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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spironolactone
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Accession:CHEBI:9241 term browser browse the term
Definition:A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Synonyms:exact_synonym: 7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
 related_synonym: Formula=C24H32O4S;   InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1;   InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N;   SMILES=[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]33CCC(=O)O3)[C@]1([H])[C@@H](CC1=CC(=O)CC[C@]21C)SC(C)=O;   espironolactona;   spironolactonum;   spironolattone
 alt_id: CHEBI:45692
 xref: Beilstein:57767;   CAS:52-01-7;   DrugBank:DB00421;   Drug_Central:2475;   HMDB:HMDB0014565;   KEGG:C07310;   KEGG:D00443
 xref_mesh: MESH:D013148
 xref: PDBeChem:SNL;   PMID:11300427;   Patent:US3013012;   Reaxys:57767;   Wikipedia:Spironolactone



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spironolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Spironolactone results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]
CTD PMID:21459122 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]
Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein
CTD PMID:15652244 PMID:17686906 PMID:19766108 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO
EXP
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein
Spironolactone results in increased expression of ABCC3 mRNA
CTD PMID:15833929 PMID:17686906 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Spironolactone results in decreased expression of ABCG5 mRNA CTD PMID:15683829 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Spironolactone results in decreased expression of ABCG8 mRNA CTD PMID:15683829 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
affects expression
decreases expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]
Spironolactone affects the expression of ACE protein
Spironolactone results in decreased expression of ACE protein
CTD PMID:15932931 PMID:18586661 PMID:30734886 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression
affects expression
EXP Spironolactone results in increased expression of ACE2 protein
Spironolactone affects the expression of ACE2 protein
CTD PMID:18586661 PMID:30734886 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:25204689 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]
CTD PMID:29782964 PMID:33359182 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
increases expression
EXP
ISO
Spironolactone results in decreased expression of AGT protein modified form
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]
Spironolactone results in increased expression of AGT protein modified form
CTD PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Spironolactone results in decreased expression of AGTR1 protein CTD PMID:18586661 PMID:19114643 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Spironolactone results in increased expression of AGTR2 protein CTD PMID:18586661 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Spironolactone results in increased expression of AHR mRNA CTD PMID:17627975 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Spironolactone results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 NCBI chr 5:151,880,002...151,905,491 JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH8A1 mRNA CTD PMID:17998271 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP [Spironolactone co-treated with Lithium] affects the expression of AQP2 protein CTD PMID:16159898 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO
EXP
Spironolactone binds to AR protein
Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
CTD PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation
decreases expression
EXP Spironolactone results in increased phosphorylation of BAD protein
Spironolactone results in decreased expression of BAD protein
CTD PMID:19114643 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Spironolactone results in increased expression of BCL2 protein CTD PMID:19114643 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Spironolactone results in increased expression of BCL2L1 protein CTD PMID:19114643 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 increases expression EXP Spironolactone results in increased expression of BECN1 protein CTD PMID:30734886 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases activity
EXP
ISO
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]
Spironolactone results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein]
Spironolactone results in decreased activity of CASP3 protein
CTD PMID:19114643 PMID:20609311 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] CTD PMID:20609311 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]] CTD PMID:20609311 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein] CTD PMID:17278980 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Ces2c carboxylesterase 2C increases expression ISO Spironolactone results in increased expression of CES2C mRNA CTD PMID:22429928 NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form CTD PMID:9302344 PMID:11300427 PMID:15842549 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Spironolactone results in decreased expression of CXCL1 mRNA CTD PMID:21135038 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression EXP Spironolactone results in decreased expression of CYBB protein CTD PMID:19114643 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Spironolactone results in increased expression of CYP11B2 mRNA CTD PMID:15218317 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Spironolactone results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Spironolactone results in increased expression of CYP3A4 mRNA CTD PMID:12505310 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11752103 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP Spironolactone results in decreased activity of CYP7A1 protein CTD PMID:15652244 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression EXP Spironolactone results in increased expression of ETS1 protein CTD PMID:20228418 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein] CTD PMID:31295448 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions
affects expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]
Spironolactone affects the expression of GAS6 protein
CTD PMID:19564549 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 PMID:25204689 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein] CTD PMID:31295448 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Spironolactone results in increased expression of GSTM1 mRNA CTD PMID:18723825 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Spironolactone results in increased expression of GSTM2 mRNA CTD PMID:18723825 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Spironolactone results in increased expression of GSTM3 mRNA; Spironolactone results in increased expression of GSTM5 mRNA CTD PMID:18723825 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP Spironolactone results in increased expression of HIF1A protein CTD PMID:20228418 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] CTD PMID:30993381 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP Spironolactone results in decreased expression of HSD11B2 mRNA CTD PMID:17587755 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Ifng interferon gamma multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein] CTD PMID:17051331 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein] CTD PMID:17051331 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein
Spironolactone results in increased expression of IL1B protein
CTD PMID:16528473 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein] CTD PMID:17051331 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
CTD PMID:17051331 PMID:30993381 PMID:33359182 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] CTD PMID:15932931 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein] CTD PMID:31295448 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression EXP Spironolactone results in increased expression of MAP1LC3B protein CTD PMID:30734886 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Spironolactone results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:17616752 PMID:19333130 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] CTD PMID:19333130 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases expression EXP Spironolactone results in decreased expression of NCF2 protein CTD PMID:19114643 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:25204689 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney] RGD PMID:24108235 RGD:38599161 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin increases expression EXP Spironolactone results in increased expression of NPHS2 protein CTD PMID:30734886 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nppa natriuretic peptide A decreases expression
multiple interactions
ISO
EXP
Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form
Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B decreases expression
multiple interactions
ISO Spironolactone results in decreased expression of NPPB protein
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
CTD PMID:11300427 PMID:21378469 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
ISO
EXP
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]
Spironolactone results in increased expression of NR1I2 mRNA
NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein
CTD PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 More... NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression
multiple interactions
increases activity
EXP
ISO
Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein
Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Spironolactone results in increased activity of NR3C2 protein
Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
CTD PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 More... NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein] CTD PMID:20508287 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Spironolactone results in increased expression of PLAT protein CTD PMID:12424430 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] CTD PMID:10100081 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis ISO PON3 protein results in increased hydrolysis of Spironolactone CTD PMID:15772423 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Spironolactone results in increased expression of PPARA mRNA CTD PMID:17627975 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prl prolactin multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] CTD PMID:33359182 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP Spironolactone results in decreased expression of RAC1 protein CTD PMID:19114643 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Ren renin multiple interactions
increases expression
decreases response to substance
ISO [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
Spironolactone results in increased expression of REN protein
REN protein results in decreased susceptibility to Spironolactone
CTD PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Spironolactone results in decreased expression of SERPINE1 protein CTD PMID:12424430 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
EXP
ISO
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA]
CTD PMID:19429930 PMID:33405908 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] CTD PMID:12668585 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:38,133,333...38,179,932 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] CTD PMID:19333130 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] CTD PMID:19333130 NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Spironolactone results in increased expression of SLCO1A4 mRNA CTD PMID:15919853 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO Spironolactone results in decreased expression of SLCO1B2 mRNA CTD PMID:15919853 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO Spironolactone results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO Spironolactone results in decreased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:17616752 PMID:19333130 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP Spironolactone results in decreased expression of TGFB1 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]
CTD PMID:15130897 PMID:16928621 PMID:25204689 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnc tenascin C multiple interactions EXP Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA] CTD PMID:21135038 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]
CTD PMID:16528473 PMID:17051331 PMID:33359182 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases activity
EXP
ISO
Spironolactone results in increased expression of UGT1A1 mRNA
Spironolactone results in increased activity of UGT1A1 protein
CTD PMID:12818378 PMID:19144771 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Spironolactone results in increased expression of UGT1A2 mRNA CTD PMID:19144771 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression
increases activity
EXP Spironolactone results in increased expression of UGT1A5 mRNA
Spironolactone results in increased activity of UGT1A5 protein
CTD PMID:12818378 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Spironolactone results in increased expression of UGT1A5 mRNA CTD PMID:19144771 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Spironolactone results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C multiple interactions
increases expression
increases activity
EXP [Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein
Spironolactone results in increased expression of UGT1A7 protein
Spironolactone results in increased activity of UGT1A7 protein
CTD PMID:17686906 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO Spironolactone results in increased expression of UGT1A9 mRNA CTD PMID:19144771 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Spironolactone results in increased expression of VEGFA protein CTD PMID:21263376 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Spironolactone results in increased expression of WT1 protein CTD PMID:30734886 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        xenobiotic 18441
          spironolactone 115
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      ketone 16925
                                        oxo steroid 9719
                                          3-oxo steroid 9282
                                            3-oxo-Delta(4) steroid 8424
                                              spironolactone 115
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