The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein]
eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]
eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein]
[eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]] eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein
eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA eplerenone results in increased activity of NOS3 protein eplerenone results in increased expression of NOS3 mRNA Eplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 protein
[eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein] eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein
[eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]
[Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]] eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein
Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] eplerenone decreases expression of protein in hippocampus of post-surgical rats
Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Spironolactone results in decreased activity of ABCB11 protein
Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA Spironolactone results in increased expression of ABCC3 mRNA [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein
Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] Spironolactone results in decreased expression of ACE protein Spironolactone affects the expression of ACE protein
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]
Spironolactone results in decreased expression of AGT protein modified form Spironolactone results in increased expression of AGT protein modified form Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]
Spironolactone binds to AR protein Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]] Spironolactone results in decreased activity of CASP3 protein Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein]
Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA]
Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein]
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein]
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein] Spironolactone affects the expression of GAS6 protein
[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]
Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]]
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
[Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein Spironolactone results in increased expression of IL1B protein
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein] Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]] Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein]
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein]
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA]
Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein]
Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
Spironolactone results in decreased expression of NPPB protein [carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein Spironolactone results in increased expression of NR1I2 mRNA NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]
Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein] Spironolactone results in increased activity of NR3C2 protein Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein]
Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium]
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein REN protein results in decreased susceptibility to Spironolactone Spironolactone results in increased expression of REN protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA] Spironolactone results in increased expression of SGK1 mRNA Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA]
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein]
Spironolactone results in decreased expression of TGFB1 protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]
Spironolactone results in increased expression of UGT1A7 protein Spironolactone results in increased activity of UGT1A7 protein [Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein
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