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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:drospirenone
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Accession:CHEBI:50838 term browser browse the term
Definition:A steroid lactone that has formula C24H30O3.
Synonyms:exact_synonym: 3-oxo-6alpha,7alpha,15alpha,16alpha-tetrahydro-7'H,16'H-dicyclopropa[6,7;15,16]-17alpha-pregn-4-ene-21,17-carbolactone
 related_synonym: 1,2-Dihydrospirorenone;   6beta,7beta;15beta,16beta-Dimethylene-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone;   Dehydrospirorenone;   Formula=C24H30O3;   InChI=1S/C24H30O3/c1-22-6-3-12(25)9-17(22)13-10-14(13)20-16(22)4-7-23(2)21(20)15-11-18(15)24(23)8-5-19(26)27-24/h9,13-16,18,20-21H,3-8,10-11H2,1-2H3/t13-,14+,15-,16+,18+,20-,21+,22-,23+,24+/m1/s1;   InChIKey=METQSPRSQINEEU-HXCATZOESA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])([C@@H]4C[C@@H]4[C@@]33CCC(=O)O3)[C@]1([H])[C@H]1C[C@H]1C1=CC(=O)CC[C@]21C;   drospirenona;   drospirenonum
 xref: Beilstein:4765500;   CAS:67392-87-4;   DrugBank:DB01395;   Drug_Central:968;   KEGG:D03917
 xref_mesh: MESH:C035144
 xref: Patent:DE2652761;   Patent:US4129564;   Wikipedia:Drospirenone


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drospirenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO drospirenone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO drospirenone binds to and results in increased activity of AR protein
drospirenone affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein CTD PMID:17418832 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:28257955 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of HSPD1 mRNA CTD PMID:19631796 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNA CTD PMID:19631796 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding EXP drospirenone binds to NR3C2 protein CTD PMID:1493716 PMID:14667981 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor affects binding ISO drospirenone binds to PGR protein CTD PMID:14667981 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Serpina6 serpin family A member 6 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SERPINA6 protein CTD PMID:11245553 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein CTD PMID:11245553 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      group 19689
        organic group 18599
          3-oxo-Delta(4)-steroid group 8425
            3-oxo-Delta(4) steroid 8425
              drospirenone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        oxo steroid 9722
                                          3-oxo steroid 9283
                                            3-oxo-Delta(4) steroid 8425
                                              drospirenone 10
paths to the root