 mRNA
Erythromycin Estolate results in decreased expression of RAD51 mRNA
CTD PMID:24412560 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of RRM2 mRNA
Erythromycin Estolate results in increased expression of RRM2 mRNA
CTD PMID:24412560 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Erythromycin Estolate results in increased expression of S100A8 mRNA CTD PMID:17522070 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression EXP Erythromycin Estolate results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Serpina7 serpin family A member 7 increases expression EXP Erythromycin Estolate results in increased expression of SERPINA7 mRNA CTD PMID:24412560 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179
JBrowse link
G Sertad3 SERTA domain containing 3 increases expression EXP Erythromycin Estolate results in increased expression of SERTAD3 mRNA CTD PMID:24412560 NCBI chr 1:84,280,945...84,284,681
Ensembl chr 1:84,280,945...84,284,663
JBrowse link
G Shcbp1 SHC binding and spindle associated 1 decreases expression
increases expression
EXP Erythromycin Estolate results in decreased expression of SHCBP1 mRNA
Erythromycin Estolate results in increased expression of SHCBP1 mRNA
CTD PMID:24412560 NCBI chr16:90,613,826...90,642,683
Ensembl chr16:90,613,870...90,641,420
JBrowse link
G Slc38a2 solute carrier family 38, member 2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLC38A2 mRNA CTD PMID:24412560 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression EXP Erythromycin Estolate results in increased expression of SLCO1A4 mRNA CTD PMID:24412560 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression EXP Erythromycin Estolate results in decreased expression of SLCO1B2 mRNA CTD PMID:17522070 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex increases expression
decreases expression
EXP Erythromycin Estolate results in increased expression of SPC25 mRNA
Erythromycin Estolate results in decreased expression of SPC25 mRNA
CTD PMID:24412560 NCBI chr 3:55,438,534...55,451,961
Ensembl chr 3:55,438,536...55,451,798
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Erythromycin Estolate results in increased expression of SPINK1 mRNA CTD PMID:24412560 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Erythromycin Estolate results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Erythromycin Estolate results in increased expression of STAT3 mRNA CTD PMID:17522070 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP Erythromycin Estolate results in increased expression of STYXL1 mRNA CTD PMID:24412560 NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271
JBrowse link
G Sugt1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone increases expression EXP Erythromycin Estolate results in increased expression of SUGT1 mRNA CTD PMID:24412560 NCBI chr15:61,873,158...61,913,983
Ensembl chr15:61,873,056...61,914,072
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TGFB3 mRNA CTD PMID:24412560 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Erythromycin Estolate results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Erythromycin Estolate results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tmcc1 transmembrane and coiled-coil domain family 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TMCC1 mRNA CTD PMID:24412560 NCBI chr 4:147,920,987...148,048,852
Ensembl chr 4:147,921,724...148,048,726
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TNFAIP3 mRNA CTD PMID:24412560 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Erythromycin Estolate results in increased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP Erythromycin Estolate results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression EXP Erythromycin Estolate results in decreased expression of TSC22D3 mRNA CTD PMID:24412560 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Ttr transthyretin decreases expression EXP Erythromycin Estolate results in decreased expression of TTR mRNA CTD PMID:17522070 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases expression EXP Erythromycin Estolate results in decreased expression of TXNRD1 mRNA CTD PMID:17522070 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP Erythromycin Estolate results in increased expression of UGT2A1 mRNA CTD PMID:24412560 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Erythromycin Estolate results in increased expression of ZC3H13 mRNA CTD PMID:24412560 NCBI chr15:57,340,522...57,405,287
Ensembl chr15:57,340,579...57,405,287
JBrowse link
G Zfp354a zinc finger protein 354A decreases expression EXP Erythromycin Estolate results in decreased expression of ZFP354A mRNA CTD PMID:24412560 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link
G Zfp574 zinc finger protein 574 increases expression EXP Erythromycin Estolate results in increased expression of ZFP574 mRNA CTD PMID:24412560 NCBI chr 1:81,952,067...81,957,330
Ensembl chr 1:81,952,067...81,957,329
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            erythronolide 174
              3-O-alpha-mycarosylerythronolide B 0
              6-deoxyerythronolide B 0
              erythromycins + 174
              erythronolide A + 174
              erythronolide B + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          macrocyclic lactone 1731
                                            macrolide 1598
                                              erythronolide 174
                                                3-O-alpha-mycarosylerythronolide B 0
                                                6-deoxyerythronolide B 0
                                                erythromycins + 174
                                                erythronolide A + 174
                                                erythronolide B + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.