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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antimineralocorticoid
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Accession:CHEBI:50843 term browser browse the term
Definition:A compound which inhibits or antagonizes the biosynthesis or actions of mineralocorticoids, a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance.


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drospirenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO drospirenone results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO drospirenone binds to and results in increased activity of AR protein
drospirenone affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased activity of CYP17A1 protein CTD PMID:17418832 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO drospirenone inhibits the reaction [HSD11B1 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] CTD PMID:28257955 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of HSPD1 mRNA CTD PMID:19631796 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in decreased expression of NOS2 mRNA CTD PMID:19631796 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding EXP drospirenone binds to NR3C2 protein CTD PMID:1493716 PMID:14667981 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pgr progesterone receptor affects binding ISO drospirenone binds to PGR protein CTD PMID:14667981 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Serpina6 serpin family A member 6 multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SERPINA6 protein CTD PMID:11245553 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
JBrowse link
G Shbg sex hormone binding globulin multiple interactions ISO [Ethinyl Estradiol co-treated with drospirenone] results in increased expression of SHBG protein CTD PMID:11245553 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 mRNA]; eplerenone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:17596522 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Cat catalase increases expression EXP eplerenone results in increased expression of CAT protein CTD PMID:17324946 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd80 Cd80 molecule multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of CD80 mRNA] CTD PMID:27773435 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 mRNA]; eplerenone inhibits the reaction [Aldosterone results in decreased expression of CDH1 protein] CTD PMID:17596522 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL1A1 mRNA] CTD PMID:27773435 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of COL3A1 mRNA] CTD PMID:27773435 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]
eplerenone results in decreased expression of COL4A1 mRNA; eplerenone results in decreased expression of COL4A1 protein
CTD PMID:18682491 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
EXP eplerenone results in decreased expression of CYBA mRNA
[trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA
CTD PMID:17324946 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases abundance
increases metabolic processing
ISO CYP3A5 protein results in increased abundance of Eplerenone metabolite
CYP3A5 protein results in increased metabolism of Eplerenone
CTD PMID:31408697 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [trandolapril co-treated with eplerenone] results in decreased expression of FN1 protein CTD PMID:17324946 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Il18 interleukin 18 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:17596522 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:17596522 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression
multiple interactions
EXP eplerenone results in decreased expression of NCF1 mRNA; eplerenone results in decreased expression of NCF1 protein
[trandolapril co-treated with eplerenone] results in decreased expression of NCF1 mRNA; [trandolapril co-treated with eplerenone] results in decreased expression of NCF1 protein
CTD PMID:17324946 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases activity
increases expression
decreases expression
EXP [Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA
eplerenone results in increased activity of NOS3 protein
eplerenone results in increased expression of NOS3 mRNA
Eplerenone results in decreased expression of NOS3 mRNA; Eplerenone results in decreased expression of NOS3 protein
CTD PMID:15974890 PMID:20571278 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP eplerenone binds to and results in decreased activity of NR3C2 protein CTD PMID:15974890 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:35,314,431...35,321,458
Ensembl chr 6:35,314,444...35,321,667
JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of OXSR1 protein CTD PMID:22949526 NCBI chr 8:127,920,349...128,009,951
Ensembl chr 8:127,920,349...128,009,951
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
eplerenone results in decreased expression of SERPINE1 mRNA; eplerenone results in decreased expression of SERPINE1 protein
CTD PMID:18682491 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of SLC12A3 protein; eplerenone inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 PMID:22949526 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions EXP eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA] CTD PMID:17596522 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP eplerenone results in increased expression of SOD1 protein CTD PMID:17324946 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP eplerenone results in increased expression of SOD2 protein CTD PMID:17324946 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stk39 serine threonine kinase 39 multiple interactions ISO [eplerenone co-treated with Sodium Chloride, Dietary] results in decreased phosphorylation of STK39 protein CTD PMID:22949526 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [Eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [Eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [Eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Eplerenone inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TGFB1 mRNA]; Eplerenone inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]
eplerenone results in decreased expression of TGFB1 mRNA; eplerenone results in decreased expression of TGFB1 protein
CTD PMID:18682491 PMID:27773435 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions
EXP eplerenone results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
CTD PMID:18682491 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Eplerenone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNF mRNA] CTD PMID:27773435 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
spironolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Spironolactone results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
ISO Spironolactone results in increased expression of ABCB1 mRNA; Spironolactone results in increased expression of ABCB1 protein
Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCB1 protein]; NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]
CTD PMID:21459122 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; [Spironolactone results in increased expression of ABCC2 protein] which results in increased transport of S-(2,4-dinitrophenyl)glutathione; Ketoconazole inhibits the reaction [Spironolactone results in increased expression of ABCC2 mRNA]
Spironolactone results in increased expression of ABCC2 mRNA; Spironolactone results in increased expression of ABCC2 protein
CTD PMID:15652244 PMID:17686906 PMID:19766108 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO
EXP
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA
[Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC3 protein
Spironolactone results in increased expression of ABCC3 mRNA
CTD PMID:15833929 PMID:17686906 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Spironolactone results in decreased expression of ABCG5 mRNA CTD PMID:15683829 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Spironolactone results in decreased expression of ABCG8 mRNA CTD PMID:15683829 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
affects expression
decreases expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA]
Spironolactone affects the expression of ACE protein
Spironolactone results in decreased expression of ACE protein
CTD PMID:15932931 PMID:18586661 PMID:30734886 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression
affects expression
EXP Spironolactone results in increased expression of ACE2 protein
Spironolactone affects the expression of ACE2 protein
CTD PMID:18586661 PMID:30734886 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:25204689 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]
Spironolactone inhibits the reaction [Letrozole results in decreased expression of ADIPOQ protein]
CTD PMID:29782964 PMID:33359182 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
increases expression
EXP
ISO
Spironolactone results in decreased expression of AGT protein modified form
Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]
Spironolactone results in increased expression of AGT protein modified form
CTD PMID:7357812 PMID:9595286 PMID:19114643 PMID:23288202 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression EXP Spironolactone results in decreased expression of AGTR1 protein CTD PMID:18586661 PMID:19114643 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Spironolactone results in increased expression of AGTR2 protein CTD PMID:18586661 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Spironolactone results in increased expression of AHR mRNA CTD PMID:17627975 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Spironolactone results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 NCBI chr 5:158,090,238...158,115,725
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Spironolactone results in increased expression of ALDH8A1 mRNA CTD PMID:17998271 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Aqp2 aquaporin 2 multiple interactions EXP [Spironolactone co-treated with Lithium] affects the expression of AQP2 protein CTD PMID:16159898 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO
EXP
Spironolactone binds to AR protein
Spironolactone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Spironolactone inhibits the reaction [Metribolone results in increased activity of AR protein]; Spironolactone inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]
CTD PMID:10053169 PMID:14565775 PMID:14751673 PMID:15589981 PMID:18324785 PMID:29162470 PMID:33049310 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation
decreases expression
EXP Spironolactone results in increased phosphorylation of BAD protein
Spironolactone results in decreased expression of BAD protein
CTD PMID:19114643 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Spironolactone results in increased expression of BCL2 protein CTD PMID:19114643 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP Spironolactone results in increased expression of BCL2L1 protein CTD PMID:19114643 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Becn1 beclin 1 increases expression EXP Spironolactone results in increased expression of BECN1 protein CTD PMID:30734886 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases activity
EXP
ISO
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]
Spironolactone results in increased activity of CASP3 protein
Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein]
Spironolactone results in decreased activity of CASP3 protein
CTD PMID:19114643 PMID:20609311 PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]] CTD PMID:20609311 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]] CTD PMID:20609311 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of CCN2 protein] CTD PMID:17278980 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Spironolactone inhibits the reaction [Desoxycorticosterone Acetate affects the localization of CDKN2A protein]; Spironolactone inhibits the reaction [Desoxycorticosterone Acetate results in increased expression of CDKN2A mRNA] CTD PMID:18504326 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Ces2c carboxylesterase 2C increases expression ISO Spironolactone results in increased expression of CES2C mRNA CTD PMID:22429928 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression ISO Spironolactone results in decreased expression of COL3A1 protein alternative form; Spironolactone results in decreased expression of COL3A1 protein modified form CTD PMID:9302344 PMID:11300427 PMID:15842549 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Spironolactone results in decreased expression of CXCL1 mRNA CTD PMID:21135038 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression EXP Spironolactone results in decreased expression of CYBB protein CTD PMID:19114643 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression EXP Spironolactone results in increased expression of CYP11B2 mRNA CTD PMID:15218317 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO Spironolactone results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions
increases expression
EXP NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:11752103 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP Spironolactone results in decreased activity of CYP7A1 protein CTD PMID:15652244 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression EXP Spironolactone results in increased expression of ETS1 protein CTD PMID:20228418 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in decreased secretion of FSHB protein] CTD PMID:31295448 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gas6 growth arrest specific 6 multiple interactions
affects expression
EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of GAS6 protein]
Spironolactone affects the expression of GAS6 protein
CTD PMID:19564549 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 PMID:25204689 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Spironolactone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in decreased expression of GSR protein] CTD PMID:31295448 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Spironolactone results in increased expression of GSTM1 mRNA CTD PMID:18723825 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Spironolactone results in increased expression of GSTM2 mRNA CTD PMID:18723825 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Spironolactone results in increased expression of GSTM3 mRNA; Spironolactone results in increased expression of GSTM5 mRNA CTD PMID:18723825 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression EXP Spironolactone results in increased expression of HIF1A protein CTD PMID:20228418 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Spironolactone results in increased expression of HMOX1 mRNA; Spironolactone results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpse heparanase multiple interactions EXP [Spironolactone co-treated with Lisinopril] inhibits the reaction [Doxorubicin results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of HPSE protein]; Spironolactone inhibits the reaction [Doxorubicin results in increased expression of HPSE protein] CTD PMID:19429930 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions ISO Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of HSD11B1 mRNA]] CTD PMID:30993381 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression EXP Spironolactone results in decreased expression of HSD11B2 mRNA CTD PMID:17587755 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Ifng interferon gamma multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein] CTD PMID:17051331 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein] CTD PMID:17051331 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [Spironolactone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein
Spironolactone results in increased expression of IL1B protein
CTD PMID:16528473 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein] CTD PMID:17051331 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of IL6 protein]
Spironolactone inhibits the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]; Spironolactone inhibits the reaction [Corticosterone promotes the reaction [[trimethyltin chloride results in increased abundance of trimethyltin] which results in increased expression of IL6 mRNA]]
CTD PMID:17051331 PMID:30993381 PMID:33359182 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Spironolactone inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] CTD PMID:15932931 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in increased secretion of LHB protein] CTD PMID:31295448 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression EXP Spironolactone results in increased expression of MAP1LC3B protein CTD PMID:30734886 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Spironolactone results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Spironolactone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased expression of MT1A protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MT1A mRNA] CTD PMID:17616752 PMID:19333130 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of MTF1 protein] CTD PMID:19333130 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
Ensembl chr 5:142,797,366...142,842,122
JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [Spironolactone results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 decreases expression EXP Spironolactone results in decreased expression of NCF2 protein CTD PMID:19114643 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:25204689 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Spironolactone inhibits reaction [sodium chloride decreases expression of Nphs1 mRNA in hyperaldosteronic kidney] RGD PMID:24108235 RGD:38599161 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin increases expression EXP Spironolactone results in increased expression of NPHS2 protein CTD PMID:30734886 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Nppa natriuretic peptide A decreases expression
multiple interactions
ISO
EXP
Spironolactone results in decreased expression of NPPA protein; Spironolactone results in decreased expression of NPPA protein modified form
Spironolactone inhibits the reaction [Aldosterone results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Spironolactone inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:9595286 PMID:11300427 PMID:19966502 PMID:23288202 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B decreases expression
multiple interactions
ISO Spironolactone results in decreased expression of NPPB protein
[carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein
CTD PMID:11300427 PMID:21378469 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
ISO
EXP
[Spironolactone binds to NR1I2 protein] which results in increased expression of ABCC3 mRNA; Spironolactone binds to and results in increased activity of NR1I2 protein
NR1I2 protein promotes the reaction [Spironolactone results in increased expression of CYP3A23-3A1 mRNA]
Spironolactone results in increased expression of NR1I2 mRNA
NR1I2 affects the reaction [Spironolactone results in increased expression of ABCB1 protein]; Spironolactone binds to and results in increased activity of NR1I2 protein
CTD PMID:11752103 PMID:15833929 PMID:15919853 PMID:16054614 PMID:17627975 PMID:21459122 PMID:33049310 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 decreases expression
multiple interactions
increases activity
EXP
ISO
Spironolactone results in decreased expression of NR3C2 mRNA; Spironolactone results in decreased expression of NR3C2 protein
Spironolactone inhibits the reaction [Aldosterone affects the ubiquitination of NR3C2 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]
Spironolactone results in increased activity of NR3C2 protein
Spironolactone inhibits the reaction [Phenylephrine results in increased localization of NR3C2 protein]
CTD PMID:15780662 PMID:17587755 PMID:19114643 PMID:19966502 PMID:22798426 PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of OLR1 protein] CTD PMID:20508287 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Spironolactone results in increased expression of PLAT protein CTD PMID:12424430 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Spironolactone inhibits the reaction [POMC protein modified form results in decreased abundance of Potassium]; Spironolactone inhibits the reaction [POMC protein modified form results in increased abundance of Sodium] CTD PMID:10100081 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pon3 paraoxonase 3 increases hydrolysis ISO PON3 protein results in increased hydrolysis of Spironolactone CTD PMID:15772423 NCBI chr 4:30,311,981...30,338,679
Ensembl chr 4:30,311,982...30,338,679
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO Spironolactone results in increased expression of PPARA mRNA CTD PMID:17627975 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prl prolactin multiple interactions EXP Spironolactone inhibits the reaction [Letrozole results in increased expression of PRL protein] CTD PMID:33359182 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression EXP Spironolactone results in decreased expression of RAC1 protein CTD PMID:19114643 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Ren renin multiple interactions
increases expression
decreases response to substance
ISO [Clonidine co-treated with Spironolactone] results in decreased expression of REN protein
Spironolactone results in increased expression of REN protein
REN protein results in decreased susceptibility to Spironolactone
CTD PMID:6998872 PMID:9595286 PMID:12014310 PMID:20016520 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Serpine1 serpin family E member 1 decreases expression ISO Spironolactone results in decreased expression of SERPINE1 protein CTD PMID:12424430 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
EXP
ISO
Spironolactone inhibits the reaction [Aldosterone results in increased expression of SGK1 mRNA]
Fulvestrant inhibits the reaction [Spironolactone results in increased expression of SGK1 mRNA]
CTD PMID:19429930 PMID:33405908 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased activity of SLC12A2 protein] CTD PMID:12668585 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:21641380 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc30a1 solute carrier family 30 member 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC30A1 mRNA] CTD PMID:19333130 NCBI chr13:110,677,810...110,681,683
Ensembl chr13:110,677,810...110,681,683
JBrowse link
G Slc39a1 solute carrier family 39 member 1 multiple interactions EXP Spironolactone inhibits the reaction [Aldosterone results in increased expression of SLC39A1 mRNA] CTD PMID:19333130 NCBI chr 2:189,609,766...189,615,367
Ensembl chr 2:189,609,800...189,615,366
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Spironolactone results in increased expression of SLCO1A4 mRNA CTD PMID:15919853 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO Spironolactone results in decreased expression of SLCO1B2 mRNA CTD PMID:15919853 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO Spironolactone results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 NCBI chr 8:111,495,443...111,577,320
Ensembl chr 8:111,495,331...111,577,833
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO Spironolactone results in decreased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in decreased activity of SOD1 protein]; Spironolactone inhibits the reaction [[Aldosterone co-treated with Sodium Chloride co-treated with Potassium Chloride] results in increased activity of SOD1 protein]; Spironolactone inhibits the reaction [Aldosterone results in increased activity of SOD1 protein] CTD PMID:17616752 PMID:19333130 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
EXP Spironolactone results in decreased expression of TGFB1 protein
Spironolactone inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; Spironolactone inhibits the reaction [Aldosterone results in increased secretion of TGFB1 protein]
CTD PMID:15130897 PMID:16928621 PMID:25204689 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnc tenascin C multiple interactions EXP Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA] CTD PMID:21135038 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Spironolactone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Spironolactone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Spironolactone inhibits the reaction [Letrozole results in increased expression of TNF protein]
CTD PMID:16528473 PMID:17051331 PMID:33359182 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases activity
EXP
ISO
Spironolactone results in increased expression of UGT1A1 mRNA
Spironolactone results in increased activity of UGT1A1 protein
CTD PMID:12818378 PMID:19144771 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Spironolactone results in increased expression of UGT1A2 mRNA CTD PMID:19144771 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression
increases activity
EXP Spironolactone results in increased expression of UGT1A5 mRNA
Spironolactone results in increased activity of UGT1A5 protein
CTD PMID:12818378 NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Spironolactone results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C multiple interactions
increases expression
increases activity
EXP [Ethinyl Estradiol co-treated with Spironolactone] results in increased activity of UGT1A7 protein; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of UGT1A7 protein
Spironolactone results in increased expression of UGT1A7 protein
Spironolactone results in increased activity of UGT1A7 protein
CTD PMID:17686906 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO Spironolactone results in increased expression of UGT1A9 mRNA CTD PMID:19144771 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Spironolactone results in increased expression of VEGFA protein CTD PMID:21263376 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Spironolactone results in increased expression of WT1 protein CTD PMID:30734886 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        pharmacological role 18842
          antagonist 16280
            hormone antagonist 11584
              antimineralocorticoid 139
                aldosterone antagonist + 139
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pharmaceutical 19321
          drug 19321
            receptor modulator 18878
              hormone receptor modulator 18867
                hormone antagonist 11584
                  antimineralocorticoid 139
                    aldosterone antagonist + 139
paths to the root