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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
multiple interactions decreases activity |
ISO |
Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Spironolactone results in decreased activity of ABCB11 protein |
CTD |
PMID:24014644 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions |
ISO |
Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein] |
CTD |
PMID:21459122 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases expression |
EXP |
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA] Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein |
CTD |
PMID:15652244 PMID:17686906 PMID:19766108 |
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions increases expression |
ISO EXP |
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA Spironolactone results in increased expression of ABCC3 mRNA [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein |
CTD |
PMID:15833929 PMID:17686906 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
decreases expression |
EXP |
Spironolactone results in decreased expression of ABCG5 mRNA |
CTD |
PMID:15683829 |
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NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
decreases expression |
EXP |
Spironolactone results in decreased expression of ABCG8 mRNA |
CTD |
PMID:15683829 |
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NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions decreases expression affects expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] Spironolactone results in decreased expression of ACE protein Spironolactone affects the expression of ACE protein |
CTD |
PMID:15932931 PMID:18586661 PMID:30734886 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression affects expression |
EXP |
Spironolactone results in increased expression of ACE2 protein Spironolactone affects the expression of ACE2 protein |
CTD |
PMID:18586661 PMID:30734886 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] |
CTD |
PMID:25204689 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein] |
CTD |
PMID:29782964 PMID:33359182 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Agt |
angiotensinogen |
decreases expression increases expression multiple interactions |
EXP ISO |
Spironolactone results in decreased expression of AGT protein modified form Spironolactone results in increased expression of AGT protein modified form Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA] |
CTD |
PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression |
EXP |
Spironolactone results in decreased expression of AGTR1 protein |
CTD |
PMID:18586661 PMID:19114643 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Agtr2 |
angiotensin II receptor, type 2 |
increases expression |
EXP |
Spironolactone results in increased expression of AGTR2 protein |
CTD |
PMID:18586661 |
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NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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G |
Ahr |
aryl hydrocarbon receptor |
increases expression |
ISO |
Spironolactone results in increased expression of AHR mRNA |
CTD |
PMID:17627975 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldh1b1 |
aldehyde dehydrogenase 1 family, member B1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH1B1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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G |
Aldh4a1 |
aldehyde dehydrogenase 4 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH4A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
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G |
Aldh8a1 |
aldehyde dehydrogenase 8 family, member A1 |
increases expression |
ISO |
Spironolactone results in increased expression of ALDH8A1 mRNA |
CTD |
PMID:17998271 |
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NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] |
CTD |
PMID:29149346 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Aqp2 |
aquaporin 2 |
multiple interactions |
EXP |
[Spironolactone co-treated with Lithium] affects the expression of AQP2 protein |
CTD |
PMID:16159898 |
|
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
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G |
Ar |
androgen receptor |
affects binding multiple interactions |
ISO EXP |
Spironolactone binds to AR protein Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein] |
CTD |
PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 PMID:29162470 PMID:33049310 More...
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Bad |
BCL2-associated agonist of cell death |
increases phosphorylation decreases expression |
EXP |
Spironolactone results in increased phosphorylation of BAD protein Spironolactone results in decreased expression of BAD protein |
CTD |
PMID:19114643 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression |
EXP |
Spironolactone results in increased expression of BCL2 protein |
CTD |
PMID:19114643 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
increases expression |
EXP |
Spironolactone results in increased expression of BCL2L1 protein |
CTD |
PMID:19114643 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Becn1 |
beclin 1 |
increases expression |
EXP |
Spironolactone results in increased expression of BECN1 protein |
CTD |
PMID:30734886 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
multiple interactions decreases activity increases activity |
EXP ISO |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]] Spironolactone results in decreased activity of CASP3 protein Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein] |
CTD |
PMID:19114643 PMID:20609311 PMID:22700542 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] |
CTD |
PMID:22700542 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] |
CTD |
PMID:20609311 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]] |
CTD |
PMID:20609311 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein] |
CTD |
PMID:17278980 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] |
CTD |
PMID:18504326 |
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NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Ces2c |
carboxylesterase 2C |
increases expression |
ISO |
Spironolactone results in increased expression of CES2C mRNA |
CTD |
PMID:22429928 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
ISO |
Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form |
CTD |
PMID:9302344 PMID:11300427 PMID:15842549 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] |
CTD |
PMID:17051331 |
|
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Ctf1 |
cardiotrophin 1 |
multiple interactions |
EXP |
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] |
CTD |
PMID:23288202 |
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NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
decreases expression |
EXP |
Spironolactone results in decreased expression of CXCL1 mRNA |
CTD |
PMID:21135038 |
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NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cybb |
cytochrome b-245 beta chain |
decreases expression |
EXP |
Spironolactone results in decreased expression of CYBB protein |
CTD |
PMID:19114643 |
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NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
increases expression |
EXP |
Spironolactone results in increased expression of CYP11B2 mRNA |
CTD |
PMID:15218317 |
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NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
Spironolactone results in decreased activity of CYP2C8 protein |
CTD |
PMID:15601807 |
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
Spironolactone results in increased expression of CYP3A4 mRNA |
CTD |
PMID:12505310 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a23-3a1 |
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 |
multiple interactions increases expression |
EXP |
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:11752103 |
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NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases activity |
EXP |
Spironolactone results in decreased activity of CYP7A1 protein |
CTD |
PMID:15652244 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
increases expression |
EXP |
Spironolactone results in increased expression of ETS1 protein |
CTD |
PMID:20228418 |
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NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Fabp4 |
fatty acid binding protein 4 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] |
CTD |
PMID:29782964 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein] |
CTD |
PMID:31295448 |
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NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Gas6 |
growth arrest specific 6 |
multiple interactions affects expression |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein] Spironolactone affects the expression of GAS6 protein |
CTD |
PMID:19564549 |
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NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] |
CTD |
PMID:24512358 PMID:25204689 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Ggt1 |
gamma-glutamyltransferase 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased activity of GGT1 protein] |
CTD |
PMID:37328115 |
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NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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G |
Greb1 |
growth regulating estrogen receptor binding 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA] |
CTD |
PMID:33405908 |
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NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein] |
CTD |
PMID:31295448 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM1 mRNA; Spironolactone results in increased expression of GSTM5 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G |
Gstm2 |
glutathione S-transferase mu 2 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM2 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstm5 |
glutathione S-transferase, mu 5 |
increases expression |
ISO |
Spironolactone results in increased expression of GSTM3 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
increases expression |
EXP |
Spironolactone results in increased expression of HIF1A protein |
CTD |
PMID:20228418 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmox1 |
heme oxygenase 1 |
increases expression |
EXP |
Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein |
CTD |
PMID:21263376 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hpse |
heparanase |
multiple interactions |
EXP |
[Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] |
CTD |
PMID:19429930 |
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NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] |
CTD |
PMID:30993381 |
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NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression |
EXP |
Spironolactone results in decreased expression of HSD11B2 mRNA |
CTD |
PMID:17587755 |
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NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein] |
CTD |
PMID:17051331 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein] |
CTD |
PMID:17051331 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] |
CTD |
PMID:18660453 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
[Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein Spironolactone results in increased expression of IL1B protein |
CTD |
PMID:16528473 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein] |
CTD |
PMID:17051331 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein] Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]] Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]; Spironolactone inhibits the reaction [Letrozole results in increased secretion of IL6 protein] |
CTD |
PMID:17051331 PMID:30993381 PMID:33359182 PMID:37328115 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of INS1 protein] |
CTD |
PMID:33359182 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] |
CTD |
PMID:29782964 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Jak2 |
Janus kinase 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:15932931 |
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NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased activity of LDHA protein] |
CTD |
PMID:37328115 |
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NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein] |
CTD |
PMID:31295448 |
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NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases expression |
EXP |
Spironolactone results in increased expression of MAP1LC3B protein |
CTD |
PMID:30734886 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
Spironolactone results in increased expression of MGST1 mRNA |
CTD |
PMID:18723825 |
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NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] |
CTD |
PMID:24101390 |
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NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mt1 |
metallothionein 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] |
CTD |
PMID:17616752 PMID:19333130 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] |
CTD |
PMID:19333130 |
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NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
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G |
Mybl1 |
MYB proto-oncogene like 1 |
multiple interactions increases expression |
ISO |
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA] |
CTD |
PMID:33405908 |
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NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
decreases expression |
EXP |
Spironolactone results in decreased expression of NCF2 protein |
CTD |
PMID:19114643 |
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NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] |
CTD |
PMID:25204689 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of NLRP3 protein] |
CTD |
PMID:37328115 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
multiple interactions |
ISO |
Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney] |
RGD |
PMID:24108235 |
RGD:38599161 |
NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
increases expression |
EXP |
Spironolactone results in increased expression of NPHS2 protein |
CTD |
PMID:30734886 |
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NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
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G |
Nppa |
natriuretic peptide A |
decreases expression multiple interactions |
ISO EXP |
Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202 |
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NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nppb |
natriuretic peptide B |
decreases expression multiple interactions |
ISO |
Spironolactone results in decreased expression of NPPB protein [carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein |
CTD |
PMID:11300427 PMID:21378469 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases expression |
ISO EXP |
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein Spironolactone results in increased expression of NR1I2 mRNA NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] |
CTD |
PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 PMID:21459122 PMID:33049310 More...
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
decreases expression multiple interactions increases activity |
EXP ISO |
Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein] Spironolactone results in increased activity of NR3C2 protein Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] |
CTD |
PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 PMID:29149346 More...
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NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein] |
CTD |
PMID:20508287 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of and results in increased secretion of PCSK9 protein] |
CTD |
PMID:37328115 |
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NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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G |
Plat |
plasminogen activator, tissue type |
increases expression |
ISO |
Spironolactone results in increased expression of PLAT protein |
CTD |
PMID:12424430 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] |
CTD |
PMID:10100081 |
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NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pon3 |
paraoxonase 3 |
increases hydrolysis |
ISO |
PON3 protein results in increased hydrolysis of Spironolactone |
CTD |
PMID:15772423 |
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NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
increases expression |
ISO |
Spironolactone results in increased expression of PPARA mRNA |
CTD |
PMID:17627975 |
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prl |
prolactin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] |
CTD |
PMID:33359182 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Rac1 |
Rac family small GTPase 1 |
decreases expression |
EXP |
Spironolactone results in decreased expression of RAC1 protein |
CTD |
PMID:19114643 |
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NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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G |
Ren |
renin |
multiple interactions decreases response to substance increases expression |
ISO |
[Clonidine co-treated with Spironolactone] results in decreased expression of REN protein REN protein results in decreased susceptibility to Spironolactone Spironolactone results in increased expression of REN protein |
CTD |
PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520 |
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NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G |
Serpine1 |
serpin family E member 1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SERPINE1 protein |
CTD |
PMID:12424430 |
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NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions increases expression |
EXP ISO |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA] Spironolactone results in increased expression of SGK1 mRNA Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA] |
CTD |
PMID:19429930 PMID:33405908 |
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NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Shbg |
sex hormone binding globulin |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Letrozole results in decreased secretion of SHBG protein] |
CTD |
PMID:37328115 |
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NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G |
Slc12a2 |
solute carrier family 12 member 2 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] |
CTD |
PMID:12668585 |
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NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:21641380 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] |
CTD |
PMID:21641380 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
multiple interactions |
ISO |
Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] |
CTD |
PMID:21641380 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc30a1 |
solute carrier family 30 member 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] |
CTD |
PMID:19333130 |
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NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
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G |
Slc39a1 |
solute carrier family 39 member 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] |
CTD |
PMID:19333130 |
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NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
increases expression |
ISO |
Spironolactone results in increased expression of SLCO1A4 mRNA |
CTD |
PMID:15919853 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO1B2 mRNA |
CTD |
PMID:15919853 |
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Slco2a1 |
solute carrier organic anion transporter family, member 2a1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO2A1 mRNA |
CTD |
PMID:15919853 |
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NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
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G |
Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases expression |
ISO |
Spironolactone results in decreased expression of SLCO2B1 mRNA |
CTD |
PMID:15919853 |
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] |
CTD |
PMID:17616752 PMID:19333130 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
Spironolactone results in increased expression of TFF1 mRNA |
CTD |
PMID:35307500 |
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NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression multiple interactions |
EXP |
Spironolactone results in decreased expression of TGFB1 protein Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein] |
CTD |
PMID:15130897 PMID:16928621 PMID:25204689 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnc |
tenascin C |
multiple interactions |
EXP |
Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA] |
CTD |
PMID:21135038 |
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NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein] |
CTD |
PMID:16528473 PMID:17051331 PMID:33359182 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression increases activity |
EXP ISO |
Spironolactone results in increased expression of UGT1A1 mRNA Spironolactone results in increased activity of UGT1A1 protein |
CTD |
PMID:12818378 PMID:19144771 |
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NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A2 mRNA |
CTD |
PMID:19144771 |
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NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a3 |
UDP glycosyltransferase 1 family, polypeptide A3 |
increases expression increases activity |
EXP |
Spironolactone results in increased expression of UGT1A5 mRNA Spironolactone results in increased activity of UGT1A5 protein |
CTD |
PMID:12818378 |
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NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A5 mRNA |
CTD |
PMID:19144771 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A6 mRNA |
CTD |
PMID:19144771 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a8 |
UDP glucuronosyltransferase family 1 member A8 |
increases activity increases expression multiple interactions |
EXP |
Spironolactone results in increased activity of UGT1A7 protein Spironolactone results in increased expression of UGT1A7 protein [Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein |
CTD |
PMID:17686906 |
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NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases expression |
ISO |
Spironolactone results in increased expression of UGT1A9 mRNA |
CTD |
PMID:19144771 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
EXP |
Spironolactone results in increased expression of VEGFA protein |
CTD |
PMID:21263376 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Wt1 |
WT1 transcription factor |
increases expression |
EXP |
Spironolactone results in increased expression of WT1 protein |
CTD |
PMID:30734886 |
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NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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